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Protein

Alpha-2-HS-glycoprotein

Gene

Ahsg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in differentiation.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-6798695 Neutrophil degranulation
R-MMU-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI25.020

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2-HS-glycoprotein
Alternative name(s):
Countertrypin
Fetuin-A
Gene namesi
Name:Ahsg
Synonyms:Fetua
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:107189 Ahsg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000889119 – 345Alpha-2-HS-glycoproteinAdd BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 336PROSITE-ProRule annotation
Disulfide bondi89 ↔ 100PROSITE-ProRule annotation
Glycosylationi99N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi114 ↔ 132PROSITE-ProRule annotation
Modified residuei134PhosphoserineBy similarity1
Modified residuei135PhosphothreonineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Disulfide bondi146 ↔ 149PROSITE-ProRule annotation
Glycosylationi156N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi176N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi208 ↔ 219PROSITE-ProRule annotation
Disulfide bondi230 ↔ 247PROSITE-ProRule annotation
Modified residuei305PhosphoserineBy similarity1
Modified residuei309PhosphoserineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP29699
PeptideAtlasiP29699
PRIDEiP29699

2D gel databases

REPRODUCTION-2DPAGEiIPI00128249

PTM databases

GlyConnecti729
iPTMnetiP29699
PhosphoSitePlusiP29699
SwissPalmiP29699

Expressioni

Tissue specificityi

Liver is the major site of synthesis, but fetuin is also expressed in limb buds and other extrahepatic tissues during development.

Gene expression databases

BgeeiENSMUSG00000022868
CleanExiMM_AHSG
ExpressionAtlasiP29699 baseline and differential
GenevisibleiP29699 MM

Interactioni

Protein-protein interaction databases

BioGridi198039, 2 interactors
IntActiP29699, 8 interactors
MINTiP29699
STRINGi10090.ENSMUSP00000023583

Structurei

3D structure databases

ProteinModelPortaliP29699
SMRiP29699
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 133Cystatin fetuin-A-type 1PROSITE-ProRule annotationAdd BLAST115
Domaini144 – 250Cystatin fetuin-A-type 2PROSITE-ProRule annotationAdd BLAST107

Sequence similaritiesi

Belongs to the fetuin family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IK8F Eukaryota
ENOG4111RIP LUCA
GeneTreeiENSGT00530000063413
HOGENOMiHOG000290189
HOVERGENiHBG051607
InParanoidiP29699
OMAiETTCHVL
OrthoDBiEOG091G0FHG
PhylomeDBiP29699
TreeFamiTF333729

Family and domain databases

CDDicd00042 CY, 2 hits
InterProiView protein in InterPro
IPR000010 Cystatin_dom
IPR025760 Cystatin_Fetuin_A
IPR001363 Prot_inh_fetuin_CS
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 2 hits
PROSITEiView protein in PROSITE
PS51529 CYSTATIN_FETUIN_A, 2 hits
PS01254 FETUIN_1, 1 hit
PS01255 FETUIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLVLLLCF AQLWGCQSAP QGTGLGFREL ACDDPEAEQV ALLAVDYLNN
60 70 80 90 100
HLLQGFKQVL NQIDKVKVWS RRPFGVVYEM EVDTLETTCH ALDPTPLANC
110 120 130 140 150
SVRQLTEHAV EGDCDFHILK QDGQFRVMHT QCHSTPDSAE DVRKLCPRCP
160 170 180 190 200
LLTPFNDTNV VHTVNTALAA FNTQNNGTYF KLVEISRAQN VPLPVSTLVE
210 220 230 240 250
FVIAATDCTA KEVTDPAKCN LLAEKQHGFC KANLMHNLGG EEVSVACKLF
260 270 280 290 300
QTQPQPANAN AVGPVPTANA ALPADPPASV VVGPVVVPRG LSDHRTYHDL
310 320 330 340
RHAFSPVASV ESASGETLHS PKVGQPGAAG PVSPMCPGRI RHFKI
Length:345
Mass (Da):37,326
Last modified:April 1, 1993 - v1
Checksum:i4B7B9C9B1410658E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71R → RQ in CAA05210 (PubMed:9395485).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S96534 mRNA Translation: AAB22070.1
AF007900 Genomic DNA Translation: AAB81718.1
AJ002146 Genomic DNA Translation: CAA05210.1
BC012678 mRNA Translation: AAH12678.1
BC019822 mRNA Translation: AAH19822.1
CCDSiCCDS28071.1
PIRiS21094
RefSeqiNP_038493.1, NM_013465.2
UniGeneiMm.197554

Genome annotation databases

EnsembliENSMUST00000023583; ENSMUSP00000023583; ENSMUSG00000022868
GeneIDi11625
KEGGimmu:11625
UCSCiuc007ysr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFETUA_MOUSE
AccessioniPrimary (citable) accession number: P29699
Secondary accession number(s): O35634
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 18, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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