UniProtKB - P29375 (KDM5A_HUMAN)
Lysine-specific demethylase 5A
KDM5A
Functioni
Catalytic activityi
- 3 2-oxoglutarate + N6,N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl4-[histone H3] + 3 succinate3 PublicationsEC:1.14.11.673 Publications
Cofactori
Activity regulationi
Kineticsi
- KM=9 µM for 2-oxoglutarate1 Publication
- KM=2.9 µM for histone H3K4me31 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 409 | 2-oxoglutarate2 Publications | 1 | |
Metal bindingi | 483 | Iron; catalyticPROSITE-ProRule annotation4 Publications | 1 | |
Metal bindingi | 485 | Iron; catalytic4 Publications | 1 | |
Binding sitei | 491 | 2-oxoglutarate2 Publications | 1 | |
Binding sitei | 493 | 2-oxoglutarate2 Publications | 1 | |
Binding sitei | 501 | 2-oxoglutarate2 Publications | 1 | |
Metal bindingi | 571 | Iron; catalyticPROSITE-ProRule annotation4 Publications | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 293 – 343 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 676 – 728 | C5HC2Combined sources2 PublicationsAdd BLAST | 53 | |
Zinc fingeri | 1161 – 1218 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 58 | |
Zinc fingeri | 1607 – 1661 | PHD-type 31 PublicationAdd BLAST | 55 |
GO - Molecular functioni
- chromatin DNA binding Source: Ensembl
- dioxygenase activity Source: UniProtKB-KW
- DNA binding Source: GDB
- histone binding Source: UniProtKB
- histone demethylase activity Source: GO_Central
- histone demethylase activity (H3-dimethyl-K4 specific) Source: CAFA
- histone demethylase activity (H3-trimethyl-K4 specific) Source: CAFA
- methylated histone binding Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
- transcription regulatory region sequence-specific DNA binding Source: CAFA
- zinc ion binding Source: UniProtKB
GO - Biological processi
- chromatin remodeling Source: GO_Central
- circadian regulation of gene expression Source: UniProtKB
- histone H3-K4 demethylation Source: CAFA
- male gonad development Source: Ensembl
- negative regulation of histone deacetylase activity Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of DNA-binding transcription factor activity Source: CAFA
- spermatogenesis Source: Ensembl
Keywordsi
Molecular function | Activator, Chromatin regulator, Developmental protein, Dioxygenase, Oxidoreductase |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Ligand | Iron, Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000073614-MONOMER |
PathwayCommonsi | P29375 |
Reactomei | R-HSA-3214842, HDMs demethylate histones |
SIGNORi | P29375 |
Names & Taxonomyi
Protein namesi | Recommended name: Lysine-specific demethylase 5A (EC:1.14.11.673 Publications)Alternative name(s): Histone demethylase JARID1A Jumonji/ARID domain-containing protein 1A Retinoblastoma-binding protein 2 Short name: RBBP-2 [histone H3]-trimethyl-L-lysine(4) demethylase 5ACurated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9886, KDM5A |
MIMi | 180202, gene |
neXtProti | NX_P29375 |
VEuPathDBi | HostDB:ENSG00000073614.11 |
Subcellular locationi
Nucleus
- histone methyltransferase complex Source: GO_Central
- nucleolus Source: UniProtKB-SubCell
- nucleoplasm Source: Reactome
- nucleus Source: CAFA
Other locations
- protein-DNA complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 112 | R → E: Decreases DNA-binding. 1 Publication | 1 | |
Mutagenesisi | 152 | K → E: Abolishes DNA-binding. 1 Publication | 1 | |
Mutagenesisi | 156 | S → D: Decreases DNA-binding. 1 Publication | 1 | |
Mutagenesisi | 157 | L → E: Decreases DNA-binding. 1 Publication | 1 | |
Mutagenesisi | 626 | C → S: No effect on lysine-specific histone demethylase activity; when associated with S-636. 1 Publication | 1 | |
Mutagenesisi | 636 | C → S: No effect on lysine-specific histone demethylase activity; when associated with S-626. 1 Publication | 1 | |
Mutagenesisi | 1609 | V → G: No effect on interaction with histone H3 di- and trimethylated at 'Lys-4'. 1 Publication | 1 | |
Mutagenesisi | 1625 | W → A: Abolishes interaction with histone H3 di- and trimethylated at 'Lys-4'. 1 Publication | 1 | |
Mutagenesisi | 1634 – 1635 | EW → AA: Abolishes interaction with histone H3 di- and trimethylated at 'Lys-4'. 1 Publication | 2 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 1485 – 1486 | Breakpoint for translocation to form the NUP98-KDM5A fusion protein1 Publication | 2 |
Organism-specific databases
DisGeNETi | 5927 |
OpenTargetsi | ENSG00000073614 |
PharmGKBi | PA34250 |
Miscellaneous databases
Pharosi | P29375, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2424504 |
GuidetoPHARMACOLOGYi | 2680 |
Genetic variation databases
BioMutai | KDM5A |
DMDMi | 215274124 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200584 | 1 – 1690 | Lysine-specific demethylase 5AAdd BLAST | 1690 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 191 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 204 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1007 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1111 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1330 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1331 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1343 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1345 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1438 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1488 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1595 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 1598 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1603 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1666 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P29375 |
jPOSTi | P29375 |
MassIVEi | P29375 |
MaxQBi | P29375 |
PaxDbi | P29375 |
PeptideAtlasi | P29375 |
PRIDEi | P29375 |
ProteomicsDBi | 54559 [P29375-1] 54560 [P29375-2] |
PTM databases
iPTMneti | P29375 |
PhosphoSitePlusi | P29375 |
SwissPalmi | P29375 |
Expressioni
Gene expression databases
Bgeei | ENSG00000073614, Expressed in peritoneum and 253 other tissues |
ExpressionAtlasi | P29375, baseline and differential |
Genevisiblei | P29375, HS |
Organism-specific databases
HPAi | ENSG00000073614, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with SUZ12; the interaction is direct (By similarity).
Interacts with the viral protein-binding domain of RB1.
Interacts with ESR1, MYC, MYCN and LMO2.
Interacts with HDAC1 (By similarity).
Interacts with ARNTL/BMAL1 and CLOCK.
Interacts (via PHD-type 1 zinc finger) with histone H3 unmodified at 'Lys-4' and (via PHD-type 3 zinc finger) with histone H3 di- and trimethylated at 'Lys-4' (PubMed:19430464).
By similarity8 PublicationsBinary interactionsi
P29375
With | #Exp. | IntAct |
---|---|---|
RB1 [P06400] | 2 | EBI-1560836,EBI-491274 |
GO - Molecular functioni
- histone binding Source: UniProtKB
- methylated histone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111862, 40 interactors |
DIPi | DIP-472N |
IntActi | P29375, 23 interactors |
MINTi | P29375 |
STRINGi | 9606.ENSP00000382688 |
Chemistry databases
BindingDBi | P29375 |
Miscellaneous databases
RNActi | P29375, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P29375 |
SMRi | P29375 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P29375 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 60 | JmjNPROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 84 – 174 | ARIDPROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 437 – 603 | JmjCPROSITE-ProRule annotationAdd BLAST | 167 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1623 – 1690 | Interaction with LMO21 PublicationAdd BLAST | 68 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 419 – 423 | GSGFP motifBy similarity | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1492 – 1587 | Lys-richAdd BLAST | 96 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 293 – 343 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 676 – 728 | C5HC2Combined sources2 PublicationsAdd BLAST | 53 | |
Zinc fingeri | 1161 – 1218 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 58 | |
Zinc fingeri | 1607 – 1661 | PHD-type 31 PublicationAdd BLAST | 55 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1246, Eukaryota |
GeneTreei | ENSGT00940000157170 |
HOGENOMi | CLU_000991_2_0_1 |
InParanoidi | P29375 |
OMAi | KWAPVAP |
OrthoDBi | 664180at2759 |
PhylomeDBi | P29375 |
TreeFami | TF106476 |
Family and domain databases
DisProti | DP02224 |
Gene3Di | 1.10.150.60, 1 hit 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR001606, ARID_dom IPR036431, ARID_dom_sf IPR003347, JmjC_dom IPR003349, JmjN IPR013637, Lys_sp_deMease-like_dom IPR019786, Zinc_finger_PHD-type_CS IPR004198, Znf_C5HC2 IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF01388, ARID, 1 hit PF02373, JmjC, 1 hit PF02375, JmjN, 1 hit PF00628, PHD, 2 hits PF08429, PLU-1, 1 hit PF02928, zf-C5HC2, 1 hit |
SMARTi | View protein in SMART SM00501, BRIGHT, 1 hit SM00558, JmjC, 1 hit SM00545, JmjN, 1 hit SM00249, PHD, 3 hits |
SUPFAMi | SSF46774, SSF46774, 1 hit SSF57903, SSF57903, 3 hits |
PROSITEi | View protein in PROSITE PS51011, ARID, 1 hit PS51184, JMJC, 1 hit PS51183, JMJN, 1 hit PS01359, ZF_PHD_1, 2 hits PS50016, ZF_PHD_2, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGVGPGGYA AEFVPPPECP VFEPSWEEFT DPLSFIGRIR PLAEKTGICK
60 70 80 90 100
IRPPKDWQPP FACEVKSFRF TPRVQRLNEL EAMTRVRLDF LDQLAKFWEL
110 120 130 140 150
QGSTLKIPVV ERKILDLYAL SKIVASKGGF EMVTKEKKWS KVGSRLGYLP
160 170 180 190 200
GKGTGSLLKS HYERILYPYE LFQSGVSLMG VQMPNLDLKE KVEPEVLSTD
210 220 230 240 250
TQTSPEPGTR MNILPKRTRR VKTQSESGDV SRNTELKKLQ IFGAGPKVVG
260 270 280 290 300
LAMGTKDKED EVTRRRKVTN RSDAFNMQMR QRKGTLSVNF VDLYVCMFCG
310 320 330 340 350
RGNNEDKLLL CDGCDDSYHT FCLIPPLPDV PKGDWRCPKC VAEECSKPRE
360 370 380 390 400
AFGFEQAVRE YTLQSFGEMA DNFKSDYFNM PVHMVPTELV EKEFWRLVSS
410 420 430 440 450
IEEDVIVEYG ADISSKDFGS GFPVKDGRRK ILPEEEEYAL SGWNLNNMPV
460 470 480 490 500
LEQSVLAHIN VDISGMKVPW LYVGMCFSSF CWHIEDHWSY SINYLHWGEP
510 520 530 540 550
KTWYGVPSHA AEQLEEVMRE LAPELFESQP DLLHQLVTIM NPNVLMEHGV
560 570 580 590 600
PVYRTNQCAG EFVVTFPRAY HSGFNQGYNF AEAVNFCTAD WLPIGRQCVN
610 620 630 640 650
HYRRLRRHCV FSHEELIFKM AADPECLDVG LAAMVCKELT LMTEEETRLR
660 670 680 690 700
ESVVQMGVLM SEEEVFELVP DDERQCSACR TTCFLSALTC SCNPERLVCL
710 720 730 740 750
YHPTDLCPCP MQKKCLRYRY PLEDLPSLLY GVKVRAQSYD TWVSRVTEAL
760 770 780 790 800
SANFNHKKDL IELRVMLEDA EDRKYPENDL FRKLRDAVKE AETCASVAQL
810 820 830 840 850
LLSKKQKHRQ SPDSGRTRTK LTVEELKAFV QQLFSLPCVI SQARQVKNLL
860 870 880 890 900
DDVEEFHERA QEAMMDETPD SSKLQMLIDM GSSLYVELPE LPRLKQELQQ
910 920 930 940 950
ARWLDEVRLT LSDPQQVTLD VMKKLIDSGV GLAPHHAVEK AMAELQELLT
960 970 980 990 1000
VSERWEEKAK VCLQARPRHS VASLESIVNE AKNIPAFLPN VLSLKEALQK
1010 1020 1030 1040 1050
AREWTAKVEA IQSGSNYAYL EQLESLSAKG RPIPVRLEAL PQVESQVAAA
1060 1070 1080 1090 1100
RAWRERTGRT FLKKNSSHTL LQVLSPRTDI GVYGSGKNRR KKVKELIEKE
1110 1120 1130 1140 1150
KEKDLDLEPL SDLEEGLEET RDTAMVVAVF KEREQKEIEA MHSLRAANLA
1160 1170 1180 1190 1200
KMTMVDRIEE VKFCICRKTA SGFMLQCELC KDWFHNSCVP LPKSSSQKKG
1210 1220 1230 1240 1250
SSWQAKEVKF LCPLCMRSRR PRLETILSLL VSLQKLPVRL PEGEALQCLT
1260 1270 1280 1290 1300
ERAMSWQDRA RQALATDELS SALAKLSVLS QRMVEQAARE KTEKIISAEL
1310 1320 1330 1340 1350
QKAAANPDLQ GHLPSFQQSA FNRVVSSVSS SPRQTMDYDD EETDSDEDIR
1360 1370 1380 1390 1400
ETYGYDMKDT ASVKSSSSLE PNLFCDEEIP IKSEEVVTHM WTAPSFCAEH
1410 1420 1430 1440 1450
AYSSASKSCS QGSSTPRKQP RKSPLVPRSL EPPVLELSPG AKAQLEELMM
1460 1470 1480 1490 1500
VGDLLEVSLD ETQHIWRILQ ATHPPSEDRF LHIMEDDSME EKPLKVKGKD
1510 1520 1530 1540 1550
SSEKKRKRKL EKVEQLFGEG KQKSKELKKM DKPRKKKLKL GADKSKELNK
1560 1570 1580 1590 1600
LAKKLAKEEE RKKKKEKAAA AKVELVKEST EKKREKKVLD IPSKYDWSGA
1610 1620 1630 1640 1650
EESDDENAVC AAQNCQRPCK DKVDWVQCDG GCDEWFHQVC VGVSPEMAEN
1660 1670 1680 1690
EDYICINCAK KQGPVSPGPA PPPSFIMSYK LPMEDLKETS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EV89 | E7EV89_HUMAN | Lysine-specific demethylase 5A | KDM5A | 715 | Annotation score: | ||
F5GZR8 | F5GZR8_HUMAN | Lysine-specific demethylase 5A | KDM5A | 131 | Annotation score: | ||
F5GZ99 | F5GZ99_HUMAN | Lysine-specific demethylase 5A | KDM5A | 126 | Annotation score: | ||
F5H322 | F5H322_HUMAN | Lysine-specific demethylase 5A | KDM5A | 122 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1411 | Q → QVFFGK in AAB28544 (PubMed:8414517).Curated | 1 | |
Sequence conflicti | 1547 | E → K in AAB28544 (PubMed:8414517).Curated | 1 | |
Sequence conflicti | 1612 – 1614 | AQN → EPD in AAB28544 (PubMed:8414517).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032984 | 865 | M → T. Corresponds to variant dbSNP:rs11062385Ensembl. | 1 | |
Natural variantiVAR_032985 | 1190 | P → A. Corresponds to variant dbSNP:rs2229353Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035746 | 1623 – 1690 | VDWVQ…LKETS → GVVFVTEEERDKKY in isoform 2. 1 PublicationAdd BLAST | 68 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S66431 mRNA Translation: AAB28544.1 Frameshift. AB209999 mRNA Translation: BAE06081.1 Different initiation. AC005844 Genomic DNA No translation available. AC007406 Genomic DNA No translation available. BC048307 mRNA Translation: AAH48307.1 Different termination. BC053893 mRNA Translation: AAH53893.1 Different termination. BC110916 mRNA Translation: AAI10917.1 Different termination. |
CCDSi | CCDS41736.1 [P29375-1] |
PIRi | I78879 |
RefSeqi | NP_001036068.1, NM_001042603.2 [P29375-1] |
Genome annotation databases
Ensembli | ENST00000399788; ENSP00000382688; ENSG00000073614 [P29375-1] |
GeneIDi | 5927 |
KEGGi | hsa:5927 |
UCSCi | uc001qif.3, human [P29375-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S66431 mRNA Translation: AAB28544.1 Frameshift. AB209999 mRNA Translation: BAE06081.1 Different initiation. AC005844 Genomic DNA No translation available. AC007406 Genomic DNA No translation available. BC048307 mRNA Translation: AAH48307.1 Different termination. BC053893 mRNA Translation: AAH53893.1 Different termination. BC110916 mRNA Translation: AAI10917.1 Different termination. |
CCDSi | CCDS41736.1 [P29375-1] |
PIRi | I78879 |
RefSeqi | NP_001036068.1, NM_001042603.2 [P29375-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2JXJ | NMR | - | A | 85-175 | [»] | |
2KGG | NMR | - | A | 1609-1659 | [»] | |
2KGI | NMR | - | A | 1609-1659 | [»] | |
3GL6 | X-ray | 1.90 | A | 1609-1659 | [»] | |
5C11 | X-ray | 2.80 | A | 1609-1659 | [»] | |
5CEH | X-ray | 3.14 | A | 12-797 | [»] | |
5E6H | X-ray | 2.24 | A | 1-87 | [»] | |
A | 348-588 | [»] | ||||
5ISL | X-ray | 1.69 | A | 1-87 | [»] | |
A | 348-588 | [»] | ||||
5IVB | X-ray | 1.39 | A | 1-87 | [»] | |
A | 348-588 | [»] | ||||
5IVC | X-ray | 1.57 | A | 1-87 | [»] | |
A | 348-588 | [»] | ||||
5IVE | X-ray | 1.78 | A | 1-87 | [»] | |
A | 348-588 | [»] | ||||
5IVF | X-ray | 1.68 | A | 1-87 | [»] | |
A | 348-588 | [»] | ||||
5IVJ | X-ray | 1.57 | A | 1-87 | [»] | |
A | 348-588 | [»] | ||||
5IVV | X-ray | 1.85 | A | 1-87 | [»] | |
A | 348-588 | [»] | ||||
5IVY | X-ray | 1.45 | A | 1-87 | [»] | |
A | 348-588 | [»] | ||||
5IW0 | X-ray | 1.63 | A | 1-87 | [»] | |
A | 348-588 | [»] | ||||
5IWF | X-ray | 2.29 | A | 1-87 | [»] | |
A | 348-588 | [»] | ||||
5K4L | X-ray | 3.18 | A/B | 12-797 | [»] | |
5V9P | X-ray | 3.00 | A | 12-797 | [»] | |
5V9T | X-ray | 3.05 | A/B | 12-797 | [»] | |
6BGU | X-ray | 1.68 | A | 1-588 | [»] | |
6BGV | X-ray | 1.59 | A | 1-588 | [»] | |
6BGW | X-ray | 1.64 | A | 1-588 | [»] | |
6BGX | X-ray | 1.88 | A | 1-588 | [»] | |
6BGY | X-ray | 1.22 | A | 1-588 | [»] | |
6BGZ | X-ray | 1.69 | A | 1-588 | [»] | |
6BH0 | X-ray | 1.99 | A | 1-588 | [»] | |
6BH1 | X-ray | 1.93 | A | 1-588 | [»] | |
6BH2 | X-ray | 1.45 | A | 1-588 | [»] | |
6BH3 | X-ray | 1.70 | A | 1-588 | [»] | |
6BH4 | X-ray | 2.05 | A | 1-588 | [»] | |
6BH5 | X-ray | 1.65 | A | 1-588 | [»] | |
6DQ4 | X-ray | 1.39 | A | 1-588 | [»] | |
6DQ5 | X-ray | 1.89 | A | 1-588 | [»] | |
6DQ6 | X-ray | 1.59 | A | 1-588 | [»] | |
6DQ7 | X-ray | 1.85 | A | 1-588 | [»] | |
6DQ8 | X-ray | 1.46 | A | 1-588 | [»] | |
6DQ9 | X-ray | 1.75 | A | 1-588 | [»] | |
6DQA | X-ray | 1.89 | A | 1-588 | [»] | |
6DQB | X-ray | 1.79 | A | 1-588 | [»] | |
6DQC | X-ray | 1.75 | A | 1-588 | [»] | |
6DQD | X-ray | 1.99 | A | 1-588 | [»] | |
6DQE | X-ray | 1.69 | A | 1-588 | [»] | |
6DQF | X-ray | 1.69 | A | 1-588 | [»] | |
BMRBi | P29375 | |||||
SMRi | P29375 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111862, 40 interactors |
DIPi | DIP-472N |
IntActi | P29375, 23 interactors |
MINTi | P29375 |
STRINGi | 9606.ENSP00000382688 |
Chemistry databases
BindingDBi | P29375 |
ChEMBLi | CHEMBL2424504 |
GuidetoPHARMACOLOGYi | 2680 |
PTM databases
iPTMneti | P29375 |
PhosphoSitePlusi | P29375 |
SwissPalmi | P29375 |
Genetic variation databases
BioMutai | KDM5A |
DMDMi | 215274124 |
Proteomic databases
EPDi | P29375 |
jPOSTi | P29375 |
MassIVEi | P29375 |
MaxQBi | P29375 |
PaxDbi | P29375 |
PeptideAtlasi | P29375 |
PRIDEi | P29375 |
ProteomicsDBi | 54559 [P29375-1] 54560 [P29375-2] |
Protocols and materials databases
Antibodypediai | 1751, 206 antibodies |
Genome annotation databases
Ensembli | ENST00000399788; ENSP00000382688; ENSG00000073614 [P29375-1] |
GeneIDi | 5927 |
KEGGi | hsa:5927 |
UCSCi | uc001qif.3, human [P29375-1] |
Organism-specific databases
CTDi | 5927 |
DisGeNETi | 5927 |
GeneCardsi | KDM5A |
HGNCi | HGNC:9886, KDM5A |
HPAi | ENSG00000073614, Low tissue specificity |
MIMi | 180202, gene |
neXtProti | NX_P29375 |
OpenTargetsi | ENSG00000073614 |
PharmGKBi | PA34250 |
VEuPathDBi | HostDB:ENSG00000073614.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1246, Eukaryota |
GeneTreei | ENSGT00940000157170 |
HOGENOMi | CLU_000991_2_0_1 |
InParanoidi | P29375 |
OMAi | KWAPVAP |
OrthoDBi | 664180at2759 |
PhylomeDBi | P29375 |
TreeFami | TF106476 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000073614-MONOMER |
PathwayCommonsi | P29375 |
Reactomei | R-HSA-3214842, HDMs demethylate histones |
SIGNORi | P29375 |
Miscellaneous databases
BioGRID-ORCSi | 5927, 6 hits in 902 CRISPR screens |
ChiTaRSi | KDM5A, human |
EvolutionaryTracei | P29375 |
GeneWikii | JARID1A |
GenomeRNAii | 5927 |
Pharosi | P29375, Tchem |
PROi | PR:P29375 |
RNActi | P29375, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000073614, Expressed in peritoneum and 253 other tissues |
ExpressionAtlasi | P29375, baseline and differential |
Genevisiblei | P29375, HS |
Family and domain databases
DisProti | DP02224 |
Gene3Di | 1.10.150.60, 1 hit 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR001606, ARID_dom IPR036431, ARID_dom_sf IPR003347, JmjC_dom IPR003349, JmjN IPR013637, Lys_sp_deMease-like_dom IPR019786, Zinc_finger_PHD-type_CS IPR004198, Znf_C5HC2 IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF01388, ARID, 1 hit PF02373, JmjC, 1 hit PF02375, JmjN, 1 hit PF00628, PHD, 2 hits PF08429, PLU-1, 1 hit PF02928, zf-C5HC2, 1 hit |
SMARTi | View protein in SMART SM00501, BRIGHT, 1 hit SM00558, JmjC, 1 hit SM00545, JmjN, 1 hit SM00249, PHD, 3 hits |
SUPFAMi | SSF46774, SSF46774, 1 hit SSF57903, SSF57903, 3 hits |
PROSITEi | View protein in PROSITE PS51011, ARID, 1 hit PS51184, JMJC, 1 hit PS51183, JMJN, 1 hit PS01359, ZF_PHD_1, 2 hits PS50016, ZF_PHD_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KDM5A_HUMAN | |
Accessioni | P29375Primary (citable) accession number: P29375 Secondary accession number(s): A8MV76, Q4LE72, Q86XZ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 10, 2021 | |
This is version 203 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families