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UniProtKB - P29692 (EF1D_HUMAN)

Entry version 225 (25 May 2022)
Sequence version 5 (23 Jan 2007)
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Protein

Elongation factor 1-delta

Gene

EEF1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.

Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Elongation factor
Biological processProtein biosynthesis, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P29692

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156842, Eukaryotic Translation Elongation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P29692

SIGNOR Signaling Network Open Resource

More...SIGNORi		P29692

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Elongation factor 1-delta
Short name:
EF-1-delta
Alternative name(s):
Antigen NY-CO-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EEF1D
Synonyms:EF1D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3211, EEF1D

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		130592, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P29692

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000104529

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1936

MalaCards human disease database

More...MalaCardsi		EEF1D

Open Targets

More...OpenTargetsi		ENSG00000104529

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27647

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P29692, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295739

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		EEF1D

Domain mapping of disease mutations (DMDM)

More...DMDMi		20141357

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001550462 – 281Elongation factor 1-deltaAdd BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei17N6-acetyllysineCombined sources1
Modified residuei37PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei73PhosphothreonineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei106PhosphoserineBy similarity1
Modified residuei107N6-acetyllysineCombined sources1
Modified residuei117N6-acetyllysine; alternateCombined sources1
Modified residuei117N6-succinyllysine; alternateBy similarity1
Modified residuei119PhosphoserineCombined sources1
Modified residuei129PhosphothreonineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Modified residuei147PhosphothreonineCombined sources1
Modified residuei162Phosphoserine; by CK2Combined sources1 Publication1
Isoform 3 (identifier: P29692-3)
Modified residuei40PhosphoserineCombined sources1
Isoform 2 (identifier: P29692-2)
Modified residuei91PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-500
CPTAC-501

Encyclopedia of Proteome Dynamics

More...EPDi		P29692

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P29692

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P29692

MaxQB - The MaxQuant DataBase

More...MaxQBi		P29692

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P29692

PeptideAtlas

More...PeptideAtlasi		P29692

PRoteomics IDEntifications database

More...PRIDEi		P29692

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19276
54603 [P29692-1]
54604 [P29692-2]
54605 [P29692-3]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P29692-1 [P29692-1]
P29692-3 [P29692-3]
P29692-4 [P29692-4]

2D gel databases

USC-OGP 2-DE database

More...OGPi		P29692

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P29692

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P29692

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P29692

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P29692

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is specifically expressed in brain, cerebellum and testis.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress. Also induced following exposure to ionizing radiation.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000104529, Expressed in tendon of biceps brachii and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P29692, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P29692, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000104529, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

EF-1 is composed of 4 subunits: alpha, beta, delta isoform 1, and gamma.

Isoform 2 interacts with HSF1 and NFE2L2.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108256, 258 interactors

Protein interaction database and analysis system

More...IntActi		P29692, 151 interactors

Molecular INTeraction database

More...MINTi		P29692

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000410059

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P29692, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1281
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P29692

Biological Magnetic Resonance Data Bank

More...BMRBi		P29692

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P29692

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni80 – 115Leucine-zipperAdd BLAST36
Regioni118 – 172DisorderedSequence analysisAdd BLAST55
Regioni173 – 281Catalytic (GEF)Add BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi151 – 165Acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EF-1-beta/EF-1-delta family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1668, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183014

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020166_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P29692

Identification of Orthologs from Complete Genome Data

More...OMAi		RVWLDKP

Database of Orthologous Groups

More...OrthoDBi		1464823at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P29692

TreeFam database of animal gene trees

More...TreeFami		TF313134

Family and domain databases

Conserved Domains Database

More...CDDi		cd00292, EF1B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036219, eEF-1beta-like_sf
IPR018940, EF-1_beta_acid_region_euk
IPR014038, EF1B_bsu/dsu_GNE
IPR014717, Transl_elong_EF1B/ribosomal_S6
IPR001326, Transl_elong_EF1B_B/D_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10587, EF-1_beta_acid, 1 hit
PF00736, EF1_GNE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01182, EF-1_beta_acid, 1 hit
SM00888, EF1_GNE, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54984, SSF54984, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00824, EF1BD_1, 1 hit
PS00825, EF1BD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 39 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P29692-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATNFLAHEK IWFDKFKYDD AERRFYEQMN GPVAGASRQE NGASVILRDI 
        60         70         80         90        100
ARARENIQKS LAGSSGPGAS SGTSGDHGEL VVRIASLEVE NQSLRGVVQE 
       110        120        130        140        150
LQQAISKLEA RLNVLEKSSP GHRATAPQTQ HVSPMRQVEP PAKKPATPAE 
       160        170        180        190        200
DDEDDDIDLF GSDNEEEDKE AAQLREERLR QYAEKKAKKP ALVAKSSILL 
       210        220        230        240        250
DVKPWDDETD MAQLEACVRS IQLDGLVWGA SKLVPVGYGI RKLQIQCVVE 
       260        270        280 
DDKVGTDLLE EEITKFEEHV QSVDIAAFNK I
Length:281
Mass (Da):31,122
Last modified:January 23, 2007 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE778D6D5D09BD6C
GO
Isoform 2 (identifier: P29692-2) [UniParc]FASTAAdd to basket
Also known as: eEF1BdeltaL

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRSGKASCTL...VSSLRPNRKM

Show »
Length:647
Mass (Da):71,408
Checksum:iA4CADBF40FCFCC09
GO
Isoform 3 (identifier: P29692-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-63: Missing.

Show »
Length:257
Mass (Da):28,558
Checksum:iE38BA673BE18FBE5
GO
Isoform 4 (identifier: P29692-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-96: Missing.

Show »
Length:262
Mass (Da):29,071
Checksum:i7F9682E53B69BC17
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 39 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PRY8E9PRY8_HUMAN
Elongation factor 1-delta
EEF1D
697Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1X7A0A087X1X7_HUMAN
Elongation factor 1-delta
EEF1D
631Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN71E9PN71_HUMAN
Elongation factor 1-delta
EEF1D
190Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRL0E9PRL0_HUMAN
Elongation factor 1-delta
EEF1D
257Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJV8E9PJV8_HUMAN
Elongation factor 1-delta
EEF1D
179Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN56E9PN56_HUMAN
Elongation factor 1-delta
EEF1D
180Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPY1E9PPY1_HUMAN
Elongation factor 1-delta
EEF1D
157Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQR8E9PQR8_HUMAN
Elongation factor 1-delta
EEF1D
300Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQZ1E9PQZ1_HUMAN
Elongation factor 1-delta
EEF1D
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK01E9PK01_HUMAN
Elongation factor 1-delta
EEF1D
261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti34A → R in CAA79716 (PubMed:8334168).Curated1
Sequence conflicti44S → T in CAA79716 (PubMed:8334168).Curated1
Sequence conflicti209T → A in BAG56855 (PubMed:14702039).Curated1
Isoform 2 (identifier: P29692-2)
Sequence conflicti189D → E in AAP35906 (Ref. 3) Curated1
Sequence conflicti189D → E in EAW82228 (PubMed:14702039).Curated1
Sequence conflicti189D → E in AAH07847 (PubMed:16421571).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0378841M → MRSGKASCTLETVWEDKHKY EEAERRFYEHEATQAAASAQ QLPAEGPAMNGPGQDDPEDA DEAEAPDGGSRRDPRKSQDS RKPLQKKRKRSPKSGLGPAD LALLGLSAERVWLDKSLFDQ AESSYRQKLADVAAQAAWPP ALAPWGLCTHGNQVACHHVT WGIWVNKSSFDQAERAFVEW SQALLLAPDGSRRQGTPNTG QQVAVPDLAHQPSPPVNGQP PLGSLQALVREVWLEKPRYD AAERGFYEALFDGHPPGKVR LQERAGLAEGARRGRRDRRG RNILGNKRAGLRRADGEAPS ALPYCYFLQKDAEAPWLSKP AYDSAECRHHAAEALRVAWC LEAASLSHRPGPRSGLSVSS LRPNRKM in isoform 2. 2 Publications1
Alternative sequenceiVSP_04381240 – 63Missing in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_04596078 – 96Missing in isoform 4. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z21507 mRNA Translation: CAA79716.1
BT007242 mRNA Translation: AAP35906.1
AK293339 mRNA Translation: BAG56855.1
AC067930 Genomic DNA No translation available.
CH471162 Genomic DNA Translation: EAW82227.1
CH471162 Genomic DNA Translation: EAW82228.1
CH471162 Genomic DNA Translation: EAW82229.1
CH471162 Genomic DNA Translation: EAW82230.1
CH471162 Genomic DNA Translation: EAW82232.1
BC007847 mRNA Translation: AAH07847.1
BC009907 mRNA Translation: AAH09907.1
BC012819 mRNA Translation: AAH12819.1
BC062535 mRNA Translation: AAH62535.1
BC094806 mRNA Translation: AAH94806.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47930.1 [P29692-3]
CCDS56559.1 [P29692-4]
CCDS6404.1 [P29692-2]
CCDS6405.1 [P29692-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S34626

NCBI Reference Sequences

More...RefSeqi		NP_001123525.2, NM_001130053.3 [P29692-2]
NP_001123527.1, NM_001130055.3 [P29692-1]
NP_001123528.1, NM_001130056.3 [P29692-3]
NP_001123529.1, NM_001130057.3 [P29692-1]
NP_001182132.1, NM_001195203.2 [P29692-4]
NP_001276879.1, NM_001289950.2 [P29692-1]
NP_001304672.1, NM_001317743.2 [P29692-3]
NP_001317575.1, NM_001330646.1 [P29692-3]
NP_001951.2, NM_001960.5 [P29692-1]
NP_115754.3, NM_032378.5 [P29692-2]
XP_005250880.1, XM_005250823.1 [P29692-2]
XP_006716585.1, XM_006716522.1 [P29692-2]
XP_006716586.1, XM_006716523.1 [P29692-2]
XP_006716587.1, XM_006716524.1 [P29692-2]
XP_006716588.1, XM_006716525.1 [P29692-1]
XP_011515207.1, XM_011516905.2 [P29692-2]
XP_011515208.1, XM_011516906.2 [P29692-2]
XP_016868659.1, XM_017013170.1 [P29692-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000317198.10; ENSP00000317399.6; ENSG00000104529.19
ENST00000395119.7; ENSP00000378551.3; ENSG00000104529.19
ENST00000419152.7; ENSP00000388261.2; ENSG00000104529.19
ENST00000442189.6; ENSP00000391944.2; ENSG00000104529.19 [P29692-2]
ENST00000524624.5; ENSP00000435697.1; ENSG00000104529.19 [P29692-3]
ENST00000526838.5; ENSP00000436507.1; ENSG00000104529.19 [P29692-4]
ENST00000528610.5; ENSP00000431763.1; ENSG00000104529.19 [P29692-3]
ENST00000529272.5; ENSP00000434872.1; ENSG00000104529.19
ENST00000529516.6; ENSP00000431742.2; ENSG00000104529.19 [P29692-4]
ENST00000530191.6; ENSP00000436542.2; ENSG00000104529.19
ENST00000530445.6; ENSP00000436933.2; ENSG00000104529.19
ENST00000531218.6; ENSP00000434448.2; ENSG00000104529.19
ENST00000533494.6; ENSP00000433412.2; ENSG00000104529.19
ENST00000534377.6; ENSP00000431460.2; ENSG00000104529.19 [P29692-3]
ENST00000534380.6; ENSP00000433611.2; ENSG00000104529.19
ENST00000614575.4; ENSP00000478340.2; ENSG00000273594.4
ENST00000615067.4; ENSP00000479653.1; ENSG00000273594.4
ENST00000615698.4; ENSP00000483527.1; ENSG00000273594.4
ENST00000618139.4; ENSP00000484536.2; ENSG00000104529.19 [P29692-2]
ENST00000619144.4; ENSP00000477608.1; ENSG00000273594.4 [P29692-2]
ENST00000620155.3; ENSP00000480505.1; ENSG00000273594.4 [P29692-2]
ENST00000631698.1; ENSP00000488672.1; ENSG00000273594.4 [P29692-4]
ENST00000632587.1; ENSP00000487680.1; ENSG00000273594.4
ENST00000632675.1; ENSP00000488026.1; ENSG00000273594.4 [P29692-3]
ENST00000632965.1; ENSP00000488275.1; ENSG00000273594.4 [P29692-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1936

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1936

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000618139.4; ENSP00000484536.2; NM_001130053.5; NP_001123525.3 [P29692-2]

UCSC genome browser

More...UCSCi		uc003yyr.4, human [P29692-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21507 mRNA Translation: CAA79716.1
BT007242 mRNA Translation: AAP35906.1
AK293339 mRNA Translation: BAG56855.1
AC067930 Genomic DNA No translation available.
CH471162 Genomic DNA Translation: EAW82227.1
CH471162 Genomic DNA Translation: EAW82228.1
CH471162 Genomic DNA Translation: EAW82229.1
CH471162 Genomic DNA Translation: EAW82230.1
CH471162 Genomic DNA Translation: EAW82232.1
BC007847 mRNA Translation: AAH07847.1
BC009907 mRNA Translation: AAH09907.1
BC012819 mRNA Translation: AAH12819.1
BC062535 mRNA Translation: AAH62535.1
BC094806 mRNA Translation: AAH94806.1
CCDSiCCDS47930.1 [P29692-3]
CCDS56559.1 [P29692-4]
CCDS6404.1 [P29692-2]
CCDS6405.1 [P29692-1]
PIRiS34626
RefSeqiNP_001123525.2, NM_001130053.3 [P29692-2]
NP_001123527.1, NM_001130055.3 [P29692-1]
NP_001123528.1, NM_001130056.3 [P29692-3]
NP_001123529.1, NM_001130057.3 [P29692-1]
NP_001182132.1, NM_001195203.2 [P29692-4]
NP_001276879.1, NM_001289950.2 [P29692-1]
NP_001304672.1, NM_001317743.2 [P29692-3]
NP_001317575.1, NM_001330646.1 [P29692-3]
NP_001951.2, NM_001960.5 [P29692-1]
NP_115754.3, NM_032378.5 [P29692-2]
XP_005250880.1, XM_005250823.1 [P29692-2]
XP_006716585.1, XM_006716522.1 [P29692-2]
XP_006716586.1, XM_006716523.1 [P29692-2]
XP_006716587.1, XM_006716524.1 [P29692-2]
XP_006716588.1, XM_006716525.1 [P29692-1]
XP_011515207.1, XM_011516905.2 [P29692-2]
XP_011515208.1, XM_011516906.2 [P29692-2]
XP_016868659.1, XM_017013170.1 [P29692-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MVMNMR-A153-192[»]
2MVNNMR-A153-192[»]
2N51NMR-A153-281[»]
5JPOX-ray2.00E1-30[»]
AlphaFoldDBiP29692
BMRBiP29692
SMRiP29692
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108256, 258 interactors
IntActiP29692, 151 interactors
MINTiP29692
STRINGi9606.ENSP00000410059

Chemistry databases

ChEMBLiCHEMBL4295739

PTM databases

iPTMnetiP29692
MetOSiteiP29692
PhosphoSitePlusiP29692
SwissPalmiP29692

Genetic variation databases

BioMutaiEEF1D
DMDMi20141357

2D gel databases

OGPiP29692

Proteomic databases

CPTACiCPTAC-500
CPTAC-501
EPDiP29692
jPOSTiP29692
MassIVEiP29692
MaxQBiP29692
PaxDbiP29692
PeptideAtlasiP29692
PRIDEiP29692
ProteomicsDBi19276
54603 [P29692-1]
54604 [P29692-2]
54605 [P29692-3]
TopDownProteomicsiP29692-1 [P29692-1]
P29692-3 [P29692-3]
P29692-4 [P29692-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27948, 315 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		1936

Genome annotation databases

EnsembliENST00000317198.10; ENSP00000317399.6; ENSG00000104529.19
ENST00000395119.7; ENSP00000378551.3; ENSG00000104529.19
ENST00000419152.7; ENSP00000388261.2; ENSG00000104529.19
ENST00000442189.6; ENSP00000391944.2; ENSG00000104529.19 [P29692-2]
ENST00000524624.5; ENSP00000435697.1; ENSG00000104529.19 [P29692-3]
ENST00000526838.5; ENSP00000436507.1; ENSG00000104529.19 [P29692-4]
ENST00000528610.5; ENSP00000431763.1; ENSG00000104529.19 [P29692-3]
ENST00000529272.5; ENSP00000434872.1; ENSG00000104529.19
ENST00000529516.6; ENSP00000431742.2; ENSG00000104529.19 [P29692-4]
ENST00000530191.6; ENSP00000436542.2; ENSG00000104529.19
ENST00000530445.6; ENSP00000436933.2; ENSG00000104529.19
ENST00000531218.6; ENSP00000434448.2; ENSG00000104529.19
ENST00000533494.6; ENSP00000433412.2; ENSG00000104529.19
ENST00000534377.6; ENSP00000431460.2; ENSG00000104529.19 [P29692-3]
ENST00000534380.6; ENSP00000433611.2; ENSG00000104529.19
ENST00000614575.4; ENSP00000478340.2; ENSG00000273594.4
ENST00000615067.4; ENSP00000479653.1; ENSG00000273594.4
ENST00000615698.4; ENSP00000483527.1; ENSG00000273594.4
ENST00000618139.4; ENSP00000484536.2; ENSG00000104529.19 [P29692-2]
ENST00000619144.4; ENSP00000477608.1; ENSG00000273594.4 [P29692-2]
ENST00000620155.3; ENSP00000480505.1; ENSG00000273594.4 [P29692-2]
ENST00000631698.1; ENSP00000488672.1; ENSG00000273594.4 [P29692-4]
ENST00000632587.1; ENSP00000487680.1; ENSG00000273594.4
ENST00000632675.1; ENSP00000488026.1; ENSG00000273594.4 [P29692-3]
ENST00000632965.1; ENSP00000488275.1; ENSG00000273594.4 [P29692-3]
GeneIDi1936
KEGGihsa:1936
MANE-SelectiENST00000618139.4; ENSP00000484536.2; NM_001130053.5; NP_001123525.3 [P29692-2]
UCSCiuc003yyr.4, human [P29692-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1936
DisGeNETi1936

GeneCards: human genes, protein and diseases

More...GeneCardsi		EEF1D
HGNCiHGNC:3211, EEF1D
HPAiENSG00000104529, Low tissue specificity
MalaCardsiEEF1D
MIMi130592, gene
neXtProtiNX_P29692
OpenTargetsiENSG00000104529
PharmGKBiPA27647
VEuPathDBiHostDB:ENSG00000104529

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1668, Eukaryota
GeneTreeiENSGT00950000183014
HOGENOMiCLU_020166_0_0_1
InParanoidiP29692
OMAiRVWLDKP
OrthoDBi1464823at2759
PhylomeDBiP29692
TreeFamiTF313134

Enzyme and pathway databases

PathwayCommonsiP29692
ReactomeiR-HSA-156842, Eukaryotic Translation Elongation
SignaLinkiP29692
SIGNORiP29692

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1936, 13 hits in 1077 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		EEF1D, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		EEF1D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1936
PharosiP29692, Tbio

Protein Ontology

More...PROi		PR:P29692
RNActiP29692, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000104529, Expressed in tendon of biceps brachii and 247 other tissues
ExpressionAtlasiP29692, baseline and differential
GenevisibleiP29692, HS

Family and domain databases

CDDicd00292, EF1B, 1 hit
Gene3Di3.30.70.60, 1 hit
InterProiView protein in InterPro
IPR036219, eEF-1beta-like_sf
IPR018940, EF-1_beta_acid_region_euk
IPR014038, EF1B_bsu/dsu_GNE
IPR014717, Transl_elong_EF1B/ribosomal_S6
IPR001326, Transl_elong_EF1B_B/D_CS
PfamiView protein in Pfam
PF10587, EF-1_beta_acid, 1 hit
PF00736, EF1_GNE, 1 hit
SMARTiView protein in SMART
SM01182, EF-1_beta_acid, 1 hit
SM00888, EF1_GNE, 1 hit
SUPFAMiSSF54984, SSF54984, 1 hit
PROSITEiView protein in PROSITE
PS00824, EF1BD_1, 1 hit
PS00825, EF1BD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEF1D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29692
Secondary accession number(s): B4DDU4
, D3DWK3, E9PBQ9, Q4VBZ6, Q969J1, Q96I38
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: May 25, 2022
This is version 225 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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