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Protein

Gap junction alpha-3 protein

Gene

GJA3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-GGA-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-3 protein
Alternative name(s):
Connexin-56
Short name:
Cx56
Gene namesi
Name:GJA3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 19CytoplasmicSequence analysisAdd BLAST18
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 76ExtracellularSequence analysisAdd BLAST36
Transmembranei77 – 99HelicalSequence analysisAdd BLAST23
Topological domaini100 – 169CytoplasmicSequence analysisAdd BLAST70
Transmembranei170 – 192HelicalSequence analysisAdd BLAST23
Topological domaini193 – 224ExtracellularSequence analysisAdd BLAST32
Transmembranei225 – 247HelicalSequence analysisAdd BLAST23
Topological domaini248 – 511CytoplasmicSequence analysisAdd BLAST264

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000578782 – 511Gap junction alpha-3 proteinAdd BLAST510

Proteomic databases

PaxDbiP29415
PRIDEiP29415

PTM databases

iPTMnetiP29415

Expressioni

Gene expression databases

BgeeiENSGALG00000017137

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. This particular connexin forms both junctional and non-junctional ("hemi-") channels. During early stages of lens development, interacts with the C-terminus of MIP.1 Publication

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027629

Structurei

3D structure databases

ProteinModelPortaliP29415
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3Z Eukaryota
ENOG410ZC96 LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiP29415
KOiK07612
OMAiTTVEMHE
OrthoDBiEOG091G0BF2
PhylomeDBiP29415
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002262 Connexin46
IPR034634 Connexin_C
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF12 PTHR11984:SF12, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
SUPFAMiSSF118220 SSF118220, 2 hits
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSFLGRL LENAQEHSTV IGKVWLTVLF IFRILVLGAA AEEVWGDEQS
60 70 80 90 100
DFTCNTQQPG CENVCYDKAF PISHIRFWVL QIIFVSTPTL IYLGHVLHIV
110 120 130 140 150
RMEEKRKEKE EELKKRGSVK DNNYPGAATS GGGSGGGNNF KDPPIKMGKE
160 170 180 190 200
KLPIRDERGR IRMGGALLRT YIFNIIFKTL FEVGFIVGQY FLYGFELKPV
210 220 230 240 250
YQCSRPPCPH TVDCFISRPT EKTIFIIFML VVASVSLLLN MLEIYHLGWK
260 270 280 290 300
KLKQGMTSQY SLEMPVTTLT PVMVTGESKP VSLPPPAPPV VVTTTAPAPV
310 320 330 340 350
LPDTRAVTPL LAPVTMAPYY AAAAPRTRPP SNTASMASYP VAPPVPENRH
360 370 380 390 400
RAVTPTPVST PVTIPTPIPT PTPAIINYFN SKSNALAAEQ NWVNMAAEQQ
410 420 430 440 450
GKAPSSSAGS STPSSVRHPL PEQEEPLEQL LPLPAGPPIT TTNSGSSTSL
460 470 480 490 500
SGASGSKWDV EGEEELAEER PISATCTTVE MHEPPLLVDT RRLSRASKSS
510
SSRARSDDLA V
Length:511
Mass (Da):55,793
Last modified:January 23, 2007 - v3
Checksum:i7A19FA40079B42DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02838 Genomic DNA Translation: AAA48737.2
PIRiA45338
RefSeqiNP_001035734.1, NM_001040644.1
XP_015133694.1, XM_015278208.1
XP_015133700.1, XM_015278214.1
UniGeneiGga.33719

Genome annotation databases

EnsembliENSGALT00000027682; ENSGALP00000027629; ENSGALG00000017137
GeneIDi428084
KEGGigga:428084

Similar proteinsi

Entry informationi

Entry nameiCXA3_CHICK
AccessioniPrimary (citable) accession number: P29415
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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