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UniProtKB - P29371 (NK3R_HUMAN)

Entry version 173 (29 Sep 2021)
Sequence version 1 (01 Dec 1992)
Previous versions | rss
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Protein

Neuromedin-K receptor

Gene

TACR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P29371

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-380095, Tachykinin receptors bind tachykinins
R-HSA-416476, G alpha (q) signalling events

SIGNOR Signaling Network Open Resource

More...SIGNORi		P29371

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuromedin-K receptor
Short name:
NKR
Alternative name(s):
NK-3 receptor
Short name:
NK-3R
Neurokinin B receptor
Tachykinin receptor 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TACR3
Synonyms:NK3R, TAC3R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11528, TACR3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		162332, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P29371

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000169836

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 84ExtracellularSequence analysisAdd BLAST84
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei85 – 107Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini108 – 117CytoplasmicSequence analysis10
Transmembranei118 – 139Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini140 – 159ExtracellularSequence analysisAdd BLAST20
Transmembranei160 – 181Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini182 – 201CytoplasmicSequence analysisAdd BLAST20
Transmembranei202 – 222Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini223 – 245ExtracellularSequence analysisAdd BLAST23
Transmembranei246 – 270Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini271 – 299CytoplasmicSequence analysisAdd BLAST29
Transmembranei300 – 321Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini322 – 334ExtracellularSequence analysisAdd BLAST13
Transmembranei335 – 359Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini360 – 465CytoplasmicSequence analysisAdd BLAST106

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypogonadotropic hypogonadism 11 with or without anosmia (HH11)3 Publications
The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in TACR3 as well as in other HH-associated genes including FGFR1, SPRY4 and KAL1 (PubMed:23643382).1 Publication
Disease descriptionA disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06917793G → D in HH11; unequivocal evidence of impaired receptor signaling. 1 PublicationCorresponds to variant dbSNP:rs121918124EnsemblClinVar.1
Natural variantiVAR_072976137F → V in HH11. 1 Publication1
Natural variantiVAR_072977346M → V in HH11. 1 PublicationCorresponds to variant dbSNP:rs200148989Ensembl.1
Natural variantiVAR_069178353P → S in HH11; unequivocal evidence of impaired receptor signaling. 1 PublicationCorresponds to variant dbSNP:rs121918125EnsemblClinVar.1
Natural variantiVAR_069963364R → Q in HH11; the patient also carries a mutation in FGFR1. 1 PublicationCorresponds to variant dbSNP:rs150288991Ensembl.1

Keywords - Diseasei

Disease variant, Hypogonadotropic hypogonadism

Organism-specific databases

DisGeNET

More...DisGeNETi		6870

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		TACR3

MalaCards human disease database

More...MalaCardsi		TACR3
MIMi614840, phenotype

Open Targets

More...OpenTargetsi		ENSG00000169836

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		478, Kallmann syndrome
432, Normosmic congenital hypogonadotropic hypogonadism

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36304

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P29371, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4429

Drug and drug target database

More...DrugBanki		DB04872, Osanetant
DB11692, Pavinetant
DB06429, Talnetant

DrugCentral

More...DrugCentrali		P29371

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		362

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TACR3

Domain mapping of disease mutations (DMDM)

More...DMDMi		128364

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000698991 – 465Neuromedin-K receptorAdd BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi158 ↔ 233PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi374S-palmitoyl cysteineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P29371

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P29371

PeptideAtlas

More...PeptideAtlasi		P29371

PRoteomics IDEntifications database

More...PRIDEi		P29371

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54552

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P29371

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P29371, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P29371

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P29371

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000169836, Expressed in calcaneal tendon and 30 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P29371, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000169836, Tissue enhanced (brain, urinary bladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112733, 72 interactors

Protein interaction database and analysis system

More...IntActi		P29371, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000303325

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P29371

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P29371, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P29371

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni415 – 465DisorderedSequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi436 – 465Polar residuesSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4219, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153745

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_6_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P29371

Identification of Orthologs from Complete Genome Data

More...OMAi		PQCLYSI

Database of Orthologous Groups

More...OrthoDBi		715197at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P29371

TreeFam database of animal gene trees

More...TreeFami		TF315303

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR001681, Neurokn_rcpt
IPR001013, NK3_rcpt

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN
PR01026, NEUROKININ3R
PR00244, NEUROKININR

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P29371-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLPAAETW IDGGGGVGAD AVNLTASLAA GAATGAVETG WLQLLDQAGN 
        60         70         80         90        100
LSSSPSALGL PVASPAPSQP WANLTNQFVQ PSWRIALWSL AYGVVVAVAV 
       110        120        130        140        150
LGNLIVIWII LAHKRMRTVT NYFLVNLAFS DASMAAFNTL VNFIYALHSE 
       160        170        180        190        200
WYFGANYCRF QNFFPITAVF ASIYSMTAIA VDRYMAIIDP LKPRLSATAT 
       210        220        230        240        250
KIVIGSIWIL AFLLAFPQCL YSKTKVMPGR TLCFVQWPEG PKQHFTYHII 
       260        270        280        290        300
VIILVYCFPL LIMGITYTIV GITLWGGEIP GDTCDKYHEQ LKAKRKVVKM 
       310        320        330        340        350
MIIVVMTFAI CWLPYHIYFI LTAIYQQLNR WKYIQQVYLA SFWLAMSSTM 
       360        370        380        390        400
YNPIIYCCLN KRFRAGFKRA FRWCPFIKVS SYDELELKTT RFHPNRQSSM 
       410        420        430        440        450
YTVTRMESMT VVFDPNDADT TRSSRKKRAT PRDPSFNGCS RRNSKSASAT 
       460 
SSFISSPYTS VDEYS
Length:465
Mass (Da):52,202
Last modified:December 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98E88D4BC9DBD315
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3T → I in AAB21706 (PubMed:1312036).Curated1
Sequence conflicti63A → R in AAB21706 (PubMed:1312036).Curated1
Sequence conflicti439C → F in CAA46291 (PubMed:1312928).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06917793G → D in HH11; unequivocal evidence of impaired receptor signaling. 1 PublicationCorresponds to variant dbSNP:rs121918124EnsemblClinVar.1
Natural variantiVAR_072976137F → V in HH11. 1 Publication1
Natural variantiVAR_049422286K → R May contribute to hypogonadotropic hypogonadism in patients carrying disease-causing mutations in FGFR1. 1 PublicationCorresponds to variant dbSNP:rs2276973EnsemblClinVar.1
Natural variantiVAR_072977346M → V in HH11. 1 PublicationCorresponds to variant dbSNP:rs200148989Ensembl.1
Natural variantiVAR_069178353P → S in HH11; unequivocal evidence of impaired receptor signaling. 1 PublicationCorresponds to variant dbSNP:rs121918125EnsemblClinVar.1
Natural variantiVAR_069963364R → Q in HH11; the patient also carries a mutation in FGFR1. 1 PublicationCorresponds to variant dbSNP:rs150288991Ensembl.1
Natural variantiVAR_049423449A → T May contribute to hypogonadotropic hypogonadism in patients carrying disease-causing mutations in SPRY4 or KAL1. 1 PublicationCorresponds to variant dbSNP:rs17033889EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M89473 mRNA Translation: AAA36366.1
S86392 S86390 Genomic DNA Translation: AAB21706.1
X65172 X65176 Genomic DNA Translation: CAA46291.1
AY462099 mRNA Translation: AAR23926.1
BC121806 mRNA Translation: AAI21807.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3664.1

Protein sequence database of the Protein Information Resource

More...PIRi		JQ1517

NCBI Reference Sequences

More...RefSeqi		NP_001050.1, NM_001059.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000304883; ENSP00000303325; ENSG00000169836

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6870

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6870

UCSC genome browser

More...UCSCi		uc003hxe.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89473 mRNA Translation: AAA36366.1
S86392 S86390 Genomic DNA Translation: AAB21706.1
X65172 X65176 Genomic DNA Translation: CAA46291.1
AY462099 mRNA Translation: AAR23926.1
BC121806 mRNA Translation: AAI21807.1
CCDSiCCDS3664.1
PIRiJQ1517
RefSeqiNP_001050.1, NM_001059.2

3D structure databases

SMRiP29371
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112733, 72 interactors
IntActiP29371, 1 interactor
STRINGi9606.ENSP00000303325

Chemistry databases

BindingDBiP29371
ChEMBLiCHEMBL4429
DrugBankiDB04872, Osanetant
DB11692, Pavinetant
DB06429, Talnetant
DrugCentraliP29371
GuidetoPHARMACOLOGYi362

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP29371, 3 sites
iPTMnetiP29371
PhosphoSitePlusiP29371

Genetic variation databases

BioMutaiTACR3
DMDMi128364

Proteomic databases

MassIVEiP29371
PaxDbiP29371
PeptideAtlasiP29371
PRIDEiP29371
ProteomicsDBi54552
TopDownProteomicsiP29371

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1543, 367 antibodies

The DNASU plasmid repository

More...DNASUi		6870

Genome annotation databases

EnsembliENST00000304883; ENSP00000303325; ENSG00000169836
GeneIDi6870
KEGGihsa:6870
UCSCiuc003hxe.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6870
DisGeNETi6870

GeneCards: human genes, protein and diseases

More...GeneCardsi		TACR3
GeneReviewsiTACR3
HGNCiHGNC:11528, TACR3
HPAiENSG00000169836, Tissue enhanced (brain, urinary bladder)
MalaCardsiTACR3
MIMi162332, gene
614840, phenotype
neXtProtiNX_P29371
OpenTargetsiENSG00000169836
Orphaneti478, Kallmann syndrome
432, Normosmic congenital hypogonadotropic hypogonadism
PharmGKBiPA36304
VEuPathDBiHostDB:ENSG00000169836

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4219, Eukaryota
GeneTreeiENSGT00940000153745
HOGENOMiCLU_009579_6_1_1
InParanoidiP29371
OMAiPQCLYSI
OrthoDBi715197at2759
PhylomeDBiP29371
TreeFamiTF315303

Enzyme and pathway databases

PathwayCommonsiP29371
ReactomeiR-HSA-380095, Tachykinin receptors bind tachykinins
R-HSA-416476, G alpha (q) signalling events
SIGNORiP29371

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6870, 5 hits in 1013 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TACR3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Tachykinin_receptor_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6870
PharosiP29371, Tchem

Protein Ontology

More...PROi		PR:P29371
RNActiP29371, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000169836, Expressed in calcaneal tendon and 30 other tissues
GenevisibleiP29371, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR001681, Neurokn_rcpt
IPR001013, NK3_rcpt
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR01026, NEUROKININ3R
PR00244, NEUROKININR
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNK3R_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29371
Secondary accession number(s): Q0P510
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 29, 2021
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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