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Entry version 190 (07 Apr 2021)
Sequence version 3 (23 Nov 2004)
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Protein

RNA-binding motif, single-stranded-interacting protein 1

Gene

RBMS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processDNA replication

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P29558

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding motif, single-stranded-interacting protein 1
Alternative name(s):
Single-stranded DNA-binding protein MSSP-1
Suppressor of CDC2 with RNA-binding motif 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBMS1
Synonyms:C2orf12, MSSP, MSSP1, SCR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9907, RBMS1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602310, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P29558

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000153250.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5937

Open Targets

More...
OpenTargetsi
ENSG00000153250

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34273

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P29558, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RBMS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
55977783

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000817981 – 406RNA-binding motif, single-stranded-interacting protein 1Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei208PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P29558

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P29558

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P29558

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P29558

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29558

PeptideAtlas

More...
PeptideAtlasi
P29558

PRoteomics IDEntifications database

More...
PRIDEi
P29558

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
54586 [P29558-1]
54587 [P29558-2]
54588 [P29558-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P29558

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
P29558

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P29558

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest amounts are found in placenta, lung and heart.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at highest levels during the G1 to S transition of the cell cycle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000153250, Expressed in placenta and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P29558, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P29558, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000153250, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
111872, 180 interactors

Protein interaction database and analysis system

More...
IntActi
P29558, 18 interactors

Molecular INTeraction database

More...
MINTi
P29558

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000294904

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P29558, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1406
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P29558

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P29558

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 135RRM 1PROSITE-ProRule annotationAdd BLAST74
Domaini141 – 226RRM 2PROSITE-ProRule annotationAdd BLAST86

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4733, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156082

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P29558

Identification of Orthologs from Complete Genome Data

More...
OMAi
EGEVRLX

Database of Orthologous Groups

More...
OrthoDBi
810893at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P29558

TreeFam database of animal gene trees

More...
TreeFami
TF314644

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12470, RRM1_MSSP1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002343, Hud_Sxl_RNA
IPR034404, MSSP1_RRM1
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076, RRM_1, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00961, HUDSXLRNA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360, RRM, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P29558-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKVWKQQMY PQYATYYYPQ YLQAKQSLVP AHPMAPPSPS TTSSNNNSSS
60 70 80 90 100
SSNSGWDQLS KTNLYIRGLP PHTTDQDLVK LCQPYGKIVS TKAILDKTTN
110 120 130 140 150
KCKGYGFVDF DSPAAAQKAV SALKASGVQA QMAKQQEQDP TNLYISNLPL
160 170 180 190 200
SMDEQELENM LKPFGQVIST RILRDSSGTS RGVGFARMES TEKCEAVIGH
210 220 230 240 250
FNGKFIKTPP GVSAPTEPLL CKFADGGQKK RQNPNKYIPN GRPWHREGEV
260 270 280 290 300
RLAGMTLTYD PTTAAIQNGF YPSPYSIATN RMITQTSITP YIASPVSAYQ
310 320 330 340 350
VQSPSWMQPQ PYILQHPGAV LTPSMEHTMS LQPASMISPL AQQMSHLSLG
360 370 380 390 400
STGTYMPATS AMQGAYLPQY AHMQTTAVPV EEASGQQQVA VETSNDHSPY

TFQPNK
Length:406
Mass (Da):44,505
Last modified:November 23, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97EAAD2B0A5E01C6
GO
Isoform 2 (identifier: P29558-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-252: Missing.

Show »
Length:403
Mass (Da):44,137
Checksum:i614911BB16E670B1
GO
Isoform 4 (identifier: P29558-4) [UniParc]FASTAAdd to basket
Also known as: MSSP-2

The sequence of this isoform differs from the canonical sequence as follows:
     26-38: QSLVPAHPMAPPS → FGRHSGIPSEKEE
     39-406: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:38
Mass (Da):4,632
Checksum:i6D0758AEEAA3012B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Y5H0F6Y5H0_HUMAN
RNA-binding motif, single-stranded-...
RBMS1
386Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ETU5E7ETU5_HUMAN
RNA-binding motif, single-stranded-...
RBMS1
370Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPF2E7EPF2_HUMAN
RNA-binding motif, single-stranded-...
RBMS1
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAX93095 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA45923 differs from that shown. Reason: Frameshift.Curated
The sequence CAA45923 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA54628 differs from that shown. Reason: Erroneous translation. Wrong coding sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti132M → K in CAA45923 (PubMed:8134115).Curated1
Sequence conflicti315 – 316QH → HD in CAA54628 (PubMed:7838710).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03779026 – 38QSLVP…MAPPS → FGRHSGIPSEKEE in isoform 4. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_03779139 – 406Missing in isoform 4. 1 PublicationAdd BLAST368
Alternative sequenceiVSP_011930250 – 252Missing in isoform 2. 2 Publications3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D28482 mRNA Translation: BAA05841.1
X77494 mRNA Translation: CAA54628.1 Sequence problems.
AC092153 Genomic DNA Translation: AAX93095.1 Sequence problems.
AC104598 Genomic DNA Translation: AAX93183.1
AC131754 Genomic DNA Translation: AAY15005.1
BC012992 mRNA Translation: AAH12992.1
BC012993 mRNA Translation: AAH12993.1
BC018951 mRNA Translation: AAH18951.1
X64652 mRNA Translation: CAA45923.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2213.1 [P29558-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
I38042
S19873
S47659
S53612

NCBI Reference Sequences

More...
RefSeqi
NP_002888.1, NM_002897.4 [P29558-2]
NP_058520.1, NM_016836.3 [P29558-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000348849; ENSP00000294904; ENSG00000153250 [P29558-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5937

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5937

UCSC genome browser

More...
UCSCi
uc002ubo.4, human [P29558-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28482 mRNA Translation: BAA05841.1
X77494 mRNA Translation: CAA54628.1 Sequence problems.
AC092153 Genomic DNA Translation: AAX93095.1 Sequence problems.
AC104598 Genomic DNA Translation: AAX93183.1
AC131754 Genomic DNA Translation: AAY15005.1
BC012992 mRNA Translation: AAH12992.1
BC012993 mRNA Translation: AAH12993.1
BC018951 mRNA Translation: AAH18951.1
X64652 mRNA Translation: CAA45923.1 Sequence problems.
CCDSiCCDS2213.1 [P29558-1]
PIRiI38042
S19873
S47659
S53612
RefSeqiNP_002888.1, NM_002897.4 [P29558-2]
NP_058520.1, NM_016836.3 [P29558-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X5ONMR-A123-223[»]
SMRiP29558
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111872, 180 interactors
IntActiP29558, 18 interactors
MINTiP29558
STRINGi9606.ENSP00000294904

PTM databases

iPTMnetiP29558
MetOSiteiP29558
PhosphoSitePlusiP29558

Genetic variation databases

BioMutaiRBMS1
DMDMi55977783

Proteomic databases

EPDiP29558
jPOSTiP29558
MassIVEiP29558
MaxQBiP29558
PaxDbiP29558
PeptideAtlasiP29558
PRIDEiP29558
ProteomicsDBi54586 [P29558-1]
54587 [P29558-2]
54588 [P29558-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
19068, 293 antibodies

The DNASU plasmid repository

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DNASUi
5937

Genome annotation databases

EnsembliENST00000348849; ENSP00000294904; ENSG00000153250 [P29558-1]
GeneIDi5937
KEGGihsa:5937
UCSCiuc002ubo.4, human [P29558-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5937
DisGeNETi5937

GeneCards: human genes, protein and diseases

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GeneCardsi
RBMS1
HGNCiHGNC:9907, RBMS1
HPAiENSG00000153250, Low tissue specificity
MIMi602310, gene
neXtProtiNX_P29558
OpenTargetsiENSG00000153250
PharmGKBiPA34273
VEuPathDBiHostDB:ENSG00000153250.17

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4733, Eukaryota
GeneTreeiENSGT00940000156082
InParanoidiP29558
OMAiEGEVRLX
OrthoDBi810893at2759
PhylomeDBiP29558
TreeFamiTF314644

Enzyme and pathway databases

PathwayCommonsiP29558

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
5937, 22 hits in 988 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RBMS1, human
EvolutionaryTraceiP29558

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RBMS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5937
PharosiP29558, Tbio

Protein Ontology

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PROi
PR:P29558
RNActiP29558, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000153250, Expressed in placenta and 228 other tissues
ExpressionAtlasiP29558, baseline and differential
GenevisibleiP29558, HS

Family and domain databases

CDDicd12470, RRM1_MSSP1, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR002343, Hud_Sxl_RNA
IPR034404, MSSP1_RRM1
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
PfamiView protein in Pfam
PF00076, RRM_1, 2 hits
PRINTSiPR00961, HUDSXLRNA
SMARTiView protein in SMART
SM00360, RRM, 2 hits
SUPFAMiSSF54928, SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBMS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29558
Secondary accession number(s): Q14869
, Q15433, Q53P46, Q53QX8, Q53RG6, Q8WV20
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 23, 2004
Last modified: April 7, 2021
This is version 190 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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