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Protein

RNA-binding motif, single-stranded-interacting protein 1

Gene

RBMS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.

GO - Molecular functioni

  • double-stranded DNA binding Source: UniProtKB
  • mRNA 3'-UTR binding Source: GO_Central
  • poly(A) binding Source: GO_Central
  • poly(U) RNA binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • single-stranded DNA binding Source: UniProtKB

GO - Biological processi

  • DNA replication Source: UniProtKB
  • RNA processing Source: ProtInc

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding motif, single-stranded-interacting protein 1
Alternative name(s):
Single-stranded DNA-binding protein MSSP-1
Suppressor of CDC2 with RNA-binding motif 2
Gene namesi
Name:RBMS1
Synonyms:C2orf12, MSSP, MSSP1, SCR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000153250.17
HGNCiHGNC:9907 RBMS1
MIMi602310 gene
neXtProtiNX_P29558

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5937
OpenTargetsiENSG00000153250
PharmGKBiPA34273

Polymorphism and mutation databases

BioMutaiRBMS1
DMDMi55977783

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817981 – 406RNA-binding motif, single-stranded-interacting protein 1Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei208PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP29558
MaxQBiP29558
PaxDbiP29558
PeptideAtlasiP29558
PRIDEiP29558
ProteomicsDBi54586
54587 [P29558-2]
54588 [P29558-4]

PTM databases

iPTMnetiP29558
PhosphoSitePlusiP29558

Expressioni

Tissue specificityi

Highest amounts are found in placenta, lung and heart.

Developmental stagei

Expressed at highest levels during the G1 to S transition of the cell cycle.

Gene expression databases

BgeeiENSG00000153250 Expressed in 214 organ(s), highest expression level in placenta
CleanExiHS_RBMS1
ExpressionAtlasiP29558 baseline and differential
GenevisibleiP29558 HS

Organism-specific databases

HPAiHPA047943
HPA061791

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TFCP2Q128003EBI-5462600,EBI-717422

Protein-protein interaction databases

BioGridi111872, 52 interactors
IntActiP29558, 6 interactors
MINTiP29558
STRINGi9606.ENSP00000294904

Structurei

Secondary structure

1406
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP29558
SMRiP29558
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29558

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 135RRM 1PROSITE-ProRule annotationAdd BLAST74
Domaini141 – 226RRM 2PROSITE-ProRule annotationAdd BLAST86

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4733 Eukaryota
ENOG410XRB5 LUCA
GeneTreeiENSGT00760000118913
HOVERGENiHBG053108
InParanoidiP29558
OMAiYTHVQTT
OrthoDBiEOG091G0FXS
PhylomeDBiP29558
TreeFamiTF314644

Family and domain databases

CDDicd12470 RRM1_MSSP1, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR002343 Hud_Sxl_RNA
IPR034404 MSSP1_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P29558-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKVWKQQMY PQYATYYYPQ YLQAKQSLVP AHPMAPPSPS TTSSNNNSSS
60 70 80 90 100
SSNSGWDQLS KTNLYIRGLP PHTTDQDLVK LCQPYGKIVS TKAILDKTTN
110 120 130 140 150
KCKGYGFVDF DSPAAAQKAV SALKASGVQA QMAKQQEQDP TNLYISNLPL
160 170 180 190 200
SMDEQELENM LKPFGQVIST RILRDSSGTS RGVGFARMES TEKCEAVIGH
210 220 230 240 250
FNGKFIKTPP GVSAPTEPLL CKFADGGQKK RQNPNKYIPN GRPWHREGEV
260 270 280 290 300
RLAGMTLTYD PTTAAIQNGF YPSPYSIATN RMITQTSITP YIASPVSAYQ
310 320 330 340 350
VQSPSWMQPQ PYILQHPGAV LTPSMEHTMS LQPASMISPL AQQMSHLSLG
360 370 380 390 400
STGTYMPATS AMQGAYLPQY AHMQTTAVPV EEASGQQQVA VETSNDHSPY

TFQPNK
Length:406
Mass (Da):44,505
Last modified:November 23, 2004 - v3
Checksum:i97EAAD2B0A5E01C6
GO
Isoform 2 (identifier: P29558-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-252: Missing.

Show »
Length:403
Mass (Da):44,137
Checksum:i614911BB16E670B1
GO
Isoform 4 (identifier: P29558-4) [UniParc]FASTAAdd to basket
Also known as: MSSP-2

The sequence of this isoform differs from the canonical sequence as follows:
     26-38: QSLVPAHPMAPPS → FGRHSGIPSEKEE
     39-406: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:38
Mass (Da):4,632
Checksum:i6D0758AEEAA3012B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Y5H0F6Y5H0_HUMAN
RNA-binding motif, single-stranded-...
RBMS1
386Annotation score:
E7ETU5E7ETU5_HUMAN
RNA-binding motif, single-stranded-...
RBMS1
370Annotation score:
E7EPF2E7EPF2_HUMAN
RNA-binding motif, single-stranded-...
RBMS1
127Annotation score:

Sequence cautioni

The sequence AAX93095 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA45923 differs from that shown. Reason: Frameshift at positions 319 and 360.Curated
The sequence CAA45923 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA54628 differs from that shown. Reason: Erroneous translation. Wrong coding sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132M → K in CAA45923 (PubMed:8134115).Curated1
Sequence conflicti315 – 316QH → HD in CAA54628 (PubMed:7838710).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03779026 – 38QSLVP…MAPPS → FGRHSGIPSEKEE in isoform 4. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_03779139 – 406Missing in isoform 4. 1 PublicationAdd BLAST368
Alternative sequenceiVSP_011930250 – 252Missing in isoform 2. 2 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28482 mRNA Translation: BAA05841.1
X77494 mRNA Translation: CAA54628.1 Sequence problems.
AC092153 Genomic DNA Translation: AAX93095.1 Sequence problems.
AC104598 Genomic DNA Translation: AAX93183.1
AC131754 Genomic DNA Translation: AAY15005.1
BC012992 mRNA Translation: AAH12992.1
BC012993 mRNA Translation: AAH12993.1
BC018951 mRNA Translation: AAH18951.1
X64652 mRNA Translation: CAA45923.1 Sequence problems.
CCDSiCCDS2213.1 [P29558-1]
PIRiI38042
S19873
S47659
S53612
RefSeqiNP_002888.1, NM_002897.4 [P29558-2]
NP_058520.1, NM_016836.3 [P29558-1]
UniGeneiHs.470412
Hs.708357

Genome annotation databases

EnsembliENST00000348849; ENSP00000294904; ENSG00000153250 [P29558-1]
GeneIDi5937
KEGGihsa:5937
UCSCiuc002ubo.4 human [P29558-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28482 mRNA Translation: BAA05841.1
X77494 mRNA Translation: CAA54628.1 Sequence problems.
AC092153 Genomic DNA Translation: AAX93095.1 Sequence problems.
AC104598 Genomic DNA Translation: AAX93183.1
AC131754 Genomic DNA Translation: AAY15005.1
BC012992 mRNA Translation: AAH12992.1
BC012993 mRNA Translation: AAH12993.1
BC018951 mRNA Translation: AAH18951.1
X64652 mRNA Translation: CAA45923.1 Sequence problems.
CCDSiCCDS2213.1 [P29558-1]
PIRiI38042
S19873
S47659
S53612
RefSeqiNP_002888.1, NM_002897.4 [P29558-2]
NP_058520.1, NM_016836.3 [P29558-1]
UniGeneiHs.470412
Hs.708357

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X5ONMR-A123-223[»]
ProteinModelPortaliP29558
SMRiP29558
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111872, 52 interactors
IntActiP29558, 6 interactors
MINTiP29558
STRINGi9606.ENSP00000294904

PTM databases

iPTMnetiP29558
PhosphoSitePlusiP29558

Polymorphism and mutation databases

BioMutaiRBMS1
DMDMi55977783

Proteomic databases

EPDiP29558
MaxQBiP29558
PaxDbiP29558
PeptideAtlasiP29558
PRIDEiP29558
ProteomicsDBi54586
54587 [P29558-2]
54588 [P29558-4]

Protocols and materials databases

DNASUi5937
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348849; ENSP00000294904; ENSG00000153250 [P29558-1]
GeneIDi5937
KEGGihsa:5937
UCSCiuc002ubo.4 human [P29558-1]

Organism-specific databases

CTDi5937
DisGeNETi5937
EuPathDBiHostDB:ENSG00000153250.17
GeneCardsiRBMS1
HGNCiHGNC:9907 RBMS1
HPAiHPA047943
HPA061791
MIMi602310 gene
neXtProtiNX_P29558
OpenTargetsiENSG00000153250
PharmGKBiPA34273
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4733 Eukaryota
ENOG410XRB5 LUCA
GeneTreeiENSGT00760000118913
HOVERGENiHBG053108
InParanoidiP29558
OMAiYTHVQTT
OrthoDBiEOG091G0FXS
PhylomeDBiP29558
TreeFamiTF314644

Miscellaneous databases

ChiTaRSiRBMS1 human
EvolutionaryTraceiP29558
GeneWikiiRBMS1
GenomeRNAii5937
PROiPR:P29558
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153250 Expressed in 214 organ(s), highest expression level in placenta
CleanExiHS_RBMS1
ExpressionAtlasiP29558 baseline and differential
GenevisibleiP29558 HS

Family and domain databases

CDDicd12470 RRM1_MSSP1, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR002343 Hud_Sxl_RNA
IPR034404 MSSP1_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRBMS1_HUMAN
AccessioniPrimary (citable) accession number: P29558
Secondary accession number(s): Q14869
, Q15433, Q53P46, Q53QX8, Q53RG6, Q8WV20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 23, 2004
Last modified: November 7, 2018
This is version 173 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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