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Protein

AT-rich interactive domain-containing protein 4A

Gene

ARID4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: GDB
  • DNA-binding transcription factor activity Source: ProtInc
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • histone deacetylase activity Source: Reactome
  • transcription regulatory region DNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3214815 HDACs deacetylate histones

SIGNOR Signaling Network Open Resource

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SIGNORi
P29374

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 4A
Short name:
ARID domain-containing protein 4A
Alternative name(s):
Retinoblastoma-binding protein 1
Short name:
RBBP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARID4A
Synonyms:RBBP1, RBP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000032219.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9885 ARID4A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
180201 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P29374

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi583Y → A: No effect on binding to trimethylated lysines. 1 Publication1
Mutagenesisi592Y → A: Significantly reduces affinity for trimethylated lysines. 1 Publication1
Mutagenesisi612Y → A: Abolishes binding to trimethylated lysines. 1 Publication1
Mutagenesisi615W → A: Abolishes binding to trimethylated lysines. 1 Publication1
Mutagenesisi619Y → A: Abolishes binding to trimethylated lysines. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5926

Open Targets

More...
OpenTargetsi
ENSG00000032219

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34249

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3709855

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARID4A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
206729929

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002005801 – 1257AT-rich interactive domain-containing protein 4AAdd BLAST1257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki481Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki513Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei676PhosphoserineCombined sources1
Modified residuei716PhosphoserineCombined sources1
Cross-linki718Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki738Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki759Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei864PhosphoserineCombined sources1
Modified residuei1109PhosphoserineCombined sources1
Modified residuei1145PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P29374

MaxQB - The MaxQuant DataBase

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MaxQBi
P29374

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P29374

PeptideAtlas

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PeptideAtlasi
P29374

PRoteomics IDEntifications database

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PRIDEi
P29374

ProteomicsDB human proteome resource

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ProteomicsDBi
54556
54557 [P29374-2]
54558 [P29374-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P29374

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P29374

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000032219 Expressed in 221 organ(s), highest expression level in frontal cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_ARID4A
HS_RBP1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P29374 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P29374 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA048899

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, BRMS1, HDAC1 and HDAC2 (PubMed:14581478). Interacts with BRMS1 (PubMed:14581478). Interacts with RB1 (PubMed:8414517, PubMed:8455946). Interacts with ARID4B (PubMed:17043311). Interacts with AR (PubMed:23487765).5 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111861, 33 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3321 SIN3A histone deacetylase complex
CPX-3322 SIN3B histone deacetylase complex
CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P29374

Database of interacting proteins

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DIPi
DIP-463N

Protein interaction database and analysis system

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IntActi
P29374, 9 interactors

Molecular INTeraction database

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MINTi
P29374

STRING: functional protein association networks

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STRINGi
9606.ENSP00000347602

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P29374

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P29374

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P29374

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini309 – 401ARIDPROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4 – 121DNA-binding1 PublicationAdd BLAST118
Regioni568 – 635Chromodomain-like2 PublicationsAdd BLAST68
Regioni951 – 964Retinoblastoma protein bindingSequence analysisAdd BLAST14

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The function of the chromodomain-like region is uncertain (PubMed:22247551, PubMed:29408527). One study suggests that it mediates binding to lysine-methylated histone tails, with strongest affinity for H4K20me3 and H3K36me3 (PubMed:22247551). However, another study failed to find any interaction between this domain and histone H4K20me3 peptide (PubMed:29408527).2 Publications

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2744 Eukaryota
KOG3001 Eukaryota
ENOG410Y2AP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156159

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000015398

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG058247

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P29374

KEGG Orthology (KO)

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KOi
K19194

Identification of Orthologs from Complete Genome Data

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OMAi
DQCAKEK

Database of Orthologous Groups

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OrthoDBi
EOG091G0EG4

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P29374

TreeFam database of animal gene trees

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TreeFami
TF106427

Family and domain databases

Conserved Domains Database

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CDDi
cd00024 CHROMO, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.150.60, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR012603 RBB1NT
IPR002999 Tudor
IPR025995 Tudor-knot

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01388 ARID, 1 hit
PF08169 RBB1NT, 1 hit
PF11717 Tudor-knot, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00501 BRIGHT, 1 hit
SM00298 CHROMO, 1 hit
SM00333 TUDOR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46774 SSF46774, 1 hit
SSF54160 SSF54160, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51011 ARID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform I (identifier: P29374-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKAADEPAYL TVGTDVSAKY RGAFCEAKIK TVKRLVKVKV LLKQDNTTQL
60 70 80 90 100
VQDDQVKGPL RVGAIVETRT SDGSFQEAII SKLTDASWYT VVFDDGDERT
110 120 130 140 150
LRRTSLCLKG ERHFAESETL DQLPLTNPEH FGTPVIAKKT NRGRRSSLPV
160 170 180 190 200
TEDEKEEESS EEEDEDKRRL NDELLGKVVS VVSATERTEW YPALVISPSC
210 220 230 240 250
NDDITVKKDQ CLVRSFIDSK FYSIARKDIK EVDILNLPES ELSTKPGLQK
260 270 280 290 300
ASIFLKTRVV PDNWKMDISE ILESSSSDDE DGPAEENDEE KEKEAKKTEE
310 320 330 340 350
EVPEEELDPE ERDNFLQQLY KFMEDRGTPI NKPPVLGYKD LNLFKLFRLV
360 370 380 390 400
YHQGGCDNID SGAVWKQIYM DLGIPILNSA ASYNVKTAYR KYLYGFEEYC
410 420 430 440 450
RSANIQFRTV HHHEPKVKEE KKDLEESMEE ALKLDQEMPL TEVKSEPEEN
460 470 480 490 500
IDSNSESERE EIELKSPRGR RRIARDVNSI KKEIEEEKTE DKLKDNDTEN
510 520 530 540 550
KDVDDDYETA EKKENELLLG RKNTPKQKEK KIKKQEDSDK DSDEEEEKSQ
560 570 580 590 600
EREETESKCD SEGEEDEEDM EPCLTGTKVK VKYGRGKTQK IYEASIKSTE
610 620 630 640 650
IDDGEVLYLV HYYGWNVRYD EWVKADRIIW PLDKGGPKKK QKKKAKNKED
660 670 680 690 700
SEKDEKRDEE RQKSKRGRPP LKSTLSSNMP YGLSKTANSE GKSDSCSSDS
710 720 730 740 750
ETEDALEKNL INEELSLKDE LEKNENLNDD KLDEENPKIS AHILKENDRT
760 770 780 790 800
QMQPLETLKL EVGENEQIVQ IFGNKMEKTE EVKKEAEKSP KGKGRRSKTK
810 820 830 840 850
DLSLEIIKIS SFGQNEAGSE PHIEAHSLEL SSLDNKNFSS ATEDEIDQCV
860 870 880 890 900
KEKKLKRKIL GQSSPEKKIR IENGMEMTNT VSQERTSDCI GSEGMKNLNF
910 920 930 940 950
EQHFERENEG MPSLIAESNQ CIQQLTSERF DSPAEETVNI PLKEDEDAMP
960 970 980 990 1000
LIGPETLVCH EVDLDDLDEK DKTSIEDVAV ESSESNSLVS IPPALPPVVQ
1010 1020 1030 1040 1050
HNFSVASPLT LSQDESRSVK SESDITIEVD SIAEESQEGL CERESANGFE
1060 1070 1080 1090 1100
TNVASGTCSI IVQERESREK GQKRPSDGNS GLMAKKQKRT PKRTSAAAKN
1110 1120 1130 1140 1150
EKNGTGQSSD SEDLPVLDNS SKCTPVKHLN VSKPQKLARS PARISPHIKD
1160 1170 1180 1190 1200
GEKDKHREKH PNSSPRTYKW SFQLNELDNM NSTERISFLQ EKLQEIRKYY
1210 1220 1230 1240 1250
MSLKSEVATI DRRRKRLKKK DREVSHAGAS MSSASSDTGM SPSSSSPPQN

VLAVECR
Length:1,257
Mass (Da):142,752
Last modified:September 23, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B3F6A5AFB7588CF
GO
Isoform II (identifier: P29374-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1121-1174: Missing.

Show »
Length:1,203
Mass (Da):136,495
Checksum:iB2A06AA7071AAAE2
GO
Isoform III (identifier: P29374-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1106-1174: Missing.
     1175-1175: N → D

Show »
Length:1,188
Mass (Da):134,951
Checksum:i0576FA849F761B54
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C485H7C485_HUMAN
AT-rich interactive domain-containi...
ARID4A
748Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1W3C9J1W3_HUMAN
AT-rich interactive domain-containi...
ARID4A
265Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIF4C9JIF4_HUMAN
AT-rich interactive domain-containi...
ARID4A
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAR5F8WAR5_HUMAN
AT-rich interactive domain-containi...
ARID4A
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti385V → L in AAB28543 (PubMed:8414517).Curated1
Sequence conflicti618R → S in AAB28543 (PubMed:8414517).Curated1
Sequence conflicti653K → V in AAB25833 (PubMed:8455946).Curated1
Sequence conflicti653K → V in AAB25834 (PubMed:8455946).Curated1
Sequence conflicti653K → V in AAB25835 (PubMed:8455946).Curated1
Sequence conflicti1178D → S no nucleotide entry (PubMed:1857421).Curated1
Sequence conflicti1196 – 1201IRKYYM → SENIICL no nucleotide entry (PubMed:1857421).Curated6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031566412H → P. Corresponds to variant dbSNP:rs34982206Ensembl.1
Natural variantiVAR_031567724N → S. Corresponds to variant dbSNP:rs2230098Ensembl.1
Natural variantiVAR_031568779T → A1 PublicationCorresponds to variant dbSNP:rs1051858Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0043711106 – 1174Missing in isoform III. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_0043731121 – 1174Missing in isoform II. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_0043721175N → D in isoform III. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
S66427 mRNA Translation: AAB28543.1
AL132989 Genomic DNA No translation available.
AL139021 Genomic DNA No translation available.
S57153 mRNA Translation: AAB25833.1
S57160 mRNA Translation: AAB25834.1
S57162 mRNA Translation: AAB25835.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS45114.1 [P29374-2]
CCDS9732.1 [P29374-1]
CCDS9733.1 [P29374-3]

Protein sequence database of the Protein Information Resource

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PIRi
I58383

NCBI Reference Sequences

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RefSeqi
NP_002883.3, NM_002892.3 [P29374-1]
NP_075376.2, NM_023000.2 [P29374-2]
NP_075377.2, NM_023001.2 [P29374-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.161000

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000348476; ENSP00000344556; ENSG00000032219 [P29374-3]
ENST00000355431; ENSP00000347602; ENSG00000032219 [P29374-1]
ENST00000395168; ENSP00000378597; ENSG00000032219 [P29374-2]
ENST00000431317; ENSP00000397368; ENSG00000032219 [P29374-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5926

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5926

UCSC genome browser

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UCSCi
uc001xdo.4 human [P29374-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S66427 mRNA Translation: AAB28543.1
AL132989 Genomic DNA No translation available.
AL139021 Genomic DNA No translation available.
S57153 mRNA Translation: AAB25833.1
S57160 mRNA Translation: AAB25834.1
S57162 mRNA Translation: AAB25835.2
CCDSiCCDS45114.1 [P29374-2]
CCDS9732.1 [P29374-1]
CCDS9733.1 [P29374-3]
PIRiI58383
RefSeqiNP_002883.3, NM_002892.3 [P29374-1]
NP_075376.2, NM_023000.2 [P29374-2]
NP_075377.2, NM_023001.2 [P29374-3]
UniGeneiHs.161000

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LCCNMR-A568-635[»]
2MAMNMR-A4-121[»]
2YRVNMR-A170-273[»]
6BPHX-ray1.85A568-635[»]
ProteinModelPortaliP29374
SMRiP29374
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111861, 33 interactors
ComplexPortaliCPX-3321 SIN3A histone deacetylase complex
CPX-3322 SIN3B histone deacetylase complex
CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CORUMiP29374
DIPiDIP-463N
IntActiP29374, 9 interactors
MINTiP29374
STRINGi9606.ENSP00000347602

Chemistry databases

ChEMBLiCHEMBL3709855

PTM databases

iPTMnetiP29374
PhosphoSitePlusiP29374

Polymorphism and mutation databases

BioMutaiARID4A
DMDMi206729929

Proteomic databases

EPDiP29374
MaxQBiP29374
PaxDbiP29374
PeptideAtlasiP29374
PRIDEiP29374
ProteomicsDBi54556
54557 [P29374-2]
54558 [P29374-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5926
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348476; ENSP00000344556; ENSG00000032219 [P29374-3]
ENST00000355431; ENSP00000347602; ENSG00000032219 [P29374-1]
ENST00000395168; ENSP00000378597; ENSG00000032219 [P29374-2]
ENST00000431317; ENSP00000397368; ENSG00000032219 [P29374-3]
GeneIDi5926
KEGGihsa:5926
UCSCiuc001xdo.4 human [P29374-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5926
DisGeNETi5926
EuPathDBiHostDB:ENSG00000032219.18

GeneCards: human genes, protein and diseases

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GeneCardsi
ARID4A

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0037655
HGNCiHGNC:9885 ARID4A
HPAiHPA048899
MIMi180201 gene
neXtProtiNX_P29374
OpenTargetsiENSG00000032219
PharmGKBiPA34249

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2744 Eukaryota
KOG3001 Eukaryota
ENOG410Y2AP LUCA
GeneTreeiENSGT00940000156159
HOGENOMiHOG000015398
HOVERGENiHBG058247
InParanoidiP29374
KOiK19194
OMAiDQCAKEK
OrthoDBiEOG091G0EG4
PhylomeDBiP29374
TreeFamiTF106427

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
SIGNORiP29374

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARID4A human
EvolutionaryTraceiP29374

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ARID4A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5926

Protein Ontology

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PROi
PR:P29374

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000032219 Expressed in 221 organ(s), highest expression level in frontal cortex
CleanExiHS_ARID4A
HS_RBP1
ExpressionAtlasiP29374 baseline and differential
GenevisibleiP29374 HS

Family and domain databases

CDDicd00024 CHROMO, 1 hit
Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR012603 RBB1NT
IPR002999 Tudor
IPR025995 Tudor-knot
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF08169 RBB1NT, 1 hit
PF11717 Tudor-knot, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SM00298 CHROMO, 1 hit
SM00333 TUDOR, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
SSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARI4A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29374
Secondary accession number(s): Q15991, Q15992, Q15993
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: September 23, 2008
Last modified: December 5, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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