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Entry version 209 (16 Oct 2019)
Sequence version 3 (23 Sep 2008)
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Protein

DNA-3-methyladenine glycosylase

Gene

MPG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine. EC:3.2.2.21

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Binding to SSBP1 in mitochondria inhibits glycosylase activity in the context of a single-stranded DNA (ssDNA), but not a double-stranded DNA (dsDNA) substrates.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.2.21 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110331 Cleavage of the damaged purine
R-HSA-110357 Displacement of DNA glycosylase by APEX1

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P29372

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-3-methyladenine glycosylase (EC:3.2.2.21)
Alternative name(s):
3-alkyladenine DNA glycosylase
3-methyladenine DNA glycosidase
ADPG
N-methylpurine-DNA glycosylase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MPG
Synonyms:AAG, ANPG, MID1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:7211 MPG

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
156565 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P29372

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Mitochondrion nucleoid, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4350

Open Targets

More...
OpenTargetsi
ENSG00000103152

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30917

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P29372

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3396943

Drug and drug target database

More...
DrugBanki
DB00515 Cisplatin
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

DrugCentral

More...
DrugCentrali
P29372

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MPG

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 17MitochondrionSequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000010006518 – 298DNA-3-methyladenine glycosylaseAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei78PhosphoserineCombined sources1
Modified residuei252PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P29372

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P29372

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P29372

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29372

PeptideAtlas

More...
PeptideAtlasi
P29372

PRoteomics IDEntifications database

More...
PRIDEi
P29372

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
33913
54553 [P29372-1]
54554 [P29372-2]
62987

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P29372-1 [P29372-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P29372

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P29372

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P29372

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000103152 Expressed in 222 organ(s), highest expression level in tibial artery

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P29372 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P29372 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006531

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds MBD1. Binds SSBP1.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110490, 75 interactors

Protein interaction database and analysis system

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IntActi
P29372, 22 interactors

Molecular INTeraction database

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MINTi
P29372

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000219431

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P29372

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P29372

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P29372

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA glycosylase MPG family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4486 Eukaryota
COG2094 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009825

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000224224

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P29372

KEGG Orthology (KO)

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KOi
K03652

Identification of Orthologs from Complete Genome Data

More...
OMAi
VEAYHHT

Database of Orthologous Groups

More...
OrthoDBi
1500650at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P29372

TreeFam database of animal gene trees

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TreeFami
TF331768

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00540 AAG, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.10.300.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00527 3MGH, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011034 Formyl_transferase-like_C_sf
IPR003180 MPG
IPR036995 MPG_sf

The PANTHER Classification System

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PANTHERi
PTHR10429 PTHR10429, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02245 Pur_DNA_glyco, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50486 SSF50486, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00567 3mg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P29372-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVTPALQMKK PKQFCRRMGQ KKQRPARAGQ PHSSSDAAQA PAEQPHSSSD
60 70 80 90 100
AAQAPCPRER CLGPPTTPGP YRSIYFSSPK GHLTRLGLEF FDQPAVPLAR
110 120 130 140 150
AFLGQVLVRR LPNGTELRGR IVETEAYLGP EDEAAHSRGG RQTPRNRGMF
160 170 180 190 200
MKPGTLYVYI IYGMYFCMNI SSQGDGACVL LRALEPLEGL ETMRQLRSTL
210 220 230 240 250
RKGTASRVLK DRELCSGPSK LCQALAINKS FDQRDLAQDE AVWLERGPLE
260 270 280 290
PSEPAVVAAA RVGVGHAGEW ARKPLRFYVR GSPWVSVVDR VAEQDTQA
Length:298
Mass (Da):32,869
Last modified:September 23, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBEA8C4CB250D572B
GO
Isoform 2 (identifier: P29372-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MVTPALQMKKPK → MPARSGA
     195-196: QL → HV

Show »
Length:293
Mass (Da):32,181
Checksum:i81BE31859298D43C
GO
Isoform 3 (identifier: P29372-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MVTPALQMKKPK → MPARSGA

Show »
Length:293
Mass (Da):32,186
Checksum:i6F710D76409B2D81
GO
Isoform 4 (identifier: P29372-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.

Note: Gene prediction based on EST data.
Show »
Length:281
Mass (Da):30,824
Checksum:i6826A6C692AABA9C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2IDA3A2IDA3_HUMAN
DNA-3-methyladenine glycosylase
MPG Z69720.1-004
251Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13Q → QV in AAK61213 (PubMed:11157797).Curated1
Sequence conflicti29 – 31GQP → ARA in AAB19537 (PubMed:1874728).Curated3
Sequence conflicti44Q → R in AAB19537 (PubMed:1874728).Curated1
Sequence conflicti69 – 71GPY → SKD in AAA58369 (PubMed:1645538).Curated3
Sequence conflicti69 – 71GPY → SKD in CAA39875 (PubMed:1645538).Curated3
Sequence conflicti82H → L in AAA58369 (PubMed:1645538).Curated1
Sequence conflicti82H → L in CAA39875 (PubMed:1645538).Curated1
Sequence conflicti134A → P in AAA58627 (PubMed:1924375).Curated1
Sequence conflicti287V → E in AAA58369 (PubMed:1645538).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01913822K → Q1 PublicationCorresponds to variant dbSNP:rs3176383Ensembl.1
Natural variantiVAR_01483164P → L. Corresponds to variant dbSNP:rs2308315Ensembl.1
Natural variantiVAR_01483271Y → H1 PublicationCorresponds to variant dbSNP:rs2266607Ensembl.1
Natural variantiVAR_05009693Q → R. Corresponds to variant dbSNP:rs25671Ensembl.1
Natural variantiVAR_014833120R → C. Corresponds to variant dbSNP:rs2308313Ensembl.1
Natural variantiVAR_014834141R → Q. Corresponds to variant dbSNP:rs2308312Ensembl.1
Natural variantiVAR_014835258A → V1 PublicationCorresponds to variant dbSNP:rs769193Ensembl.1
Natural variantiVAR_014836298A → S1 PublicationCorresponds to variant dbSNP:rs2234949Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0466781 – 17Missing in isoform 4. CuratedAdd BLAST17
Alternative sequenceiVSP_0032491 – 12MVTPA…MKKPK → MPARSGA in isoform 2 and isoform 3. 3 PublicationsAdd BLAST12
Alternative sequenceiVSP_035485195 – 196QL → HV in isoform 2. 2 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M74905 mRNA Translation: AAA58627.1
L10752 mRNA Translation: AAF77073.1
AY258284 mRNA Translation: AAP82229.1
AY305873 mRNA Translation: AAQ95215.1
AF499437 Genomic DNA Translation: AAM14628.1
AE006462 Genomic DNA Translation: AAK61213.1
Z69720 Genomic DNA Translation: CAA93540.1
Z69720 Genomic DNA Translation: CAI95610.1
CH471112 Genomic DNA Translation: EAW85871.1
BC014991 mRNA Translation: AAH14991.1
S51033 mRNA Translation: AAB19537.1
X56528 mRNA Translation: CAA39875.1
M71215 mRNA Translation: AAA58369.1
M99626 mRNA Translation: AAB46421.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32345.1 [P29372-4]
CCDS32346.1 [P29372-1]
CCDS42087.1 [P29372-5]

Protein sequence database of the Protein Information Resource

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PIRi
A40798
A41230
A47471
JN0062

NCBI Reference Sequences

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RefSeqi
NP_001015052.1, NM_001015052.2 [P29372-4]
NP_001015054.1, NM_001015054.2 [P29372-5]
NP_002425.2, NM_002434.3 [P29372-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000219431; ENSP00000219431; ENSG00000103152 [P29372-1]
ENST00000356432; ENSP00000348809; ENSG00000103152 [P29372-4]
ENST00000397817; ENSP00000380918; ENSG00000103152 [P29372-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4350

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4350

UCSC genome browser

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UCSCi
uc002cfm.4 human [P29372-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74905 mRNA Translation: AAA58627.1
L10752 mRNA Translation: AAF77073.1
AY258284 mRNA Translation: AAP82229.1
AY305873 mRNA Translation: AAQ95215.1
AF499437 Genomic DNA Translation: AAM14628.1
AE006462 Genomic DNA Translation: AAK61213.1
Z69720 Genomic DNA Translation: CAA93540.1
Z69720 Genomic DNA Translation: CAI95610.1
CH471112 Genomic DNA Translation: EAW85871.1
BC014991 mRNA Translation: AAH14991.1
S51033 mRNA Translation: AAB19537.1
X56528 mRNA Translation: CAA39875.1
M71215 mRNA Translation: AAA58369.1
M99626 mRNA Translation: AAB46421.1
CCDSiCCDS32345.1 [P29372-4]
CCDS32346.1 [P29372-1]
CCDS42087.1 [P29372-5]
PIRiA40798
A41230
A47471
JN0062
RefSeqiNP_001015052.1, NM_001015052.2 [P29372-4]
NP_001015054.1, NM_001015054.2 [P29372-5]
NP_002425.2, NM_002434.3 [P29372-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BNKX-ray2.70A80-295[»]
1EWNX-ray2.10A80-298[»]
1F4RX-ray2.40A80-298[»]
1F6OX-ray2.40A80-298[»]
3QI5X-ray2.20A/B84-298[»]
3UBYX-ray2.00A/B84-298[»]
SMRiP29372
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110490, 75 interactors
IntActiP29372, 22 interactors
MINTiP29372
STRINGi9606.ENSP00000219431

Chemistry databases

BindingDBiP29372
ChEMBLiCHEMBL3396943
DrugBankiDB00515 Cisplatin
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride
DrugCentraliP29372

PTM databases

iPTMnetiP29372
PhosphoSitePlusiP29372
SwissPalmiP29372

Polymorphism and mutation databases

BioMutaiMPG

Proteomic databases

EPDiP29372
jPOSTiP29372
MassIVEiP29372
PaxDbiP29372
PeptideAtlasiP29372
PRIDEiP29372
ProteomicsDBi33913
54553 [P29372-1]
54554 [P29372-2]
62987
TopDownProteomicsiP29372-1 [P29372-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4350

Genome annotation databases

EnsembliENST00000219431; ENSP00000219431; ENSG00000103152 [P29372-1]
ENST00000356432; ENSP00000348809; ENSG00000103152 [P29372-4]
ENST00000397817; ENSP00000380918; ENSG00000103152 [P29372-5]
GeneIDi4350
KEGGihsa:4350
UCSCiuc002cfm.4 human [P29372-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4350
DisGeNETi4350

GeneCards: human genes, protein and diseases

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GeneCardsi
MPG
HGNCiHGNC:7211 MPG
HPAiHPA006531
MIMi156565 gene
neXtProtiNX_P29372
OpenTargetsiENSG00000103152
PharmGKBiPA30917

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4486 Eukaryota
COG2094 LUCA
GeneTreeiENSGT00390000009825
HOGENOMiHOG000224224
InParanoidiP29372
KOiK03652
OMAiVEAYHHT
OrthoDBi1500650at2759
PhylomeDBiP29372
TreeFamiTF331768

Enzyme and pathway databases

BRENDAi3.2.2.21 2681
ReactomeiR-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110331 Cleavage of the damaged purine
R-HSA-110357 Displacement of DNA glycosylase by APEX1
SABIO-RKiP29372

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MPG human
EvolutionaryTraceiP29372

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MPG_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4350
PharosiP29372

Protein Ontology

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PROi
PR:P29372

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103152 Expressed in 222 organ(s), highest expression level in tibial artery
ExpressionAtlasiP29372 baseline and differential
GenevisibleiP29372 HS

Family and domain databases

CDDicd00540 AAG, 1 hit
Gene3Di3.10.300.10, 1 hit
HAMAPiMF_00527 3MGH, 1 hit
InterProiView protein in InterPro
IPR011034 Formyl_transferase-like_C_sf
IPR003180 MPG
IPR036995 MPG_sf
PANTHERiPTHR10429 PTHR10429, 1 hit
PfamiView protein in Pfam
PF02245 Pur_DNA_glyco, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
TIGRFAMsiTIGR00567 3mg, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei3MG_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29372
Secondary accession number(s): G5E9E2
, Q13770, Q15275, Q15961, Q5J9I4, Q96BZ6, Q96S33, Q9NNX5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: September 23, 2008
Last modified: October 16, 2019
This is version 209 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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