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Protein

Metallothionein-1

Gene
N/A
Organism
Homarus americanus (American lobster)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals. The different forms of lobster metallothioneins may have different biological functions. Class I MTS in marine crustacea are involved in the sequestration of elevated levels of heavy-metal ions. Binds 6 metal ions. Known to bind cadmium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi4Divalent metal cation; cluster B1
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi9Divalent metal cation; cluster B1
Metal bindingi11Divalent metal cation; cluster B1
Metal bindingi16Divalent metal cation; cluster B1
Metal bindingi20Divalent metal cation; cluster B1
Metal bindingi22Divalent metal cation; cluster B1
Metal bindingi25Divalent metal cation; cluster B1
Metal bindingi27Divalent metal cation; cluster B1
Metal bindingi30Divalent metal cation; cluster A1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi39Divalent metal cation; cluster A1
Metal bindingi45Divalent metal cation; cluster A1
Metal bindingi49Divalent metal cation; cluster A1
Metal bindingi53Divalent metal cation; cluster A1
Metal bindingi55Divalent metal cation; cluster A1
Metal bindingi56Divalent metal cation; cluster A1

GO - Molecular functioni

Keywordsi

LigandCadmium, Copper, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Alternative name(s):
CuMT-1
OrganismiHomarus americanus (American lobster)
Taxonomic identifieri6706 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMulticrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaNephropoideaNephropidaeHomarus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973421 – 58Metallothionein-1Add BLAST58

Proteomic databases

PRIDEiP29499

Structurei

Secondary structure

158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP29499
SMRiP29499
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29499

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28BetaAdd BLAST28
Regioni29 – 58AlphaAdd BLAST30

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002045 Metalthion_crustacean
IPR017854 Metalthion_dom_sf
PRINTSiPR00858 MTCRUSTACEAN
SUPFAMiSSF57868 SSF57868, 2 hits

Sequencei

Sequence statusi: Complete.

P29499-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PGPCCKDKCE CAEGGCKTGC KCTSCRCAPC EKCTSGCKCP SKDECAKTCS

KPCSCCXX
Length:58
Mass (Da):5,977
Last modified:November 1, 1997 - v2
Checksum:i176ABAAF60A32F96
GO

Sequence databases

PIRiA37039

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA37039

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J5LNMR-A29-56[»]
1J5MNMR-A1-28[»]
ProteinModelPortaliP29499
SMRiP29499
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP29499

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP29499

Family and domain databases

InterProiView protein in InterPro
IPR002045 Metalthion_crustacean
IPR017854 Metalthion_dom_sf
PRINTSiPR00858 MTCRUSTACEAN
SUPFAMiSSF57868 SSF57868, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMT1_HOMAM
AccessioniPrimary (citable) accession number: P29499
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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