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Protein

Protein S100-G

Gene

S100G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi18 – 311; low affinityAdd BLAST14
Calcium bindingi58 – 692; high affinityAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: ProtInc
  • transition metal ion binding Source: InterPro
  • vitamin D binding Source: UniProtKB-KW

Keywordsi

LigandCalcium, Metal-binding, Vitamin D

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-G
Alternative name(s):
Calbindin-D9k
S100 calcium-binding protein G
Vitamin D-dependent calcium-binding protein, intestinal
Short name:
CABP
Gene namesi
Name:S100G
Synonyms:CABP9K, CALB3, S100D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000169906.5
HGNCiHGNC:1436 S100G
MIMi302020 gene
neXtProtiNX_P29377

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169906
PharmGKBiPA26028

Chemistry databases

DrugBankiDB04464 N-Formylmethionine

Polymorphism and mutation databases

BioMutaiS100G
DMDMi115387

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001440272 – 79Protein S100-GAdd BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei42PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP29377
PeptideAtlasiP29377
PRIDEiP29377
ProteomicsDBi54565

PTM databases

iPTMnetiP29377
PhosphoSitePlusiP29377

Expressioni

Gene expression databases

BgeeiENSG00000169906 Expressed in 33 organ(s), highest expression level in duodenum
CleanExiHS_S100G
GenevisibleiP29377 HS

Organism-specific databases

HPAiCAB017688
HPA055873

Interactioni

Protein-protein interaction databases

BioGridi107246, 1 interactor
STRINGi9606.ENSP00000369547

Structurei

3D structure databases

ProteinModelPortaliP29377
SMRiP29377
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini45 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST35

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J1CR Eukaryota
ENOG4111C34 LUCA
GeneTreeiENSGT00530000064238
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP29377
KOiK14734
OMAiLLIQTEF
OrthoDBiEOG091G137D
PhylomeDBiP29377
TreeFamiTF332727

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
IPR028489 S100G
PANTHERiPTHR11639:SF73 PTHR11639:SF73, 1 hit
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29377-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTKKSPEEL KRIFEKYAAK EGDPDQLSKD ELKLLIQAEF PSLLKGPNTL
60 70
DDLFQELDKN GDGEVSFEEF QVLVKKISQ
Length:79
Mass (Da):9,016
Last modified:January 23, 2007 - v2
Checksum:i30416A681485B690
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79Q → S in AAA35637 (PubMed:8308886).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65869 mRNA Translation: CAA46699.1
L13220 mRNA Translation: AAA35638.1
L13042 Genomic DNA Translation: AAA35637.1
AL445467 Genomic DNA No translation available.
BC112174 mRNA Translation: AAI12175.1
CCDSiCCDS14176.1
PIRiJN0246
RefSeqiNP_004048.1, NM_004057.2
XP_016885330.1, XM_017029841.1
UniGeneiHs.639

Genome annotation databases

EnsembliENST00000380200; ENSP00000369547; ENSG00000169906
GeneIDi795
KEGGihsa:795
UCSCiuc004cxn.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65869 mRNA Translation: CAA46699.1
L13220 mRNA Translation: AAA35638.1
L13042 Genomic DNA Translation: AAA35637.1
AL445467 Genomic DNA No translation available.
BC112174 mRNA Translation: AAI12175.1
CCDSiCCDS14176.1
PIRiJN0246
RefSeqiNP_004048.1, NM_004057.2
XP_016885330.1, XM_017029841.1
UniGeneiHs.639

3D structure databases

ProteinModelPortaliP29377
SMRiP29377
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107246, 1 interactor
STRINGi9606.ENSP00000369547

Chemistry databases

DrugBankiDB04464 N-Formylmethionine

PTM databases

iPTMnetiP29377
PhosphoSitePlusiP29377

Polymorphism and mutation databases

BioMutaiS100G
DMDMi115387

Proteomic databases

PaxDbiP29377
PeptideAtlasiP29377
PRIDEiP29377
ProteomicsDBi54565

Protocols and materials databases

DNASUi795
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380200; ENSP00000369547; ENSG00000169906
GeneIDi795
KEGGihsa:795
UCSCiuc004cxn.2 human

Organism-specific databases

CTDi795
EuPathDBiHostDB:ENSG00000169906.5
GeneCardsiS100G
HGNCiHGNC:1436 S100G
HPAiCAB017688
HPA055873
MIMi302020 gene
neXtProtiNX_P29377
OpenTargetsiENSG00000169906
PharmGKBiPA26028
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1CR Eukaryota
ENOG4111C34 LUCA
GeneTreeiENSGT00530000064238
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP29377
KOiK14734
OMAiLLIQTEF
OrthoDBiEOG091G137D
PhylomeDBiP29377
TreeFamiTF332727

Miscellaneous databases

GeneWikiiS100G
GenomeRNAii795
PROiPR:P29377
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169906 Expressed in 33 organ(s), highest expression level in duodenum
CleanExiHS_S100G
GenevisibleiP29377 HS

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
IPR028489 S100G
PANTHERiPTHR11639:SF73 PTHR11639:SF73, 1 hit
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS100G_HUMAN
AccessioniPrimary (citable) accession number: P29377
Secondary accession number(s): Q5JS49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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