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Protein

Alpha-lactalbumin

Gene

Lalba

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi98 – 109Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMilk protein
Biological processLactose biosynthesis
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-5653890 Lactose synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-lactalbumin
Alternative name(s):
Lactose synthase B protein
Gene namesi
Name:Lalba
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96742 Lalba

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001844621 – 143Alpha-lactalbuminAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 140
Disulfide bondi48 ↔ 131
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi81 ↔ 97
Disulfide bondi93 ↔ 111

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP29752
PeptideAtlasiP29752
PRIDEiP29752

PTM databases

PhosphoSitePlusiP29752

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiENSMUSG00000022991 Expressed in 55 organ(s), highest expression level in inguinal mammary gland
CleanExiMM_LALBA
ExpressionAtlasiP29752 baseline and differential
GenevisibleiP29752 MM

Interactioni

Subunit structurei

Lactose synthase (LS) is heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
B4GALT1P0803710EBI-1031454,EBI-1031436From Bos taurus.

Protein-protein interaction databases

IntActiP29752, 1 interactor
STRINGi10090.ENSMUSP00000023726

Structurei

Secondary structure

1143
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP29752
SMRiP29752
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29752

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX41 Eukaryota
ENOG410ZQK6 LUCA
GeneTreeiENSGT00550000074398
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiP29752
KOiK00704
OMAiLAHKPLC
OrthoDBiEOG091G0R9V
PhylomeDBiP29752
TreeFamiTF324882

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000545 Lactalbumin
IPR023346 Lysozyme-like_dom_sf
PANTHERiPTHR11407:SF32 PTHR11407:SF32, 1 hit
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00136 LACTALBUMIN
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29752-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMHFVPLFLV CILSLPAFQA TELTKCKVSH AIKDIDGYQG ISLLEWACVL
60 70 80 90 100
FHTSGYDTQA VVNDNGSTEY GLFQISDRFW CKSSEFPESE NICGISCDKL
110 120 130 140
LDDELDDDIA CAKKILAIKG IDYWKAYKPM CSEKLEQWRC EKP
Length:143
Mass (Da):16,260
Last modified:April 1, 1993 - v1
Checksum:i0322892711FF4309
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80909 mRNA Translation: AAA37208.1
M87863 Genomic DNA Translation: AAA37209.1
BC006922 mRNA Translation: AAH06922.1
BC069916 mRNA Translation: AAH69916.1
CCDSiCCDS27795.1
PIRiJC1302
RefSeqiNP_034809.1, NM_010679.1
XP_006520580.1, XM_006520517.1
UniGeneiMm.448567
Mm.5074

Genome annotation databases

EnsembliENSMUST00000023726; ENSMUSP00000023726; ENSMUSG00000022991
GeneIDi16770
KEGGimmu:16770
UCSCiuc007xmo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80909 mRNA Translation: AAA37208.1
M87863 Genomic DNA Translation: AAA37209.1
BC006922 mRNA Translation: AAH06922.1
BC069916 mRNA Translation: AAH69916.1
CCDSiCCDS27795.1
PIRiJC1302
RefSeqiNP_034809.1, NM_010679.1
XP_006520580.1, XM_006520517.1
UniGeneiMm.448567
Mm.5074

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NF5X-ray2.00A/C21-143[»]
1NHEX-ray2.50A/C21-143[»]
1NKHX-ray2.00A/C21-143[»]
1NMMX-ray2.00A/C21-143[»]
1NQIX-ray2.00A/C21-143[»]
1NWGX-ray2.32A/C21-143[»]
1O23X-ray2.32A/C21-143[»]
1OQMX-ray2.10A/C21-143[»]
1PZYX-ray2.30A/C21-143[»]
1YROX-ray1.90A/C21-143[»]
2FYCX-ray2.00A/C21-143[»]
2FYDX-ray2.00A/C21-143[»]
ProteinModelPortaliP29752
SMRiP29752
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP29752, 1 interactor
STRINGi10090.ENSMUSP00000023726

PTM databases

PhosphoSitePlusiP29752

Proteomic databases

PaxDbiP29752
PeptideAtlasiP29752
PRIDEiP29752

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023726; ENSMUSP00000023726; ENSMUSG00000022991
GeneIDi16770
KEGGimmu:16770
UCSCiuc007xmo.1 mouse

Organism-specific databases

CTDi3906
MGIiMGI:96742 Lalba

Phylogenomic databases

eggNOGiENOG410IX41 Eukaryota
ENOG410ZQK6 LUCA
GeneTreeiENSGT00550000074398
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiP29752
KOiK00704
OMAiLAHKPLC
OrthoDBiEOG091G0R9V
PhylomeDBiP29752
TreeFamiTF324882

Enzyme and pathway databases

ReactomeiR-MMU-5653890 Lactose synthesis

Miscellaneous databases

ChiTaRSiLalba mouse
EvolutionaryTraceiP29752
PROiPR:P29752
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022991 Expressed in 55 organ(s), highest expression level in inguinal mammary gland
CleanExiMM_LALBA
ExpressionAtlasiP29752 baseline and differential
GenevisibleiP29752 MM

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000545 Lactalbumin
IPR023346 Lysozyme-like_dom_sf
PANTHERiPTHR11407:SF32 PTHR11407:SF32, 1 hit
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00136 LACTALBUMIN
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLALBA_MOUSE
AccessioniPrimary (citable) accession number: P29752
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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