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Protein

Cellular retinoic acid-binding protein 2

Gene

CRABP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinoic acid binding Source: Ensembl
  • retinoid binding Source: ProtInc
  • retinol binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiR-HSA-5362517 Signaling by Retinoic Acid
SIGNORiP29373

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular retinoic acid-binding protein 2
Alternative name(s):
Cellular retinoic acid-binding protein II
Short name:
CRABP-II
Gene namesi
Name:CRABP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143320.8
HGNCiHGNC:2339 CRABP2
MIMi180231 gene
neXtProtiNX_P29373

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi21K → A: Loss of ligand-induced nuclear import; when associated with A-30 and A-31. 1 Publication1
Mutagenesisi30R → A: Loss of ligand-induced nuclear import; when associated with A-21 and A-31. 1 Publication1
Mutagenesisi31K → A: Loss of ligand-induced nuclear import; when associated with A-21 and A-30. 1 Publication1

Organism-specific databases

DisGeNETi1382
OpenTargetsiENSG00000143320
PharmGKBiPA26859

Chemistry databases

ChEMBLiCHEMBL2221342
DrugBankiDB00523 Alitretinoin
DB00755 Tretinoin

Polymorphism and mutation databases

BioMutaiCRABP2
DMDMi132401

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674151 – 138Cellular retinoic acid-binding protein 2Add BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki102Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication

Post-translational modificationi

Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP29373
MaxQBiP29373
PaxDbiP29373
PeptideAtlasiP29373
PRIDEiP29373
ProteomicsDBi54555

2D gel databases

DOSAC-COBS-2DPAGEiP29373

PTM databases

iPTMnetiP29373
PhosphoSitePlusiP29373

Expressioni

Inductioni

By retinoic acid.

Gene expression databases

BgeeiENSG00000143320 Expressed in 172 organ(s), highest expression level in ectocervix
CleanExiHS_CRABP2
ExpressionAtlasiP29373 baseline and differential
GenevisibleiP29373 HS

Organism-specific databases

HPAiHPA004135

Interactioni

Subunit structurei

Interacts with RXR and RARA (By similarity). Interacts with importin alpha.By similarity2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi107773, 13 interactors
IntActiP29373, 4 interactors
STRINGi9606.ENSP00000357204

Structurei

Secondary structure

1138
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP29373
SMRiP29373
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29373

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 135Retinoic acid binding3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi21 – 31Nuclear localization signalAdd BLAST11

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004831
HOVERGENiHBG005633
InParanoidiP29373
KOiK17289
OMAiNMMLRKI
OrthoDBiEOG091G0QSV
PhylomeDBiP29373
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR031281 CRABP2
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF60 PTHR11955:SF60, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P29373-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNFSGNWKI IRSENFEELL KVLGVNVMLR KIAVAAASKP AVEIKQEGDT
60 70 80 90 100
FYIKTSTTVR TTEINFKVGE EFEEQTVDGR PCKSLVKWES ENKMVCEQKL
110 120 130
LKGEGPKTSW TRELTNDGEL ILTMTADDVV CTRVYVRE
Length:138
Mass (Da):15,693
Last modified:January 23, 2007 - v2
Checksum:i982833700775B377
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SYZ4Q5SYZ4_HUMAN
Cellular retinoic acid-binding prot...
CRABP2
82Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68867 mRNA Translation: AAA52068.1
M97815, M97814 Genomic DNA Translation: AAA58430.1
CR450357 mRNA Translation: CAG29353.1
BT019827 mRNA Translation: AAV38630.1
AK312007 mRNA Translation: BAG34945.1
AB593017 mRNA Translation: BAJ83972.1
AL590666 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52921.1
CH471121 Genomic DNA Translation: EAW52922.1
BC001109 mRNA Translation: AAH01109.1
CCDSiCCDS1152.1
PIRiA45057 RJHU2
RefSeqiNP_001186652.1, NM_001199723.1
NP_001869.1, NM_001878.3
XP_016855832.1, XM_017000343.1
UniGeneiHs.405662

Genome annotation databases

EnsembliENST00000368221; ENSP00000357204; ENSG00000143320
ENST00000368222; ENSP00000357205; ENSG00000143320
ENST00000621784; ENSP00000482841; ENSG00000143320
GeneIDi1382
KEGGihsa:1382
UCSCiuc001fpr.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68867 mRNA Translation: AAA52068.1
M97815, M97814 Genomic DNA Translation: AAA58430.1
CR450357 mRNA Translation: CAG29353.1
BT019827 mRNA Translation: AAV38630.1
AK312007 mRNA Translation: BAG34945.1
AB593017 mRNA Translation: BAJ83972.1
AL590666 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52921.1
CH471121 Genomic DNA Translation: EAW52922.1
BC001109 mRNA Translation: AAH01109.1
CCDSiCCDS1152.1
PIRiA45057 RJHU2
RefSeqiNP_001186652.1, NM_001199723.1
NP_001869.1, NM_001878.3
XP_016855832.1, XM_017000343.1
UniGeneiHs.405662

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BLRNMR-A2-138[»]
1BM5NMR-A2-138[»]
1CBQX-ray2.20A2-138[»]
1CBSX-ray1.80A2-138[»]
1XCAX-ray2.30A/B2-138[»]
2CBSX-ray2.10A2-138[»]
2FR3X-ray1.48A2-138[»]
2FRSX-ray1.51A/B2-138[»]
2FS6X-ray1.35A/B2-138[»]
2FS7X-ray1.55A/B2-138[»]
2G78X-ray1.70A2-138[»]
2G79X-ray1.69A2-138[»]
2G7BX-ray1.18A2-138[»]
3CBSX-ray2.00A2-138[»]
3CR6X-ray1.22A2-138[»]
3CWKX-ray1.60A2-138[»]
3D95X-ray1.20A/B2-138[»]
3D96X-ray1.71A/B2-138[»]
3D97X-ray1.50A/B2-138[»]
3F8AX-ray1.95A2-138[»]
3F9DX-ray2.00A/B2-138[»]
3FA6X-ray1.54A/B2-138[»]
3FA7X-ray1.90A/B2-138[»]
3FA8X-ray1.78A/B2-138[»]
3FA9X-ray1.94A/B2-138[»]
3FEKX-ray1.51A/B2-138[»]
3FELX-ray1.85A/B2-138[»]
3FENX-ray1.56A/B2-138[»]
3FEPX-ray2.60A2-138[»]
3I17X-ray1.68A/B2-138[»]
4I9RX-ray2.60A2-138[»]
4I9SX-ray2.58A2-138[»]
4M6SX-ray2.47A2-138[»]
4M7MX-ray2.57A2-138[»]
4QGVX-ray1.73A/B2-138[»]
4QGWX-ray1.77A/B2-138[»]
4QGXX-ray1.47A/B2-138[»]
4YBPX-ray1.83A2-138[»]
4YBUX-ray1.92A2-138[»]
4YCEX-ray1.95A2-138[»]
4YCHX-ray1.96A2-138[»]
4YDAX-ray1.95A2-138[»]
4YDBX-ray2.03A2-138[»]
4YFPX-ray1.95A2-138[»]
4YFQX-ray1.62A2-138[»]
4YFRX-ray1.95A2-138[»]
4YGGX-ray1.90A2-138[»]
4YGHX-ray2.10A2-138[»]
4YGZX-ray2.06A2-138[»]
4YH0X-ray2.14A2-138[»]
4YKMX-ray1.58A/B2-138[»]
4YKOX-ray1.57A/B2-138[»]
5HZQX-ray1.75A/B1-138[»]
ProteinModelPortaliP29373
SMRiP29373
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107773, 13 interactors
IntActiP29373, 4 interactors
STRINGi9606.ENSP00000357204

Chemistry databases

ChEMBLiCHEMBL2221342
DrugBankiDB00523 Alitretinoin
DB00755 Tretinoin

PTM databases

iPTMnetiP29373
PhosphoSitePlusiP29373

Polymorphism and mutation databases

BioMutaiCRABP2
DMDMi132401

2D gel databases

DOSAC-COBS-2DPAGEiP29373

Proteomic databases

EPDiP29373
MaxQBiP29373
PaxDbiP29373
PeptideAtlasiP29373
PRIDEiP29373
ProteomicsDBi54555

Protocols and materials databases

DNASUi1382
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368221; ENSP00000357204; ENSG00000143320
ENST00000368222; ENSP00000357205; ENSG00000143320
ENST00000621784; ENSP00000482841; ENSG00000143320
GeneIDi1382
KEGGihsa:1382
UCSCiuc001fpr.4 human

Organism-specific databases

CTDi1382
DisGeNETi1382
EuPathDBiHostDB:ENSG00000143320.8
GeneCardsiCRABP2
HGNCiHGNC:2339 CRABP2
HPAiHPA004135
MIMi180231 gene
neXtProtiNX_P29373
OpenTargetsiENSG00000143320
PharmGKBiPA26859
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004831
HOVERGENiHBG005633
InParanoidiP29373
KOiK17289
OMAiNMMLRKI
OrthoDBiEOG091G0QSV
PhylomeDBiP29373
TreeFamiTF316894

Enzyme and pathway databases

ReactomeiR-HSA-5362517 Signaling by Retinoic Acid
SIGNORiP29373

Miscellaneous databases

EvolutionaryTraceiP29373
GeneWikiiCRABP2
GenomeRNAii1382
PROiPR:P29373
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143320 Expressed in 172 organ(s), highest expression level in ectocervix
CleanExiHS_CRABP2
ExpressionAtlasiP29373 baseline and differential
GenevisibleiP29373 HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR031281 CRABP2
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF60 PTHR11955:SF60, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRABP2_HUMAN
AccessioniPrimary (citable) accession number: P29373
Secondary accession number(s): B2R4Z8
, D3DVC5, F1T098, Q6ICN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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