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Protein

Cytochrome c oxidase subunit 2

Gene

mt-co2

Organism
Scaphirhynchus platorynchus (Shovelnose sturgeon) (Acipenser platorynchus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:mt-co2
Synonyms:coii, coxii, mtco2
Encoded oniMitochondrion
OrganismiScaphirhynchus platorynchus (Shovelnose sturgeon) (Acipenser platorynchus)
Taxonomic identifieri7910 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiChondrosteiAcipenseriformesAcipenseridaeScaphirhynchus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26Mitochondrial intermembraneSequence analysisAdd BLAST26
Transmembranei27 – 48HelicalCuratedAdd BLAST22
Topological domaini49 – 62Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei63 – ›64HelicalCurated›2

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836841 – ›64Cytochrome c oxidase subunit 2Add BLAST›64

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90, 1 hit
InterProiView protein in InterPro
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF02790 COX2_TM, 1 hit
SUPFAMiSSF81464 SSF81464, 1 hit
PROSITEiView protein in PROSITE
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Fragment.

P29662-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHPSQLGFQ DAASPVMEEL XHFHDHTLMI VFLISTLVXY IIVAMVSTKL
60
TNKYVLDSQE IEIV
Length:64
Mass (Da):7,239
Last modified:April 1, 1993 - v1
Checksum:i6E4EC5BA1A7CEB1D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei641

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64920 Genomic DNA Translation: AAB01482.1 Sequence problems.

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64920 Genomic DNA Translation: AAB01482.1 Sequence problems.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.287.90, 1 hit
InterProiView protein in InterPro
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF02790 COX2_TM, 1 hit
SUPFAMiSSF81464 SSF81464, 1 hit
PROSITEiView protein in PROSITE
PS50999 COX2_TM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_SCAPL
AccessioniPrimary (citable) accession number: P29662
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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