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UniProtKB - P29475 (NOS1_HUMAN)

Entry version 227 (10 Feb 2021)
Sequence version 2 (01 Oct 1996)
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Protein

Nitric oxide synthase, brain

Gene

NOS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Stimulated by calcium/calmodulin. Inhibited by n-Nos-inhibiting protein (PIN) which may prevent the dimerization of the protein. Inhibited by NOSIP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi420Iron (heme axial ligand)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi886 – 917FMNPROSITE-ProRule annotationAdd BLAST32
Nucleotide bindingi1032 – 1043FADBy similarityAdd BLAST12
Nucleotide bindingi1175 – 1185FADBy similarityAdd BLAST11
Nucleotide bindingi1250 – 1268NADPBy similarityAdd BLAST19
Nucleotide bindingi1348 – 1363NADPBy similarityAdd BLAST16

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Oxidoreductase
LigandFAD, Flavoprotein, FMN, Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS01647-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.14.13.39, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P29475

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1222556, ROS and RNS production in phagocytes
R-HSA-392154, Nitric oxide stimulates guanylate cyclase
R-HSA-5578775, Ion homeostasis

SIGNOR Signaling Network Open Resource

More...SIGNORi		P29475

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nitric oxide synthase, brain (EC:1.14.13.39)
Alternative name(s):
Constitutive NOS
NC-NOS
NOS type I
Neuronal NOS
Short name:
N-NOS
Short name:
nNOS
Peptidyl-cysteine S-nitrosylase NOS1
bNOS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7872, NOS1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		163731, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P29475

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000089250.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4842

MalaCards human disease database

More...MalaCardsi		NOS1

Open Targets

More...OpenTargetsi		ENSG00000089250

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		930, Idiopathic achalasia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA252

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P29475, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3568

Drug and drug target database

More...DrugBanki		DB02143, 1-hydroxy-2-isopropylguanidine
DB02727, 2-butyl-1-hydroxyguanidine
DB01997, 3-Bromo-7-Nitroindazole
DB03892, 5-N-Allyl-arginine
DB03710, [(1S)-4-(1-Aminobutylideneamino)-1-carboxybutyl]azanium
DB00155, Citrulline
DB00843, Donepezil
DB00997, Doxorubicin
DB03147, Flavin adenine dinucleotide
DB03247, Flavin mononucleotide
DB01942, Formic acid
DB01221, Ketamine
DB02077, L-N(omega)-nitroarginine-(4R)-amino-L-proline amide
DB01821, L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide
DB09241, Methylene blue
DB03144, N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine
DB03449, N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide
DB02044, N-[3-(aminomethyl)benzyl]acetamidine
DB02644, N-omega-propyl-L-arginine
DB08019, N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine
DB08018, N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE
DB02027, N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine
DB03461, Nicotinamide adenine dinucleotide phosphate
DB04223, Nitroarginine
DB06096, NXN-188
DB02991, S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea
DB03707, S-Ethyl-N-Phenyl-Isothiourea

DrugCentral

More...DrugCentrali		P29475

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1251

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NOS1

Domain mapping of disease mutations (DMDM)

More...DMDMi		1709333

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001709211 – 1434Nitric oxide synthase, brainAdd BLAST1434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei852PhosphoserineBy similarity1
Modified residuei862PhosphoserineBy similarity1
Modified residuei863PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P29475

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P29475

MaxQB - The MaxQuant DataBase

More...MaxQBi		P29475

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P29475

PeptideAtlas

More...PeptideAtlasi		P29475

PRoteomics IDEntifications database

More...PRIDEi		P29475

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20446
50171
54578 [P29475-1]
54579 [P29475-2]
54580 [P29475-3]
54581 [P29475-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P29475

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P29475

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000089250, Expressed in vastus lateralis and 134 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P29475, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P29475, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000089250, Group enriched (brain, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON.

Forms a ternary complex with CAPON and RASD1.

Forms a ternary complex with CAPON and SYN1.

Interacts with ZDHHC23.

Interacts with NOSIP; which may impair its synaptic location (By similarity).

Interacts with HTR4.

Interacts with VAC14 (By similarity).

Interacts with SLC6A4 (By similarity).

Interacts (via N-terminal domain) with DLG4 (via N-terminal tandem pair of PDZ domains) (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110905, 18 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P29475

Database of interacting proteins

More...DIPi		DIP-40999N

Protein interaction database and analysis system

More...IntActi		P29475, 5 interactors

Molecular INTeraction database

More...MINTi		P29475

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000477999

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P29475

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P29475, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11434
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P29475

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P29475

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 99PDZPROSITE-ProRule annotationAdd BLAST83
Domaini760 – 940Flavodoxin-likePROSITE-ProRule annotationAdd BLAST181
Domaini995 – 1242FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST248

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 205Interaction with NOSIPBy similarityAdd BLAST205
Regioni163 – 245PIN (nNOS-inhibiting protein) bindingAdd BLAST83
Regioni730 – 750Calmodulin-bindingSequence analysisAdd BLAST21
Regioni755 – 774Tetrahydrobiopterin-bindingBy similarityAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles. Mediates interaction with VAC14 (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1158, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159357

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001570_16_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P29475

Identification of Orthologs from Complete Genome Data

More...OMAi		ERGHFYV

Database for complete collections of gene phylogenies

More...PhylomeDBi		P29475

TreeFam database of animal gene trees

More...TreeFami		TF324410

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.990.10, 1 hit
2.30.42.10, 1 hit
3.40.50.360, 1 hit
3.40.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003097, CysJ-like_FAD-binding
IPR017927, FAD-bd_FR_type
IPR001094, Flavdoxin-like
IPR008254, Flavodoxin/NO_synth
IPR001709, Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039, Flavoprotein-like_sf
IPR039261, FNR_nucleotide-bd
IPR023173, NADPH_Cyt_P450_Rdtase_alpha
IPR012144, NOS_euk
IPR004030, NOS_N
IPR036119, NOS_N_sf
IPR001433, OxRdtase_FAD/NAD-bd
IPR001478, PDZ
IPR036034, PDZ_sf
IPR017938, Riboflavin_synthase-like_b-brl

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00667, FAD_binding_1, 1 hit
PF00258, Flavodoxin_1, 1 hit
PF00175, NAD_binding_1, 1 hit
PF02898, NO_synthase, 1 hit
PF00595, PDZ, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000333, NOS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00369, FLAVODOXIN
PR00371, FPNCR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50156, SSF50156, 1 hit
SSF52218, SSF52218, 1 hit
SSF52343, SSF52343, 1 hit
SSF56512, SSF56512, 1 hit
SSF63380, SSF63380, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51384, FAD_FR, 1 hit
PS50902, FLAVODOXIN_LIKE, 1 hit
PS60001, NOS, 1 hit
PS50106, PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Isoform 3 is produced by different alternative splicing events implicating either the untranslated exons TEX1 (TN-NOS) or TEX1B (TN-NOSB) leading to a N-terminally truncated protein which possesses enzymatic activity comparable to that of isoform 1. The C-terminally truncated isoform 4 is produced by insertion of the TEX2 exon between exons 3 and 4 of isoform 1, leading to a frameshift and a premature stop codon.1 Publication

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P29475-1) [UniParc]FASTAAdd to basket
Also known as: N-NOS-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDHMFGVQQ IQPNVISVRL FKRKVGGLGF LVKERVSKPP VIISDLIRGG 
        60         70         80         90        100
AAEQSGLIQA GDIILAVNGR PLVDLSYDSA LEVLRGIASE THVVLILRGP 
       110        120        130        140        150
EGFTTHLETT FTGDGTPKTI RVTQPLGPPT KAVDLSHQPP AGKEQPLAVD 
       160        170        180        190        200
GASGPGNGPQ HAYDDGQEAG SLPHANGLAP RPPGQDPAKK ATRVSLQGRG 
       210        220        230        240        250
ENNELLKEIE PVLSLLTSGS RGVKGGAPAK AEMKDMGIQV DRDLDGKSHK 
       260        270        280        290        300
PLPLGVENDR VFNDLWGKGN VPVVLNNPYS EKEQPPTSGK QSPTKNGSPS 
       310        320        330        340        350
KCPRFLKVKN WETEVVLTDT LHLKSTLETG CTEYICMGSI MHPSQHARRP 
       360        370        380        390        400
EDVRTKGQLF PLAKEFIDQY YSSIKRFGSK AHMERLEEVN KEIDTTSTYQ 
       410        420        430        440        450
LKDTELIYGA KHAWRNASRC VGRIQWSKLQ VFDARDCTTA HGMFNYICNH 
       460        470        480        490        500
VKYATNKGNL RSAITIFPQR TDGKHDFRVW NSQLIRYAGY KQPDGSTLGD 
       510        520        530        540        550
PANVQFTEIC IQQGWKPPRG RFDVLPLLLQ ANGNDPELFQ IPPELVLEVP 
       560        570        580        590        600
IRHPKFEWFK DLGLKWYGLP AVSNMLLEIG GLEFSACPFS GWYMGTEIGV 
       610        620        630        640        650
RDYCDNSRYN ILEEVAKKMN LDMRKTSSLW KDQALVEINI AVLYSFQSDK 
       660        670        680        690        700
VTIVDHHSAT ESFIKHMENE YRCRGGCPAD WVWIVPPMSG SITPVFHQEM 
       710        720        730        740        750
LNYRLTPSFE YQPDPWNTHV WKGTNGTPTK RRAIGFKKLA EAVKFSAKLM 
       760        770        780        790        800
GQAMAKRVKA TILYATETGK SQAYAKTLCE IFKHAFDAKV MSMEEYDIVH 
       810        820        830        840        850
LEHETLVLVV TSTFGNGDPP ENGEKFGCAL MEMRHPNSVQ EERKSYKVRF 
       860        870        880        890        900
NSVSSYSDSQ KSSGDGPDLR DNFESAGPLA NVRFSVFGLG SRAYPHFCAF 
       910        920        930        940        950
GHAVDTLLEE LGGERILKMR EGDELCGQEE AFRTWAKKVF KAACDVFCVG 
       960        970        980        990       1000
DDVNIEKANN SLISNDRSWK RNKFRLTFVA EAPELTQGLS NVHKKRVSAA 
      1010       1020       1030       1040       1050
RLLSRQNLQS PKSSRSTIFV RLHTNGSQEL QYQPGDHLGV FPGNHEDLVN 
      1060       1070       1080       1090       1100
ALIERLEDAP PVNQMVKVEL LEERNTALGV ISNWTDELRL PPCTIFQAFK 
      1110       1120       1130       1140       1150
YYLDITTPPT PLQLQQFASL ATSEKEKQRL LVLSKGLQEY EEWKWGKNPT 
      1160       1170       1180       1190       1200
IVEVLEEFPS IQMPATLLLT QLSLLQPRYY SISSSPDMYP DEVHLTVAIV 
      1210       1220       1230       1240       1250
SYRTRDGEGP IHHGVCSSWL NRIQADELVP CFVRGAPSFH LPRNPQVPCI 
      1260       1270       1280       1290       1300
LVGPGTGIAP FRSFWQQRQF DIQHKGMNPC PMVLVFGCRQ SKIDHIYREE 
      1310       1320       1330       1340       1350
TLQAKNKGVF RELYTAYSRE PDKPKKYVQD ILQEQLAESV YRALKEQGGH 
      1360       1370       1380       1390       1400
IYVCGDVTMA ADVLKAIQRI MTQQGKLSAE DAGVFISRMR DDNRYHEDIF 
      1410       1420       1430 
GVTLRTYEVT NRLRSESIAF IEESKKDTDE VFSS
Length:1,434
Mass (Da):160,970
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99235793B953BF37
GO
Isoform 2 (identifier: P29475-2) [UniParc]FASTAAdd to basket
Also known as: N-NOS-2

The sequence of this isoform differs from the canonical sequence as follows:
     509-613: Missing.

Show »
Length:1,329
Mass (Da):148,919
Checksum:iDF791B80FDB12302
GO
Isoform 3 (identifier: P29475-3) [UniParc]FASTAAdd to basket
Also known as: TN-NOS, TN-NOSB

The sequence of this isoform differs from the canonical sequence as follows:
     1-336: Missing.

Show »
Length:1,098
Mass (Da):125,113
Checksum:iA1CD5C5012436233
GO
Isoform 4 (identifier: P29475-4) [UniParc]FASTAAdd to basket
Also known as: TEX2-insertion

The sequence of this isoform differs from the canonical sequence as follows:
     285-407: PPTSGKQSPT...TYQLKDTELI → MRKLRITEGF...PKPTWKGWKR
     408-1434: Missing.

Show »
Length:407
Mass (Da):43,838
Checksum:i7E9420C658EFACD2
GO
Isoform 5 (identifier: P29475-5) [UniParc]FASTAAdd to basket
Also known as: nNOSmu

The sequence of this isoform differs from the canonical sequence as follows:
     844-844: K → KYPEPLRFFPRKGPPLPNGDTEVHGLAAARDSQHR

Show »
Length:1,468
Mass (Da):164,779
Checksum:i95906AC90699A0E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J5P6C9J5P6_HUMAN
Nitric oxide synthase
NOS1
1,433Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti131K → E in AAB49040 (PubMed:8879752).Curated1
Sequence conflicti178 – 184LAPRPPG → WPQAPR (PubMed:7678401).Curated7
Sequence conflicti178 – 184LAPRPPG → WPQAPR (PubMed:8879752).Curated7
Sequence conflicti492 – 493QP → HR in AAA36376 (PubMed:7678401).Curated2
Sequence conflicti549V → L in AAA36376 (PubMed:7678401).Curated1
Sequence conflicti563G → A in AAA36376 (PubMed:7678401).Curated1
Sequence conflicti1407Y → I in AAA36376 (PubMed:7678401).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018948228P → S1 PublicationCorresponds to variant dbSNP:rs9658279Ensembl.1
Natural variantiVAR_018949394D → A1 PublicationCorresponds to variant dbSNP:rs9658356EnsemblClinVar.1
Natural variantiVAR_018950725N → D1 PublicationCorresponds to variant dbSNP:rs9658403EnsemblClinVar.1
Natural variantiVAR_018951864G → D1 PublicationCorresponds to variant dbSNP:rs9658445EnsemblClinVar.1
Natural variantiVAR_0189521064Q → R1 PublicationCorresponds to variant dbSNP:rs9658482Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0035711 – 336Missing in isoform 3. CuratedAdd BLAST336
Alternative sequenceiVSP_003572285 – 407PPTSG…DTELI → MRKLRITEGFGVQRGSHNHP PPQENSPPQRMAAPPSVHAS SRSRTGRLRWFSLTPSTLRA HWKRDALSTSAWAPSCILLS MQGGLKTSAQKDSSSLSPKS LLINTIHQLKDLAPKPTWKG WKR in isoform 4. CuratedAdd BLAST123
Alternative sequenceiVSP_003573408 – 1434Missing in isoform 4. CuratedAdd BLAST1027
Alternative sequenceiVSP_003574509 – 613Missing in isoform 2. 2 PublicationsAdd BLAST105
Alternative sequenceiVSP_044916844K → KYPEPLRFFPRKGPPLPNGD TEVHGLAAARDSQHR in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U17327 mRNA Translation: AAA62405.1
U17326 U17325 Genomic DNA Translation: AAB60654.1 Sequence problems.
D16408 mRNA Translation: BAA03895.1
L02881 mRNA Translation: AAA36376.1
U31466 mRNA Translation: AAB49040.1
U66362 Genomic DNA No translation available.
AY445095 Genomic DNA Translation: AAR07069.1
AC026364 Genomic DNA No translation available.
AC068799 Genomic DNA No translation available.
AC073864 Genomic DNA No translation available.
AJ004918 mRNA Translation: CAA06218.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41842.1 [P29475-1]
CCDS55890.1 [P29475-5]

Protein sequence database of the Protein Information Resource

More...PIRi		G01946

NCBI Reference Sequences

More...RefSeqi		NP_000611.1, NM_000620.4 [P29475-1]
NP_001191142.1, NM_001204213.1 [P29475-3]
NP_001191143.1, NM_001204214.1 [P29475-3]
NP_001191147.1, NM_001204218.1 [P29475-5]
XP_011536700.1, XM_011538398.2
XP_016874834.1, XM_017019345.1
XP_016874835.1, XM_017019346.1
XP_016874836.1, XM_017019347.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000317775; ENSP00000320758; ENSG00000089250 [P29475-1]
ENST00000338101; ENSP00000337459; ENSG00000089250 [P29475-5]
ENST00000618760; ENSP00000477999; ENSG00000089250 [P29475-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4842

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4842

UCSC genome browser

More...UCSCi		uc001twm.3, human [P29475-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Nitric oxide synthase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17327 mRNA Translation: AAA62405.1
U17326 U17325 Genomic DNA Translation: AAB60654.1 Sequence problems.
D16408 mRNA Translation: BAA03895.1
L02881 mRNA Translation: AAA36376.1
U31466 mRNA Translation: AAB49040.1
U66362 Genomic DNA No translation available.
AY445095 Genomic DNA Translation: AAR07069.1
AC026364 Genomic DNA No translation available.
AC068799 Genomic DNA No translation available.
AC073864 Genomic DNA No translation available.
AJ004918 mRNA Translation: CAA06218.1
CCDSiCCDS41842.1 [P29475-1]
CCDS55890.1 [P29475-5]
PIRiG01946
RefSeqiNP_000611.1, NM_000620.4 [P29475-1]
NP_001191142.1, NM_001204213.1 [P29475-3]
NP_001191143.1, NM_001204214.1 [P29475-3]
NP_001191147.1, NM_001204218.1 [P29475-5]
XP_011536700.1, XM_011538398.2
XP_016874834.1, XM_017019345.1
XP_016874835.1, XM_017019346.1
XP_016874836.1, XM_017019347.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D1NX-ray2.03A/B/C/D302-721[»]
4UCHX-ray2.20A/B302-723[»]
4UH5X-ray1.98A/B302-722[»]
4UH6X-ray1.98A/B302-722[»]
4V3UX-ray2.30A/B/C/D302-721[»]
5ADFX-ray1.97A/B302-722[»]
5ADGX-ray1.98A/B302-722[»]
5ADIX-ray2.20A/B302-722[»]
5FVUX-ray2.22A/B302-722[»]
5FVVX-ray2.05A/B302-722[»]
5FVWX-ray2.20A/B302-722[»]
5FVXX-ray2.30A/B302-722[»]
5UO1X-ray1.90A/B302-722[»]
5UO2X-ray1.95A/B302-722[»]
5UO3X-ray2.20A/B302-722[»]
5UO4X-ray2.00A/B302-722[»]
5UO5X-ray2.00A/B302-722[»]
5UO6X-ray1.96A/B302-722[»]
5UO7X-ray2.06A/B302-722[»]
5VUVX-ray1.98A/B302-722[»]
5VUWX-ray2.03A/B302-722[»]
5VUXX-ray2.30A/B302-722[»]
5VUYX-ray2.15A/B302-722[»]
5VUZX-ray1.97A/B302-722[»]
5VV0X-ray1.80A/B302-722[»]
5VV1X-ray1.95A/B302-722[»]
5VV2X-ray2.00A/B302-722[»]
5VV3X-ray2.18A/B302-722[»]
5VV4X-ray2.10A/B302-722[»]
5VV5X-ray2.15A/B302-722[»]
6AUYX-ray1.92A/B302-722[»]
6AUZX-ray2.00A/B302-722[»]
6AV0X-ray2.00A/B302-722[»]
6AV1X-ray2.45A/B302-722[»]
6AV2X-ray2.10A/B302-722[»]
6AV3X-ray1.95A/B302-722[»]
6AV4X-ray1.87A/B302-722[»]
6AV5X-ray1.90A/B302-722[»]
6CICX-ray1.75A/B302-722[»]
6CIDX-ray1.75A/B302-722[»]
6NG1X-ray2.15A/B302-722[»]
6NG2X-ray1.93A/B302-722[»]
6NG4X-ray1.78A/B302-722[»]
6NG5X-ray1.96A/B302-722[»]
6NG6X-ray2.04A/B302-722[»]
6NG7X-ray2.00A/B302-722[»]
6NG8X-ray1.90A/B302-722[»]
6NGAX-ray1.98A/B302-722[»]
6NGBX-ray1.90A/B302-722[»]
6NGCX-ray2.00A/B302-722[»]
6NGDX-ray1.80A/B302-722[»]
6NGEX-ray2.10A/B302-722[»]
6NGFX-ray1.99A/B302-722[»]
6NGHX-ray2.00A/B302-722[»]
6NGIX-ray1.80A/B302-722[»]
6NHBX-ray2.03A/B302-722[»]
6NHCX-ray2.16A/B302-722[»]
6PNAX-ray1.95A/B302-722[»]
6PNBX-ray2.05A/B302-722[»]
6PNCX-ray2.15A/B302-722[»]
6PNDX-ray2.40A/B302-722[»]
6PNEX-ray2.10A/B302-722[»]
6PNFX-ray2.10A/B302-722[»]
6PNGX-ray1.77A/B302-722[»]
6PNHX-ray1.85A/B302-722[»]
6PO5X-ray1.82A/B302-722[»]
6PO7X-ray1.95A/B302-722[»]
6PO8X-ray1.90A/B302-722[»]
6PO9X-ray1.81A/B302-722[»]
6POAX-ray1.81A/B302-722[»]
6POBX-ray1.95A/B302-722[»]
6POCX-ray2.00A/B302-722[»]
6POTX-ray2.30A/B302-722[»]
BMRBiP29475
SMRiP29475
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110905, 18 interactors
CORUMiP29475
DIPiDIP-40999N
IntActiP29475, 5 interactors
MINTiP29475
STRINGi9606.ENSP00000477999

Chemistry databases

BindingDBiP29475
ChEMBLiCHEMBL3568
DrugBankiDB02143, 1-hydroxy-2-isopropylguanidine
DB02727, 2-butyl-1-hydroxyguanidine
DB01997, 3-Bromo-7-Nitroindazole
DB03892, 5-N-Allyl-arginine
DB03710, [(1S)-4-(1-Aminobutylideneamino)-1-carboxybutyl]azanium
DB00155, Citrulline
DB00843, Donepezil
DB00997, Doxorubicin
DB03147, Flavin adenine dinucleotide
DB03247, Flavin mononucleotide
DB01942, Formic acid
DB01221, Ketamine
DB02077, L-N(omega)-nitroarginine-(4R)-amino-L-proline amide
DB01821, L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide
DB09241, Methylene blue
DB03144, N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine
DB03449, N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide
DB02044, N-[3-(aminomethyl)benzyl]acetamidine
DB02644, N-omega-propyl-L-arginine
DB08019, N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine
DB08018, N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE
DB02027, N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine
DB03461, Nicotinamide adenine dinucleotide phosphate
DB04223, Nitroarginine
DB06096, NXN-188
DB02991, S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea
DB03707, S-Ethyl-N-Phenyl-Isothiourea
DrugCentraliP29475
GuidetoPHARMACOLOGYi1251

PTM databases

iPTMnetiP29475
PhosphoSitePlusiP29475

Genetic variation databases

BioMutaiNOS1
DMDMi1709333

Proteomic databases

jPOSTiP29475
MassIVEiP29475
MaxQBiP29475
PaxDbiP29475
PeptideAtlasiP29475
PRIDEiP29475
ProteomicsDBi20446
50171
54578 [P29475-1]
54579 [P29475-2]
54580 [P29475-3]
54581 [P29475-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P29475, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3691, 908 antibodies

The DNASU plasmid repository

More...DNASUi		4842

Genome annotation databases

EnsembliENST00000317775; ENSP00000320758; ENSG00000089250 [P29475-1]
ENST00000338101; ENSP00000337459; ENSG00000089250 [P29475-5]
ENST00000618760; ENSP00000477999; ENSG00000089250 [P29475-5]
GeneIDi4842
KEGGihsa:4842
UCSCiuc001twm.3, human [P29475-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4842
DisGeNETi4842

GeneCards: human genes, protein and diseases

More...GeneCardsi		NOS1
HGNCiHGNC:7872, NOS1
HPAiENSG00000089250, Group enriched (brain, skeletal muscle)
MalaCardsiNOS1
MIMi163731, gene
neXtProtiNX_P29475
OpenTargetsiENSG00000089250
Orphaneti930, Idiopathic achalasia
PharmGKBiPA252
VEuPathDBiHostDB:ENSG00000089250.18

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1158, Eukaryota
GeneTreeiENSGT00940000159357
HOGENOMiCLU_001570_16_0_1
InParanoidiP29475
OMAiERGHFYV
PhylomeDBiP29475
TreeFamiTF324410

Enzyme and pathway databases

BioCyciMetaCyc:HS01647-MONOMER
BRENDAi1.14.13.39, 2681
PathwayCommonsiP29475
ReactomeiR-HSA-1222556, ROS and RNS production in phagocytes
R-HSA-392154, Nitric oxide stimulates guanylate cyclase
R-HSA-5578775, Ion homeostasis
SIGNORiP29475

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4842, 4 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NOS1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NOS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4842
PharosiP29475, Tchem

Protein Ontology

More...PROi		PR:P29475
RNActiP29475, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000089250, Expressed in vastus lateralis and 134 other tissues
ExpressionAtlasiP29475, baseline and differential
GenevisibleiP29475, HS

Family and domain databases

Gene3Di1.20.990.10, 1 hit
2.30.42.10, 1 hit
3.40.50.360, 1 hit
3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR003097, CysJ-like_FAD-binding
IPR017927, FAD-bd_FR_type
IPR001094, Flavdoxin-like
IPR008254, Flavodoxin/NO_synth
IPR001709, Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039, Flavoprotein-like_sf
IPR039261, FNR_nucleotide-bd
IPR023173, NADPH_Cyt_P450_Rdtase_alpha
IPR012144, NOS_euk
IPR004030, NOS_N
IPR036119, NOS_N_sf
IPR001433, OxRdtase_FAD/NAD-bd
IPR001478, PDZ
IPR036034, PDZ_sf
IPR017938, Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00667, FAD_binding_1, 1 hit
PF00258, Flavodoxin_1, 1 hit
PF00175, NAD_binding_1, 1 hit
PF02898, NO_synthase, 1 hit
PF00595, PDZ, 1 hit
PIRSFiPIRSF000333, NOS, 1 hit
PRINTSiPR00369, FLAVODOXIN
PR00371, FPNCR
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SUPFAMiSSF50156, SSF50156, 1 hit
SSF52218, SSF52218, 1 hit
SSF52343, SSF52343, 1 hit
SSF56512, SSF56512, 1 hit
SSF63380, SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384, FAD_FR, 1 hit
PS50902, FLAVODOXIN_LIKE, 1 hit
PS60001, NOS, 1 hit
PS50106, PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29475
Secondary accession number(s): E9PH30, O75713
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 1, 1996
Last modified: February 10, 2021
This is version 227 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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