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Protein

Non-receptor tyrosine-protein kinase TYK2

Gene

TYK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei930ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1023Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi903 – 911ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.10.2 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1059683 Interleukin-6 signaling
R-HSA-110056 MAPK3 (ERK1) activation
R-HSA-112411 MAPK1 (ERK2) activation
R-HSA-449836 Other interleukin signaling
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-8984722 Interleukin-35 Signalling
R-HSA-9020591 Interleukin-12 signaling
R-HSA-9020933 Interleukin-23 signaling
R-HSA-9020956 Interleukin-27 signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P29597

SIGNOR Signaling Network Open Resource

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SIGNORi
P29597

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-receptor tyrosine-protein kinase TYK2 (EC:2.7.10.2)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TYK2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105397.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12440 TYK2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
176941 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P29597

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency 35 (IMD35)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
See also OMIM:611521

Organism-specific databases

DisGeNET

More...
DisGeNETi
7297

MalaCards human disease database

More...
MalaCardsi
TYK2
MIMi611521 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000105397

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98842 Lymphomatoid papulosis
300865 Primary cutaneous anaplastic large cell lymphoma
331226 Susceptibility to infection due to TYK2 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37094

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3553

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2269

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TYK2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56405328

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000881771 – 1187Non-receptor tyrosine-protein kinase TYK2Add BLAST1187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei292PhosphotyrosineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei525PhosphoserineBy similarity1
Modified residuei604PhosphotyrosineBy similarity1
Modified residuei884PhosphoserineCombined sources1
Modified residuei1054Phosphotyrosine; by autocatalysis1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P29597

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P29597

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P29597

PeptideAtlas

More...
PeptideAtlasi
P29597

PRoteomics IDEntifications database

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PRIDEi
P29597

ProteomicsDB human proteome resource

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ProteomicsDBi
54601

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P29597

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P29597

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000105397 Expressed in 226 organ(s), highest expression level in spleen

CleanEx database of gene expression profiles

More...
CleanExi
HS_TYK2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P29597 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P29597 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA005157

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with JAKMIP1.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113148, 103 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-382 Interleukin-12-receptor complex
CPX-383 Interleukin-23-receptor complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P29597

Database of interacting proteins

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DIPi
DIP-1062N

Protein interaction database and analysis system

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IntActi
P29597, 45 interactors

Molecular INTeraction database

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MINTi
P29597

STRING: functional protein association networks

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STRINGi
9606.ENSP00000264818

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P29597

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P29597

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P29597

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P29597

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 431FERMPROSITE-ProRule annotationAdd BLAST406
Domaini450 – 529SH2; atypicalAdd BLAST80
Domaini589 – 875Protein kinase 1PROSITE-ProRule annotationAdd BLAST287
Domaini897 – 1176Protein kinase 2PROSITE-ProRule annotationAdd BLAST280

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FERM domain mediates interaction with JAKMIP1.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0197 Eukaryota
COG0515 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159869

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049158

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006195

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P29597

KEGG Orthology (KO)

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KOi
K11219

Identification of Orthologs from Complete Genome Data

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OMAi
KYQGQAP

Database of Orthologous Groups

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OrthoDBi
EOG091G01IS

Database for complete collections of gene phylogenies

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PhylomeDBi
P29597

TreeFam database of animal gene trees

More...
TreeFami
TF327041

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR000299 FERM_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016251 Tyr_kinase_non-rcpt_Jak/Tyk2
IPR016045 Tyr_kinase_non-rcpt_TYK2_N

Pfam protein domain database

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Pfami
View protein in Pfam
PF07714 Pkinase_Tyr, 2 hits

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000636 TyrPK_Jak, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01823 JANUSKINASE
PR00109 TYRKINASE
PR01827 YKINASETYK2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM00252 SH2, 1 hit
SM00219 TyrKc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031 SSF47031, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

P29597-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLRHWGMAR GSKPVGDGAQ PMAAMGGLKV LLHWAGPGGG EPWVTFSESS
60 70 80 90 100
LTAEEVCIHI AHKVGITPPC FNLFALFDAQ AQVWLPPNHI LEIPRDASLM
110 120 130 140 150
LYFRIRFYFR NWHGMNPREP AVYRCGPPGT EASSDQTAQG MQLLDPASFE
160 170 180 190 200
YLFEQGKHEF VNDVASLWEL STEEEIHHFK NESLGMAFLH LCHLALRHGI
210 220 230 240 250
PLEEVAKKTS FKDCIPRSFR RHIRQHSALT RLRLRNVFRR FLRDFQPGRL
260 270 280 290 300
SQQMVMVKYL ATLERLAPRF GTERVPVCHL RLLAQAEGEP CYIRDSGVAP
310 320 330 340 350
TDPGPESAAG PPTHEVLVTG TGGIQWWPVE EEVNKEEGSS GSSGRNPQAS
360 370 380 390 400
LFGKKAKAHK AVGQPADRPR EPLWAYFCDF RDITHVVLKE HCVSIHRQDN
410 420 430 440 450
KCLELSLPSR AAALSFVSLV DGYFRLTADS SHYLCHEVAP PRLVMSIRDG
460 470 480 490 500
IHGPLLEPFV QAKLRPEDGL YLIHWSTSHP YRLILTVAQR SQAPDGMQSL
510 520 530 540 550
RLRKFPIEQQ DGAFVLEGWG RSFPSVRELG AALQGCLLRA GDDCFSLRRC
560 570 580 590 600
CLPQPGETSN LIIMRGARAS PRTLNLSQLS FHRVDQKEIT QLSHLGQGTR
610 620 630 640 650
TNVYEGRLRV EGSGDPEEGK MDDEDPLVPG RDRGQELRVV LKVLDPSHHD
660 670 680 690 700
IALAFYETAS LMSQVSHTHL AFVHGVCVRG PENIMVTEYV EHGPLDVWLR
710 720 730 740 750
RERGHVPMAW KMVVAQQLAS ALSYLENKNL VHGNVCGRNI LLARLGLAEG
760 770 780 790 800
TSPFIKLSDP GVGLGALSRE ERVERIPWLA PECLPGGANS LSTAMDKWGF
810 820 830 840 850
GATLLEICFD GEAPLQSRSP SEKEHFYQRQ HRLPEPSCPQ LATLTSQCLT
860 870 880 890 900
YEPTQRPSFR TILRDLTRLQ PHNLADVLTV NPDSPASDPT VFHKRYLKKI
910 920 930 940 950
RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK ALKADCGPQH RSGWKQEIDI
960 970 980 990 1000
LRTLYHEHII KYKGCCEDQG EKSLQLVMEY VPLGSLRDYL PRHSIGLAQL
1010 1020 1030 1040 1050
LLFAQQICEG MAYLHAQHYI HRDLAARNVL LDNDRLVKIG DFGLAKAVPE
1060 1070 1080 1090 1100
GHEYYRVRED GDSPVFWYAP ECLKEYKFYY ASDVWSFGVT LYELLTHCDS
1110 1120 1130 1140 1150
SQSPPTKFLE LIGIAQGQMT VLRLTELLER GERLPRPDKC PCEVYHLMKN
1160 1170 1180
CWETEASFRP TFENLIPILK TVHEKYQGQA PSVFSVC
Length:1,187
Mass (Da):133,650
Last modified:December 7, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF76C25D6A919EDBC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PM19E9PM19_HUMAN
Tyrosine-protein kinase
TYK2
1,002Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPF2E9PPF2_HUMAN
Tyrosine-protein kinase
TYK2
921Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM33K7EM33_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJR6K7EJR6_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQL2E9PQL2_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE24H0YE24_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCT7H0YCT7_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQE9E9PQE9_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE41H0YE41_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti869L → V in CAA38449 (PubMed:2216457).Curated1
Sequence conflicti882P → R in CAA38449 (PubMed:2216457).Curated1
Sequence conflicti887 – 888SD → VG in CAA38449 (PubMed:2216457).Curated2
Sequence conflicti891V → T in CAA38449 (PubMed:2216457).Curated1
Sequence conflicti1016A → S in AAH14243 (PubMed:15489334).Curated1
Sequence conflicti1017 – 1018QH → HD in CAA38449 (PubMed:2216457).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0205974R → H1 PublicationCorresponds to variant dbSNP:rs12720343Ensembl.1
Natural variantiVAR_03779781A → V. Corresponds to variant dbSNP:rs1049619Ensembl.1
Natural variantiVAR_020598197R → H1 PublicationCorresponds to variant dbSNP:rs12720263EnsemblClinVar.1
Natural variantiVAR_020599362V → F3 PublicationsCorresponds to variant dbSNP:rs2304256EnsemblClinVar.1
Natural variantiVAR_020600363G → S2 PublicationsCorresponds to variant dbSNP:rs2304255EnsemblClinVar.1
Natural variantiVAR_041870386V → M1 PublicationCorresponds to variant dbSNP:rs55956017Ensembl.1
Natural variantiVAR_037798442R → Q. Corresponds to variant dbSNP:rs2304254Ensembl.1
Natural variantiVAR_020286684I → S3 PublicationsCorresponds to variant dbSNP:rs12720356EnsemblClinVar.1
Natural variantiVAR_041871703R → W1 PublicationCorresponds to variant dbSNP:rs55882956EnsemblClinVar.1
Natural variantiVAR_041872732H → R in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_037799820P → H. Corresponds to variant dbSNP:rs34046749EnsemblClinVar.1
Natural variantiVAR_041873928A → V1 PublicationCorresponds to variant dbSNP:rs35018800EnsemblClinVar.1
Natural variantiVAR_0418741104P → A1 PublicationCorresponds to variant dbSNP:rs34536443EnsemblClinVar.1
Natural variantiVAR_0418751163E → G1 PublicationCorresponds to variant dbSNP:rs55886939EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X54637 mRNA Translation: CAA38449.1
AY549314 Genomic DNA Translation: AAS37680.1
BC014243 mRNA Translation: AAH14243.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12236.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S12127 TVHUY2

NCBI Reference Sequences

More...
RefSeqi
NP_003322.3, NM_003331.4
XP_011526547.1, XM_011528245.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.75516

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264818; ENSP00000264818; ENSG00000105397
ENST00000525621; ENSP00000431885; ENSG00000105397

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7297

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7297

UCSC genome browser

More...
UCSCi
uc002moc.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

TYK2base

TYK2 mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54637 mRNA Translation: CAA38449.1
AY549314 Genomic DNA Translation: AAS37680.1
BC014243 mRNA Translation: AAH14243.1
CCDSiCCDS12236.1
PIRiS12127 TVHUY2
RefSeqiNP_003322.3, NM_003331.4
XP_011526547.1, XM_011528245.1
UniGeneiHs.75516

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LXNX-ray2.50A888-1182[»]
3LXPX-ray1.65A888-1182[»]
3NYXX-ray2.50A885-1176[»]
3NZ0X-ray2.00A885-1176[»]
3ZONX-ray2.15A541-873[»]
4GFOX-ray2.30A884-1176[»]
4GIHX-ray2.00A885-1176[»]
4GIIX-ray2.31A885-1176[»]
4GJ2X-ray2.40A885-1176[»]
4GJ3X-ray2.50A885-1176[»]
4GVJX-ray2.03A885-1176[»]
4OLIX-ray2.80A566-1187[»]
4PO6X-ray1.99A23-583[»]
4PY1X-ray2.16A888-1182[»]
4WOVX-ray1.80A/B575-869[»]
5C01X-ray2.15A/B556-871[»]
5C03X-ray1.90A/B556-871[»]
5F1ZX-ray2.65A884-1176[»]
5F20X-ray2.91A884-1176[»]
5TKDX-ray1.92A/B575-869[»]
5WALX-ray2.45A884-1176[»]
6AAMX-ray1.98A888-1182[»]
6DBKX-ray2.00A888-1182[»]
6DBMX-ray2.37A888-1182[»]
ProteinModelPortaliP29597
SMRiP29597
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113148, 103 interactors
ComplexPortaliCPX-382 Interleukin-12-receptor complex
CPX-383 Interleukin-23-receptor complex
CORUMiP29597
DIPiDIP-1062N
IntActiP29597, 45 interactors
MINTiP29597
STRINGi9606.ENSP00000264818

Chemistry databases

BindingDBiP29597
ChEMBLiCHEMBL3553
GuidetoPHARMACOLOGYi2269

PTM databases

iPTMnetiP29597
PhosphoSitePlusiP29597

Polymorphism and mutation databases

BioMutaiTYK2
DMDMi56405328

Proteomic databases

EPDiP29597
MaxQBiP29597
PaxDbiP29597
PeptideAtlasiP29597
PRIDEiP29597
ProteomicsDBi54601

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7297
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264818; ENSP00000264818; ENSG00000105397
ENST00000525621; ENSP00000431885; ENSG00000105397
GeneIDi7297
KEGGihsa:7297
UCSCiuc002moc.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7297
DisGeNETi7297
EuPathDBiHostDB:ENSG00000105397.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TYK2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0202831
HGNCiHGNC:12440 TYK2
HPAiHPA005157
MalaCardsiTYK2
MIMi176941 gene
611521 phenotype
neXtProtiNX_P29597
OpenTargetsiENSG00000105397
Orphaneti98842 Lymphomatoid papulosis
300865 Primary cutaneous anaplastic large cell lymphoma
331226 Susceptibility to infection due to TYK2 deficiency
PharmGKBiPA37094

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00940000159869
HOGENOMiHOG000049158
HOVERGENiHBG006195
InParanoidiP29597
KOiK11219
OMAiKYQGQAP
OrthoDBiEOG091G01IS
PhylomeDBiP29597
TreeFamiTF327041

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
ReactomeiR-HSA-1059683 Interleukin-6 signaling
R-HSA-110056 MAPK3 (ERK1) activation
R-HSA-112411 MAPK1 (ERK2) activation
R-HSA-449836 Other interleukin signaling
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-8984722 Interleukin-35 Signalling
R-HSA-9020591 Interleukin-12 signaling
R-HSA-9020933 Interleukin-23 signaling
R-HSA-9020956 Interleukin-27 signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
SignaLinkiP29597
SIGNORiP29597

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TYK2 human
EvolutionaryTraceiP29597

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Tyrosine_kinase_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7297

Protein Ontology

More...
PROi
PR:P29597

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105397 Expressed in 226 organ(s), highest expression level in spleen
CleanExiHS_TYK2
ExpressionAtlasiP29597 baseline and differential
GenevisibleiP29597 HS

Family and domain databases

InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR000299 FERM_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016251 Tyr_kinase_non-rcpt_Jak/Tyk2
IPR016045 Tyr_kinase_non-rcpt_TYK2_N
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 2 hits
PIRSFiPIRSF000636 TyrPK_Jak, 1 hit
PRINTSiPR01823 JANUSKINASE
PR00109 TYRKINASE
PR01827 YKINASETYK2
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00252 SH2, 1 hit
SM00219 TyrKc, 2 hits
SUPFAMiSSF47031 SSF47031, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTYK2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29597
Secondary accession number(s): Q6QB10, Q96CH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 7, 2004
Last modified: December 5, 2018
This is version 204 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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