UniProtKB - P29534 (VCAM1_RAT)
Vascular cell adhesion protein 1
Vcam1
Functioni
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
GO - Molecular functioni
- cell adhesion molecule binding Source: RGD
- integrin binding Source: RGD
- primary amine oxidase activity Source: RGD
GO - Biological processi
- acute inflammatory response Source: RGD
- aging Source: RGD
- amine metabolic process Source: RGD
- calcium-mediated signaling using intracellular calcium source Source: RGD
- cardiac neuron differentiation Source: RGD
- cell adhesion Source: RGD
- cell-cell adhesion in response to extracellular stimulus Source: RGD
- cell chemotaxis Source: RGD
- cell-matrix adhesion Source: RGD
- cellular response to amyloid-beta Source: RGD
- cellular response to glucose stimulus Source: RGD
- cellular response to tumor necrosis factor Source: RGD
- cellular response to vascular endothelial growth factor stimulus Source: RGD
- chorio-allantoic fusion Source: RGD
- chronic inflammatory response Source: RGD
- embryonic placenta morphogenesis Source: RGD
- heart development Source: RGD
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: RGD
- heterotypic cell-cell adhesion Source: RGD
- innervation Source: RGD
- leukocyte cell-cell adhesion Source: RGD
- leukocyte tethering or rolling Source: RGD
- membrane to membrane docking Source: RGD
- positive regulation of T cell proliferation Source: RGD
- response to ethanol Source: RGD
- response to hypoxia Source: RGD
- response to ionizing radiation Source: RGD
- response to lipopolysaccharide Source: RGD
- response to nicotine Source: RGD
- response to nutrient Source: RGD
- response to zinc ion Source: RGD
Keywordsi
Biological process | Cell adhesion, Host-virus interaction |
Enzyme and pathway databases
Reactomei | R-RNO-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-RNO-216083, Integrin cell surface interactions |
Names & Taxonomyi
Protein namesi | Recommended name: Vascular cell adhesion protein 1Short name: V-CAM 1 Short name: VCAM-1 Alternative name(s): CD_antigen: CD106 |
Gene namesi | Name:Vcam1 Synonyms:Vcam-1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3952, Vcam1 |
Subcellular locationi
Other locations
Cytoskeleton
- podosome Source: RGD
Endoplasmic reticulum
- endoplasmic reticulum Source: RGD
Endosome
- early endosome Source: RGD
Extracellular region or secreted
- extracellular space Source: RGD
Golgi apparatus
- Golgi apparatus Source: RGD
Plasma Membrane
- alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex Source: RGD
- apical plasma membrane Source: RGD
- external side of plasma membrane Source: RGD
- integral component of plasma membrane Source: GO_Central
- sarcolemma Source: RGD
Other locations
- apical part of cell Source: RGD
- cell periphery Source: RGD
- cell surface Source: RGD
- filopodium Source: RGD
- microvillus Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 698 | ExtracellularSequence analysisAdd BLAST | 674 | |
Transmembranei | 699 – 720 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 721 – 739 | CytoplasmicSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | CuratedAdd BLAST | 24 | |
ChainiPRO_0000014999 | 25 – 739 | Vascular cell adhesion protein 1Add BLAST | 715 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 47 ↔ 95 | PROSITE-ProRule annotation | ||
Disulfide bondi | 52 ↔ 99 | PROSITE-ProRule annotation | ||
Disulfide bondi | 137 ↔ 195 | PROSITE-ProRule annotation | ||
Disulfide bondi | 246 ↔ 291 | PROSITE-ProRule annotation | ||
Glycosylationi | 273 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 335 ↔ 383 | PROSITE-ProRule annotation | ||
Glycosylationi | 424 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 531 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 534 ↔ 579 | PROSITE-ProRule annotation | ||
Glycosylationi | 561 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 650 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P29534 |
PRIDEi | P29534 |
PTM databases
CarbonylDBi | P29534 |
GlyGeni | P29534, 5 sites |
PhosphoSitePlusi | P29534 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000014333, Expressed in spleen and 20 other tissues |
ExpressionAtlasi | P29534, baseline and differential |
Genevisiblei | P29534, RN |
Interactioni
Subunit structurei
Binds to ECMV-D capsid proteins and acts as a receptor for this virus.
By similarityGO - Molecular functioni
- cell adhesion molecule binding Source: RGD
- integrin binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019377 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 111 | Ig-like C2-type 1Add BLAST | 87 | |
Domaini | 119 – 212 | Ig-like C2-type 2Add BLAST | 94 | |
Domaini | 223 – 309 | Ig-like C2-type 3Add BLAST | 87 | |
Domaini | 312 – 397 | Ig-like C2-type 4Add BLAST | 86 | |
Domaini | 408 – 506 | Ig-like C2-type 5Add BLAST | 99 | |
Domaini | 514 – 595 | Ig-like C2-type 6Add BLAST | 82 | |
Domaini | 601 – 682 | Ig-like C2-type 7Add BLAST | 82 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSKQ, Eukaryota |
GeneTreei | ENSGT00940000156511 |
InParanoidi | P29534 |
OMAi | YTIHKAQ |
OrthoDBi | 544376at2759 |
PhylomeDBi | P29534 |
TreeFami | TF333571 |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR003987, ICAM_VCAM_N IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR008424, Ig_C2-set IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR003989, VCAM-1 |
PANTHERi | PTHR13771:SF14, PTHR13771:SF14, 6 hits |
Pfami | View protein in Pfam PF05790, C2-set, 2 hits PF07679, I-set, 2 hits PF00047, ig, 1 hit PF13895, Ig_2, 1 hit |
PRINTSi | PR01472, ICAMVCAM1 PR01474, VCAM1 |
SMARTi | View protein in SMART SM00409, IG, 5 hits SM00408, IGc2, 5 hits |
SUPFAMi | SSF48726, SSF48726, 7 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MPVKMVAIFG ASTVLWILFA VSQAFKIEIS PEYKTLAQIG DSMLLTCSTT
60 70 80 90 100
GCESPSFSWR TQIDSPLNGK VKTEGAKSVL TMDPVSFENE HSYLCTATCN
110 120 130 140 150
SGKLERGIQV DIYSFPKDPE IQFSGPLEVG KPVMVKCLAP DVYPIDRLEI
160 170 180 190 200
ELFKGDRLMK KQDFVDEMAK KSLETKSLEV IFTPVIEDIE KALVCRAKLY
210 220 230 240 250
IDQTDSIPKE RETVRELQVY TSPKNTEISV HPSTRLHEGA AVTMTCASEG
260 270 280 290 300
LPAPEIFWSK KLDNGVLQLL SGNATLTLIA MRMEDSGIYV CEGVNLVGRD
310 320 330 340 350
KTEVELIVQE KPFTVDISPG SQVAAQVGDS VVLTCAAVGC DSPSFSWRTQ
360 370 380 390 400
TDSPLNGEVR DEGATSTLTL SPVGVEDEHS YLCTVTCQRR KLEKTIQVEV
410 420 430 440 450
YSFPEDPEIE ISGPLVHGRP VTVNCTVPNV YPFDHLEIEL LKGETTLLNK
460 470 480 490 500
FLREEIGTKS LETKSLEMTF IPTAEDTGKA LVCLAKLHSS QMESEPKQRQ
510 520 530 540 550
STQTLYVNVA PKEPTIWVSP SPVPEEGSPV NLTCSSDGFP TPKILWSRQL
560 570 580 590 600
KNGELQPLSQ NTTLSFMATK MEDSGIYVCE GINEAGISKK SVELIIQGSS
610 620 630 640 650
KDIQLTVFPS KSVKEGDTVI ISCTCGSVPE IWIILKKKAK TGDMVLKSVN
660 670 680 690 700
GSYTIRKAQL QDAGVYECES KTEVGSQLRS LTLDVKGKEN NKDYFSPELL
710 720 730
ALYFASSLVI PAIGMIIYFA RKANMKGSYS LVEAQKSKV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K127 | A0A0G2K127_RAT | Vascular cell adhesion protein 1 | Vcam1 | 606 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | V → G in CAA45254 (PubMed:1377031).Curated | 1 | |
Sequence conflicti | 122 – 123 | QF → HL in CAA45254 (PubMed:1377031).Curated | 2 | |
Sequence conflicti | 166 | D → N in CAA45254 (PubMed:1377031).Curated | 1 | |
Sequence conflicti | 739 | V → G in CAA45254 (PubMed:1377031).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84488 mRNA Translation: AAA42332.1 X63722 mRNA Translation: CAA45254.1 BC089812 mRNA Translation: AAH89812.1 |
PIRi | JS0675 |
RefSeqi | NP_037021.1, NM_012889.1 |
Genome annotation databases
Ensembli | ENSRNOT00000019377; ENSRNOP00000019377; ENSRNOG00000014333 ENSRNOT00000078806; ENSRNOP00000071423; ENSRNOG00000014333 |
GeneIDi | 25361 |
KEGGi | rno:25361 |
UCSCi | RGD:3952, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84488 mRNA Translation: AAA42332.1 X63722 mRNA Translation: CAA45254.1 BC089812 mRNA Translation: AAH89812.1 |
PIRi | JS0675 |
RefSeqi | NP_037021.1, NM_012889.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019377 |
PTM databases
CarbonylDBi | P29534 |
GlyGeni | P29534, 5 sites |
PhosphoSitePlusi | P29534 |
Proteomic databases
PaxDbi | P29534 |
PRIDEi | P29534 |
Genome annotation databases
Ensembli | ENSRNOT00000019377; ENSRNOP00000019377; ENSRNOG00000014333 ENSRNOT00000078806; ENSRNOP00000071423; ENSRNOG00000014333 |
GeneIDi | 25361 |
KEGGi | rno:25361 |
UCSCi | RGD:3952, rat |
Organism-specific databases
CTDi | 7412 |
RGDi | 3952, Vcam1 |
Phylogenomic databases
eggNOGi | ENOG502QSKQ, Eukaryota |
GeneTreei | ENSGT00940000156511 |
InParanoidi | P29534 |
OMAi | YTIHKAQ |
OrthoDBi | 544376at2759 |
PhylomeDBi | P29534 |
TreeFami | TF333571 |
Enzyme and pathway databases
Reactomei | R-RNO-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-RNO-216083, Integrin cell surface interactions |
Miscellaneous databases
PROi | PR:P29534 |
Gene expression databases
Bgeei | ENSRNOG00000014333, Expressed in spleen and 20 other tissues |
ExpressionAtlasi | P29534, baseline and differential |
Genevisiblei | P29534, RN |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR003987, ICAM_VCAM_N IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR008424, Ig_C2-set IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR003989, VCAM-1 |
PANTHERi | PTHR13771:SF14, PTHR13771:SF14, 6 hits |
Pfami | View protein in Pfam PF05790, C2-set, 2 hits PF07679, I-set, 2 hits PF00047, ig, 1 hit PF13895, Ig_2, 1 hit |
PRINTSi | PR01472, ICAMVCAM1 PR01474, VCAM1 |
SMARTi | View protein in SMART SM00409, IG, 5 hits SM00408, IGc2, 5 hits |
SUPFAMi | SSF48726, SSF48726, 7 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | VCAM1_RAT | |
Accessioni | P29534Primary (citable) accession number: P29534 Secondary accession number(s): Q5FVS3, Q63669 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |