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Protein

Type-1A angiotensin II receptor

Gene

Agtr1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1A angiotensin II receptor
Alternative name(s):
Angiotensin II type-1A receptor
Short name:
AT1A
Gene namesi
Name:Agtr1a
Synonyms:Agtr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:87964 Agtr1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 52Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini53 – 64CytoplasmicSequence analysisAdd BLAST12
Transmembranei65 – 87Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini88 – 102ExtracellularSequence analysisAdd BLAST15
Transmembranei103 – 124Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini125 – 142CytoplasmicSequence analysisAdd BLAST18
Transmembranei143 – 162Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini163 – 192ExtracellularSequence analysisAdd BLAST30
Transmembranei193 – 214Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini215 – 240CytoplasmicSequence analysisAdd BLAST26
Transmembranei241 – 262Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini263 – 275ExtracellularSequence analysisAdd BLAST13
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 359CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5741

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691551 – 359Type-1A angiotensin II receptorAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi355S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP29754
PRIDEiP29754

PTM databases

iPTMnetiP29754
PhosphoSitePlusiP29754

Expressioni

Gene expression databases

BgeeiENSMUSG00000049115
CleanExiMM_AGTR1A
ExpressionAtlasiP29754 baseline and differential
GenevisibleiP29754 MM

Interactioni

Subunit structurei

Interacts with MAS1 (By similarity). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AgtrapQ9WVK07EBI-765178,EBI-645964

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198029, 3 interactors
CORUMiP29754
IntActiP29754, 2 interactors
MINTiP29754
STRINGi10090.ENSMUSP00000070958

Structurei

3D structure databases

ProteinModelPortaliP29754
SMRiP29754
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000234122
HOVERGENiHBG104998
InParanoidiP29754
KOiK04166
OMAiYTLIWKT
OrthoDBiEOG091G0C1Y
PhylomeDBiP29754
TreeFamiTF330024

Family and domain databases

CDDicd15192 7tmA_AT1R, 1 hit
InterProiView protein in InterPro
IPR000190 ATII_AT1_rcpt
IPR000248 ATII_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00241 ANGIOTENSINR
PR00635 ANGIOTENSN1R
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P29754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNSSTEDG IKRIQDDCPR AGRHSYIFVM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLMAGLAS LPAVIHRNVY FIENTNITVC AFHYESRNST LPIGLGLTKN
210 220 230 240 250
ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFR IIMAIVLFFF
260 270 280 290 300
FSWVPHQIFT FLDVLIQLGV IHDCKIADIV DTAMPITICI AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK KYFLQLLKYI PPKAKSHSSL STKMSTLSYR PSDNMSSAAK

KPASCSEVE
Length:359
Mass (Da):40,856
Last modified:April 1, 1993 - v1
Checksum:i966958A738D8F53E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7T → I (PubMed:1497638).Curated1
Sequence conflicti20 – 21RA → IS (PubMed:1497638).Curated2
Sequence conflicti38I → M (PubMed:1497638).Curated1
Sequence conflicti134M → K (PubMed:1497638).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S37484 Genomic DNA Translation: AAB22269.1
BC036175 mRNA Translation: AAH36175.1
CCDSiCCDS26415.1
PIRiJH0621
RefSeqiNP_796296.1, NM_177322.3
XP_006516597.1, XM_006516534.1
XP_011242566.1, XM_011244264.2
UniGeneiMm.35062

Genome annotation databases

EnsembliENSMUST00000066412; ENSMUSP00000070958; ENSMUSG00000049115
GeneIDi11607
KEGGimmu:11607
UCSCiuc007pyu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAGTRA_MOUSE
AccessioniPrimary (citable) accession number: P29754
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 18, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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