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Protein

Non-receptor tyrosine-protein kinase TYK2

Gene

TYK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei930ATPPROSITE-ProRule annotation1
Active sitei1023Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi903 – 911ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
ReactomeiR-HSA-1059683 Interleukin-6 signaling
R-HSA-110056 MAPK3 (ERK1) activation
R-HSA-112411 MAPK1 (ERK2) activation
R-HSA-449836 Other interleukin signaling
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-8984722 Interleukin-35 Signalling
R-HSA-9020591 Interleukin-12 signaling
R-HSA-9020933 Interleukin-23 signaling
R-HSA-9020956 Interleukin-27 signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
SignaLinkiP29597
SIGNORiP29597

Names & Taxonomyi

Protein namesi
Recommended name:
Non-receptor tyrosine-protein kinase TYK2 (EC:2.7.10.2)
Gene namesi
Name:TYK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105397.13
HGNCiHGNC:12440 TYK2
MIMi176941 gene
neXtProtiNX_P29597

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 35 (IMD35)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
See also OMIM:611521

Organism-specific databases

DisGeNETi7297
MalaCardsiTYK2
MIMi611521 phenotype
OpenTargetsiENSG00000105397
Orphaneti331226 Autosomal recessive hyper-IgE syndrome due to TYK2 deficiency
85408 Juvenile rheumatoid factor-negative polyarthritis
85410 Oligoarticular juvenile arthritis
PharmGKBiPA37094

Chemistry databases

ChEMBLiCHEMBL3553
GuidetoPHARMACOLOGYi2269

Polymorphism and mutation databases

BioMutaiTYK2
DMDMi56405328

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000881771 – 1187Non-receptor tyrosine-protein kinase TYK2Add BLAST1187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei292PhosphotyrosineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei525PhosphoserineBy similarity1
Modified residuei604PhosphotyrosineBy similarity1
Modified residuei884PhosphoserineCombined sources1
Modified residuei1054Phosphotyrosine; by autocatalysis1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP29597
MaxQBiP29597
PaxDbiP29597
PeptideAtlasiP29597
PRIDEiP29597
ProteomicsDBi54601

PTM databases

iPTMnetiP29597
PhosphoSitePlusiP29597

Expressioni

Tissue specificityi

Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.1 Publication

Gene expression databases

BgeeiENSG00000105397 Expressed in 226 organ(s), highest expression level in spleen
CleanExiHS_TYK2
ExpressionAtlasiP29597 baseline and differential
GenevisibleiP29597 HS

Organism-specific databases

HPAiHPA005157

Interactioni

Subunit structurei

Interacts with JAKMIP1.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113148, 101 interactors
ComplexPortaliCPX-382 Interleukin-12-receptor complex
CPX-383 Interleukin-23-receptor complex
CORUMiP29597
DIPiDIP-1062N
IntActiP29597, 45 interactors
MINTiP29597
STRINGi9606.ENSP00000264818

Chemistry databases

BindingDBiP29597

Structurei

Secondary structure

11187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP29597
SMRiP29597
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29597

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 431FERMPROSITE-ProRule annotationAdd BLAST406
Domaini450 – 529SH2; atypicalAdd BLAST80
Domaini589 – 875Protein kinase 1PROSITE-ProRule annotationAdd BLAST287
Domaini897 – 1176Protein kinase 2PROSITE-ProRule annotationAdd BLAST280

Domaini

The FERM domain mediates interaction with JAKMIP1.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140909
HOGENOMiHOG000049158
HOVERGENiHBG006195
InParanoidiP29597
KOiK11219
OMAiTVFHKRY
OrthoDBiEOG091G01IS
PhylomeDBiP29597
TreeFamiTF327041

Family and domain databases

InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR000299 FERM_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016251 Tyr_kinase_non-rcpt_Jak/Tyk2
IPR016045 Tyr_kinase_non-rcpt_TYK2_N
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 2 hits
PIRSFiPIRSF000636 TyrPK_Jak, 1 hit
PRINTSiPR01823 JANUSKINASE
PR00109 TYRKINASE
PR01827 YKINASETYK2
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00252 SH2, 1 hit
SM00219 TyrKc, 2 hits
SUPFAMiSSF47031 SSF47031, 1 hit
SSF55550 SSF55550, 2 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

P29597-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLRHWGMAR GSKPVGDGAQ PMAAMGGLKV LLHWAGPGGG EPWVTFSESS
60 70 80 90 100
LTAEEVCIHI AHKVGITPPC FNLFALFDAQ AQVWLPPNHI LEIPRDASLM
110 120 130 140 150
LYFRIRFYFR NWHGMNPREP AVYRCGPPGT EASSDQTAQG MQLLDPASFE
160 170 180 190 200
YLFEQGKHEF VNDVASLWEL STEEEIHHFK NESLGMAFLH LCHLALRHGI
210 220 230 240 250
PLEEVAKKTS FKDCIPRSFR RHIRQHSALT RLRLRNVFRR FLRDFQPGRL
260 270 280 290 300
SQQMVMVKYL ATLERLAPRF GTERVPVCHL RLLAQAEGEP CYIRDSGVAP
310 320 330 340 350
TDPGPESAAG PPTHEVLVTG TGGIQWWPVE EEVNKEEGSS GSSGRNPQAS
360 370 380 390 400
LFGKKAKAHK AVGQPADRPR EPLWAYFCDF RDITHVVLKE HCVSIHRQDN
410 420 430 440 450
KCLELSLPSR AAALSFVSLV DGYFRLTADS SHYLCHEVAP PRLVMSIRDG
460 470 480 490 500
IHGPLLEPFV QAKLRPEDGL YLIHWSTSHP YRLILTVAQR SQAPDGMQSL
510 520 530 540 550
RLRKFPIEQQ DGAFVLEGWG RSFPSVRELG AALQGCLLRA GDDCFSLRRC
560 570 580 590 600
CLPQPGETSN LIIMRGARAS PRTLNLSQLS FHRVDQKEIT QLSHLGQGTR
610 620 630 640 650
TNVYEGRLRV EGSGDPEEGK MDDEDPLVPG RDRGQELRVV LKVLDPSHHD
660 670 680 690 700
IALAFYETAS LMSQVSHTHL AFVHGVCVRG PENIMVTEYV EHGPLDVWLR
710 720 730 740 750
RERGHVPMAW KMVVAQQLAS ALSYLENKNL VHGNVCGRNI LLARLGLAEG
760 770 780 790 800
TSPFIKLSDP GVGLGALSRE ERVERIPWLA PECLPGGANS LSTAMDKWGF
810 820 830 840 850
GATLLEICFD GEAPLQSRSP SEKEHFYQRQ HRLPEPSCPQ LATLTSQCLT
860 870 880 890 900
YEPTQRPSFR TILRDLTRLQ PHNLADVLTV NPDSPASDPT VFHKRYLKKI
910 920 930 940 950
RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK ALKADCGPQH RSGWKQEIDI
960 970 980 990 1000
LRTLYHEHII KYKGCCEDQG EKSLQLVMEY VPLGSLRDYL PRHSIGLAQL
1010 1020 1030 1040 1050
LLFAQQICEG MAYLHAQHYI HRDLAARNVL LDNDRLVKIG DFGLAKAVPE
1060 1070 1080 1090 1100
GHEYYRVRED GDSPVFWYAP ECLKEYKFYY ASDVWSFGVT LYELLTHCDS
1110 1120 1130 1140 1150
SQSPPTKFLE LIGIAQGQMT VLRLTELLER GERLPRPDKC PCEVYHLMKN
1160 1170 1180
CWETEASFRP TFENLIPILK TVHEKYQGQA PSVFSVC
Length:1,187
Mass (Da):133,650
Last modified:December 7, 2004 - v3
Checksum:iF76C25D6A919EDBC
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PM19E9PM19_HUMAN
Tyrosine-protein kinase
TYK2
1,002Annotation score:
E9PPF2E9PPF2_HUMAN
Tyrosine-protein kinase
TYK2
921Annotation score:
K7EM33K7EM33_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
135Annotation score:
K7EJR6K7EJR6_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
142Annotation score:
E9PQL2E9PQL2_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
118Annotation score:
H0YE24H0YE24_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
64Annotation score:
H0YCT7H0YCT7_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
82Annotation score:
H0YE41H0YE41_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
194Annotation score:
E9PQE9E9PQE9_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
134Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti869L → V in CAA38449 (PubMed:2216457).Curated1
Sequence conflicti882P → R in CAA38449 (PubMed:2216457).Curated1
Sequence conflicti887 – 888SD → VG in CAA38449 (PubMed:2216457).Curated2
Sequence conflicti891V → T in CAA38449 (PubMed:2216457).Curated1
Sequence conflicti1016A → S in AAH14243 (PubMed:15489334).Curated1
Sequence conflicti1017 – 1018QH → HD in CAA38449 (PubMed:2216457).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0205974R → H1 PublicationCorresponds to variant dbSNP:rs12720343Ensembl.1
Natural variantiVAR_03779781A → V. Corresponds to variant dbSNP:rs1049619Ensembl.1
Natural variantiVAR_020598197R → H1 PublicationCorresponds to variant dbSNP:rs12720263EnsemblClinVar.1
Natural variantiVAR_020599362V → F3 PublicationsCorresponds to variant dbSNP:rs2304256EnsemblClinVar.1
Natural variantiVAR_020600363G → S2 PublicationsCorresponds to variant dbSNP:rs2304255EnsemblClinVar.1
Natural variantiVAR_041870386V → M1 PublicationCorresponds to variant dbSNP:rs55956017Ensembl.1
Natural variantiVAR_037798442R → Q. Corresponds to variant dbSNP:rs2304254Ensembl.1
Natural variantiVAR_020286684I → S3 PublicationsCorresponds to variant dbSNP:rs12720356EnsemblClinVar.1
Natural variantiVAR_041871703R → W1 PublicationCorresponds to variant dbSNP:rs55882956EnsemblClinVar.1
Natural variantiVAR_041872732H → R in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_037799820P → H. Corresponds to variant dbSNP:rs34046749EnsemblClinVar.1
Natural variantiVAR_041873928A → V1 PublicationCorresponds to variant dbSNP:rs35018800EnsemblClinVar.1
Natural variantiVAR_0418741104P → A1 PublicationCorresponds to variant dbSNP:rs34536443EnsemblClinVar.1
Natural variantiVAR_0418751163E → G1 PublicationCorresponds to variant dbSNP:rs55886939EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54637 mRNA Translation: CAA38449.1
AY549314 Genomic DNA Translation: AAS37680.1
BC014243 mRNA Translation: AAH14243.1
CCDSiCCDS12236.1
PIRiS12127 TVHUY2
RefSeqiNP_003322.3, NM_003331.4
XP_011526547.1, XM_011528245.1
UniGeneiHs.75516

Genome annotation databases

EnsembliENST00000264818; ENSP00000264818; ENSG00000105397
ENST00000525621; ENSP00000431885; ENSG00000105397
GeneIDi7297
KEGGihsa:7297
UCSCiuc002moc.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

TYK2base

TYK2 mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54637 mRNA Translation: CAA38449.1
AY549314 Genomic DNA Translation: AAS37680.1
BC014243 mRNA Translation: AAH14243.1
CCDSiCCDS12236.1
PIRiS12127 TVHUY2
RefSeqiNP_003322.3, NM_003331.4
XP_011526547.1, XM_011528245.1
UniGeneiHs.75516

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LXNX-ray2.50A888-1182[»]
3LXPX-ray1.65A888-1182[»]
3NYXX-ray2.50A885-1176[»]
3NZ0X-ray2.00A885-1176[»]
3ZONX-ray2.15A541-873[»]
4GFOX-ray2.30A884-1176[»]
4GIHX-ray2.00A885-1176[»]
4GIIX-ray2.31A885-1176[»]
4GJ2X-ray2.40A885-1176[»]
4GJ3X-ray2.50A885-1176[»]
4GVJX-ray2.03A885-1176[»]
4OLIX-ray2.80A566-1187[»]
4PO6X-ray1.99A23-583[»]
4PY1X-ray2.16A888-1182[»]
4WOVX-ray1.80A/B575-869[»]
5C01X-ray2.15A/B556-871[»]
5C03X-ray1.90A/B556-871[»]
5F1ZX-ray2.65A884-1176[»]
5F20X-ray2.91A884-1176[»]
5TKDX-ray1.92A/B575-869[»]
5WALX-ray2.45A884-1176[»]
6AAMX-ray1.98A888-1182[»]
6DBKX-ray2.00A888-1182[»]
6DBMX-ray2.37A888-1182[»]
ProteinModelPortaliP29597
SMRiP29597
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113148, 101 interactors
ComplexPortaliCPX-382 Interleukin-12-receptor complex
CPX-383 Interleukin-23-receptor complex
CORUMiP29597
DIPiDIP-1062N
IntActiP29597, 45 interactors
MINTiP29597
STRINGi9606.ENSP00000264818

Chemistry databases

BindingDBiP29597
ChEMBLiCHEMBL3553
GuidetoPHARMACOLOGYi2269

PTM databases

iPTMnetiP29597
PhosphoSitePlusiP29597

Polymorphism and mutation databases

BioMutaiTYK2
DMDMi56405328

Proteomic databases

EPDiP29597
MaxQBiP29597
PaxDbiP29597
PeptideAtlasiP29597
PRIDEiP29597
ProteomicsDBi54601

Protocols and materials databases

DNASUi7297
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264818; ENSP00000264818; ENSG00000105397
ENST00000525621; ENSP00000431885; ENSG00000105397
GeneIDi7297
KEGGihsa:7297
UCSCiuc002moc.5 human

Organism-specific databases

CTDi7297
DisGeNETi7297
EuPathDBiHostDB:ENSG00000105397.13
GeneCardsiTYK2
H-InvDBiHIX0202831
HGNCiHGNC:12440 TYK2
HPAiHPA005157
MalaCardsiTYK2
MIMi176941 gene
611521 phenotype
neXtProtiNX_P29597
OpenTargetsiENSG00000105397
Orphaneti331226 Autosomal recessive hyper-IgE syndrome due to TYK2 deficiency
85408 Juvenile rheumatoid factor-negative polyarthritis
85410 Oligoarticular juvenile arthritis
PharmGKBiPA37094
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140909
HOGENOMiHOG000049158
HOVERGENiHBG006195
InParanoidiP29597
KOiK11219
OMAiTVFHKRY
OrthoDBiEOG091G01IS
PhylomeDBiP29597
TreeFamiTF327041

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
ReactomeiR-HSA-1059683 Interleukin-6 signaling
R-HSA-110056 MAPK3 (ERK1) activation
R-HSA-112411 MAPK1 (ERK2) activation
R-HSA-449836 Other interleukin signaling
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-8984722 Interleukin-35 Signalling
R-HSA-9020591 Interleukin-12 signaling
R-HSA-9020933 Interleukin-23 signaling
R-HSA-9020956 Interleukin-27 signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
SignaLinkiP29597
SIGNORiP29597

Miscellaneous databases

ChiTaRSiTYK2 human
EvolutionaryTraceiP29597
GeneWikiiTyrosine_kinase_2
GenomeRNAii7297
PROiPR:P29597
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105397 Expressed in 226 organ(s), highest expression level in spleen
CleanExiHS_TYK2
ExpressionAtlasiP29597 baseline and differential
GenevisibleiP29597 HS

Family and domain databases

InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR000299 FERM_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016251 Tyr_kinase_non-rcpt_Jak/Tyk2
IPR016045 Tyr_kinase_non-rcpt_TYK2_N
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 2 hits
PIRSFiPIRSF000636 TyrPK_Jak, 1 hit
PRINTSiPR01823 JANUSKINASE
PR00109 TYRKINASE
PR01827 YKINASETYK2
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00252 SH2, 1 hit
SM00219 TyrKc, 2 hits
SUPFAMiSSF47031 SSF47031, 1 hit
SSF55550 SSF55550, 2 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTYK2_HUMAN
AccessioniPrimary (citable) accession number: P29597
Secondary accession number(s): Q6QB10, Q96CH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 7, 2004
Last modified: October 10, 2018
This is version 202 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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