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UniProtKB - P29618 (CDKA1_ORYSJ)
Protein
Cyclin-dependent kinase A-1
Gene
CDKA-1
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 33 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 127 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 18 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cyclin binding Source: GO_Central
- cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine kinase activity Source: RHEA
- RNA polymerase II CTD heptapeptide repeat kinase activity Source: UniProtKB-EC
GO - Biological processi
- G1/S transition of mitotic cell cycle Source: GO_Central
- protein phosphorylation Source: GO_Central
- regulation of G2/M transition of mitotic cell cycle Source: GO_Central
- regulation of gene expression Source: GO_Central
- regulation of meiotic cell cycle Source: GO_Central
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PlantReactomei | R-OSA-9640760, G1 phase R-OSA-9640887, G1/S transition |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CDKA-1 Synonyms:CDC2-1 Ordered Locus Names:Os03g0118400, LOC_Os03g02680 |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Other locations
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- cytoplasm Source: GO_Central
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 161 | T → A: Loss of phosphorylation by CDKD-1. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085755 | 1 – 294 | Cyclin-dependent kinase A-1Add BLAST | 294 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 14 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 15 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 161 | Phosphothreonine; by CAK1 Publication | 1 |
Post-translational modificationi
Phosphorylated at Thr-161 by CDKD-1.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P29618 |
PTM databases
iPTMneti | P29618 |
Expressioni
Tissue specificityi
Expressed in the dividing region of the root apex and in differentiated cells such as those in the sclerenchyma, pericycle and parenchyma of the central cylinder.1 Publication
Developmental stagei
Expressed throughout the cell cycle.1 Publication
Inductioni
By submergence. Down-regulated by cytokinin.2 Publications
Interactioni
GO - Molecular functioni
- cyclin binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 4530.OS03T0118400-01 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 287 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 284 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0594, Eukaryota |
InParanoidi | P29618 |
OrthoDBi | 1010560at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P29618-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQYEKEEKI GEGTYGVVYR ARDKVTNETI ALKKIRLEQE DEGVPSTAIR
60 70 80 90 100
EISLLKEMHH GNIVRLHDVI HSEKRIYLVF EYLDLDLKKF MDSCPEFAKN
110 120 130 140 150
PTLIKSYLYQ ILRGVAYCHS HRVLHRDLKP QNLLIDRRTN ALKLADFGLA
160 170 180 190 200
RAFGIPVRTF THEVVTLWYR APEILLGSRQ YSTPVDMWSV GCIFAEMVNQ
210 220 230 240 250
KPLFPGDSEI DELFKIFRVL GTPNEQSWPG VSSLPDYKSA FPKWQAQDLA
260 270 280 290
TIVPTLDPAG LDLLSKMLRY EPNKRITARQ ALEHEYFKDL EMVQ
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0P0VSB9 | A0A0P0VSB9_ORYSJ | Os03g0118400 protein | Os03g0118400, OSNPB_030118400 | 164 | Annotation score: | ||
A0A0P0VSA1 | A0A0P0VSA1_ORYSJ | Os03g0118400 protein | Os03g0118400, OSNPB_030118400 | 108 | Annotation score: | ||
A0A0P0VS98 | A0A0P0VS98_ORYSJ | Os03g0118400 protein | Os03g0118400, OSNPB_030118400 | 77 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60374 mRNA Translation: CAA42922.1 DP000009 Genomic DNA Translation: ABF93669.1 AP008209 Genomic DNA Translation: BAF10686.1 AP014959 Genomic DNA No translation available. |
PIRi | S22440 |
RefSeqi | XP_015631633.1, XM_015776147.1 |
Genome annotation databases
GeneIDi | 4331415 |
KEGGi | osa:4331415 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60374 mRNA Translation: CAA42922.1 DP000009 Genomic DNA Translation: ABF93669.1 AP008209 Genomic DNA Translation: BAF10686.1 AP014959 Genomic DNA No translation available. |
PIRi | S22440 |
RefSeqi | XP_015631633.1, XM_015776147.1 |
3D structure databases
AlphaFoldDBi | P29618 |
SMRi | P29618 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4530.OS03T0118400-01 |
PTM databases
iPTMneti | P29618 |
Proteomic databases
PaxDbi | P29618 |
Genome annotation databases
GeneIDi | 4331415 |
KEGGi | osa:4331415 |
Phylogenomic databases
eggNOGi | KOG0594, Eukaryota |
InParanoidi | P29618 |
OrthoDBi | 1010560at2759 |
Enzyme and pathway databases
PlantReactomei | R-OSA-9640760, G1 phase R-OSA-9640887, G1/S transition |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDKA1_ORYSJ | |
Accessioni | P29618Primary (citable) accession number: P29618 Secondary accession number(s): Q10SL8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | May 25, 2022 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations - SIMILARITY comments
Index of protein domains and families