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Protein

Transketolase

Gene

TKT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei37SubstrateBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei37Important for catalytic activityBy similarity1
Binding sitei40Thiamine pyrophosphate1
Binding sitei77Thiamine pyrophosphate1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi155Magnesium1
Binding sitei156Thiamine pyrophosphate; via amide nitrogen1
Metal bindingi185Magnesium1
Binding sitei185Thiamine pyrophosphate1
Metal bindingi187Magnesium; via carbonyl oxygen1
Binding sitei244Thiamine pyrophosphate1
Binding sitei258SubstrateBy similarity1
Binding sitei258Thiamine pyrophosphate1
Sitei258Important for catalytic activityBy similarity1
Binding sitei318SubstrateBy similarity1
Binding sitei345SubstrateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei366Proton donorBy similarity1
Binding sitei392Thiamine pyrophosphate1
Binding sitei416SubstrateBy similarity1
Binding sitei424SubstrateBy similarity1
Binding sitei428Thiamine pyrophosphate1
Binding sitei474SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi123 – 125Thiamine pyrophosphate3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandCalcium, Magnesium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.2.1.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate
R-HSA-71336 Pentose phosphate pathway

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P29401

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transketolase (EC:2.2.1.11 Publication)
Short name:
TK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TKT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163931.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11834 TKT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606781 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P29401

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Short stature, developmental delay, and congenital heart defects (SDDHD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome characterized by short stature, developmental delay, intellectual disability and congenital heart defects including ventricular septal defect, atrial septal defect and patent foramen ovale. Cataract and uveitis are observed in some patients.
See also OMIM:617044
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_077030318R → C in SDDHD; decreased of transketolase activity. 1 PublicationCorresponds to variant dbSNP:rs782092363EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...
DisGeNETi
7086

MalaCards human disease database

More...
MalaCardsi
TKT
MIMi617044 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000163931

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
488618 Transketolase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36537

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4983

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TKT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1729976

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001918941 – 623TransketolaseAdd BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei3PhosphoserineCombined sources1
Modified residuei6N6-acetyllysineCombined sources1
Modified residuei11N6-acetyllysineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Modified residuei144N6-acetyllysineCombined sources1
Modified residuei204N6-acetyllysineCombined sources1
Modified residuei232N6-acetyllysineBy similarity1
Modified residuei241N6-acetyllysineCombined sources1
Modified residuei260N6-acetyllysineCombined sources1
Modified residuei275PhosphotyrosineCombined sources1
Modified residuei287PhosphothreonineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei345PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki352Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei538N6-acetyllysineBy similarity1
Modified residuei603N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P29401

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29401

PeptideAtlas

More...
PeptideAtlasi
P29401

PRoteomics IDEntifications database

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PRIDEi
P29401

ProteomicsDB human proteome resource

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ProteomicsDBi
54568

Consortium for Top Down Proteomics

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TopDownProteomicsi
P29401-1 [P29401-1]

2D gel databases

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00643920

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P29401

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P29401

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P29401

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000163931 Expressed in 239 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

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CleanExi
HS_TKT

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P29401 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P29401 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029480
HPA029481

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TERF1P542742EBI-1050560,EBI-710997

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112941, 181 interactors

Protein interaction database and analysis system

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IntActi
P29401, 26 interactors

Molecular INTeraction database

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MINTi
P29401

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000405455

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P29401

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1623
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P29401

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P29401

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P29401

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transketolase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0523 Eukaryota
COG0021 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155552

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000243868

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004036

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P29401

KEGG Orthology (KO)

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KOi
K00615

Identification of Orthologs from Complete Genome Data

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OMAi
DCITARV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03M5

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P29401

TreeFam database of animal gene trees

More...
TreeFami
TF313097

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.920, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR020826 Transketolase_BS
IPR033248 Transketolase_C
IPR005474 Transketolase_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
PF00456 Transketolase_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00861 Transket_pyr, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00801 TRANSKETOLASE_1, 1 hit
PS00802 TRANSKETOLASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P29401-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESYHKPDQQ KLQALKDTAN RLRISSIQAT TAAGSGHPTS CCSAAEIMAV
60 70 80 90 100
LFFHTMRYKS QDPRNPHNDR FVLSKGHAAP ILYAVWAEAG FLAEAELLNL
110 120 130 140 150
RKISSDLDGH PVPKQAFTDV ATGSLGQGLG AACGMAYTGK YFDKASYRVY
160 170 180 190 200
CLLGDGELSE GSVWEAMAFA SIYKLDNLVA ILDINRLGQS DPAPLQHQMD
210 220 230 240 250
IYQKRCEAFG WHAIIVDGHS VEELCKAFGQ AKHQPTAIIA KTFKGRGITG
260 270 280 290 300
VEDKESWHGK PLPKNMAEQI IQEIYSQIQS KKKILATPPQ EDAPSVDIAN
310 320 330 340 350
IRMPSLPSYK VGDKIATRKA YGQALAKLGH ASDRIIALDG DTKNSTFSEI
360 370 380 390 400
FKKEHPDRFI ECYIAEQNMV SIAVGCATRN RTVPFCSTFA AFFTRAFDQI
410 420 430 440 450
RMAAISESNI NLCGSHCGVS IGEDGPSQMA LEDLAMFRSV PTSTVFYPSD
460 470 480 490 500
GVATEKAVEL AANTKGICFI RTSRPENAII YNNNEDFQVG QAKVVLKSKD
510 520 530 540 550
DQVTVIGAGV TLHEALAAAE LLKKEKINIR VLDPFTIKPL DRKLILDSAR
560 570 580 590 600
ATKGRILTVE DHYYEGGIGE AVSSAVVGEP GITVTHLAVN RVPRSGKPAE
610 620
LLKMFGIDRD AIAQAVRGLI TKA
Length:623
Mass (Da):67,878
Last modified:October 1, 1996 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i176C89C02FD2712B
GO
Isoform 2 (identifier: P29401-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-146: S → SLPSSWDYS

Note: No experimental confirmation available.
Show »
Length:631
Mass (Da):68,814
Checksum:iE64388EFD41AB530
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1R6A0A0B4J1R6_HUMAN
Transketolase
TKT
457Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W888F8W888_HUMAN
Transketolase
TKT
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PFF2E9PFF2_HUMAN
Transketolase
TKT
334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAX4F8WAX4_HUMAN
Transketolase
TKT
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30 – 31TT → SS in CAA47919 (PubMed:8419340).Curated2
Sequence conflicti46E → V in CAA47919 (PubMed:8419340).Curated1
Sequence conflicti224 – 230LCKAFGQ → AVQGLCE AA sequence (PubMed:1567394).Curated7
Sequence conflicti366E → G in BAG56942 (PubMed:14702039).Curated1
Sequence conflicti426P → A in CAA47919 (PubMed:8419340).Curated1
Sequence conflicti585 – 587THL → KTM in AAA61222 (Ref. 2) Curated3
Sequence conflicti608 – 623DRDAI…LITKA → TGMPLHKL AA sequence (PubMed:1567394).CuratedAdd BLAST16

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052634181I → V. Corresponds to variant dbSNP:rs17052920Ensembl.1
Natural variantiVAR_077030318R → C in SDDHD; decreased of transketolase activity. 1 PublicationCorresponds to variant dbSNP:rs782092363EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045566146S → SLPSSWDYS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X67688 mRNA Translation: CAA47919.1
L12711 mRNA Translation: AAA61222.1
U55017 mRNA Translation: AAA98961.1
AK289454 mRNA Translation: BAF82143.1
AK293438 mRNA Translation: BAG56942.1
AC097015 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65281.1
BC008615 mRNA Translation: AAH08615.1
BC009970 mRNA Translation: AAH09970.1
BC024026 mRNA Translation: AAH24026.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS2871.1 [P29401-1]
CCDS58834.1 [P29401-2]

Protein sequence database of the Protein Information Resource

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PIRi
A45050

NCBI Reference Sequences

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RefSeqi
NP_001055.1, NM_001064.3 [P29401-1]
NP_001128527.1, NM_001135055.2 [P29401-1]
NP_001244957.1, NM_001258028.1 [P29401-2]
XP_011532356.1, XM_011534054.1 [P29401-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.89643

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000423516; ENSP00000391481; ENSG00000163931 [P29401-2]
ENST00000423525; ENSP00000405455; ENSG00000163931 [P29401-1]
ENST00000462138; ENSP00000417773; ENSG00000163931 [P29401-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7086

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7086

UCSC genome browser

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UCSCi
uc011beq.4 human [P29401-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Transketolase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67688 mRNA Translation: CAA47919.1
L12711 mRNA Translation: AAA61222.1
U55017 mRNA Translation: AAA98961.1
AK289454 mRNA Translation: BAF82143.1
AK293438 mRNA Translation: BAG56942.1
AC097015 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65281.1
BC008615 mRNA Translation: AAH08615.1
BC009970 mRNA Translation: AAH09970.1
BC024026 mRNA Translation: AAH24026.2
CCDSiCCDS2871.1 [P29401-1]
CCDS58834.1 [P29401-2]
PIRiA45050
RefSeqiNP_001055.1, NM_001064.3 [P29401-1]
NP_001128527.1, NM_001135055.2 [P29401-1]
NP_001244957.1, NM_001258028.1 [P29401-2]
XP_011532356.1, XM_011534054.1 [P29401-2]
UniGeneiHs.89643

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MOSX-ray1.75A3-618[»]
3OOYX-ray2.05A/B10-620[»]
4KXUX-ray0.98A1-623[»]
4KXVX-ray0.97A1-623[»]
4KXWX-ray0.97A1-623[»]
4KXXX-ray1.03A1-623[»]
4KXYX-ray1.26A/B1-623[»]
ProteinModelPortaliP29401
SMRiP29401
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112941, 181 interactors
IntActiP29401, 26 interactors
MINTiP29401
STRINGi9606.ENSP00000405455

Chemistry databases

BindingDBiP29401
ChEMBLiCHEMBL4983

PTM databases

iPTMnetiP29401
PhosphoSitePlusiP29401
SwissPalmiP29401

Polymorphism and mutation databases

BioMutaiTKT
DMDMi1729976

2D gel databases

REPRODUCTION-2DPAGEiIPI00643920

Proteomic databases

EPDiP29401
PaxDbiP29401
PeptideAtlasiP29401
PRIDEiP29401
ProteomicsDBi54568
TopDownProteomicsiP29401-1 [P29401-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7086
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423516; ENSP00000391481; ENSG00000163931 [P29401-2]
ENST00000423525; ENSP00000405455; ENSG00000163931 [P29401-1]
ENST00000462138; ENSP00000417773; ENSG00000163931 [P29401-1]
GeneIDi7086
KEGGihsa:7086
UCSCiuc011beq.4 human [P29401-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7086
DisGeNETi7086
EuPathDBiHostDB:ENSG00000163931.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TKT
HGNCiHGNC:11834 TKT
HPAiHPA029480
HPA029481
MalaCardsiTKT
MIMi606781 gene
617044 phenotype
neXtProtiNX_P29401
OpenTargetsiENSG00000163931
Orphaneti488618 Transketolase deficiency
PharmGKBiPA36537

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0523 Eukaryota
COG0021 LUCA
GeneTreeiENSGT00940000155552
HOGENOMiHOG000243868
HOVERGENiHBG004036
InParanoidiP29401
KOiK00615
OMAiDCITARV
OrthoDBiEOG091G03M5
PhylomeDBiP29401
TreeFamiTF313097

Enzyme and pathway databases

BRENDAi2.2.1.1 2681
ReactomeiR-HSA-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate
R-HSA-71336 Pentose phosphate pathway
SABIO-RKiP29401

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TKT human
EvolutionaryTraceiP29401

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7086

Protein Ontology

More...
PROi
PR:P29401

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163931 Expressed in 239 organ(s), highest expression level in blood
CleanExiHS_TKT
ExpressionAtlasiP29401 baseline and differential
GenevisibleiP29401 HS

Family and domain databases

Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR020826 Transketolase_BS
IPR033248 Transketolase_C
IPR005474 Transketolase_N
PfamiView protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
PF00456 Transketolase_N, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
PROSITEiView protein in PROSITE
PS00801 TRANSKETOLASE_1, 1 hit
PS00802 TRANSKETOLASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTKT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29401
Secondary accession number(s): A8K089
, B4DE31, E7EPA7, Q8TBA3, Q96HH3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 1, 1996
Last modified: December 5, 2018
This is version 199 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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