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Protein

Mitochondrial-processing peptidase subunit alpha

Gene

MPP

Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves presequences (transit peptides) from mitochondrial protein precursors.By similarity
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. Mediate formation of the complex between cytochromes c and c1.

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

Catalytic activityi

Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.
Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+.

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Oxidoreductase, Protease
Biological processElectron transport, Respiratory chain, Transport

Protein family/group databases

MEROPSiM16.971

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial-processing peptidase subunit alpha (EC:3.4.24.64)
Alternative name(s):
Alpha-MPP
Ubiquinol-cytochrome-c reductase subunit II (EC:1.10.2.2)
Gene namesi
Name:MPP
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000026776? – 504Mitochondrial-processing peptidase subunit alpha
Transit peptidei1 – ?Mitochondrion

Proteomic databases

PRIDEiP29677
ProMEXiP29677

PTM databases

CarbonylDBiP29677

Expressioni

Gene expression databases

ExpressionAtlasiP29677 baseline

Interactioni

Subunit structurei

Heterodimer of alpha and beta subunits.

Protein-protein interaction databases

IntActiP29677, 1 interactor
STRINGi4113.PGSC0003DMT400000784

Structurei

3D structure databases

ProteinModelPortaliP29677
SMRiP29677
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2067 Eukaryota
COG0612 LUCA
InParanoidiP29677
KOiK01412

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
SUPFAMiSSF63411 SSF63411, 2 hits
PROSITEiView protein in PROSITE
PS00143 INSULINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRCASSRLS SLKARQGNRV LTRFSSSAAV ATKPSGGLFS WITGDTSSSV
60 70 80 90 100
TPLDFPLNDV KLSPPLPDYV EPAKTQITTL ANGLKVASEA SVNPAASIGL
110 120 130 140 150
YVDCGSIYET PASYGATHLL ERMAFKSTLN RSHLRIVREI EAIGGNVTAS
160 170 180 190 200
ASREHMIYTY DALKTYVPQM VEMLADCVRN PAFLDWEVKE QLEKVKAEIS
210 220 230 240 250
EYSKNPQHLL LEAVHSAGYA GPYGNSLMAT EATINRLNST VLEEFVAENY
260 270 280 290 300
TAPRMVLAAS GVEHEEFLKV AEPLLSDLPK VATIEEPKPV YVGGDYRCQA
310 320 330 340 350
DAEMTHFALA FEVPGGWMSE KESMTLTVLQ MLMGGGGSFS AGGPGKGMYS
360 370 380 390 400
RLYLRVLNQY PQIHAFSAFS SIYNNTGLFG IQGTTSSDFG PQAVDVAVKE
410 420 430 440 450
LIAVANPSEV DQVQLNRAKQ ATKSAILMNL ESRMVASEDI GRQLLTYGER
460 470 480 490 500
NPVEHFLKAI DAVSAKDIAS VVQKLISSPL TMASYGDVLS LPSYDAVSSR

FRSK
Length:504
Mass (Da):54,677
Last modified:April 1, 1993 - v1
Checksum:iFD3053688571D987
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66284 mRNA Translation: CAA46990.1
PIRiS23558
RefSeqiNP_001275168.1, NM_001288239.1
UniGeneiStu.18155

Genome annotation databases

GeneIDi102580877
KEGGisot:102580877

Similar proteinsi

Entry informationi

Entry nameiMPPA_SOLTU
AccessioniPrimary (citable) accession number: P29677
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 20, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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