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Protein

Sialidase

Gene
N/A
Organism
Clostridium septicum
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sialidases have been suggested to be pathogenic factors in microbial infections.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei396SubstrateBy similarity1
Active sitei421Proton acceptorBy similarity1
Binding sitei688SubstrateBy similarity1
Binding sitei873SubstrateSequence analysis1
Active sitei912NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiCBM32 Carbohydrate-Binding Module Family 32
GH33 Glycoside Hydrolase Family 33

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase (EC:3.2.1.18)
Alternative name(s):
Neuraminidase
OrganismiClostridium septicum
Taxonomic identifieri1504 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001203127 – 1014SialidaseAdd BLAST988

Proteomic databases

PRIDEiP29767

Structurei

3D structure databases

ProteinModelPortaliP29767
SMRiP29767
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 186F5/8 type CPROSITE-ProRule annotationAdd BLAST148
Repeati431 – 442BNR 1Add BLAST12
Repeati563 – 574BNR 2Add BLAST12
Repeati627 – 638BNR 3Add BLAST12
Repeati700 – 711BNR 4Add BLAST12

Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR004124 Glyco_hydro_33_N
IPR011040 Sialidase
IPR026856 Sialidase_fam
IPR036278 Sialidase_sf
PANTHERiPTHR10628 PTHR10628, 1 hit
PfamiView protein in Pfam
PF13088 BNR_2, 1 hit
PF00754 F5_F8_type_C, 1 hit
PF02973 Sialidase, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF49899 SSF49899, 1 hit
SSF50939 SSF50939, 2 hits
PROSITEiView protein in PROSITE
PS50022 FA58C_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29767-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKKIMSIL VSAFLITNLS SNIIFADIKE NVYINQYSEG NRSQPIAEKL
60 70 80 90 100
VPRSEIQASA TSALTGEGPE KAIDGNTSTL WHTPWAGVDI QINPQSLTLK
110 120 130 140 150
LGKTRNISSI CVTPRQEGTN GMITDYKIYS GDDVIAEGKW KSDSSDKYVV
160 170 180 190 200
FDNPISTDNI RIEAISTVGD ENNKHASIAE VEVYELADTP VKLAESNNKV
210 220 230 240 250
INNGNGGNYE GDISEISLLE EGTAIIRFTN NGSSLFSISN NERTNEHFHV
260 270 280 290 300
YINGGAIGYE LRKQSGNLAT GSVNKALNAG INTIAFKAEK GKGYSIYLNG
310 320 330 340 350
EKILTSSSIT ANFLSTLEGL NTLSLGKTDR PSGSNEYNFT GEIDFFELYS
360 370 380 390 400
KPLADRYLKE RTGETTSKDL PFPEGAVKTE PVDIFTPGEL GSNNFRIPAL
410 420 430 440 450
YTTKDGTVLA SIDVRKGGGH DAPNNIDTGI KRSTDGGVTW DEGKIILDYP
460 470 480 490 500
GASSAIDTSL LQDDETGRIF LIVTHFAEGY GFGNSKTGSG YVEIEGKRYL
510 520 530 540 550
KLLGANDTIY TVREGVVYDS NGEATNYTVD NNNELYENGN RIGNVLLSNS
560 570 580 590 600
PLKVMGTSFL SLIYSDDDGQ TWSDPIDLNK EVKTDWMRFL GTGPGKGHQI
610 620 630 640 650
KTGRYAGRLL FPVYLTNASG FQSSAVIYSD DNGATWNIGE TATDGRLMDN
660 670 680 690 700
GDRASAETIT TNTSGGVGQL TECQVVEMPN GQLKMFMRNT GGNSGRVRIA
710 720 730 740 750
TSFDGGATWE DDVVRDENIK EPYCQLSVIN YSQKIDGKDA IIFAIPDANY
760 770 780 790 800
PNRVNGTVRV GLITENGSYE NGEPRYDIEW RYNKVVAPGT YGYSCLSEMP
810 820 830 840 850
NGEIGLFYEG RGSRQMSFTR MNIDYLKADL LQDVPAANIK SYTTNSENNI
860 870 880 890 900
YDPGDKISLN VTFDQTVSLI GDRTITADIG GKEVLLTLAN SKGGSEYTFE
910 920 930 940 950
GTVPADISNG NYTITIKGKS GLKIVNVVNK VTDITEDRNT GLNVQVGEEV
960 970 980 990 1000
QSVDKTLLQD LVDSTSNLIK EDYTEESWIL YEKALEVANK FLVNEIAVQE
1010
EVDAAKPTLE NAYK
Length:1,014
Mass (Da):110,653
Last modified:April 1, 1993 - v1
Checksum:iC4F49233473A2FAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63266 Genomic DNA Translation: CAA44916.1
PIRiS15994 NMCLSS

Entry informationi

Entry nameiNANH_CLOSE
AccessioniPrimary (citable) accession number: P29767
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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