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UniProtKB - P29392 (SPAD1_BOVIN)
Protein
Spermadhesin-1
Gene
SPADH1
Organism
Bos taurus (Bovine)
Status
Functioni
Stimulates cell division and progesterone secretion of bovine granulosa cells in vitro in a potent and dose dependent manner. This protein appears to be a potent growth factor with effects on ovarian granulosa cells.
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
GO - Biological processi
- single fertilization Source: InterPro
Keywordsi
Molecular function | Growth factor |
Names & Taxonomyi
Protein namesi | Recommended name: Spermadhesin-1Alternative name(s): Acidic seminal fluid protein Short name: ASFP |
Gene namesi | Name:SPADH1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000010796 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 1 PublicationAdd BLAST | 20 | |
ChainiPRO_0000033187 | 21 – 134 | Spermadhesin-1Add BLAST | 114 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 30 ↔ 51 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 74 ↔ 95 | PROSITE-ProRule annotation1 Publication |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P29392 |
PRIDEi | P29392 |
Expressioni
Tissue specificityi
Seminal vesicle tissue, ampulla and weakly in tissue of epididymis.
Interactioni
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000014297 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P29392 |
SMRi | P29392 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P29392 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 131 | CUBPROSITE-ProRule annotationAdd BLAST | 102 |
Sequence similaritiesi
Belongs to the spermadhesin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502TD48, Eukaryota |
GeneTreei | ENSGT00390000012112 |
InParanoidi | P29392 |
OMAi | AFSTFYY |
OrthoDBi | 1512831at2759 |
Family and domain databases
CDDi | cd00041, CUB, 1 hit |
Gene3Di | 2.60.120.290, 1 hit |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR035914, Sperma_CUB_dom_sf IPR000124, Spermadhesin |
Pfami | View protein in Pfam PF00431, CUB, 1 hit |
SMARTi | View protein in SMART SM00042, CUB, 1 hit |
SUPFAMi | SSF49854, SSF49854, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS00985, SPERMADHESIN_1, 1 hit PS00986, SPERMADHESIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P29392-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLSSVIPWA LLLSTATVDS MDWLPRNTNC GGILKEESGV IATYYGPKTN
60 70 80 90 100
CVWTIQMPPE YHVRVSIQYL QLNCNKESLE IIDGLPGSPV LGKICEGSLM
110 120 130
DYRSSGSIMT VKYIREPEHP ASFYEVLYFQ DPQA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 43 | T → H AA sequence (PubMed:1898381).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84603 mRNA Translation: AAA30745.1 BC110191 mRNA Translation: AAI10192.1 |
PIRi | JQ1403 |
RefSeqi | NP_777041.1, NM_174616.3 |
Genome annotation databases
Ensembli | ENSBTAT00000014297; ENSBTAP00000014297; ENSBTAG00000010796 |
GeneIDi | 282373 |
KEGGi | bta:282373 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84603 mRNA Translation: AAA30745.1 BC110191 mRNA Translation: AAI10192.1 |
PIRi | JQ1403 |
RefSeqi | NP_777041.1, NM_174616.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1SFP | X-ray | 1.90 | A | 21-134 | [»] | |
AlphaFoldDBi | P29392 | |||||
SMRi | P29392 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000014297 |
Proteomic databases
PaxDbi | P29392 |
PRIDEi | P29392 |
Genome annotation databases
Ensembli | ENSBTAT00000014297; ENSBTAP00000014297; ENSBTAG00000010796 |
GeneIDi | 282373 |
KEGGi | bta:282373 |
Organism-specific databases
CTDi | 282373 |
VEuPathDBi | HostDB:ENSBTAG00000010796 |
Phylogenomic databases
eggNOGi | ENOG502TD48, Eukaryota |
GeneTreei | ENSGT00390000012112 |
InParanoidi | P29392 |
OMAi | AFSTFYY |
OrthoDBi | 1512831at2759 |
Miscellaneous databases
EvolutionaryTracei | P29392 |
Family and domain databases
CDDi | cd00041, CUB, 1 hit |
Gene3Di | 2.60.120.290, 1 hit |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR035914, Sperma_CUB_dom_sf IPR000124, Spermadhesin |
Pfami | View protein in Pfam PF00431, CUB, 1 hit |
SMARTi | View protein in SMART SM00042, CUB, 1 hit |
SUPFAMi | SSF49854, SSF49854, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS00985, SPERMADHESIN_1, 1 hit PS00986, SPERMADHESIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SPAD1_BOVIN | |
Accessioni | P29392Primary (citable) accession number: P29392 Secondary accession number(s): Q2YDJ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families