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Protein

Gap junction alpha-3 protein

Gene

Gja3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  • gap junction channel activity Source: RGD
  • identical protein binding Source: RGD

GO - Biological processi

  • cell communication Source: InterPro
  • response to hydrogen peroxide Source: RGD
  • response to pH Source: RGD
  • visual perception Source: InterPro

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-3 protein
Alternative name(s):
Connexin-46
Short name:
Cx46
Gene namesi
Name:Gja3
Synonyms:Cxn-46
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621820 Gja3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 76ExtracellularSequence analysisAdd BLAST36
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 158CytoplasmicSequence analysisAdd BLAST61
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 207ExtracellularSequence analysisAdd BLAST28
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 416CytoplasmicSequence analysisAdd BLAST188

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578121 – 416Gap junction alpha-3 proteinAdd BLAST416

Proteomic databases

PaxDbiP29414
PRIDEiP29414

Expressioni

Tissue specificityi

Most abundant in lens, but also present in heart and kidney.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and non-junctional ("hemi-") channels.

GO - Molecular functioni

  • identical protein binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011699

Structurei

3D structure databases

ProteinModelPortaliP29414
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3Z Eukaryota
ENOG410ZC96 LUCA
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiP29414
KOiK07612
PhylomeDBiP29414

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002262 Connexin46
IPR034634 Connexin_C
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF12 PTHR11984:SF12, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01133 CONNEXINA3
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
SUPFAMiSSF118220 SSF118220, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P29414-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSFLGRL LENAQEHSTV IGKVWLTVLF IFRILVLGAA AEEVWGDEQS
60 70 80 90 100
DFTCNTQQPG CENVCYDRAF PISHIRFWAL QIIFVSTPTL IYLGHVLHIV
110 120 130 140 150
RMEEKKKERE EELLRRDNPQ HGRGREPMRT GSPRDPPLRD DRGKVRIAGA
160 170 180 190 200
LLRTYVFNII FKTLFEVGFI AGQYFLYGFQ LQPLYRCDRW PCPNTVDCFI
210 220 230 240 250
SRPTEKTIFV IFMLAVACAS LVLNMLEIYH LGWKKLKQGV TNHFNPDASE
260 270 280 290 300
VRHKPLDPLS EAANSGPPSV SIGLPPYYTH PACPTVQGKA TGFPGAPLLP
310 320 330 340 350
ADFTVVTLND AQGRGHPVKH CNGHHLTTEQ NWASLGAEPQ TPASKPSSAA
360 370 380 390 400
SSPHGRKGLT DSSGSSLEES ALVVTPEGEQ ALATTVEMHS PPLVLLDPER
410
SSKSSSGRAR PGDLAI
Length:416
Mass (Da):46,013
Last modified:January 23, 2007 - v2
Checksum:i8232B98E0C3A1F8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57970 mRNA Translation: CAA41036.1
PIRiS25764
RefSeqiNP_077352.1, NM_024376.2
UniGeneiRn.10345

Genome annotation databases

GeneIDi79217
KEGGirno:79217
UCSCiRGD:621820 rat

Similar proteinsi

Entry informationi

Entry nameiCXA3_RAT
AccessioniPrimary (citable) accession number: P29414
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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