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Protein

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Gene

RAM2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate.

Miscellaneous

Present with 396 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

GO - Molecular functioni

  • CAAX-protein geranylgeranyltransferase activity Source: SGD
  • protein farnesyltransferase activity Source: SGD
  • protein geranylgeranyltransferase activity Source: SGD

GO - Biological processi

  • peptide pheromone maturation Source: SGD
  • protein farnesylation Source: SGD
  • protein geranylgeranylation Source: SGD

Keywordsi

Molecular functionPrenyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-38

Names & Taxonomyi

Protein namesi
Recommended name:
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC:2.5.1.58, EC:2.5.1.59)
Alternative name(s):
CAAX farnesyltransferase subunit alpha
FTase-alpha
Ras proteins prenyltransferase subunit alpha
Type I protein geranyl-geranyltransferase subunit alpha
Short name:
GGTase-I-alpha
Gene namesi
Name:RAM2
Ordered Locus Names:YKL019W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL019W
SGDiS000001502 RAM2

Subcellular locationi

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2406

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197541 – 316Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaAdd BLAST316

Proteomic databases

MaxQBiP29703
PaxDbiP29703
PRIDEiP29703

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34112, 136 interactors
ComplexPortaliCPX-1634 Protein farnesyltransferase complex
CPX-1635 Protein geranylgeranyltransferase type I complex
DIPiDIP-1233N
IntActiP29703, 11 interactors
MINTiP29703
STRINGi4932.YKL019W

Chemistry databases

BindingDBiP29703

Structurei

3D structure databases

ProteinModelPortaliP29703
SMRiP29703
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati47 – 81PFTA 1Add BLAST35
Repeati89 – 123PFTA 2Add BLAST35
Repeati125 – 159PFTA 3Add BLAST35
Repeati160 – 193PFTA 4Add BLAST34
Repeati199 – 233PFTA 5Add BLAST35

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00550000074935
HOGENOMiHOG000188957
InParanoidiP29703
KOiK05955
OMAiHDVIRRK
OrthoDBiEOG092C426P

Family and domain databases

InterProiView protein in InterPro
IPR002088 Prenyl_trans_a
PfamiView protein in Pfam
PF01239 PPTA, 4 hits
PROSITEiView protein in PROSITE
PS51147 PFTA, 5 hits

Sequencei

Sequence statusi: Complete.

P29703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEYDYSDVK PLPIETDLQD ELCRIMYTED YKRLMGLARA LISLNELSPR
60 70 80 90 100
ALQLTAEIID VAPAFYTIWN YRFNIVRHMM SESEDTVLYL NKELDWLDEV
110 120 130 140 150
TLNNPKNYQI WSYRQSLLKL HPSPSFKREL PILKLMIDDD SKNYHVWSYR
160 170 180 190 200
KWCCLFFSDF QHELAYASDL IETDIYNNSA WTHRMFYWVN AKDVISKVEL
210 220 230 240 250
ADELQFIMDK IQLVPQNISP WTYLRGFQEL FHDRLQWDSK VVDFATTFIG
260 270 280 290 300
DVLSLPIGSP EDLPEIESSY ALEFLAYHWG ADPCTRDNAV KAYSLLAIKY
310
DPIRKNLWHH KINNLN
Length:316
Mass (Da):37,508
Last modified:April 1, 1993 - v1
Checksum:iD828519BB9914608
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88584 Genomic DNA Translation: AAA34957.1
Z28019 Genomic DNA Translation: CAA81854.1
L24760 Genomic DNA Translation: AAA20574.1
BK006944 Genomic DNA Translation: DAA09136.1
PIRiA41626
RefSeqiNP_012906.3, NM_001179585.3

Genome annotation databases

EnsemblFungiiYKL019W; YKL019W; YKL019W
GeneIDi853849
KEGGisce:YKL019W

Similar proteinsi

Entry informationi

Entry nameiFNTA_YEAST
AccessioniPrimary (citable) accession number: P29703
Secondary accession number(s): D6VXR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 18, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

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