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Entry version 197 (26 Feb 2020)
Sequence version 3 (24 Mar 2009)
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Protein

Homeobox protein prospero

Gene

pros

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Homeodomain protein that controls neuronal identity (PubMed:1842358). As a transcriptional factor, regulates the expression of ftz, eve and en in a subset of neuroblast progeny and modulates the transcriptional activity of other homeodomain proteins such as Dfd (PubMed:12429095, PubMed:15837198, PubMed:9380747). Required for proper neuronal differentiation, axonal outgrowth and pathfinding of most or all neurons and their precursors in central and peripheral nervous systems (PubMed:20152183, PubMed:27510969, PubMed:1720353, PubMed:1842358, PubMed:1540176, PubMed:11051550, PubMed:18342578, PubMed:23056424, PubMed:16564014). Regulates asymmetric stem cell self-renewal together with brat (PubMed:16564014).10 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein prospero
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pros
ORF Names:CG17228
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004595 pros

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethal, results in the aberrant expression of the homeobox genes ftz, eve and en in a subset of neuroblasts, and in axonal outgrowth and pathfinding defects in both motoneurons and sensory neurons.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002088841 – 1703Homeobox protein prosperoAdd BLAST1703

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei479Phosphoserine1 Publication1
Modified residuei482Phosphoserine1 Publication1
Modified residuei485Phosphoserine1 Publication1
Modified residuei497Phosphoserine1 Publication1
Modified residuei651Phosphoserine1 Publication1
Modified residuei654Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29617

PRoteomics IDEntifications database

More...
PRIDEi
P29617

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P29617

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In embryos, expressed mainly in neuronal precursors but detected also in cells lining the gut and Garland cells (at protein level) (PubMed:20152183, PubMed:27510969, PubMed:1720353, PubMed:1540176). Expressed during embryogenesis in different cells of the central and peripheral nervous system including neuroblasts and ganglion mother cells (GMC) (PubMed:1720353, PubMed:1842358).5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004595 Expressed in embryo and 67 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P29617 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P29617 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1582Interaction with DNACombined sources2 Publications1
Sitei1587Interaction with DNACombined sources2 Publications1
Sitei1590Interaction with DNACombined sources2 Publications1
Sitei1591Interaction with DNACombined sources2 Publications1
Sitei1594Interaction with DNACombined sources2 Publications1
Sitei1597Interaction with DNACombined sources2 Publications1
Sitei1676Interaction with DNACombined sources2 Publications1

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
66496, 29 interactors

Protein interaction database and analysis system

More...
IntActi
P29617, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0293146

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11703
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P29617

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P29617

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1545 – 1603Prospero-type homeoPROSITE-ProRule annotationAdd BLAST59
Domaini1604 – 1703ProsperoPROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1545 – 1703Homeo-ProsperoPROSITE-ProRule annotationAdd BLAST159

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1291 – 1298Nuclear localization signal8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi516 – 564Gln-richAdd BLAST49
Compositional biasi570 – 586Asn-richAdd BLAST17
Compositional biasi618 – 654Ser-richAdd BLAST37
Compositional biasi1000 – 1348Gln-richAdd BLAST349
Compositional biasi1427 – 1437His-richAdd BLAST11

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.PROSITE-ProRule annotation2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Prospero homeodomain family.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3779 Eukaryota
ENOG410ZE21 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154790

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P29617

KEGG Orthology (KO)

More...
KOi
K20211

Identification of Orthologs from Complete Genome Data

More...
OMAi
SMMLDQD

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.500, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023082 Homeo_prospero_dom
IPR037131 Homeo_prospero_dom_sf
IPR009057 Homeobox-like_sf
IPR039350 Prospero_homeodomain

The PANTHER Classification System

More...
PANTHERi
PTHR12198 PTHR12198, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05044 HPD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51818 HOMEO_PROSPERO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform MImported (identifier: P29617-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMSSEEYEAD CFGLYSDENN VLLKANEPET TAATKQQHQP QFQQQQQQQQ
60 70 80 90 100
QQQQHHHQHQ QPPPSSNGHT SPIPSQVNGD GSAANCGESG KTNTNTGSHS
110 120 130 140 150
HSNSGNTNTD ADKEQEREKA KEKANEEESE DSDDDVVVVL EGCEGNASSS
160 170 180 190 200
SSSSNSNSNA SSNNHKAAAT TTTTATTANH CNRSGGSSRS HRSARSSRQI
210 220 230 240 250
SQSTAVGKTT TCAAKKPTAA QATTTTAKNS NSNSNVNVNV NVNSNGSGNG
260 270 280 290 300
NANSKVNRRS RQRSLSKDIN NQPASSNSNS NSSNNSSNSN GGATATAAGF
310 320 330 340 350
MSSAAAAAAG AAGGGALFQP QSVSTANSSS SNNNNSSTPA ALATHSPTSN
360 370 380 390 400
SPVSGASSAS SLLTAAFGNL FGGSSAKMLN ELFGRQMKQA QDATSGLPQS
410 420 430 440 450
LDNAMLAAAM ETATSAELLI GSLNSTSKLL QQQHNNNSIA PANSTPMSNG
460 470 480 490 500
TNASISPGSA HSSSHSHQGV SPKGSRRVSA CSDRSLEAAA ADVAGGSPPR
510 520 530 540 550
AASVSSLNGG ASSGEQHQSQ LQHDLVAHHM LRNILQGKKE LMQLDQELRT
560 570 580 590 600
AMQQQQQQLQ EKEQLHSKLN NNNNNNIAAT ANNNNNTTME SINLIDDSEM
610 620 630 640 650
ADIKIKSEPQ TAPQPQQSPH GSSHSSRSGS GSGSHSSMAS DGSLRRKSSD
660 670 680 690 700
SLDSHGAQDD AQDEEDAAPT GQRSESRAPE EPQLPTKKES VDDMLDEVEL
710 720 730 740 750
LGLHSRGSDM DSLASPSHSD MMLLDKDDVL DEDDDDDCVE QKTSGSGCLK
760 770 780 790 800
KPGMDLKRAR VENIVSGMRC SPSSGLAQAG QLQVNGCKKR KLYQPQQHAM
810 820 830 840 850
ERYVAAAAGL NFGLNLQSMM LDQEDSESNE LESPQIQQKR VEKNALKSQL
860 870 880 890 900
RSMQEQLAEM QQKYVQLCSR MEQESECQEL DQDQDVEQEQ EPDNGSSDHI
910 920 930 940 950
ELSPSPTLTG DGDVSPNHKE ETGQERPGSS SPSPSPLKPK TSLGESSDSG
960 970 980 990 1000
ANMLSQMMSK MMSGKLHNPL VGVGHPALPQ GFPPLLQHMG DMSHAAAMYQ
1010 1020 1030 1040 1050
QFFFEQEARM AKEAAEQQQQ QQQQQQQQQQ QQQQEQQRRF EQEQQEQQRR
1060 1070 1080 1090 1100
KEEQQQQIQR QQQHLQQLQQ QQMEQQHVAT AAPRPQMHHP APARLPTRMG
1110 1120 1130 1140 1150
GAAGHTALKS ELSEKFQMLR ANNNSSMMRM SGTDLEGLAD VLKSEITTSL
1160 1170 1180 1190 1200
SALVDTIVTR FVHQRRLFSK QADSVTAAAE QLNKDLLLAS QILDRKSPRT
1210 1220 1230 1240 1250
KVADRPQNGP TPATQSAAAM FQAPKTPQGM NPVAAAALYN SMTGPFCLPP
1260 1270 1280 1290 1300
DQQQQQQTAQ QQQSAQQQQQ SSQQTQQQLE QNEALSLVVT PKKKRHKVTD
1310 1320 1330 1340 1350
TRITPRTVSR ILAQDGVVPP TGGPPSTPQQ QQQQQQQQQQ QQQQQQQQAS
1360 1370 1380 1390 1400
NGGNSNATPA QSPTRSSGGA AYHPQPPPPP PPMMPVSLPT SVAIPNPSLH
1410 1420 1430 1440 1450
ESKVFSPYSP FFNPHAAAGQ ATAAQLHQHH QQHHPHHQSM QLSSSPPGSL
1460 1470 1480 1490 1500
GALMDSRDSP PLPHPPSMLH PALLAAAHHG GSPDYKTCLR AVMDAQDRQS
1510 1520 1530 1540 1550
ECNSADMQFD GMAPTISFYK QMQLKTEHQE SLMAKHCESL TPLHSSTLTP
1560 1570 1580 1590 1600
MHLRKAKLMF FWVRYPSSAV LKMYFPDIKF NKNNTAQLVK WFSNFREFYY
1610 1620 1630 1640 1650
IQMEKYARQA VTEGIKTPDD LLIAGDSELY RVLNLHYNRN NHIEVPQNFR
1660 1670 1680 1690 1700
FVVESTLREF FRAIQGGKDT EQSWKKSIYK IISRMDDPVP EYFKSPNFLE

QLE
Length:1,703
Mass (Da):184,980
Last modified:March 24, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35040F15C1CBB1D8
GO
Isoform IImported (identifier: P29617-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1216-1216: S → SGNNGSLLLA...PPPHIRPSPT
     1516-1544: Missing.

Show »
Length:1,835
Mass (Da):198,422
Checksum:i9C9F48EEEF8D2F3A
GO
Isoform HImported (identifier: P29617-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1516-1544: Missing.

Show »
Length:1,674
Mass (Da):181,539
Checksum:i7B55B08222C636A6
GO
Isoform JImported (identifier: P29617-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-300: Missing.

Show »
Length:1,403
Mass (Da):153,569
Checksum:i9EFB9973E24E238E
GO
Isoform LImported (identifier: P29617-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-300: Missing.
     1516-1544: Missing.

Show »
Length:1,374
Mass (Da):150,128
Checksum:i2561D9655D3F47FE
GO
Isoform KImported (identifier: P29617-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-300: Missing.
     1216-1216: S → SGNNGSLLLA...PPPHIRPSPT
     1516-1544: Missing.

Show »
Length:1,535
Mass (Da):167,011
Checksum:i5EBE662B6D5F7053
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4K630A0A0B4K630_DROME
Prospero, isoform I
pros 01, 02, 0244, 0320, 0441
1,835Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K6Q6A0A0B4K6Q6_DROME
Prospero, isoform H
pros 01, 02, 0244, 0320, 0441
1,674Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA28841 differs from that shown. Reason: Frameshift.Curated
The sequence AAL28228 differs from that shown. Reason: Frameshift.Curated
The sequence AAL28228 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAT94492 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA01464 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA77802 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49 – 57QQQQQQHHH → HHQ in AAA28841 (PubMed:1720353).Curated9
Sequence conflicti124 – 135ANEEE…DSDDD → RTKRSPRIPTTT in AAA28841 (PubMed:1720353).CuratedAdd BLAST12
Sequence conflicti175A → G in AAA28841 (PubMed:1720353).Curated1
Sequence conflicti230S → L in AAA28841 (PubMed:1720353).Curated1
Sequence conflicti283S → R in AAA28841 (PubMed:1720353).Curated1
Sequence conflicti293A → R in AAA28841 (PubMed:1720353).Curated1
Sequence conflicti376 – 398AKMLN…TSGLP → GQDAERAVWPPDEAGPGRNE WPA in AAA28841 (PubMed:1720353).CuratedAdd BLAST23
Sequence conflicti376 – 398AKMLN…TSGLP → GQDAERAVWPPDEAGPGRNE WPA in AAF05703 (PubMed:11051550).CuratedAdd BLAST23
Sequence conflicti420 – 444IGSLN…APANS → NLALQFHVQVAAAAAITTAL LPPIG in AAA28841 (PubMed:1720353).CuratedAdd BLAST25
Sequence conflicti420 – 444IGSLN…APANS → NLALQFHVQVAAAAAITTAL LPPIG in AAF05703 (PubMed:11051550).CuratedAdd BLAST25
Sequence conflicti718H → Q in BAA01464 (PubMed:1540176).Curated1
Sequence conflicti977A → C in AAA28841 (PubMed:1720353).Curated1
Sequence conflicti1102A → S in AAA28841 (PubMed:1720353).Curated1
Sequence conflicti1258T → S in AAA28841 (PubMed:1720353).Curated1
Sequence conflicti1348Q → QQQQQ in AAA28841 (PubMed:1720353).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0595981 – 300Missing in isoform J, isoform L and isoform K. CuratedAdd BLAST300
Alternative sequenceiVSP_0023071216S → SGNNGSLLLANSQMPSQTTA SGSSAQQQQQQNAQQQHQGS QQQQQQNVVQQQNVAQQQHM QQQQQQQQSHPLLPPNCQQL ISAPRLNGSQLSFASPAAAA AAAMGLQMHHAAAAAAMSAQ QQQQQSGDPGANTNPNSGPA NPTNSSLSTLNIPPPHIRPS PT in isoform I and isoform K. 1 Publication1
Alternative sequenceiVSP_0023081516 – 1544Missing in isoform I, isoform H, isoform L and isoform K. 2 PublicationsAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M81389 mRNA Translation: AAA28841.1 Frameshift.
AE014297 Genomic DNA Translation: AAF54628.3
AE014297 Genomic DNA Translation: AAN13500.3
AE014297 Genomic DNA Translation: AAN13501.3
AE014297 Genomic DNA Translation: AFH06364.1
Z11743 mRNA Translation: CAA77802.1 Different initiation.
D10609 mRNA Translation: BAA01464.1 Different initiation.
BT015263 mRNA Translation: AAT94492.1 Different initiation.
AF190403 Genomic DNA Translation: AAF05703.1
AY060680 mRNA Translation: AAL28228.1 Sequence problems.

Protein sequence database of the Protein Information Resource

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PIRi
S24548

NCBI Reference Sequences

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RefSeqi
NP_001247046.1, NM_001260117.2 [P29617-1]
NP_524317.4, NM_079593.6 [P29617-5]
NP_731565.4, NM_169386.3 [P29617-7]
NP_788636.3, NM_176459.4 [P29617-6]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0304603; FBpp0293145; FBgn0004595 [P29617-4]
FBtr0304604; FBpp0293146; FBgn0004595 [P29617-2]
FBtr0304605; FBpp0293147; FBgn0004595 [P29617-5]
FBtr0304606; FBpp0293148; FBgn0004595 [P29617-7]
FBtr0304607; FBpp0293149; FBgn0004595 [P29617-6]
FBtr0304608; FBpp0293150; FBgn0004595 [P29617-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
41363

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG17228

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81389 mRNA Translation: AAA28841.1 Frameshift.
AE014297 Genomic DNA Translation: AAF54628.3
AE014297 Genomic DNA Translation: AAN13500.3
AE014297 Genomic DNA Translation: AAN13501.3
AE014297 Genomic DNA Translation: AFH06364.1
Z11743 mRNA Translation: CAA77802.1 Different initiation.
D10609 mRNA Translation: BAA01464.1 Different initiation.
BT015263 mRNA Translation: AAT94492.1 Different initiation.
AF190403 Genomic DNA Translation: AAF05703.1
AY060680 mRNA Translation: AAL28228.1 Sequence problems.
PIRiS24548
RefSeqiNP_001247046.1, NM_001260117.2 [P29617-1]
NP_524317.4, NM_079593.6 [P29617-5]
NP_731565.4, NM_169386.3 [P29617-7]
NP_788636.3, NM_176459.4 [P29617-6]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MIJX-ray2.05A1545-1696[»]
1XPXX-ray2.80A1541-1703[»]
SMRiP29617
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi66496, 29 interactors
IntActiP29617, 3 interactors
STRINGi7227.FBpp0293146

PTM databases

iPTMnetiP29617

Proteomic databases

PaxDbiP29617
PRIDEiP29617

Genome annotation databases

EnsemblMetazoaiFBtr0304603; FBpp0293145; FBgn0004595 [P29617-4]
FBtr0304604; FBpp0293146; FBgn0004595 [P29617-2]
FBtr0304605; FBpp0293147; FBgn0004595 [P29617-5]
FBtr0304606; FBpp0293148; FBgn0004595 [P29617-7]
FBtr0304607; FBpp0293149; FBgn0004595 [P29617-6]
FBtr0304608; FBpp0293150; FBgn0004595 [P29617-1]
GeneIDi41363
KEGGidme:Dmel_CG17228

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41363
FlyBaseiFBgn0004595 pros

Phylogenomic databases

eggNOGiKOG3779 Eukaryota
ENOG410ZE21 LUCA
GeneTreeiENSGT00940000154790
InParanoidiP29617
KOiK20211
OMAiSMMLDQD

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
pros fly
EvolutionaryTraceiP29617

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41363

Protein Ontology

More...
PROi
PR:P29617

Gene expression databases

BgeeiFBgn0004595 Expressed in embryo and 67 other tissues
ExpressionAtlasiP29617 baseline and differential
GenevisibleiP29617 DM

Family and domain databases

Gene3Di1.10.10.500, 1 hit
InterProiView protein in InterPro
IPR023082 Homeo_prospero_dom
IPR037131 Homeo_prospero_dom_sf
IPR009057 Homeobox-like_sf
IPR039350 Prospero_homeodomain
PANTHERiPTHR12198 PTHR12198, 1 hit
PfamiView protein in Pfam
PF05044 HPD, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51818 HOMEO_PROSPERO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPROS_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29617
Secondary accession number(s): A0A0B4K660
, Q6AWI5, Q95SP0, Q9U6A2, Q9VGP8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: March 24, 2009
Last modified: February 26, 2020
This is version 197 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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