UniProtKB - P29549 (TEBA_STENO)
Protein
Telomere-binding protein subunit alpha
Gene
MAC-56A
moreOrganism
Sterkiella nova (Ciliate) (Oxytricha nova)
Status
Functioni
May function as protective capping of the single-stranded telomeric overhang. May also participate in telomere length regulation during DNA replication. Binds specifically to the T4G4-containing extension on the 3'strand and protects this region of the telomere from nuclease digestion and chemical modification.
Miscellaneous
The sequence of the A (or alanine) version is shown. The S (or serine) version differs in only two positions, and the K version in only one. There may be other versions in addition to the S, A, and K versions.
GO - Molecular functioni
- single-stranded telomeric DNA binding Source: CAFA
GO - Biological processi
- telomere capping Source: CAFA
Keywordsi
Molecular function | DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Telomere-binding protein subunit alphaAlternative name(s): TEBP alpha Telomere-binding protein 56 kDa subunit |
Gene namesi | Name:MAC-56A AND Name:MAC-56K AND Name:MAC-56S |
Organismi | Sterkiella nova (Ciliate) (Oxytricha nova) |
Taxonomic identifieri | 200597 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Ciliophora › Intramacronucleata › Spirotrichea › Stichotrichia › Sporadotrichida › Oxytrichidae › Stylonychinae › Sterkiella |
Subcellular locationi
GO - Cellular componenti
- nuclear chromosome, telomeric region Source: InterPro
- protein-containing complex Source: CAFA
- telomere cap complex Source: CAFA
Keywords - Cellular componenti
Chromosome, Nucleus, TelomerePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121735 | 1 – 495 | Telomere-binding protein subunit alphaAdd BLAST | 495 |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta subunit.
Protein-protein interaction databases
DIPi | DIP-6194N |
MINTi | P29549 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P29549 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P29549 |
Family & Domainsi
Sequence similaritiesi
Belongs to the telombin family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR028389, POT1 IPR011564, Telomer_end-bd_POT1/Cdc13 IPR003415, Telomere-bd_alpha |
PANTHERi | PTHR14513, PTHR14513, 2 hits |
Pfami | View protein in Pfam PF02765, POT1, 2 hits |
PIRSFi | PIRSF015848, TEBP_alpha, 1 hit |
SMARTi | View protein in SMART SM00976, Telo_bind, 1 hit |
SUPFAMi | SSF50249, SSF50249, 3 hits |
i Sequence
Sequence statusi: Complete.
P29549-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTAAKQNRS TSRVSKKKTA APKEGAAKKS DKGHKYEYVE LAKASLTSAQ
60 70 80 90 100
PQHFYAVVID ATFPYKTNQE RYICSLKIVD PTLYLKQQKG AGDASDYATL
110 120 130 140 150
VLYAKRFEDL PIIHRAGDII RVHRATLRLY NGQRQFNANV FYSSSWALFS
160 170 180 190 200
TDKRSVTQEI NNQDAVSDTT PFSFSSKHAT IEKNEISILQ NLRKWANQYF
210 220 230 240 250
SSYSVISSDM YTALNKAQAQ KGDFDVVAKI LQVHELDEYT NELKLKDASG
260 270 280 290 300
QVFYTLSLKL KFPHVRTGEV VRIRSATYDE TSTQKKVLIL SHYSNIITFI
310 320 330 340 350
QSSKLAKELR AKIQDDHSVE VASLKKNVSL NAVVLTEVDK KHAALPSTSL
360 370 380 390 400
QDLFHHADSD KELQAQDTFR TQFYVTKIEP SDVKEWVKGY DRKTKKSSSL
410 420 430 440 450
KGASGKGDNI FQVQFLVKDA STQLNNNTYR VLLYTQDGLG ANFFNVKADN
460 470 480 490
LHKNADARKK LEDSAELLTK FNSYVDAVVE RRNGFYLIKD TKLIY
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 21 | A → S in K version. | 1 | |
Natural varianti | 311 | A → S in S version. | 1 | |
Natural varianti | 456 | D → E in S version. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M68931 Genomic DNA Translation: AAA29398.1 M68930 Genomic DNA Translation: AAA29399.1 X59724 Genomic DNA Translation: CAA42409.1 |
PIRi | A41221 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M68931 Genomic DNA Translation: AAA29398.1 M68930 Genomic DNA Translation: AAA29399.1 X59724 Genomic DNA Translation: CAA42409.1 |
PIRi | A41221 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JB7 | X-ray | 1.86 | A | 1-495 | [»] | |
1K8G | X-ray | 2.60 | A/B/C | 1-320 | [»] | |
1KIX | X-ray | 2.70 | A | 1-495 | [»] | |
1OTC | X-ray | 2.80 | A | 1-495 | [»] | |
1PA6 | X-ray | 2.45 | A | 36-495 | [»] | |
1PH1 | X-ray | 2.51 | A | 35-495 | [»] | |
1PH2 | X-ray | 3.10 | A | 36-494 | [»] | |
1PH3 | X-ray | 2.30 | A | 36-495 | [»] | |
1PH4 | X-ray | 2.30 | A | 36-495 | [»] | |
1PH5 | X-ray | 2.30 | A | 36-494 | [»] | |
1PH6 | X-ray | 2.10 | A | 35-495 | [»] | |
1PH7 | X-ray | 2.90 | A | 36-495 | [»] | |
1PH8 | X-ray | 2.36 | A | 36-495 | [»] | |
1PH9 | X-ray | 2.50 | A | 36-495 | [»] | |
1PHJ | X-ray | 2.50 | A | 35-495 | [»] | |
2I0Q | X-ray | 1.91 | A | 1-495 | [»] | |
SMRi | P29549 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-6194N |
MINTi | P29549 |
Miscellaneous databases
EvolutionaryTracei | P29549 |
Family and domain databases
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR028389, POT1 IPR011564, Telomer_end-bd_POT1/Cdc13 IPR003415, Telomere-bd_alpha |
PANTHERi | PTHR14513, PTHR14513, 2 hits |
Pfami | View protein in Pfam PF02765, POT1, 2 hits |
PIRSFi | PIRSF015848, TEBP_alpha, 1 hit |
SMARTi | View protein in SMART SM00976, Telo_bind, 1 hit |
SUPFAMi | SSF50249, SSF50249, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TEBA_STENO | |
Accessioni | P29549Primary (citable) accession number: P29549 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families