UniProtKB - P29752 (LALBA_MOUSE)
Protein
Alpha-lactalbumin
Gene
Lalba
Organism
Mus musculus (Mouse)
Status
Functioni
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 98 – 109 | Add BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- lactose synthase activity Source: InterPro
GO - Biological processi
- lactose biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Milk protein |
Biological process | Lactose biosynthesis |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-5653890, Lactose synthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-lactalbuminAlternative name(s): Lactose synthase B protein |
Gene namesi | Name:Lalba |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96742, Lalba |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Add BLAST | 20 | |
ChainiPRO_0000018446 | 21 – 143 | Alpha-lactalbuminAdd BLAST | 123 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 26 ↔ 140 | |||
Disulfide bondi | 48 ↔ 131 | |||
Glycosylationi | 65 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 81 ↔ 97 | |||
Disulfide bondi | 93 ↔ 111 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P29752 |
PeptideAtlasi | P29752 |
PRIDEi | P29752 |
PTM databases
GlyGeni | P29752, 1 site |
PhosphoSitePlusi | P29752 |
Expressioni
Tissue specificityi
Mammary gland specific. Secreted in milk.
Gene expression databases
Bgeei | ENSMUSG00000022991, Expressed in inguinal mammary gland and 82 other tissues |
ExpressionAtlasi | P29752, baseline and differential |
Genevisiblei | P29752, MM |
Interactioni
Subunit structurei
Lactose synthase (LS) is heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).
3 PublicationsBinary interactionsi
P29752
With | #Exp. | IntAct |
---|---|---|
B4GALT1 [P08037] from Bos taurus. | 10 | EBI-1031454,EBI-1031436 |
Protein-protein interaction databases
IntActi | P29752, 1 interactor |
STRINGi | 10090.ENSMUSP00000023726 |
Miscellaneous databases
RNActi | P29752, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P29752 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P29752 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 143 | C-type lysozymePROSITE-ProRule annotationAdd BLAST | 123 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502T8BJ, Eukaryota |
GeneTreei | ENSGT00940000161726 |
HOGENOMi | CLU_111620_0_1_1 |
InParanoidi | P29752 |
OMAi | KCELSQV |
OrthoDBi | 1551203at2759 |
PhylomeDBi | P29752 |
TreeFami | TF324882 |
Family and domain databases
InterProi | View protein in InterPro IPR001916, Glyco_hydro_22 IPR019799, Glyco_hydro_22_CS IPR000545, Lactalbumin IPR023346, Lysozyme-like_dom_sf |
PANTHERi | PTHR11407:SF32, PTHR11407:SF32, 1 hit |
Pfami | View protein in Pfam PF00062, Lys, 1 hit |
PRINTSi | PR00136, LACTALBUMIN PR00135, LYZLACT |
SMARTi | View protein in SMART SM00263, LYZ1, 1 hit |
SUPFAMi | SSF53955, SSF53955, 1 hit |
PROSITEi | View protein in PROSITE PS00128, GLYCOSYL_HYDROL_F22_1, 1 hit PS51348, GLYCOSYL_HYDROL_F22_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P29752-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMHFVPLFLV CILSLPAFQA TELTKCKVSH AIKDIDGYQG ISLLEWACVL
60 70 80 90 100
FHTSGYDTQA VVNDNGSTEY GLFQISDRFW CKSSEFPESE NICGISCDKL
110 120 130 140
LDDELDDDIA CAKKILAIKG IDYWKAYKPM CSEKLEQWRC EKP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80909 mRNA Translation: AAA37208.1 M87863 Genomic DNA Translation: AAA37209.1 BC006922 mRNA Translation: AAH06922.1 BC069916 mRNA Translation: AAH69916.1 |
CCDSi | CCDS27795.1 |
PIRi | JC1302 |
RefSeqi | NP_034809.1, NM_010679.1 XP_006520580.1, XM_006520517.1 |
Genome annotation databases
Ensembli | ENSMUST00000023726; ENSMUSP00000023726; ENSMUSG00000022991 |
GeneIDi | 16770 |
KEGGi | mmu:16770 |
UCSCi | uc007xmo.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80909 mRNA Translation: AAA37208.1 M87863 Genomic DNA Translation: AAA37209.1 BC006922 mRNA Translation: AAH06922.1 BC069916 mRNA Translation: AAH69916.1 |
CCDSi | CCDS27795.1 |
PIRi | JC1302 |
RefSeqi | NP_034809.1, NM_010679.1 XP_006520580.1, XM_006520517.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1NF5 | X-ray | 2.00 | A/C | 21-143 | [»] | |
1NHE | X-ray | 2.50 | A/C | 21-143 | [»] | |
1NKH | X-ray | 2.00 | A/C | 21-143 | [»] | |
1NMM | X-ray | 2.00 | A/C | 21-143 | [»] | |
1NQI | X-ray | 2.00 | A/C | 21-143 | [»] | |
1NWG | X-ray | 2.32 | A/C | 21-143 | [»] | |
1O23 | X-ray | 2.32 | A/C | 21-143 | [»] | |
1OQM | X-ray | 2.10 | A/C | 21-143 | [»] | |
1PZY | X-ray | 2.30 | A/C | 21-143 | [»] | |
1YRO | X-ray | 1.90 | A/C | 21-143 | [»] | |
2FYC | X-ray | 2.00 | A/C | 21-143 | [»] | |
2FYD | X-ray | 2.00 | A/C | 21-143 | [»] | |
SMRi | P29752 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P29752, 1 interactor |
STRINGi | 10090.ENSMUSP00000023726 |
PTM databases
GlyGeni | P29752, 1 site |
PhosphoSitePlusi | P29752 |
Proteomic databases
PaxDbi | P29752 |
PeptideAtlasi | P29752 |
PRIDEi | P29752 |
Protocols and materials databases
Antibodypediai | 13654, 354 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000023726; ENSMUSP00000023726; ENSMUSG00000022991 |
GeneIDi | 16770 |
KEGGi | mmu:16770 |
UCSCi | uc007xmo.1, mouse |
Organism-specific databases
CTDi | 3906 |
MGIi | MGI:96742, Lalba |
Phylogenomic databases
eggNOGi | ENOG502T8BJ, Eukaryota |
GeneTreei | ENSGT00940000161726 |
HOGENOMi | CLU_111620_0_1_1 |
InParanoidi | P29752 |
OMAi | KCELSQV |
OrthoDBi | 1551203at2759 |
PhylomeDBi | P29752 |
TreeFami | TF324882 |
Enzyme and pathway databases
Reactomei | R-MMU-5653890, Lactose synthesis |
Miscellaneous databases
BioGRID-ORCSi | 16770, 1 hit in 17 CRISPR screens |
ChiTaRSi | Lalba, mouse |
EvolutionaryTracei | P29752 |
PROi | PR:P29752 |
RNActi | P29752, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022991, Expressed in inguinal mammary gland and 82 other tissues |
ExpressionAtlasi | P29752, baseline and differential |
Genevisiblei | P29752, MM |
Family and domain databases
InterProi | View protein in InterPro IPR001916, Glyco_hydro_22 IPR019799, Glyco_hydro_22_CS IPR000545, Lactalbumin IPR023346, Lysozyme-like_dom_sf |
PANTHERi | PTHR11407:SF32, PTHR11407:SF32, 1 hit |
Pfami | View protein in Pfam PF00062, Lys, 1 hit |
PRINTSi | PR00136, LACTALBUMIN PR00135, LYZLACT |
SMARTi | View protein in SMART SM00263, LYZ1, 1 hit |
SUPFAMi | SSF53955, SSF53955, 1 hit |
PROSITEi | View protein in PROSITE PS00128, GLYCOSYL_HYDROL_F22_1, 1 hit PS51348, GLYCOSYL_HYDROL_F22_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LALBA_MOUSE | |
Accessioni | P29752Primary (citable) accession number: P29752 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries