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Entry version 188 (08 May 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Cellular retinoic acid-binding protein 2

Gene

CRABP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinoic acid binding Source: Ensembl
  • retinoid binding Source: ProtInc
  • retinol binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5362517 Signaling by Retinoic Acid

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P29373

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cellular retinoic acid-binding protein 2
Alternative name(s):
Cellular retinoic acid-binding protein II
Short name:
CRABP-II
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRABP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2339 CRABP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
180231 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P29373

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi21K → A: Loss of ligand-induced nuclear import; when associated with A-30 and A-31. 1 Publication1
Mutagenesisi30R → A: Loss of ligand-induced nuclear import; when associated with A-21 and A-31. 1 Publication1
Mutagenesisi31K → A: Loss of ligand-induced nuclear import; when associated with A-21 and A-30. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1382

Open Targets

More...
OpenTargetsi
ENSG00000143320

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26859

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2221342

Drug and drug target database

More...
DrugBanki
DB00523 Alitretinoin
DB00755 Tretinoin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CRABP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
132401

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000674151 – 138Cellular retinoic acid-binding protein 2Add BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki102Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P29373

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P29373

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P29373

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29373

PeptideAtlas

More...
PeptideAtlasi
P29373

PRoteomics IDEntifications database

More...
PRIDEi
P29373

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54555

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P29373

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P29373

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P29373

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By retinoic acid.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143320 Expressed in 172 organ(s), highest expression level in ectocervix

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P29373 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P29373 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004135

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RXR and RARA (By similarity). Interacts with importin alpha.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107773, 16 interactors

Protein interaction database and analysis system

More...
IntActi
P29373, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000482841

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1138
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BLRNMR-A2-138[»]
1BM5NMR-A2-138[»]
1CBQX-ray2.20A2-138[»]
1CBSX-ray1.80A2-138[»]
1XCAX-ray2.30A/B2-138[»]
2CBSX-ray2.10A2-138[»]
2FR3X-ray1.48A2-138[»]
2FRSX-ray1.51A/B2-138[»]
2FS6X-ray1.35A/B2-138[»]
2FS7X-ray1.55A/B2-138[»]
2G78X-ray1.70A2-138[»]
2G79X-ray1.69A2-138[»]
2G7BX-ray1.18A2-138[»]
3CBSX-ray2.00A2-138[»]
3CR6X-ray1.22A2-138[»]
3CWKX-ray1.60A2-138[»]
3D95X-ray1.20A/B2-138[»]
3D96X-ray1.71A/B2-138[»]
3D97X-ray1.50A/B2-138[»]
3F8AX-ray1.95A2-138[»]
3F9DX-ray2.00A/B2-138[»]
3FA6X-ray1.54A/B2-138[»]
3FA7X-ray1.90A/B2-138[»]
3FA8X-ray1.78A/B2-138[»]
3FA9X-ray1.94A/B2-138[»]
3FEKX-ray1.51A/B2-138[»]
3FELX-ray1.85A/B2-138[»]
3FENX-ray1.56A/B2-138[»]
3FEPX-ray2.60A2-138[»]
3I17X-ray1.68A/B2-138[»]
4I9RX-ray2.60A2-138[»]
4I9SX-ray2.58A2-138[»]
4M6SX-ray2.47A2-138[»]
4M7MX-ray2.57A2-138[»]
4QGVX-ray1.73A/B2-138[»]
4QGWX-ray1.77A/B2-138[»]
4QGXX-ray1.47A/B2-138[»]
4YBPX-ray1.83A2-138[»]
4YBUX-ray1.92A2-138[»]
4YCEX-ray1.95A2-138[»]
4YCHX-ray1.96A2-138[»]
4YDAX-ray1.95A2-138[»]
4YDBX-ray2.03A2-138[»]
4YFPX-ray1.95A2-138[»]
4YFQX-ray1.62A2-138[»]
4YFRX-ray1.95A2-138[»]
4YGGX-ray1.90A2-138[»]
4YGHX-ray2.10A2-138[»]
4YGZX-ray2.06A2-138[»]
4YH0X-ray2.14A2-138[»]
4YKMX-ray1.58A/B2-138[»]
4YKOX-ray1.57A/B2-138[»]
5HZQX-ray1.75A/B1-138[»]
5OGBX-ray1.80A1-138[»]
6HKRX-ray1.50A1-138[»]
6MOPX-ray1.90A2-138[»]
6MOQX-ray2.20A2-138[»]
6MORX-ray1.79A2-138[»]
6MOVX-ray1.75A2-138[»]
6MOXX-ray2.18A2-138[»]
6MPKX-ray1.58A2-138[»]
6MQIX-ray1.87A2-138[»]
6MQJX-ray2.12A2-138[»]
6MQWX-ray2.09A2-138[»]
6MQXX-ray2.01A2-138[»]
6MQYX-ray1.90A2-138[»]
6MQZX-ray2.07A2-138[»]
6MR0X-ray2.65A2-138[»]
6NNXX-ray1.87A2-138[»]
6NNYX-ray1.67A2-138[»]
6NOEX-ray1.97A2-138[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P29373

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P29373

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni133 – 135Retinoic acid binding3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi21 – 31Nuclear localization signalAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4015 Eukaryota
ENOG4111US8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157619

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000004831

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P29373

KEGG Orthology (KO)

More...
KOi
K17289

Identification of Orthologs from Complete Genome Data

More...
OMAi
WEMKSSE

Database of Orthologous Groups

More...
OrthoDBi
1443155at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P29373

TreeFam database of animal gene trees

More...
TreeFami
TF316894

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.128.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012674 Calycin
IPR031281 CRABP2
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11955 PTHR11955, 1 hit
PTHR11955:SF60 PTHR11955:SF60, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00061 Lipocalin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00178 FATTYACIDBP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50814 SSF50814, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00214 FABP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P29373-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNFSGNWKI IRSENFEELL KVLGVNVMLR KIAVAAASKP AVEIKQEGDT
60 70 80 90 100
FYIKTSTTVR TTEINFKVGE EFEEQTVDGR PCKSLVKWES ENKMVCEQKL
110 120 130
LKGEGPKTSW TRELTNDGEL ILTMTADDVV CTRVYVRE
Length:138
Mass (Da):15,693
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i982833700775B377
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SYZ4Q5SYZ4_HUMAN
Cellular retinoic acid-binding prot...
CRABP2
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M68867 mRNA Translation: AAA52068.1
M97815, M97814 Genomic DNA Translation: AAA58430.1
CR450357 mRNA Translation: CAG29353.1
BT019827 mRNA Translation: AAV38630.1
AK312007 mRNA Translation: BAG34945.1
AB593017 mRNA Translation: BAJ83972.1
AL590666 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52921.1
CH471121 Genomic DNA Translation: EAW52922.1
BC001109 mRNA Translation: AAH01109.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1152.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A45057 RJHU2

NCBI Reference Sequences

More...
RefSeqi
NP_001186652.1, NM_001199723.1
NP_001869.1, NM_001878.3
XP_016855832.1, XM_017000343.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368221; ENSP00000357204; ENSG00000143320
ENST00000368222; ENSP00000357205; ENSG00000143320
ENST00000621784; ENSP00000482841; ENSG00000143320

Database of genes from NCBI RefSeq genomes

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GeneIDi
1382

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1382

UCSC genome browser

More...
UCSCi
uc001fpr.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68867 mRNA Translation: AAA52068.1
M97815, M97814 Genomic DNA Translation: AAA58430.1
CR450357 mRNA Translation: CAG29353.1
BT019827 mRNA Translation: AAV38630.1
AK312007 mRNA Translation: BAG34945.1
AB593017 mRNA Translation: BAJ83972.1
AL590666 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52921.1
CH471121 Genomic DNA Translation: EAW52922.1
BC001109 mRNA Translation: AAH01109.1
CCDSiCCDS1152.1
PIRiA45057 RJHU2
RefSeqiNP_001186652.1, NM_001199723.1
NP_001869.1, NM_001878.3
XP_016855832.1, XM_017000343.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BLRNMR-A2-138[»]
1BM5NMR-A2-138[»]
1CBQX-ray2.20A2-138[»]
1CBSX-ray1.80A2-138[»]
1XCAX-ray2.30A/B2-138[»]
2CBSX-ray2.10A2-138[»]
2FR3X-ray1.48A2-138[»]
2FRSX-ray1.51A/B2-138[»]
2FS6X-ray1.35A/B2-138[»]
2FS7X-ray1.55A/B2-138[»]
2G78X-ray1.70A2-138[»]
2G79X-ray1.69A2-138[»]
2G7BX-ray1.18A2-138[»]
3CBSX-ray2.00A2-138[»]
3CR6X-ray1.22A2-138[»]
3CWKX-ray1.60A2-138[»]
3D95X-ray1.20A/B2-138[»]
3D96X-ray1.71A/B2-138[»]
3D97X-ray1.50A/B2-138[»]
3F8AX-ray1.95A2-138[»]
3F9DX-ray2.00A/B2-138[»]
3FA6X-ray1.54A/B2-138[»]
3FA7X-ray1.90A/B2-138[»]
3FA8X-ray1.78A/B2-138[»]
3FA9X-ray1.94A/B2-138[»]
3FEKX-ray1.51A/B2-138[»]
3FELX-ray1.85A/B2-138[»]
3FENX-ray1.56A/B2-138[»]
3FEPX-ray2.60A2-138[»]
3I17X-ray1.68A/B2-138[»]
4I9RX-ray2.60A2-138[»]
4I9SX-ray2.58A2-138[»]
4M6SX-ray2.47A2-138[»]
4M7MX-ray2.57A2-138[»]
4QGVX-ray1.73A/B2-138[»]
4QGWX-ray1.77A/B2-138[»]
4QGXX-ray1.47A/B2-138[»]
4YBPX-ray1.83A2-138[»]
4YBUX-ray1.92A2-138[»]
4YCEX-ray1.95A2-138[»]
4YCHX-ray1.96A2-138[»]
4YDAX-ray1.95A2-138[»]
4YDBX-ray2.03A2-138[»]
4YFPX-ray1.95A2-138[»]
4YFQX-ray1.62A2-138[»]
4YFRX-ray1.95A2-138[»]
4YGGX-ray1.90A2-138[»]
4YGHX-ray2.10A2-138[»]
4YGZX-ray2.06A2-138[»]
4YH0X-ray2.14A2-138[»]
4YKMX-ray1.58A/B2-138[»]
4YKOX-ray1.57A/B2-138[»]
5HZQX-ray1.75A/B1-138[»]
5OGBX-ray1.80A1-138[»]
6HKRX-ray1.50A1-138[»]
6MOPX-ray1.90A2-138[»]
6MOQX-ray2.20A2-138[»]
6MORX-ray1.79A2-138[»]
6MOVX-ray1.75A2-138[»]
6MOXX-ray2.18A2-138[»]
6MPKX-ray1.58A2-138[»]
6MQIX-ray1.87A2-138[»]
6MQJX-ray2.12A2-138[»]
6MQWX-ray2.09A2-138[»]
6MQXX-ray2.01A2-138[»]
6MQYX-ray1.90A2-138[»]
6MQZX-ray2.07A2-138[»]
6MR0X-ray2.65A2-138[»]
6NNXX-ray1.87A2-138[»]
6NNYX-ray1.67A2-138[»]
6NOEX-ray1.97A2-138[»]
SMRiP29373
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107773, 16 interactors
IntActiP29373, 4 interactors
STRINGi9606.ENSP00000482841

Chemistry databases

ChEMBLiCHEMBL2221342
DrugBankiDB00523 Alitretinoin
DB00755 Tretinoin

PTM databases

iPTMnetiP29373
PhosphoSitePlusiP29373

Polymorphism and mutation databases

BioMutaiCRABP2
DMDMi132401

2D gel databases

DOSAC-COBS-2DPAGEiP29373

Proteomic databases

EPDiP29373
jPOSTiP29373
MaxQBiP29373
PaxDbiP29373
PeptideAtlasiP29373
PRIDEiP29373
ProteomicsDBi54555

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1382
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368221; ENSP00000357204; ENSG00000143320
ENST00000368222; ENSP00000357205; ENSG00000143320
ENST00000621784; ENSP00000482841; ENSG00000143320
GeneIDi1382
KEGGihsa:1382
UCSCiuc001fpr.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1382
DisGeNETi1382

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CRABP2
HGNCiHGNC:2339 CRABP2
HPAiHPA004135
MIMi180231 gene
neXtProtiNX_P29373
OpenTargetsiENSG00000143320
PharmGKBiPA26859

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00940000157619
HOGENOMiHOG000004831
InParanoidiP29373
KOiK17289
OMAiWEMKSSE
OrthoDBi1443155at2759
PhylomeDBiP29373
TreeFamiTF316894

Enzyme and pathway databases

ReactomeiR-HSA-5362517 Signaling by Retinoic Acid
SIGNORiP29373

Miscellaneous databases

EvolutionaryTraceiP29373

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CRABP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1382

Protein Ontology

More...
PROi
PR:P29373

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143320 Expressed in 172 organ(s), highest expression level in ectocervix
ExpressionAtlasiP29373 baseline and differential
GenevisibleiP29373 HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR031281 CRABP2
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF60 PTHR11955:SF60, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRABP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29373
Secondary accession number(s): B2R4Z8
, D3DVC5, F1T098, Q6ICN6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: May 8, 2019
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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