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Protein

Bud emergence protein 1

Gene

BEM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Necessary for cell polarization during vegetative growth. May link the cytoskeleton to morphogenic determinants on the cell surface.1 Publication

Miscellaneous

Present with 6490 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: SGD
  • phosphatidylinositol binding Source: GO_Central
  • protein-containing complex scaffold activity Source: SGD
  • superoxide-generating NADPH oxidase activator activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-29141-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bud emergence protein 1
Alternative name(s):
Suppressor of RHO3 protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BEM1
Synonyms:SRO1
Ordered Locus Names:YBR200W
ORF Names:YBR1412
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000404 BEM1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000649081 – 551Bud emergence protein 1Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei458PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P29366

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29366

PRoteomics IDEntifications database

More...
PRIDEi
P29366

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P29366

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AXL2 and BUD5.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
32897, 510 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3462 CLA4-BEM1-CDC24 polarity complex

Database of interacting proteins

More...
DIPi
DIP-688N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P29366

Protein interaction database and analysis system

More...
IntActi
P29366, 53 interactors

Molecular INTeraction database

More...
MINTi
P29366

STRING: functional protein association networks

More...
STRINGi
4932.YBR200W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1551
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P29366

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P29366

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P29366

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini72 – 132SH3 1PROSITE-ProRule annotationAdd BLAST61
Domaini155 – 217SH3 2PROSITE-ProRule annotationAdd BLAST63
Domaini278 – 404PXPROSITE-ProRule annotationAdd BLAST127
Domaini478 – 551PB1PROSITE-ProRule annotationAdd BLAST74

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246638

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P29366

KEGG Orthology (KO)

More...
KOi
K11237

Identification of Orthologs from Complete Genome Data

More...
OMAi
EWFIAKP

Database of Orthologous Groups

More...
OrthoDBi
EOG092C1KS9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06890 PX_Bem1p, 1 hit
cd11878 SH3_Bem1p_1, 1 hit
cd11879 SH3_Bem1p_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030507 Bem1/Scd2
IPR035550 Bem1/Scd2_PX
IPR035548 Bem1/Scd2_SH3_1
IPR035549 Bem1/Scd2_SH3_2
IPR000270 PB1_dom
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR45397 PTHR45397, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00787 PX, 1 hit
PF00018 SH3_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00666 PB1, 1 hit
SM00312 PX, 1 hit
SM00326 SH3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 2 hits
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51745 PB1, 1 hit
PS50195 PX, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P29366-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKNFKLSKR DSNGSKGRIT SADISTPSHD NGSVIKHIKT VPVRYLSSSS
60 70 80 90 100
TPVKSQRDSS PKNRHNSKDI TSPEKVIKAK YSYQAQTSKE LSFMEGEFFY
110 120 130 140 150
VSGDEKDWYK ASNPSTGKEG VVPKTYFEVF DRTKPSSVNG SNSSSRKVTN
160 170 180 190 200
DSLNMGSLYA IVLYDFKAEK ADELTTYVGE NLFICAHHNC EWFIAKPIGR
210 220 230 240 250
LGGPGLVPVG FVSIIDIATG YATGNDVIED IKSVNLPTVQ EWKSNIARYK
260 270 280 290 300
ASNISLGSVE QQQQQSITKP QNKSAKLVDG ELLVKASVES FGLEDEKYWF
310 320 330 340 350
LVCCELSNGK TRQLKRYYQD FYDLQVQLLD AFPAEAGKLR DAGGQWSKRI
360 370 380 390 400
MPYIPGPVPY VTNSITKKRK EDLNIYVADL VNLPDYISRS EMVHSLFVVL
410 420 430 440 450
NNGFDREFER DENQNNIKTL QENDTATFAT ASQTSNFAST NQDNTLTGED
460 470 480 490 500
LKLNKKLSDL SLSGSKQAPA QSTSGLKTTK IKFYYKDDIF ALMLKGDTTY
510 520 530 540 550
KELRSKIAPR IDTDNFKLQT KLFDGSGEEI KTDSQVSNII QAKLKISVHD

I
Length:551
Mass (Da):61,605
Last modified:December 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB6C525AE9A19181
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X63826 Genomic DNA Translation: CAA45320.1
Z21487 Genomic DNA Translation: CAA79687.1
Z36069 Genomic DNA Translation: CAA85162.1
BK006936 Genomic DNA Translation: DAA07316.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S23400

NCBI Reference Sequences

More...
RefSeqi
NP_009759.3, NM_001178548.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YBR200W_mRNA; YBR200W_mRNA; YBR200W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852499

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YBR200W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63826 Genomic DNA Translation: CAA45320.1
Z21487 Genomic DNA Translation: CAA79687.1
Z36069 Genomic DNA Translation: CAA85162.1
BK006936 Genomic DNA Translation: DAA07316.1
PIRiS23400
RefSeqiNP_009759.3, NM_001178548.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IP9NMR-A472-551[»]
1IPGNMR-A472-551[»]
2CZONMR-A269-418[»]
2KFKNMR-A477-551[»]
2RQVNMR-A156-260[»]
2RQWNMR-A156-260[»]
2V6VX-ray1.50A/B266-413[»]
ProteinModelPortaliP29366
SMRiP29366
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32897, 510 interactors
ComplexPortaliCPX-3462 CLA4-BEM1-CDC24 polarity complex
DIPiDIP-688N
ELMiP29366
IntActiP29366, 53 interactors
MINTiP29366
STRINGi4932.YBR200W

PTM databases

iPTMnetiP29366

Proteomic databases

MaxQBiP29366
PaxDbiP29366
PRIDEiP29366

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR200W_mRNA; YBR200W_mRNA; YBR200W
GeneIDi852499
KEGGisce:YBR200W

Organism-specific databases

SGDiS000000404 BEM1

Phylogenomic databases

HOGENOMiHOG000246638
InParanoidiP29366
KOiK11237
OMAiEWFIAKP
OrthoDBiEOG092C1KS9

Enzyme and pathway databases

BioCyciYEAST:G3O-29141-MONOMER

Miscellaneous databases

EvolutionaryTraceiP29366

Protein Ontology

More...
PROi
PR:P29366

Family and domain databases

CDDicd06890 PX_Bem1p, 1 hit
cd11878 SH3_Bem1p_1, 1 hit
cd11879 SH3_Bem1p_2, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR030507 Bem1/Scd2
IPR035550 Bem1/Scd2_PX
IPR035548 Bem1/Scd2_SH3_1
IPR035549 Bem1/Scd2_SH3_2
IPR000270 PB1_dom
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR45397 PTHR45397, 2 hits
PfamiView protein in Pfam
PF00787 PX, 1 hit
PF00018 SH3_1, 2 hits
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00312 PX, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 2 hits
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50195 PX, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBEM1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29366
Secondary accession number(s): D6VQJ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: December 5, 2018
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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