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UniProtKB - P29803 (ODPAT_HUMAN)

Entry version 188 (25 May 2022)
Sequence version 1 (01 Apr 1993)
Previous versions | rss
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Protein

Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

Gene

PDHA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

thiamine diphosphate

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Pyruvate dehydrogenase activity is inhibited by phosphorylation of PDHA2; it is reactivated by dephosphorylation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism, Tricarboxylic acid cycle
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P29803

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-204174, Regulation of pyruvate dehydrogenase (PDH) complex
R-HSA-389661, Glyoxylate metabolism and glycine degradation
R-HSA-5362517, Signaling by Retinoic Acid
R-HSA-70268, Pyruvate metabolism

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P29803

SIGNOR Signaling Network Open Resource

More...SIGNORi		P29803

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC:1.2.4.1)
Alternative name(s):
PDHE1-A type II
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDHA2
Synonyms:PDHAL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8807, PDHA2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		179061, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P29803

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163114

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi230S → A: Slightly reduces enzyme activity. 1 Publication1
Mutagenesisi291S → A: Strongly reduces enzyme activity. Increases enzyme activity in stem cells. 2 Publications1
Mutagenesisi291S → E or D: Abolishes enzyme activity. Increases neuronal cell death in response to glutamate excitotoxicity. 2 Publications1
Mutagenesisi293S → A: Increases enzyme activity in stem cells. 1 Publication1
Mutagenesisi293S → D: Abolishes enzyme activity. Increases neuronal cell death in response to glutamate excitotoxicity. 1 Publication1
Mutagenesisi298S → A: Slightly reduces enzyme activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5161

MalaCards human disease database

More...MalaCardsi		PDHA2

Open Targets

More...OpenTargetsi		ENSG00000163114

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33151

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P29803, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00157, NADH

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PDHA2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 27MitochondrionBy similarityAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002044728 – 388Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrialAdd BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei291Phosphoserine; by PDK1, PDK2, PDK3 and PDK42 Publications1
Modified residuei293Phosphoserine1 Publication1
Modified residuei298Phosphoserine; by PDK31 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-291, Ser-293 and Ser-298 by PDK family kinases inactivates the enzyme; for this phosphorylation at a single site is sufficient. Phosphorylation at Ser-293 interferes with access to active site, and thereby inactivates the enzyme. Dephosphorylation at all three sites, i.e. at Ser-291, Ser-293 and Ser-298, is required for reactivation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P29803

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P29803

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P29803

MaxQB - The MaxQuant DataBase

More...MaxQBi		P29803

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P29803

PeptideAtlas

More...PeptideAtlasi		P29803

PRoteomics IDEntifications database

More...PRIDEi		P29803

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54610

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P29803

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P29803

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis. Expressed in postmeiotic spermatogenic cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163114, Expressed in testis and 28 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P29803, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163114, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two PDHA2 and two PDHB subunits. The heterotetramer interacts with DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111187, 19 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6242, Mitochondrial pyruvate dehydrogenase complex, testis-specific variant

Protein interaction database and analysis system

More...IntActi		P29803, 9 interactors

Molecular INTeraction database

More...MINTi		P29803

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295266

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P29803, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P29803

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P29803

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0225, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063174

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_029393_5_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P29803

Identification of Orthologs from Complete Genome Data

More...OMAi		FGMPGVT

Database of Orthologous Groups

More...OrthoDBi		871160at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P29803

TreeFam database of animal gene trees

More...TreeFami		TF300742

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001017, DH_E1
IPR017597, Pyrv_DH_E1_asu_subgrp-y
IPR029061, THDP-binding

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00676, E1_dh, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52518, SSF52518, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR03182, PDH_E1_alph_y, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P29803-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAAFISRVL RRVAQKSARR VLVASRNSSN DATFEIKKCD LYLLEEGPPV 
        60         70         80         90        100
TTVLTRAEGL KYYRMMLTVR RMELKADQLY KQKFIRGFCH LCDGQEACCV 
       110        120        130        140        150
GLEAGINPSD HVITSYRAHG VCYTRGLSVR SILAELTGRR GGCAKGKGGS 
       160        170        180        190        200
MHMYTKNFYG GNGIVGAQGP LGAGIALACK YKGNDEICLT LYGDGAANQG 
       210        220        230        240        250
QIAEAFNMAA LWKLPCVFIC ENNLYGMGTS TERAAASPDY YKRGNFIPGL 
       260        270        280        290        300
KVDGMDVLCV REATKFAANY CRSGKGPILM ELQTYRYHGH SMSDPGVSYR 
       310        320        330        340        350
TREEIQEVRS KRDPIIILQD RMVNSKLATV EELKEIGAEV RKEIDDAAQF 
       360        370        380 
ATTDPEPHLE ELGHHIYSSD SSFEVRGANP WIKFKSVS
Length:388
Mass (Da):42,933
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i075B6CFF6DC73CC5
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH94760 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti127L → P in AAH66953 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034359376R → G. Corresponds to variant dbSNP:rs17024795Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M86808 Genomic DNA Translation: AAA60232.1
AK313872 mRNA Translation: BAG36600.1
BC030697 mRNA Translation: AAH30697.3
BC066953 mRNA Translation: AAH66953.2
BC094760 mRNA Translation: AAH94760.1 Different initiation.
BC119656 mRNA Translation: AAI19657.1
BC119657 mRNA Translation: AAI19658.1
BC127637 mRNA Translation: AAI27638.1
BC127638 mRNA Translation: AAI27639.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3644.1

Protein sequence database of the Protein Information Resource

More...PIRi		A37104, DEHUPT

NCBI Reference Sequences

More...RefSeqi		NP_005381.1, NM_005390.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295266.6; ENSP00000295266.4; ENSG00000163114.6

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5161

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5161

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000295266.6; ENSP00000295266.4; NM_005390.5; NP_005381.1

UCSC genome browser

More...UCSCi		uc003htr.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86808 Genomic DNA Translation: AAA60232.1
AK313872 mRNA Translation: BAG36600.1
BC030697 mRNA Translation: AAH30697.3
BC066953 mRNA Translation: AAH66953.2
BC094760 mRNA Translation: AAH94760.1 Different initiation.
BC119656 mRNA Translation: AAI19657.1
BC119657 mRNA Translation: AAI19658.1
BC127637 mRNA Translation: AAI27638.1
BC127638 mRNA Translation: AAI27639.1
CCDSiCCDS3644.1
PIRiA37104, DEHUPT
RefSeqiNP_005381.1, NM_005390.4

3D structure databases

AlphaFoldDBiP29803
SMRiP29803
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111187, 19 interactors
ComplexPortaliCPX-6242, Mitochondrial pyruvate dehydrogenase complex, testis-specific variant
IntActiP29803, 9 interactors
MINTiP29803
STRINGi9606.ENSP00000295266

Chemistry databases

DrugBankiDB00157, NADH

PTM databases

iPTMnetiP29803
PhosphoSitePlusiP29803

Genetic variation databases

BioMutaiPDHA2

Proteomic databases

EPDiP29803
jPOSTiP29803
MassIVEiP29803
MaxQBiP29803
PaxDbiP29803
PeptideAtlasiP29803
PRIDEiP29803
ProteomicsDBi54610

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25781, 155 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		5161

Genome annotation databases

EnsembliENST00000295266.6; ENSP00000295266.4; ENSG00000163114.6
GeneIDi5161
KEGGihsa:5161
MANE-SelectiENST00000295266.6; ENSP00000295266.4; NM_005390.5; NP_005381.1
UCSCiuc003htr.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5161
DisGeNETi5161

GeneCards: human genes, protein and diseases

More...GeneCardsi		PDHA2
HGNCiHGNC:8807, PDHA2
HPAiENSG00000163114, Tissue enriched (testis)
MalaCardsiPDHA2
MIMi179061, gene
neXtProtiNX_P29803
OpenTargetsiENSG00000163114
PharmGKBiPA33151
VEuPathDBiHostDB:ENSG00000163114

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0225, Eukaryota
GeneTreeiENSGT00530000063174
HOGENOMiCLU_029393_5_2_1
InParanoidiP29803
OMAiFGMPGVT
OrthoDBi871160at2759
PhylomeDBiP29803
TreeFamiTF300742

Enzyme and pathway databases

PathwayCommonsiP29803
ReactomeiR-HSA-204174, Regulation of pyruvate dehydrogenase (PDH) complex
R-HSA-389661, Glyoxylate metabolism and glycine degradation
R-HSA-5362517, Signaling by Retinoic Acid
R-HSA-70268, Pyruvate metabolism
SignaLinkiP29803
SIGNORiP29803

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5161, 13 hits in 1074 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PDHA2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Pyruvate_dehydrogenase_(lipoamide)_alpha_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5161
PharosiP29803, Tbio

Protein Ontology

More...PROi		PR:P29803
RNActiP29803, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163114, Expressed in testis and 28 other tissues
GenevisibleiP29803, HS

Family and domain databases

InterProiView protein in InterPro
IPR001017, DH_E1
IPR017597, Pyrv_DH_E1_asu_subgrp-y
IPR029061, THDP-binding
PfamiView protein in Pfam
PF00676, E1_dh, 1 hit
SUPFAMiSSF52518, SSF52518, 1 hit
TIGRFAMsiTIGR03182, PDH_E1_alph_y, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiODPAT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29803
Secondary accession number(s): B2R9Q3
, Q0VDI5, Q4VC02, Q6NXQ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 25, 2022
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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