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Protein

Serpin B3

Gene

SERPINB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH2-terminal kinase (JNK1).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei354 – 355Reactive bond2

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity Source: UniProtKB
  • protease binding Source: UniProtKB
  • serine-type endopeptidase inhibitor activity Source: GO_Central
  • virus receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiI04.008

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B3
Alternative name(s):
Protein T4-A
Squamous cell carcinoma antigen 1
Short name:
SCCA-1
Gene namesi
Name:SERPINB3
Synonyms:SCCA, SCCA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000057149.14
HGNCiHGNC:10569 SERPINB3
MIMi600517 gene
neXtProtiNX_P29508

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi341A → R: Loss of inhibitory activity. 1 Publication1
Mutagenesisi352F → A: Loss of inhibitory activity. 2 Publications1
Mutagenesisi352F → G: Loss of inhibitory activity to papain but does not decrease the suppression activity to MAPK8. 2 Publications1
Mutagenesisi354 – 355SS → PP: Loss of inhibitory activity. 1 Publication2

Organism-specific databases

DisGeNETi6317
OpenTargetsiENSG00000057149
PharmGKBiPA35538

Chemistry databases

DrugBankiDB03929 D-Serine
DB04522 Phosphonoserine

Polymorphism and mutation databases

BioMutaiSERPINB3
DMDMi20141712

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000941031 – 390Serpin B3Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP29508
MaxQBiP29508
PaxDbiP29508
PeptideAtlasiP29508
PRIDEiP29508
ProteomicsDBi54582
54583 [P29508-2]
TopDownProteomicsiP29508-1 [P29508-1]
P29508-2 [P29508-2]

2D gel databases

SWISS-2DPAGEiP29508
UCD-2DPAGEiP29508

PTM databases

iPTMnetiP29508
PhosphoSitePlusiP29508

Expressioni

Tissue specificityi

Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).1 Publication

Developmental stagei

Its expression is closely related to cellular differentiation in both normal and malignant squamous cells.

Inductioni

Strongly up-regulated in the upper epidermis of sun-exposed skin.1 Publication

Gene expression databases

BgeeiENSG00000057149 Expressed in 108 organ(s), highest expression level in ectocervix
GenevisibleiP29508 HS

Organism-specific databases

HPAiCAB018772
CAB036006
CAB036007
HPA048341
HPA049988
HPA055992

Interactioni

Subunit structurei

Interacts with MAPK8/JNK1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112223, 55 interactors
IntActiP29508, 7 interactors
MINTiP29508
STRINGi9606.ENSP00000283752

Structurei

Secondary structure

1390
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP29508
SMRiP29508
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29508

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOVERGENiHBG005957
InParanoidiP29508
KOiK13963
OMAiNYGSEAR
PhylomeDBiP29508
TreeFamiTF352619

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P29508-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSLSEANTK FMFDLFQQFR KSKENNIFYS PISITSALGM VLLGAKDNTA
60 70 80 90 100
QQIKKVLHFD QVTENTTGKA ATYHVDRSGN VHHQFQKLLT EFNKSTDAYE
110 120 130 140 150
LKIANKLFGE KTYLFLQEYL DAIKKFYQTS VESVDFANAP EESRKKINSW
160 170 180 190 200
VESQTNEKIK NLIPEGNIGS NTTLVLVNAI YFKGQWEKKF NKEDTKEEKF
210 220 230 240 250
WPNKNTYKSI QMMRQYTSFH FASLEDVQAK VLEIPYKGKD LSMIVLLPNE
260 270 280 290 300
IDGLQKLEEK LTAEKLMEWT SLQNMRETRV DLHLPRFKVE ESYDLKDTLR
310 320 330 340 350
TMGMVDIFNG DADLSGMTGS RGLVLSGVLH KAFVEVTEEG AEAAAATAVV
360 370 380 390
GFGSSPTSTN EEFHCNHPFL FFIRQNKTNS ILFYGRFSSP
Length:390
Mass (Da):44,565
Last modified:January 23, 2002 - v2
Checksum:iE5F27F986C752CFA
GO
Isoform 2 (identifier: P29508-2) [UniParc]FASTAAdd to basket
Also known as: SCCA1b

The sequence of this isoform differs from the canonical sequence as follows:
     205-256: Missing.

Show »
Length:338
Mass (Da):38,550
Checksum:i5AA4782FF0C1ABDF
GO

Sequence cautioni

The sequence AAO11731 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16F → S in CAD56658 (PubMed:12975381).Curated1
Sequence conflicti47D → N in CAD56658 (PubMed:12975381).Curated1
Sequence conflicti105N → T in CAD56658 (PubMed:12975381).Curated1
Sequence conflicti185Q → R in AAO92272 (Ref. 5) Curated1
Sequence conflicti202P → S in AAO92272 (Ref. 5) Curated1
Sequence conflicti278T → A in AAO92269 (Ref. 5) Curated1
Sequence conflicti349V → E in AAO92272 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024351351G → A Increased antiprotease activity and increased MAPK8 inhibition activity. 4 PublicationsCorresponds to variant dbSNP:rs3180227Ensembl.1
Natural variantiVAR_024352357T → A3 PublicationsCorresponds to variant dbSNP:rs1065205Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032657205 – 256Missing in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S66896 mRNA Translation: AAB20405.1
U19556 mRNA Translation: AAA97552.1
U19568
, U19559, U19560, U19562, U19565, U19567 Genomic DNA Translation: AAA86317.1
U19562, U19559, U19560 Genomic DNA Translation: AAA86316.1
AB046399 mRNA Translation: BAB40772.1
AJ515706 mRNA Translation: CAD56658.1
AY245778 mRNA Translation: AAO92269.1
AY245781 mRNA Translation: AAO92272.1
EU852041 mRNA Translation: ACF21012.1
BT006748 mRNA Translation: AAP35394.1
AK222746 mRNA Translation: BAD96466.1
AK222753 mRNA Translation: BAD96473.1
AK314805 mRNA Translation: BAG37332.1
AC069356 Genomic DNA No translation available.
CH471096 Genomic DNA Translation: EAW63156.1
CH471096 Genomic DNA Translation: EAW63157.1
BC005224 mRNA Translation: AAH05224.1
AY190327 mRNA Translation: AAO11731.1 Different initiation.
CCDSiCCDS11987.1 [P29508-1]
PIRiI38201
RefSeqiNP_008850.1, NM_006919.2 [P29508-1]
UniGeneiHs.227948

Genome annotation databases

EnsembliENST00000283752; ENSP00000283752; ENSG00000057149 [P29508-1]
ENST00000332821; ENSP00000329498; ENSG00000057149 [P29508-2]
GeneIDi6317
KEGGihsa:6317
UCSCiuc002lji.3 human [P29508-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S66896 mRNA Translation: AAB20405.1
U19556 mRNA Translation: AAA97552.1
U19568
, U19559, U19560, U19562, U19565, U19567 Genomic DNA Translation: AAA86317.1
U19562, U19559, U19560 Genomic DNA Translation: AAA86316.1
AB046399 mRNA Translation: BAB40772.1
AJ515706 mRNA Translation: CAD56658.1
AY245778 mRNA Translation: AAO92269.1
AY245781 mRNA Translation: AAO92272.1
EU852041 mRNA Translation: ACF21012.1
BT006748 mRNA Translation: AAP35394.1
AK222746 mRNA Translation: BAD96466.1
AK222753 mRNA Translation: BAD96473.1
AK314805 mRNA Translation: BAG37332.1
AC069356 Genomic DNA No translation available.
CH471096 Genomic DNA Translation: EAW63156.1
CH471096 Genomic DNA Translation: EAW63157.1
BC005224 mRNA Translation: AAH05224.1
AY190327 mRNA Translation: AAO11731.1 Different initiation.
CCDSiCCDS11987.1 [P29508-1]
PIRiI38201
RefSeqiNP_008850.1, NM_006919.2 [P29508-1]
UniGeneiHs.227948

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZV6X-ray2.70A/B/C2-390[»]
4ZK0X-ray2.15A1-390[»]
4ZK3X-ray2.00A1-390[»]
ProteinModelPortaliP29508
SMRiP29508
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112223, 55 interactors
IntActiP29508, 7 interactors
MINTiP29508
STRINGi9606.ENSP00000283752

Chemistry databases

DrugBankiDB03929 D-Serine
DB04522 Phosphonoserine

Protein family/group databases

MEROPSiI04.008

PTM databases

iPTMnetiP29508
PhosphoSitePlusiP29508

Polymorphism and mutation databases

BioMutaiSERPINB3
DMDMi20141712

2D gel databases

SWISS-2DPAGEiP29508
UCD-2DPAGEiP29508

Proteomic databases

EPDiP29508
MaxQBiP29508
PaxDbiP29508
PeptideAtlasiP29508
PRIDEiP29508
ProteomicsDBi54582
54583 [P29508-2]
TopDownProteomicsiP29508-1 [P29508-1]
P29508-2 [P29508-2]

Protocols and materials databases

DNASUi6317
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283752; ENSP00000283752; ENSG00000057149 [P29508-1]
ENST00000332821; ENSP00000329498; ENSG00000057149 [P29508-2]
GeneIDi6317
KEGGihsa:6317
UCSCiuc002lji.3 human [P29508-1]

Organism-specific databases

CTDi6317
DisGeNETi6317
EuPathDBiHostDB:ENSG00000057149.14
GeneCardsiSERPINB3
HGNCiHGNC:10569 SERPINB3
HPAiCAB018772
CAB036006
CAB036007
HPA048341
HPA049988
HPA055992
MIMi600517 gene
neXtProtiNX_P29508
OpenTargetsiENSG00000057149
PharmGKBiPA35538
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOVERGENiHBG005957
InParanoidiP29508
KOiK13963
OMAiNYGSEAR
PhylomeDBiP29508
TreeFamiTF352619

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiSERPINB3 human
EvolutionaryTraceiP29508
GeneWikiiSERPINB3
GenomeRNAii6317
PROiPR:P29508
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000057149 Expressed in 108 organ(s), highest expression level in ectocervix
GenevisibleiP29508 HS

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPB3_HUMAN
AccessioniPrimary (citable) accession number: P29508
Secondary accession number(s): A6NDM2
, B2RBT5, B3W5Y6, Q53H28, Q53YB5, Q86VF3, Q86W04, Q8IWL4, Q8IXI3, Q96J21, Q9BYF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2002
Last modified: November 7, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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