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Protein

Caspase-1

Gene

CASP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-. EC:3.4.22.36

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Specifically inhibited by the cowpox virus Crma protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2371 Publication1
Active sitei2851 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • CARD domain binding Source: UniProtKB
  • cysteine-type endopeptidase activator activity involved in apoptotic process Source: ProtInc
  • cysteine-type endopeptidase activity Source: UniProtKB
  • cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
  • cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: GO_Central
  • endopeptidase activity Source: ParkinsonsUK-UCL
  • identical protein binding Source: UniProtKB
  • kinase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processApoptosis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.4.22.36 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-448706 Interleukin-1 processing
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases
R-HSA-844456 The NLRP3 inflammasome
R-HSA-844615 The AIM2 inflammasome
R-HSA-844623 The IPAF inflammasome
R-HSA-9008059 Interleukin-37 signaling

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P29466

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P29466

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P29466

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caspase-1 (EC:3.4.22.36)
Short name:
CASP-1
Alternative name(s):
Interleukin-1 beta convertase
Short name:
IL-1BC
Interleukin-1 beta-converting enzyme
Short name:
ICE
Short name:
IL-1 beta-converting enzyme
p45
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASP1
Synonyms:IL1BC, IL1BCE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137752.22

Human Gene Nomenclature Database

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HGNCi
HGNC:1499 CASP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147678 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P29466

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi285C → A or S: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
834

Open Targets

More...
OpenTargetsi
ENSG00000137752

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26083

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4801

Drug and drug target database

More...
DrugBanki
DB07744 3-[2-(2-BENZYLOXYCARBONYLAMINO-3-METHYL-BUTYRYLAMINO)-PROPIONYLAMINO]-4-OXO-PENTANOIC ACID
DB07916 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
DB05408 IDN-6556
DB05301 LAX-101
DB01017 Minocycline
DB04875 Pralnacasan
DB05507 VX-765

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1617

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CASP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
266321

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000045211 – 119Add BLAST119
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000004522120 – 297Caspase-1 subunit p20Add BLAST178
PropeptideiPRO_0000004523298 – 316Add BLAST19
ChainiPRO_0000004524317 – 404Caspase-1 subunit p10Add BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei302PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The two subunits are derived from the precursor sequence by an autocatalytic mechanism.

Keywords - PTMi

Phosphoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P29466

MaxQB - The MaxQuant DataBase

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MaxQBi
P29466

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29466

PeptideAtlas

More...
PeptideAtlasi
P29466

PRoteomics IDEntifications database

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PRIDEi
P29466

ProteomicsDB human proteome resource

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ProteomicsDBi
54571
54572 [P29466-2]
54573 [P29466-3]
54574 [P29466-4]
54575 [P29466-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P29466

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P29466

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P29466

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Transcription and translation induced by M.tuberculosis and a number of different M.tuberculosis components; EsxA is the most potent activator tested (at protein level) (PubMed:20148899).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000137752 Expressed in 204 organ(s), highest expression level in leukocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_CASP1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P29466 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P29466 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002685
HPA003056

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17/INCA and CARD18.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107284, 42 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P29466

Database of interacting proteins

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DIPi
DIP-175N

Protein interaction database and analysis system

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IntActi
P29466, 18 interactors

Molecular INTeraction database

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MINTi
P29466

STRING: functional protein association networks

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STRINGi
9606.ENSP00000410076

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P29466

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1404
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P29466

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P29466

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P29466

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 91CARDPROSITE-ProRule annotationAdd BLAST91

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3573 Eukaryota
ENOG410ZQIE LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159114

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG076981

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P29466

KEGG Orthology (KO)

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KOi
K01370

Identification of Orthologs from Complete Genome Data

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OMAi
EYAWSCD

Database of Orthologous Groups

More...
OrthoDBi
EOG091G07NO

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P29466

TreeFam database of animal gene trees

More...
TreeFami
TF102023

Family and domain databases

Conserved Domains Database

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CDDi
cd00032 CASc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001315 CARD
IPR029030 Caspase-like_dom_sf
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR011029 DEATH-like_dom_sf
IPR002398 Pept_C14
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A

The PANTHER Classification System

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PANTHERi
PTHR10454 PTHR10454, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00619 CARD, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00376 IL1BCENZYME

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00114 CARD, 1 hit
SM00115 CASc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47986 SSF47986, 1 hit
SSF52129 SSF52129, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209 CARD, 1 hit
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: P29466-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV
60 70 80 90 100
MDKTRALIDS VIPKGAQACQ ICITYICEED SYLAGTLGLS ADQTSGNYLN
110 120 130 140 150
MQDSQGVLSS FPAPQAVQDN PAMPTSSGSE GNVKLCSLEE AQRIWKQKSA
160 170 180 190 200
EIYPIMDKSS RTRLALIICN EEFDSIPRRT GAEVDITGMT MLLQNLGYSV
210 220 230 240 250
DVKKNLTASD MTTELEAFAH RPEHKTSDST FLVFMSHGIR EGICGKKHSE
260 270 280 290 300
QVPDILQLNA IFNMLNTKNC PSLKDKPKVI IIQACRGDSP GVVWFKDSVG
310 320 330 340 350
VSGNLSLPTT EEFEDDAIKK AHIEKDFIAF CSSTPDNVSW RHPTMGSVFI
360 370 380 390 400
GRLIEHMQEY ACSCDVEEIF RKVRFSFEQP DGRAQMPTTE RVTLTRCFYL

FPGH
Length:404
Mass (Da):45,159
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABF33CF33CC71584
GO
Isoform Beta (identifier: P29466-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-112: Missing.

Show »
Length:383
Mass (Da):42,888
Checksum:iC8D92A9B235B2E6F
GO
Isoform Gamma (identifier: P29466-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-112: Missing.

Show »
Length:311
Mass (Da):35,019
Checksum:i902A4384E49282C8
GO
Isoform Delta (identifier: P29466-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-112: Missing.
     288-335: Missing.

Note: Apoptosis inactive.
Show »
Length:263
Mass (Da):29,821
Checksum:i5ED98AC7864EB0BA
GO
Isoform Epsilon (identifier: P29466-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-335: Missing.

Note: Apoptosis inactive.
Show »
Length:88
Mass (Da):10,417
Checksum:iF3D811149FCDF159
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V169G3V169_HUMAN
Caspase 1, apoptosis-related cystei...
CASP1 hCG_39362
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DVD8B4DVD8_HUMAN
Caspase-1
CASP1
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5FBZ0Q5FBZ0_HUMAN
CASP1 nirs variant 1
CASP1
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRX7A0A1W2PRX7_HUMAN
Caspase-1
CASP1
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEC7H0YEC7_HUMAN
Caspase-1
CASP1
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAT72297 differs from that shown. Probable cloning artifact.Curated
The sequence AAT72297 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti319K → R in BAD97223 (Ref. 4) Curated1
Sequence conflicti402P → L in BAD97223 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04861515R → H. Corresponds to variant dbSNP:rs1042743Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00079720 – 335Missing in isoform Epsilon. 1 PublicationAdd BLAST316
Alternative sequenceiVSP_00079920 – 112Missing in isoform Gamma and isoform Delta. 2 PublicationsAdd BLAST93
Alternative sequenceiVSP_00079892 – 112Missing in isoform Beta. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_000800288 – 335Missing in isoform Delta. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X65019 mRNA Translation: CAA46153.1
M87507 mRNA Translation: AAA66942.1
U13697 mRNA Translation: AAC50107.1
U13698 mRNA Translation: AAC50108.1
U13699 mRNA Translation: AAC50109.1
U13700 mRNA Translation: AAC50110.1
AK223503 mRNA Translation: BAD97223.1
AP001153 Genomic DNA No translation available.
BC041689 mRNA Translation: AAH41689.1
BC062327 mRNA Translation: AAH62327.1
AY660536 mRNA Translation: AAT72297.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53704.1 [P29466-3]
CCDS8329.1 [P29466-2]
CCDS8330.1 [P29466-1]
CCDS8331.1 [P29466-4]
CCDS8332.1 [P29466-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
A54263 A42677
A56084
B56084
C56084
D56084

NCBI Reference Sequences

More...
RefSeqi
NP_001214.1, NM_001223.4 [P29466-2]
NP_001244047.1, NM_001257118.2 [P29466-1]
NP_001244048.1, NM_001257119.2 [P29466-2]
NP_150634.1, NM_033292.3 [P29466-1]
NP_150635.1, NM_033293.3 [P29466-3]
NP_150636.1, NM_033294.3 [P29466-4]
NP_150637.1, NM_033295.3 [P29466-5]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.2490

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000353247; ENSP00000344132; ENSG00000137752 [P29466-5]
ENST00000436863; ENSP00000410076; ENSG00000137752 [P29466-1]
ENST00000446369; ENSP00000403260; ENSG00000137752 [P29466-4]
ENST00000525825; ENSP00000434779; ENSG00000137752 [P29466-2]
ENST00000526568; ENSP00000434250; ENSG00000137752 [P29466-3]
ENST00000531166; ENSP00000434303; ENSG00000137752 [P29466-5]
ENST00000533400; ENSP00000433138; ENSG00000137752 [P29466-1]
ENST00000534497; ENSP00000436875; ENSG00000137752 [P29466-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
834

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:834

UCSC genome browser

More...
UCSCi
uc001pig.5 human [P29466-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65019 mRNA Translation: CAA46153.1
M87507 mRNA Translation: AAA66942.1
U13697 mRNA Translation: AAC50107.1
U13698 mRNA Translation: AAC50108.1
U13699 mRNA Translation: AAC50109.1
U13700 mRNA Translation: AAC50110.1
AK223503 mRNA Translation: BAD97223.1
AP001153 Genomic DNA No translation available.
BC041689 mRNA Translation: AAH41689.1
BC062327 mRNA Translation: AAH62327.1
AY660536 mRNA Translation: AAT72297.1 Sequence problems.
CCDSiCCDS53704.1 [P29466-3]
CCDS8329.1 [P29466-2]
CCDS8330.1 [P29466-1]
CCDS8331.1 [P29466-4]
CCDS8332.1 [P29466-5]
PIRiA54263 A42677
A56084
B56084
C56084
D56084
RefSeqiNP_001214.1, NM_001223.4 [P29466-2]
NP_001244047.1, NM_001257118.2 [P29466-1]
NP_001244048.1, NM_001257119.2 [P29466-2]
NP_150634.1, NM_033292.3 [P29466-1]
NP_150635.1, NM_033293.3 [P29466-3]
NP_150636.1, NM_033294.3 [P29466-4]
NP_150637.1, NM_033295.3 [P29466-5]
UniGeneiHs.2490

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BMQX-ray2.50A131-297[»]
B317-404[»]
1IBCX-ray2.73A104-297[»]
B317-404[»]
1ICEX-ray2.60A131-297[»]
B317-404[»]
1RWKX-ray2.30A120-297[»]
B317-404[»]
1RWMX-ray2.70A120-297[»]
B317-404[»]
1RWNX-ray2.00A120-297[»]
B317-404[»]
1RWOX-ray2.10A120-297[»]
B317-404[»]
1RWPX-ray2.20A120-297[»]
B317-404[»]
1RWVX-ray2.10A120-297[»]
B317-404[»]
1RWWX-ray2.80A120-297[»]
B317-404[»]
1RWXX-ray1.85A120-297[»]
B317-404[»]
1SC1X-ray2.60A120-297[»]
B317-404[»]
1SC3X-ray1.80A120-297[»]
B317-404[»]
1SC4X-ray2.10A120-297[»]
B317-404[»]
2FQQX-ray3.30A120-297[»]
B317-404[»]
2H48X-ray2.20A120-297[»]
B317-404[»]
2H4WX-ray2.00A120-297[»]
B317-404[»]
2H4YX-ray1.90A120-297[»]
B317-404[»]
2H51X-ray2.10A120-297[»]
B317-404[»]
2H54X-ray1.80A120-297[»]
B317-404[»]
2HBQX-ray1.80A120-297[»]
B317-404[»]
2HBRX-ray2.20A120-297[»]
B317-404[»]
2HBYX-ray2.10A120-297[»]
B317-404[»]
2HBZX-ray1.90A120-297[»]
B317-404[»]
3D6FX-ray1.90A120-297[»]
B317-404[»]
3D6HX-ray2.00A120-297[»]
B317-404[»]
3D6MX-ray1.80A120-297[»]
B317-404[»]
3E4CX-ray2.05A/B104-404[»]
3NS7X-ray2.60A136-297[»]
B317-404[»]
5FNAelectron microscopy4.80A/B/C/D/E/F/G/H2-86[»]
5MMVX-ray2.15A120-297[»]
B317-404[»]
5MTKX-ray2.53A120-297[»]
B317-404[»]
6BZ9X-ray1.80A120-297[»]
B317-404[»]
6F6RX-ray1.80A118-297[»]
B317-404[»]
ProteinModelPortaliP29466
SMRiP29466
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107284, 42 interactors
CORUMiP29466
DIPiDIP-175N
IntActiP29466, 18 interactors
MINTiP29466
STRINGi9606.ENSP00000410076

Chemistry databases

BindingDBiP29466
ChEMBLiCHEMBL4801
DrugBankiDB07744 3-[2-(2-BENZYLOXYCARBONYLAMINO-3-METHYL-BUTYRYLAMINO)-PROPIONYLAMINO]-4-OXO-PENTANOIC ACID
DB07916 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
DB05408 IDN-6556
DB05301 LAX-101
DB01017 Minocycline
DB04875 Pralnacasan
DB05507 VX-765
GuidetoPHARMACOLOGYi1617

PTM databases

iPTMnetiP29466
PhosphoSitePlusiP29466

Polymorphism and mutation databases

BioMutaiCASP1
DMDMi266321

Proteomic databases

EPDiP29466
MaxQBiP29466
PaxDbiP29466
PeptideAtlasiP29466
PRIDEiP29466
ProteomicsDBi54571
54572 [P29466-2]
54573 [P29466-3]
54574 [P29466-4]
54575 [P29466-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
834
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353247; ENSP00000344132; ENSG00000137752 [P29466-5]
ENST00000436863; ENSP00000410076; ENSG00000137752 [P29466-1]
ENST00000446369; ENSP00000403260; ENSG00000137752 [P29466-4]
ENST00000525825; ENSP00000434779; ENSG00000137752 [P29466-2]
ENST00000526568; ENSP00000434250; ENSG00000137752 [P29466-3]
ENST00000531166; ENSP00000434303; ENSG00000137752 [P29466-5]
ENST00000533400; ENSP00000433138; ENSG00000137752 [P29466-1]
ENST00000534497; ENSP00000436875; ENSG00000137752 [P29466-4]
GeneIDi834
KEGGihsa:834
UCSCiuc001pig.5 human [P29466-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
834
DisGeNETi834
EuPathDBiHostDB:ENSG00000137752.22

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CASP1
HGNCiHGNC:1499 CASP1
HPAiCAB002685
HPA003056
MIMi147678 gene
neXtProtiNX_P29466
OpenTargetsiENSG00000137752
PharmGKBiPA26083

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00940000159114
HOVERGENiHBG076981
InParanoidiP29466
KOiK01370
OMAiEYAWSCD
OrthoDBiEOG091G07NO
PhylomeDBiP29466
TreeFamiTF102023

Enzyme and pathway databases

BRENDAi3.4.22.36 2681
ReactomeiR-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-448706 Interleukin-1 processing
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases
R-HSA-844456 The NLRP3 inflammasome
R-HSA-844615 The AIM2 inflammasome
R-HSA-844623 The IPAF inflammasome
R-HSA-9008059 Interleukin-37 signaling
SABIO-RKiP29466
SignaLinkiP29466
SIGNORiP29466

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CASP1 human
EvolutionaryTraceiP29466

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Caspase_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
834
PMAP-CutDBiP29466

Protein Ontology

More...
PROi
PR:P29466

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137752 Expressed in 204 organ(s), highest expression level in leukocyte
CleanExiHS_CASP1
ExpressionAtlasiP29466 baseline and differential
GenevisibleiP29466 HS

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR029030 Caspase-like_dom_sf
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR011029 DEATH-like_dom_sf
IPR002398 Pept_C14
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PANTHERiPTHR10454 PTHR10454, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00114 CARD, 1 hit
SM00115 CASc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCASP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29466
Secondary accession number(s): B5MDZ1
, Q53EY6, Q6DMQ1, Q6GSS3, Q6PI75, Q9UCN3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: December 5, 2018
This is version 209 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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