UniProtKB - P29774 (ETS3_DROME)
Protein
DNA-binding protein D-ETS-3
Gene
Ets65A
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 317 – 397 | ETSPROSITE-ProRule annotationAdd BLAST | 81 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- cell differentiation Source: GO_Central
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
Reactomei | R-DME-2559585, Oncogene Induced Senescence |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-binding protein D-ETS-3 |
Gene namesi | Name:Ets65A Synonyms:ETS3 ORF Names:CG7018 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0005658, Ets65A |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204107 | 1 – 490 | DNA-binding protein D-ETS-3Add BLAST | 490 |
Proteomic databases
PaxDbi | P29774 |
Expressioni
Tissue specificityi
Embryonic ventral nervous system, higher in the thoracic than abdominal segments.1 Publication
Developmental stagei
Expressed throughout development.1 Publication
Gene expression databases
Bgeei | FBgn0005658, Expressed in central nervous system and 32 other tissues |
ExpressionAtlasi | P29774, baseline and differential |
Genevisiblei | P29774, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 64155, 71 interactors |
IntActi | P29774, 71 interactors |
STRINGi | 7227.FBpp0076762 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 188 – 280 | Ser-richAdd BLAST | 93 |
Sequence similaritiesi
Belongs to the ETS family.Curated
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
HOGENOMi | CLU_022965_0_0_1 |
InParanoidi | P29774 |
OMAi | IKHDPHT |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR035575, Fli-1 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849:SF161, PTHR11849:SF161, 1 hit |
Pfami | View protein in Pfam PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform A (identifier: P29774-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYENSCSYQT ALDLKRVSPP TLAQVKTEEC LALGQCSPEW TSYRFHQSTF
60 70 80 90 100
EQLKQSVEKA KAALQDRSSF FGASSAFSDI YSSQRLTDSL DTLPVQSGNG
110 120 130 140 150
GGNCLGLPHN PNVGVGVAGV LNYNAVSSST AGVLSSSGNG VQRHRLDTLQ
160 170 180 190 200
PPSGCSPAVT QHGVITSSAG QVTSGTLDAV SAAPALPSLT ASSSSHVEHK
210 220 230 240 250
VRADKSTLDC ATTSSHAAAP SSSSSASDHQ QGRISGSKSS NTSGTGGGAS
260 270 280 290 300
ASGGGGSALY SSYKSSWGSH SSTQSQGYSS NALGIKHDPH SQLRQPDPYQ
310 320 330 340 350
MFGPTSSRLA SSGSGQIQLW QFLLELLSDS NNASCITWEG TNGEFKLTDP
360 370 380 390 400
DEVARRWGER KSKPNMNYDK LSRALRYYYD KNIMTKVHGK RYAYKFDFQG
410 420 430 440 450
LAAATQPAAS DPTYKYQSDL FMTPYHHSAK LSSFMSPHHG MTSSSASIFP
460 470 480 490
SAASWGNWGS PATNLYQPHS MSHVTPSHVA PHLSSYPHYA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0S0WIJ8 | A0A0S0WIJ8_DROME | Ets at 65A, isoform D | Ets65A CG13294, CG6882, D-Ets-3, D-ets-3, Dmel\CG7018 | 657 | Annotation score: | ||
A0A0S0WNC2 | A0A0S0WNC2_DROME | Ets at 65A, isoform E | Ets65A CG13294, CG6882, D-Ets-3, D-ets-3, Dmel\CG7018 | 728 | Annotation score: | ||
A0A0U1RFE7 | A0A0U1RFE7_DROME | Ets at 65A, isoform C | Ets65A CG13294, CG6882, D-Ets-3, D-ets-3, Dmel\CG7018 | 499 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001470 | 1 – 233 | Missing in isoform B. 1 PublicationAdd BLAST | 233 | |
Alternative sequenceiVSP_001471 | 234 – 260 | ISGSK…GSALY → MLDIKSSADYLSRSTGSFSN FSMLFAD in isoform B. 1 PublicationAdd BLAST | 27 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF50697.2 AE014296 Genomic DNA Translation: AAF50696.2 AY060316 mRNA Translation: AAL25355.1 AY060250 mRNA Translation: AAR88562.1 BT003453 mRNA Translation: AAO39456.1 M88473 Genomic DNA Translation: AAA28450.2 |
PIRi | S28820 |
RefSeqi | NP_523945.2, NM_079221.3 [P29774-2] NP_729142.1, NM_168156.2 [P29774-1] |
Genome annotation databases
EnsemblMetazoai | FBtr0077054; FBpp0076762; FBgn0005658 [P29774-1] FBtr0077055; FBpp0076763; FBgn0005658 [P29774-2] |
GeneIDi | 38700 |
KEGGi | dme:Dmel_CG7018 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF50697.2 AE014296 Genomic DNA Translation: AAF50696.2 AY060316 mRNA Translation: AAL25355.1 AY060250 mRNA Translation: AAR88562.1 BT003453 mRNA Translation: AAO39456.1 M88473 Genomic DNA Translation: AAA28450.2 |
PIRi | S28820 |
RefSeqi | NP_523945.2, NM_079221.3 [P29774-2] NP_729142.1, NM_168156.2 [P29774-1] |
3D structure databases
SMRi | P29774 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 64155, 71 interactors |
IntActi | P29774, 71 interactors |
STRINGi | 7227.FBpp0076762 |
Proteomic databases
PaxDbi | P29774 |
Genome annotation databases
EnsemblMetazoai | FBtr0077054; FBpp0076762; FBgn0005658 [P29774-1] FBtr0077055; FBpp0076763; FBgn0005658 [P29774-2] |
GeneIDi | 38700 |
KEGGi | dme:Dmel_CG7018 |
Organism-specific databases
CTDi | 38700 |
FlyBasei | FBgn0005658, Ets65A |
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
HOGENOMi | CLU_022965_0_0_1 |
InParanoidi | P29774 |
OMAi | IKHDPHT |
Enzyme and pathway databases
Reactomei | R-DME-2559585, Oncogene Induced Senescence |
Miscellaneous databases
BioGRID-ORCSi | 38700, 0 hits in 3 CRISPR screens |
GenomeRNAii | 38700 |
PROi | PR:P29774 |
Gene expression databases
Bgeei | FBgn0005658, Expressed in central nervous system and 32 other tissues |
ExpressionAtlasi | P29774, baseline and differential |
Genevisiblei | P29774, DM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR035575, Fli-1 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849:SF161, PTHR11849:SF161, 1 hit |
Pfami | View protein in Pfam PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ETS3_DROME | |
Accessioni | P29774Primary (citable) accession number: P29774 Secondary accession number(s): Q86P68 Q9VRU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | February 28, 2003 | |
Last modified: | February 10, 2021 | |
This is version 162 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families