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UniProtKB - P29728 (OAS2_HUMAN)

Entry version 168 (13 Feb 2019)
Sequence version 3 (23 Jan 2007)
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Protein

2'-5'-oligoadenylate synthase 2

Gene

OAS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:10464285, PubMed:9880569, PubMed:11682059). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:10464285, PubMed:9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity).1 PublicationBy similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Produced as a latent enzyme which is activated by double stranded RNA (dsRNA) generated during the course of viral infection(PubMed:9880569). The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group is tolerated (PubMed:9880569). ssRNA or dsDNA do not act as activators (PubMed:9880569). Strongly inhibited by copper, iron and zinc ions (PubMed:11682059). Partially inhibited by cobalt and nickel ions (PubMed:11682059).2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.1 mM for ATP3 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei396ATPBy similarity1
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi408Magnesium; catalyticSequence analysis1
    Metal bindingi410Magnesium; catalyticSequence analysis1
    Metal bindingi481Magnesium; catalyticSequence analysis1
    Binding sitei544ATP1 Publication1
    Binding sitei547ATP1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • 2'-5'-oligoadenylate synthetase activity Source: UniProtKB
    • ATP binding Source: UniProtKB
    • double-stranded RNA binding Source: UniProtKB
    • metal ion binding Source: UniProtKB-KW
    View the complete GO annotation on QuickGO ...

    GO - Biological processi

    View the complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionNucleotidyltransferase, RNA-binding, Transferase
    Biological processAntiviral defense, Immunity, Innate immunity
    LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:ENSG00000111335-MONOMER

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-877300 Interferon gamma signaling
    R-HSA-8983711 OAS antiviral response
    R-HSA-909733 Interferon alpha/beta signaling

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P29728

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    2'-5'-oligoadenylate synthase 2 (EC:2.7.7.843 Publications)
    Short name:
    (2-5')oligo(A) synthase 2
    Short name:
    2-5A synthase 2
    Alternative name(s):
    p69 OAS / p71 OAS1 Publication
    Short name:
    p69OAS / p71OAS1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:OAS2Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000111335.12

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:8087 OAS2

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		603350 gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P29728

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2G → A or D: No loss of activity. 1 Publication1
    Mutagenesisi408D → A: Loss of activity; when associated with A-410. 1 Publication1
    Mutagenesisi410D → A: Loss of activity; when associated with A-408. 1 Publication1
    Mutagenesisi421Y → P or A: Significant loss of activity. 1 Publication1
    Mutagenesisi481D → A: Loss of activity. 1 Publication1
    Mutagenesisi544R → A or Y: Significant loss of activity. 1 Publication1
    Mutagenesisi547K → A: Partial loss of activity. 1 Publication1
    Mutagenesisi668C → A: Loss of activity; when associated with A-669 and A-670. 1 Publication1
    Mutagenesisi669F → A: Loss of activity; when associated with A-668 and A-670. 1 Publication1
    Mutagenesisi670K → A: Loss of activity; when associated with A-668 and A-669. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		4939

    Open Targets

    More...    OpenTargetsi    		ENSG00000111335

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA31876

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		OAS2

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		116242687

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001602642 – 7192'-5'-oligoadenylate synthase 2Add BLAST718

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei378N6-acetyllysineCombined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Myristoylation is not essential for its activity.2 Publications
    Glycosylated. Glycosylation is essential for its activity.1 Publication

    Keywords - PTMi

    Acetylation, Glycoprotein, Lipoprotein, Myristate

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		P29728

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P29728

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		P29728

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P29728

    PeptideAtlas

    More...    PeptideAtlasi    		P29728

    PRoteomics IDEntifications database

    More...    PRIDEi    		P29728

    ProteomicsDB human proteome resource

    More...    ProteomicsDBi    		54606
    54607 [P29728-2]
    54608 [P29728-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P29728

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P29728

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By type I interferon (IFN) and viruses.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000111335 Expressed in 169 organ(s), highest expression level in leukocyte

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P29728 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P29728 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		CAB024984
    HPA045947

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.2 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    CLK3P497613EBI-10211452,EBI-745579

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		110993, 5 interactors

    Protein interaction database and analysis system

    More...    IntActi    		P29728, 2 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000342278

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...    ProteinModelPortali    		P29728

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P29728

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni11 – 335OAS domain 1Add BLAST325
    Regioni343 – 683OAS domain 2Add BLAST341

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi326 – 346Pro-rich (linker)Add BLAST21

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the 2-5A synthase family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG0001 Eukaryota
    COG5272 LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00510000046406

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		HOG000013200

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...    HOVERGENi    		HBG062976

    KEGG Orthology (KO)

    More...    KOi    		K14216

    Database of Orthologous Groups

    More...    OrthoDBi    		611234at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P29728

    TreeFam database of animal gene trees

    More...    TreeFami    		TF329749

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		1.10.1410.20, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR006117 2-5-oligoadenylate_synth_CS
    IPR006116 2-5-oligoadenylate_synth_N
    IPR018952 2-5-oligoAdlate_synth_1_dom2/C
    IPR038121 2-5-oligoAdlate_synth_2_sf
    IPR026774 2-5A_synthase
    IPR002934 Polymerase_NTP_transf_dom

    The PANTHER Classification System

    More...    PANTHERi    		PTHR11258 PTHR11258, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF01909 NTP_transf_2, 1 hit
    PF10421 OAS1_C, 2 hits

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00832 25A_SYNTH_1, 2 hits
    PS00833 25A_SYNTH_2, 2 hits
    PS50152 25A_SYNTH_3, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform p711 Publication (identifier: P29728-1) [UniParc]FASTAAdd to basket
    Also known as: 71 kDa1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MGNGESQLSS VPAQKLGWFI QEYLKPYEEC QTLIDEMVNT ICDVLQEPEQ 
            60         70         80         90        100
    FPLVQGVAIG GSYGRKTVLR GNSDGTLVLF FSDLKQFQDQ KRSQRDILDK 
           110        120        130        140        150
    TGDKLKFCLF TKWLKNNFEI QKSLDGFTIQ VFTKNQRISF EVLAAFNALS 
           160        170        180        190        200
    LNDNPSPWIY RELKRSLDKT NASPGEFAVC FTELQQKFFD NRPGKLKDLI 
           210        220        230        240        250
    LLIKHWHQQC QKKIKDLPSL SPYALELLTV YAWEQGCRKD NFDIAEGVRT 
           260        270        280        290        300
    VLELIKCQEK LCIYWMVNYN FEDETIRNIL LHQLQSARPV ILDPVDPTNN 
           310        320        330        340        350
    VSGDKICWQW LKKEAQTWLT SPNLDNELPA PSWNVLPAPL FTTPGHLLDK 
           360        370        380        390        400
    FIKEFLQPNK CFLEQIDSAV NIIRTFLKEN CFRQSTAKIQ IVRGGSTAKG 
           410        420        430        440        450
    TALKTGSDAD LVVFHNSLKS YTSQKNERHK IVKEIHEQLK AFWREKEEEL 
           460        470        480        490        500
    EVSFEPPKWK APRVLSFSLK SKVLNESVSF DVLPAFNALG QLSSGSTPSP 
           510        520        530        540        550
    EVYAGLIDLY KSSDLPGGEF STCFTVLQRN FIRSRPTKLK DLIRLVKHWY 
           560        570        580        590        600
    KECERKLKPK GSLPPKYALE LLTIYAWEQG SGVPDFDTAE GFRTVLELVT 
           610        620        630        640        650
    QYQQLCIFWK VNYNFEDETV RKFLLSQLQK TRPVILDPAE PTGDVGGGDR 
           660        670        680        690        700
    WCWHLLAKEA KEWLSSPCFK DGTGNPIPPW KVPTMQTPGS CGARIHPIVN 
           710 
    EMFSSRSHRI LNNNSKRNF
    Length:719
    Mass (Da):82,431
    Last modified:January 23, 2007 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B680D397D5EDB78
    GO
    Isoform p692 Publications (identifier: P29728-2) [UniParc]FASTAAdd to basket
    Also known as: 69 kDa2 Publications

    The sequence of this isoform differs from the canonical sequence as follows:
         684-687: TMQT → VKVI
         688-719: Missing.

    Show »
    Length:687
    Mass (Da):78,787
    Checksum:i34729B5A88A38B2D
    GO
    Isoform 3 (identifier: P29728-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         151-172: LNDNPSPWIYRELKRSLDKTNA → KHCWVSGEKSQRSGCQTALCNL
         173-719: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:172
    Mass (Da):19,517
    Checksum:i8CF5C0C9EE9850A9
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    A0A087X0V5A0A087X0V5_HUMAN
    2'-5'-oligoadenylate synthase 2
    OAS2
    		726Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8W1C5F8W1C5_HUMAN
    2'-5'-oligoadenylate synthase 2
    OAS2
    		270Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8VPI5F8VPI5_HUMAN
    2'-5'-oligoadenylate synthase 2
    OAS2
    		60Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti45 – 47LQE → CRN in AAA60607 (PubMed:1577824).Curated3
    Sequence conflicti45 – 47LQE → CRN in AAA60606 (PubMed:1577824).Curated3
    Sequence conflicti127F → S in AAA60607 (PubMed:1577824).Curated1
    Sequence conflicti127F → S in AAA60606 (PubMed:1577824).Curated1
    Sequence conflicti606C → G in AAA60607 (PubMed:1577824).Curated1
    Sequence conflicti606C → G in AAA60606 (PubMed:1577824).Curated1
    Sequence conflicti639A → G in AAA60607 (PubMed:1577824).Curated1
    Sequence conflicti639A → G in AAA60606 (PubMed:1577824).Curated1
    Sequence conflicti657A → D in AAA60607 (PubMed:1577824).Curated1
    Sequence conflicti657A → D in AAA60606 (PubMed:1577824).Curated1
    Sequence conflicti662 – 663EW → VR in AAA60607 (PubMed:1577824).Curated2
    Sequence conflicti662 – 663EW → VR in AAA60606 (PubMed:1577824).Curated2
    Sequence conflicti719F → FWRSSGNRF in AAA60607 (PubMed:1577824).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043354151 – 172LNDNP…DKTNA → KHCWVSGEKSQRSGCQTALC NL in isoform 3. 1 PublicationAdd BLAST22
    Alternative sequenceiVSP_043355173 – 719Missing in isoform 3. 1 PublicationAdd BLAST547
    Alternative sequenceiVSP_003741684 – 687TMQT → VKVI in isoform p69. 3 Publications4
    Alternative sequenceiVSP_003742688 – 719Missing in isoform p69. 3 PublicationsAdd BLAST32

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		M87434 mRNA Translation: AAA60607.1
    M87284 mRNA Translation: AAA60606.1
    AK292796 mRNA Translation: BAF85485.1
    AC004551 Genomic DNA No translation available.
    CH471054 Genomic DNA Translation: EAW98027.1
    BC023637 mRNA Translation: AAH23637.1
    BC049215 mRNA Translation: AAH49215.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS31906.1 [P29728-1]
    CCDS41839.1 [P29728-2]
    CCDS44982.1 [P29728-3]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		B42665

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001027903.1, NM_001032731.1 [P29728-3]
    NP_002526.2, NM_002535.2 [P29728-2]
    NP_058197.2, NM_016817.2 [P29728-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...    UniGenei    		Hs.414332

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000342315; ENSP00000342278; ENSG00000111335 [P29728-1]
    ENST00000392583; ENSP00000376362; ENSG00000111335 [P29728-2]
    ENST00000449768; ENSP00000411763; ENSG00000111335 [P29728-3]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		4939

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:4939

    UCSC genome browser

    More...    UCSCi    		uc001tuh.4 human [P29728-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		M87434 mRNA Translation: AAA60607.1
    M87284 mRNA Translation: AAA60606.1
    AK292796 mRNA Translation: BAF85485.1
    AC004551 Genomic DNA No translation available.
    CH471054 Genomic DNA Translation: EAW98027.1
    BC023637 mRNA Translation: AAH23637.1
    BC049215 mRNA Translation: AAH49215.1
    CCDSiCCDS31906.1 [P29728-1]
    CCDS41839.1 [P29728-2]
    CCDS44982.1 [P29728-3]
    PIRiB42665
    RefSeqiNP_001027903.1, NM_001032731.1 [P29728-3]
    NP_002526.2, NM_002535.2 [P29728-2]
    NP_058197.2, NM_016817.2 [P29728-1]
    UniGeneiHs.414332

    3D structure databases

    ProteinModelPortaliP29728
    SMRiP29728
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi110993, 5 interactors
    IntActiP29728, 2 interactors
    STRINGi9606.ENSP00000342278

    PTM databases

    iPTMnetiP29728
    PhosphoSitePlusiP29728

    Polymorphism and mutation databases

    BioMutaiOAS2
    DMDMi116242687

    Proteomic databases

    EPDiP29728
    jPOSTiP29728
    MaxQBiP29728
    PaxDbiP29728
    PeptideAtlasiP29728
    PRIDEiP29728
    ProteomicsDBi54606
    54607 [P29728-2]
    54608 [P29728-3]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000342315; ENSP00000342278; ENSG00000111335 [P29728-1]
    ENST00000392583; ENSP00000376362; ENSG00000111335 [P29728-2]
    ENST00000449768; ENSP00000411763; ENSG00000111335 [P29728-3]
    GeneIDi4939
    KEGGihsa:4939
    UCSCiuc001tuh.4 human [P29728-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		4939
    DisGeNETi4939
    EuPathDBiHostDB:ENSG00000111335.12

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		OAS2

    H-Invitational Database, human transcriptome db

    More...    H-InvDBi    		HIX0129679
    HGNCiHGNC:8087 OAS2
    HPAiCAB024984
    HPA045947
    MIMi603350 gene
    neXtProtiNX_P29728
    OpenTargetsiENSG00000111335
    PharmGKBiPA31876

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG0001 Eukaryota
    COG5272 LUCA
    GeneTreeiENSGT00510000046406
    HOGENOMiHOG000013200
    HOVERGENiHBG062976
    KOiK14216
    OrthoDBi611234at2759
    PhylomeDBiP29728
    TreeFamiTF329749

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000111335-MONOMER
    ReactomeiR-HSA-877300 Interferon gamma signaling
    R-HSA-8983711 OAS antiviral response
    R-HSA-909733 Interferon alpha/beta signaling
    SABIO-RKiP29728

    Miscellaneous databases

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		OAS2

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		4939

    Protein Ontology

    More...    PROi    		PR:P29728

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000111335 Expressed in 169 organ(s), highest expression level in leukocyte
    ExpressionAtlasiP29728 baseline and differential
    GenevisibleiP29728 HS

    Family and domain databases

    Gene3Di1.10.1410.20, 2 hits
    InterProiView protein in InterPro
    IPR006117 2-5-oligoadenylate_synth_CS
    IPR006116 2-5-oligoadenylate_synth_N
    IPR018952 2-5-oligoAdlate_synth_1_dom2/C
    IPR038121 2-5-oligoAdlate_synth_2_sf
    IPR026774 2-5A_synthase
    IPR002934 Polymerase_NTP_transf_dom
    PANTHERiPTHR11258 PTHR11258, 1 hit
    PfamiView protein in Pfam
    PF01909 NTP_transf_2, 1 hit
    PF10421 OAS1_C, 2 hits
    PROSITEiView protein in PROSITE
    PS00832 25A_SYNTH_1, 2 hits
    PS00833 25A_SYNTH_2, 2 hits
    PS50152 25A_SYNTH_3, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOAS2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29728
    Secondary accession number(s): A8K9T1, Q6PJ33, Q86XX8
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: January 23, 2007
    Last modified: February 13, 2019
    This is version 168 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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