Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-12 subunit beta

Gene

IL12B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.1 Publication
Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9020591 Interleukin-12 signaling
R-HSA-9020933 Interleukin-23 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P29460

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-12 subunit beta
Short name:
IL-12B
Alternative name(s):
Cytotoxic lymphocyte maturation factor 40 kDa subunit
Short name:
CLMF p40
IL-12 subunit p40
NK cell stimulatory factor chain 2
Short name:
NKSF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL12B
Synonyms:NKSF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000113302.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5970 IL12B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
161561 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P29460

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency 29 (IMD29)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. IMD29 is characterized by undetectable IL12B secretion from leukocytes. Affected individuals generally present with BCG disease after vaccination in childhood, and at least half also have Salmonella infection. Disease phenotype is relatively mild, and patients have a good prognosis.
See also OMIM:614890
Psoriasis 11 (PSORS11)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
See also OMIM:612599

Organism-specific databases

DisGeNET

More...
DisGeNETi
3593

MalaCards human disease database

More...
MalaCardsi
IL12B
MIMi612599 phenotype
614890 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000113302

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
319558 Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency
3287 Takayasu arteritis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29785

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3580484

Drug and drug target database

More...
DrugBanki
DB02763 5-Mercapto-2-Nitro-Benzoic Acid
DB05459 Briakinumab
DB05848 humanized SMART Anti-IL-12 Antibody
DB05679 Ustekinumab

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL12B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
266320

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001093023 – 328Interleukin-12 subunit betaAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi50 ↔ 90PROSITE-ProRule annotation1 Publication
Disulfide bondi131 ↔ 142PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi170 ↔ 193PROSITE-ProRule annotation1 Publication
Disulfide bondi199Interchain (with C-96 in IL12A)PROSITE-ProRule annotation1 Publication
Glycosylationi222N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi300 ↔ 327PROSITE-ProRule annotation1 Publication
GlycosylationiCAR_000187319C-linked (Man) tryptophan1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29460

PeptideAtlas

More...
PeptideAtlasi
P29460

PRoteomics IDEntifications database

More...
PRIDEi
P29460

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54570

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
296

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P29460

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P29460

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P29460

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P29460

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113302 Expressed in 18 organ(s), highest expression level in female gonad

CleanEx database of gene expression profiles

More...
CleanExi
HS_IL12B

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P29460 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040970

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109807, 3 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3290 Interleukin-23 complex
CPX-381 Interleukin-12 complex
CPX-382 Interleukin-12-receptor complex
CPX-383 Interleukin-23-receptor complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P29460

Database of interacting proteins

More...
DIPi
DIP-3774N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P29460

Protein interaction database and analysis system

More...
IntActi
P29460, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000231228

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1328
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P29460

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P29460

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P29460

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 106Ig-like C2-typeAdd BLAST84
Domaini237 – 328Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST92

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF5K Eukaryota
ENOG410YWXR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012630

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113027

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052094

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P29460

KEGG Orthology (KO)

More...
KOi
K05425

Identification of Orthologs from Complete Genome Data

More...
OMAi
CEAKNYS

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0EKV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P29460

TreeFam database of animal gene trees

More...
TreeFami
TF334829

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003530 Hematopoietin_rcpt_L_F3_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003598 Ig_sub2
IPR015528 IL-12_beta
IPR019482 IL-12_beta_cen-dom

The PANTHER Classification System

More...
PANTHERi
PTHR44982 PTHR44982, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10420 IL12p40_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038007 IL_12_beta, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01928 INTRLEUKN12B

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00408 IGc2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 1 hit
PS01354 HEMATOPO_REC_L_F3, 1 hit
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P29460-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCHQQLVISW FSLVFLASPL VAIWELKKDV YVVELDWYPD APGEMVVLTC
60 70 80 90 100
DTPEEDGITW TLDQSSEVLG SGKTLTIQVK EFGDAGQYTC HKGGEVLSHS
110 120 130 140 150
LLLLHKKEDG IWSTDILKDQ KEPKNKTFLR CEAKNYSGRF TCWWLTTIST
160 170 180 190 200
DLTFSVKSSR GSSDPQGVTC GAATLSAERV RGDNKEYEYS VECQEDSACP
210 220 230 240 250
AAEESLPIEV MVDAVHKLKY ENYTSSFFIR DIIKPDPPKN LQLKPLKNSR
260 270 280 290 300
QVEVSWEYPD TWSTPHSYFS LTFCVQVQGK SKREKKDRVF TDKTSATVIC
310 320
RKNASISVRA QDRYYSSSWS EWASVPCS
Length:328
Mass (Da):37,169
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i118FA801B8F5BB2F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti239K → N in AAA59938 (PubMed:1673147).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02000133V → I1 PublicationCorresponds to variant dbSNP:rs3213096EnsemblClinVar.1
Natural variantiVAR_049170298V → F1 PublicationCorresponds to variant dbSNP:rs3213119EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M65272 mRNA Translation: AAA35695.1
M65290 mRNA Translation: AAA59938.1
AY008847 Genomic DNA Translation: AAG32620.1
AF180563 mRNA Translation: AAD56386.1
AF512686 Genomic DNA Translation: AAM34792.1
BC067498 mRNA Translation: AAH67498.1
BC067499 mRNA Translation: AAH67499.1
BC067500 mRNA Translation: AAH67500.1
BC067501 mRNA Translation: AAH67501.1
BC067502 mRNA Translation: AAH67502.1
BC074723 mRNA Translation: AAH74723.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4346.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A38957

NCBI Reference Sequences

More...
RefSeqi
NP_002178.2, NM_002187.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.674

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000231228; ENSP00000231228; ENSG00000113302

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3593

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3593

UCSC genome browser

More...
UCSCi
uc003lxr.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

IL12Bbase

IL12B mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65272 mRNA Translation: AAA35695.1
M65290 mRNA Translation: AAA59938.1
AY008847 Genomic DNA Translation: AAG32620.1
AF180563 mRNA Translation: AAD56386.1
AF512686 Genomic DNA Translation: AAM34792.1
BC067498 mRNA Translation: AAH67498.1
BC067499 mRNA Translation: AAH67499.1
BC067500 mRNA Translation: AAH67500.1
BC067501 mRNA Translation: AAH67501.1
BC067502 mRNA Translation: AAH67502.1
BC074723 mRNA Translation: AAH74723.1
CCDSiCCDS4346.1
PIRiA38957
RefSeqiNP_002178.2, NM_002187.2
UniGeneiHs.674

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F42X-ray2.50A23-328[»]
1F45X-ray2.80A23-328[»]
3D85X-ray1.90D23-328[»]
3D87X-ray2.90B/D23-328[»]
3DUHX-ray2.30A/B23-328[»]
3HMXX-ray3.00A23-328[»]
3QWRX-ray3.25A23-328[»]
4GRWX-ray2.55B/D1-328[»]
5MJ3X-ray1.74A23-328[»]
5MJ4X-ray3.40A23-328[»]
5MXAX-ray2.50A1-328[»]
5MZVX-ray2.80A1-328[»]
5NJDX-ray3.90A/C/E/G/I/K1-328[»]
ProteinModelPortaliP29460
SMRiP29460
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109807, 3 interactors
ComplexPortaliCPX-3290 Interleukin-23 complex
CPX-381 Interleukin-12 complex
CPX-382 Interleukin-12-receptor complex
CPX-383 Interleukin-23-receptor complex
CORUMiP29460
DIPiDIP-3774N
ELMiP29460
IntActiP29460, 5 interactors
STRINGi9606.ENSP00000231228

Chemistry databases

ChEMBLiCHEMBL3580484
DrugBankiDB02763 5-Mercapto-2-Nitro-Benzoic Acid
DB05459 Briakinumab
DB05848 humanized SMART Anti-IL-12 Antibody
DB05679 Ustekinumab

PTM databases

GlyConnecti296
iPTMnetiP29460
PhosphoSitePlusiP29460
UniCarbKBiP29460

Polymorphism and mutation databases

BioMutaiIL12B
DMDMi266320

Proteomic databases

PaxDbiP29460
PeptideAtlasiP29460
PRIDEiP29460
ProteomicsDBi54570

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3593
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231228; ENSP00000231228; ENSG00000113302
GeneIDi3593
KEGGihsa:3593
UCSCiuc003lxr.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3593
DisGeNETi3593
EuPathDBiHostDB:ENSG00000113302.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IL12B
HGNCiHGNC:5970 IL12B
HPAiHPA040970
MalaCardsiIL12B
MIMi161561 gene
612599 phenotype
614890 phenotype
neXtProtiNX_P29460
OpenTargetsiENSG00000113302
Orphaneti319558 Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency
3287 Takayasu arteritis
PharmGKBiPA29785

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF5K Eukaryota
ENOG410YWXR LUCA
GeneTreeiENSGT00390000012630
HOGENOMiHOG000113027
HOVERGENiHBG052094
InParanoidiP29460
KOiK05425
OMAiCEAKNYS
OrthoDBiEOG091G0EKV
PhylomeDBiP29460
TreeFamiTF334829

Enzyme and pathway databases

ReactomeiR-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9020591 Interleukin-12 signaling
R-HSA-9020933 Interleukin-23 signaling
SIGNORiP29460

Miscellaneous databases

EvolutionaryTraceiP29460

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Interleukin-12_subunit_beta

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3593
PMAP-CutDBiP29460

Protein Ontology

More...
PROi
PR:P29460

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113302 Expressed in 18 organ(s), highest expression level in female gonad
CleanExiHS_IL12B
GenevisibleiP29460 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003530 Hematopoietin_rcpt_L_F3_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003598 Ig_sub2
IPR015528 IL-12_beta
IPR019482 IL-12_beta_cen-dom
PANTHERiPTHR44982 PTHR44982, 1 hit
PfamiView protein in Pfam
PF10420 IL12p40_C, 1 hit
PIRSFiPIRSF038007 IL_12_beta, 1 hit
PRINTSiPR01928 INTRLEUKN12B
SMARTiView protein in SMART
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01354 HEMATOPO_REC_L_F3, 1 hit
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL12B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29460
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: December 5, 2018
This is version 210 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again