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Entry version 167 (02 Jun 2021)
Sequence version 3 (25 Jul 2006)
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Protein

Triosephosphate isomerase

Gene

Tpi

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate. This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei10SubstrateBy similarity1
Binding sitei12SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei94ElectrophileBy similarity1
Active sitei164Proton acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-70171, Glycolysis
R-DME-70263, Gluconeogenesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00109;UER00189
UPA00138

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Triosephosphate isomerase (EC:5.3.1.1)
Short name:
TIM
Alternative name(s):
Triose-phosphate isomerase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tpi
ORF Names:CG2171
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0086355, Tpi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000901301 – 247Triosephosphate isomeraseAdd BLAST247

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29613

PRoteomics IDEntifications database

More...
PRIDEi
P29613

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present in substantial amounts in oocytes, declines in abundance in early embryos, and begins to increase during mid-embryogenesis. Levels peak in the third instar larva then decline during pupal stages, rising again near the time of eclosion.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0086355, Expressed in arthropod fat body and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P29613, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P29613, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
68438, 22 interactors

Protein interaction database and analysis system

More...
IntActi
P29613, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0084948

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P29613

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the triosephosphate isomerase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1643, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013354

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024251_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P29613

Identification of Orthologs from Complete Genome Data

More...
OMAi
QEVCGAI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P29613

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00311, TIM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00147_B, TIM_B, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785, Aldolase_TIM
IPR035990, TIM_sf
IPR022896, TrioseP_Isoase_bac/euk
IPR000652, Triosephosphate_isomerase
IPR020861, Triosephosphate_isomerase_AS

The PANTHER Classification System

More...
PANTHERi
PTHR21139, PTHR21139, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00121, TIM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51351, SSF51351, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00419, tim, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00171, TIM_1, 1 hit
PS51440, TIM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform B (identifier: P29613-2) [UniParc]FASTAAdd to basket
Also known as: C

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRKFCVGGN WKMNGDQKSI AEIAKTLSSA ALDPNTEVVI GCPAIYLMYA
60 70 80 90 100
RNLLPCELGL AGQNAYKVAK GAFTGEISPA MLKDIGADWV ILGHSERRAI
110 120 130 140 150
FGESDALIAE KAEHALAEGL KVIACIGETL EEREAGKTNE VVARQMCAYA
160 170 180 190 200
QKIKDWKNVV VAYEPVWAIG TGQTATPDQA QEVHAFLRQW LSDNISKEVS
210 220 230 240
ASLRIQYGGS VTAANAKELA KKPDIDGFLV GGASLKPEFV DIINARQ
Length:247
Mass (Da):26,626
Last modified:July 25, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68D7DCC8689C2D39
GO
Isoform A (identifier: P29613-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPPGVLNDLN...DCTDSNSNNM

Show »
Length:348
Mass (Da):37,939
Checksum:i6C1DCA1CA0D9134C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti186F → S in CAA40804 (PubMed:1720860).Curated1
Sequence conflicti240V → L in CAA40804 (PubMed:1720860).Curated1
Isoform A (identifier: P29613-1)
Sequence conflicti12N → I in AAS77472 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti173Q → K in strain: 178.7, 709.6, A-26, DPF-13, DPF-2, DPF-30, DPF-46, DPF-53, DPF-62, DPF-77, DPF-81, DPF-82.1, EM-10, Mali-10.2, Mali-4.2, Mali-4.4, Oregon-R, R-60, VC-805, VC-815, Z-1, Z-35, Z-44, Z-48 and Z-5. 2 Publications1
Natural varianti230V → F in strain: 709.6. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0156591M → MPPGVLNDLNRNGIQCIASV TLLQRFPYHRNHHTIPTMDQ NRPTVGGVTAEVLKAVVSEA LLGKFTAVFPKLFKCQWKTY EGQKKFYANFSTDCTDSNSN NM in isoform A. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X57576 Genomic DNA Translation: CAA40804.1
U60836 Genomic DNA Translation: AAC39041.1
U60837 Genomic DNA Translation: AAC39042.1
U60838 Genomic DNA Translation: AAC39043.1
U60839 Genomic DNA Translation: AAC39044.1
U60840 Genomic DNA Translation: AAC39045.1
U60841 Genomic DNA Translation: AAC39046.1
U60842 Genomic DNA Translation: AAC39047.1
U60843 Genomic DNA Translation: AAC39048.1
U60844 Genomic DNA Translation: AAC39049.1
U60845 Genomic DNA Translation: AAC39050.1
U60846 Genomic DNA Translation: AAC39051.1
U60847 Genomic DNA Translation: AAC39052.1
U60848 Genomic DNA Translation: AAC39053.1
U60849 Genomic DNA Translation: AAC39054.1
U60850 Genomic DNA Translation: AAC39055.1
U60851 Genomic DNA Translation: AAC39056.1
U60852 Genomic DNA Translation: AAC39057.1
U60853 Genomic DNA Translation: AAC39058.1
U60854 Genomic DNA Translation: AAC39059.1
U60855 Genomic DNA Translation: AAC39060.1
U60856 Genomic DNA Translation: AAC39061.1
U60857 Genomic DNA Translation: AAC39062.1
U60858 Genomic DNA Translation: AAC39063.1
U60859 Genomic DNA Translation: AAC39064.1
U60860 Genomic DNA Translation: AAC39065.1
AE014297 Genomic DNA Translation: AAN14218.1
AE014297 Genomic DNA Translation: AAN14219.1
BT012347 mRNA Translation: AAS77472.1
BT014664 mRNA Translation: AAT27288.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S18604

NCBI Reference Sequences

More...
RefSeqi
NP_788764.1, NM_176587.2 [P29613-1]
NP_788765.1, NM_176588.2 [P29613-2]
NP_788766.1, NM_176589.2 [P29613-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0085582; FBpp0084948; FBgn0086355 [P29613-1]
FBtr0085583; FBpp0084949; FBgn0086355 [P29613-2]
FBtr0085584; FBpp0084950; FBgn0086355 [P29613-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
43582

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG2171

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57576 Genomic DNA Translation: CAA40804.1
U60836 Genomic DNA Translation: AAC39041.1
U60837 Genomic DNA Translation: AAC39042.1
U60838 Genomic DNA Translation: AAC39043.1
U60839 Genomic DNA Translation: AAC39044.1
U60840 Genomic DNA Translation: AAC39045.1
U60841 Genomic DNA Translation: AAC39046.1
U60842 Genomic DNA Translation: AAC39047.1
U60843 Genomic DNA Translation: AAC39048.1
U60844 Genomic DNA Translation: AAC39049.1
U60845 Genomic DNA Translation: AAC39050.1
U60846 Genomic DNA Translation: AAC39051.1
U60847 Genomic DNA Translation: AAC39052.1
U60848 Genomic DNA Translation: AAC39053.1
U60849 Genomic DNA Translation: AAC39054.1
U60850 Genomic DNA Translation: AAC39055.1
U60851 Genomic DNA Translation: AAC39056.1
U60852 Genomic DNA Translation: AAC39057.1
U60853 Genomic DNA Translation: AAC39058.1
U60854 Genomic DNA Translation: AAC39059.1
U60855 Genomic DNA Translation: AAC39060.1
U60856 Genomic DNA Translation: AAC39061.1
U60857 Genomic DNA Translation: AAC39062.1
U60858 Genomic DNA Translation: AAC39063.1
U60859 Genomic DNA Translation: AAC39064.1
U60860 Genomic DNA Translation: AAC39065.1
AE014297 Genomic DNA Translation: AAN14218.1
AE014297 Genomic DNA Translation: AAN14219.1
BT012347 mRNA Translation: AAS77472.1
BT014664 mRNA Translation: AAT27288.1
PIRiS18604
RefSeqiNP_788764.1, NM_176587.2 [P29613-1]
NP_788765.1, NM_176588.2 [P29613-2]
NP_788766.1, NM_176589.2 [P29613-2]

3D structure databases

SMRiP29613
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi68438, 22 interactors
IntActiP29613, 5 interactors
STRINGi7227.FBpp0084948

Proteomic databases

PaxDbiP29613
PRIDEiP29613

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
43582

Genome annotation databases

EnsemblMetazoaiFBtr0085582; FBpp0084948; FBgn0086355 [P29613-1]
FBtr0085583; FBpp0084949; FBgn0086355 [P29613-2]
FBtr0085584; FBpp0084950; FBgn0086355 [P29613-2]
GeneIDi43582
KEGGidme:Dmel_CG2171

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43582
FlyBaseiFBgn0086355, Tpi

Phylogenomic databases

eggNOGiKOG1643, Eukaryota
GeneTreeiENSGT00390000013354
HOGENOMiCLU_024251_2_0_1
InParanoidiP29613
OMAiQEVCGAI
PhylomeDBiP29613

Enzyme and pathway databases

UniPathwayiUPA00109;UER00189
UPA00138
ReactomeiR-DME-70171, Glycolysis
R-DME-70263, Gluconeogenesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
43582, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
43582

Protein Ontology

More...
PROi
PR:P29613

Gene expression databases

BgeeiFBgn0086355, Expressed in arthropod fat body and 40 other tissues
ExpressionAtlasiP29613, baseline and differential
GenevisibleiP29613, DM

Family and domain databases

CDDicd00311, TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B, TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785, Aldolase_TIM
IPR035990, TIM_sf
IPR022896, TrioseP_Isoase_bac/euk
IPR000652, Triosephosphate_isomerase
IPR020861, Triosephosphate_isomerase_AS
PANTHERiPTHR21139, PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121, TIM, 1 hit
SUPFAMiSSF51351, SSF51351, 1 hit
TIGRFAMsiTIGR00419, tim, 1 hit
PROSITEiView protein in PROSITE
PS00171, TIM_1, 1 hit
PS51440, TIM_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPIS_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29613
Secondary accession number(s): O76995
, Q0KHY9, Q6NLI5, Q7JNU4, Q8IMJ1, Q9TY56
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 25, 2006
Last modified: June 2, 2021
This is version 167 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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