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Protein

SHC-transforming protein 1

Gene

SHC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAngiogenesis, Growth regulation, Host-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1250347 SHC1 events in ERBB4 signaling
R-HSA-167044 Signalling to RAS
R-HSA-180336 SHC1 events in EGFR signaling
R-HSA-210993 Tie2 Signaling
R-HSA-2424491 DAP12 signaling
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-381038 XBP1(S) activates chaperone genes
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-74749 Signal attenuation
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-8851805 MET activates RAS signaling
R-HSA-8853659 RET signaling
R-HSA-8983432 Interleukin-15 signaling
R-HSA-9020558 Interleukin-2 signaling
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9027284 Erythropoietin activates RAS
R-HSA-9034864 Activated NTRK3 signals through RAS
R-HSA-912526 Interleukin receptor SHC signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P29353

SIGNOR Signaling Network Open Resource

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SIGNORi
P29353

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SHC-transforming protein 1
Alternative name(s):
SHC-transforming protein 3
SHC-transforming protein A
Src homology 2 domain-containing-transforming protein C1
Short name:
SH2 domain protein C1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SHC1
Synonyms:SHC, SHCA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000160691.18

Human Gene Nomenclature Database

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HGNCi
HGNC:10840 SHC1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600560 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P29353

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi349Y → F: Alters interaction with GRB2; isoform p52Shc (in vitro). 1 Publication1
Mutagenesisi427Y → F: No effect on interaction with GRB2; isoform p52Shc (in vitro). 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
6464

Open Targets

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OpenTargetsi
ENSG00000160691

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35746

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5626

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SHC1

Domain mapping of disease mutations (DMDM)

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DMDMi
182676455

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000977311 – 583SHC-transforming protein 1Add BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei36Phosphoserine1 Publication1
Modified residuei139PhosphoserineCombined sources1
Modified residuei154N6-acetyllysineBy similarity1
Modified residuei349Phosphotyrosine3 Publications1
Modified residuei350Phosphotyrosine3 Publications1
Modified residuei427PhosphotyrosineCombined sources2 Publications1
Modified residuei453PhosphoserineCombined sources1
Isoform p52Shc (identifier: P29353-2)
Modified residuei1N-acetylmethionineCombined sources1
Isoform 7 (identifier: P29353-7)
Modified residuei1N-acetylmethionineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to FLT4 and KIT signaling. Isoform p46Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro-rich domain. Isoform p66Shc is phosphorylated on Ser-36 by PRKCB upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light (By similarity). Tyrosine phosphorylated in response to FLT3 signaling (By similarity). Tyrosine phosphorylated by activated PTK2B/PYK2 (By similarity). Tyrosine phosphorylated by ligand-activated ALK. Tyrosine phosphorylated by ligand-activated PDGFRB. Tyrosine phosphorylated by TEK/TIE2. May be tyrosine phosphorylated by activated PTK2/FAK1; tyrosine phosphorylation was seen in an astrocytoma biopsy, where PTK2/FAK1 kinase activity is high, but not in normal brain tissue. Isoform p52Shc dephosphorylation by PTPN2 may regulate interaction with GRB2.By similarity11 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P29353

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P29353

MaxQB - The MaxQuant DataBase

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MaxQBi
P29353

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P29353

PeptideAtlas

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PeptideAtlasi
P29353

PRoteomics IDEntifications database

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PRIDEi
P29353

ProteomicsDB human proteome resource

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ProteomicsDBi
54546
54547 [P29353-2]
54548 [P29353-3]
54549 [P29353-5]
54550 [P29353-6]
54551 [P29353-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P29353

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P29353

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in neural stem cells but absent in mature neurons.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000160691 Expressed in 235 organ(s), highest expression level in left coronary artery

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P29353 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P29353 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB005374
CAB016305
HPA001844

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CPNE3; this interaction may mediate the binding of CPNE3 with ERBB2 (PubMed:20010870). Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2. Interacts with tyrosine-phosphorylated CD3T and DDR2. Interacts with the N-terminal region of APS. Interacts with phosphorylated LRP1 and IRS4. Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with TRIM31. Interacts with PTPN6/SHP (tyrosine phosphorylated). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTT (By similarity). Interacts with ALK, GAB2, GRB7 and KIT. Interacts with FLT4 (tyrosine-phosphorylated). Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration. Interacts with PDGFRB (tyrosine-phosphorylated). Interacts with ERBB4. Interacts with TEK/TIE2 (tyrosine-phosphorylated). Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; in a phosphotyrosine-dependent manner. Interacts with PTK2/FAK1. Interacts with CEACAM1; this interaction is CEACAM1-phosphorylation-dependent and mediates interaction with EGFR or INSR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Interacts (via PID domain) with PEAK1 (when phosphorylated at 'Tyr-1188') (PubMed:23846654). Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (PubMed:23846654).By similarity26 Publications
(Microbial infection) Interacts with herpes simplex virus 1 UL46.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112361, 240 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P29353

Database of interacting proteins

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DIPi
DIP-699N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P29353

Protein interaction database and analysis system

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IntActi
P29353, 97 interactors

Molecular INTeraction database

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MINTi
P29353

STRING: functional protein association networks

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STRINGi
9606.ENSP00000401303

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P29353

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1583
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MILX-ray2.70A482-583[»]
1N3HNMR-A111-317[»]
1OY2NMR-A111-317[»]
1QG1NMR-I423-435[»]
1SHCNMR-A127-317[»]
1TCENMR-A480-583[»]
1WCPmodel-A127-583[»]
2L1CNMR-A127-317[»]
4JMHX-ray2.41B344-356[»]
4XWXX-ray1.87A147-311[»]
5CZIX-ray2.60B345-353[»]
6DM4X-ray1.90E/G/H425-431[»]

Database of protein disorder

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DisProti
DP00154

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P29353

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P29353

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P29353

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini156 – 339PIDPROSITE-ProRule annotationAdd BLAST184
Domaini488 – 579SH2PROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni340 – 487CH1Add BLAST148

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi411 – 474Pro-richAdd BLAST64

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

In response to a variety of growth factors, isoform p46Shc and isoform p52Shc bind to phosphorylated Trk receptors through their phosphotyrosine binding (PID) and/or SH2 domains. The PID and SH2 domains bind to specific phosphorylated tyrosine residues in the Asn-Pro-Xaa-Tyr(P) motif of the Trk receptors. Isoform p46Shc and isoform p52Shc are in turn phosphorylated on three tyrosine residues within the extended proline-rich domain. These phosphotyrosines act as docking site for GRB2 and thereby are involved in Ras activation (By similarity).By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3697 Eukaryota
ENOG410XTJN LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153127

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050121

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P29353

KEGG Orthology (KO)

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KOi
K06279

Identification of Orthologs from Complete Genome Data

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OMAi
ASDCKQI

Database of Orthologous Groups

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OrthoDBi
1351843at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P29353

TreeFam database of animal gene trees

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TreeFami
TF315807

Family and domain databases

Conserved Domains Database

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CDDi
cd01209 PTB_Shc, 1 hit
cd09925 SH2_SHC, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.29.30, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR006019 PID_Shc-like
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029586 Shc1/ShcA
IPR035676 SHC_SH2

The PANTHER Classification System

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PANTHERi
PTHR10337:SF2 PTHR10337:SF2, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00640 PID, 1 hit
PF00017 SH2, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00401 SH2DOMAIN
PR00629 SHCPIDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01179 PID, 1 hit
PS50001 SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform p66Shc (identifier: P29353-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLLPPKPKY NPLRNESLSS LEEGASGSTP PEELPSPSAS SLGPILPPLP
60 70 80 90 100
GDDSPTTLCS FFPRMSNLRL ANPAGGRPGS KGEPGRAADD GEGIVGAAMP
110 120 130 140 150
DSGPLPLLQD MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH
160 170 180 190 200
PNDKVMGPGV SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP
210 220 230 240 250
GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS LNLMAADCKQ
260 270 280 290 300
IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV
310 320 330 340 350
ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY
360 370 380 390 400
NDFPGKEPPL GGVVDMRLRE GAAPGAARPT APNAQTPSHL GATLPVGQPV
410 420 430 440 450
GGDPEVRKQM PPPPPCPGRE LFDDPSYVNV QNLDKARQAV GGAGPPNPAI
460 470 480 490 500
NGSAPRDLFD MKPFEDALRV PPPPQSVSMA EQLRGEPWFH GKLSRREAEA
510 520 530 540 550
LLQLNGDFLV RESTTTPGQY VLTGLQSGQP KHLLLVDPEG VVRTKDHRFE
560 570 580
SVSHLISYHM DNHLPIISAG SELCLQQPVE RKL
Note: Regulated by epigenetic modifications of its promoter region.
Length:583
Mass (Da):62,822
Last modified:April 8, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7EFA5CB185A548D1
GO
Isoform p52Shc (identifier: P29353-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:473
Mass (Da):51,611
Checksum:i6DDC519E3F318B6D
GO
Isoform p46Shc (identifier: P29353-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.

Show »
Length:428
Mass (Da):46,668
Checksum:i099FED4690662DD5
GO
Isoform 5 (identifier: P29353-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-214: Missing.
     215-221: PLSSILG → MSLCHRW

Note: Produced by alternative splicing.
Show »
Length:369
Mass (Da):40,415
Checksum:i46F34449B556DDD0
GO
Isoform 6 (identifier: P29353-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     417-417: P → PA

Note: Produced by alternative splicing.
Show »
Length:584
Mass (Da):62,893
Checksum:iBDB2FF81953D4FF4
GO
Isoform 7 (identifier: P29353-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.
     417-417: P → PA

Note: Produced by alternative splicing.Combined sources
Show »
Length:474
Mass (Da):51,682
Checksum:i43E1D98CBA87DB37
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T182Q5T182_HUMAN
SHC-transforming protein 1
SHC1
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y539H0Y539_HUMAN
SHC-transforming protein 1
SHC1
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6R6D0X6R6D0_HUMAN
SHC-transforming protein 1
SHC1
354Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T187Q5T187_HUMAN
SHC-transforming protein 1
SHC1
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T181Q5T181_HUMAN
SHC-transforming protein 1
SHC1
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T188Q5T188_HUMAN
SHC-transforming protein 1
SHC1
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2D → N in CAA70977 (PubMed:9192859).Curated1
Sequence conflicti21L → M in CAA70977 (PubMed:9192859).Curated1
Sequence conflicti38S → P in CAA70977 (PubMed:9192859).Curated1
Sequence conflicti95V → D in AAB49972 (PubMed:9049300).Curated1
Sequence conflicti101D → E in AAB49972 (PubMed:9049300).Curated1
Sequence conflicti430V → A in BAG70069 (PubMed:19054851).Curated1
Sequence conflicti430V → A in BAG70193 (PubMed:19054851).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042428205A → V. Corresponds to variant dbSNP:rs8191981Ensembl.1
Natural variantiVAR_051353410M → V. Corresponds to variant dbSNP:rs8191979Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0400901 – 214Missing in isoform 5. CuratedAdd BLAST214
Alternative sequenceiVSP_0161071 – 155Missing in isoform p46Shc. 1 PublicationAdd BLAST155
Alternative sequenceiVSP_0161081 – 110Missing in isoform p52Shc and isoform 7. 3 PublicationsAdd BLAST110
Alternative sequenceiVSP_040091215 – 221PLSSILG → MSLCHRW in isoform 5. Curated7
Alternative sequenceiVSP_040092417P → PA in isoform 7 and isoform 6. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X68148 mRNA Translation: CAA48251.1
U73377 mRNA Translation: AAB49972.1
Y09847 Genomic DNA Translation: CAA70977.1
AK292143 mRNA Translation: BAF84832.1
AK315842 mRNA Translation: BAF98733.1
AB451255 mRNA Translation: BAG70069.1
AB451379 mRNA Translation: BAG70193.1
AL451085 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53168.1
CH471121 Genomic DNA Translation: EAW53169.1
CH471121 Genomic DNA Translation: EAW53170.1
CH471121 Genomic DNA Translation: EAW53171.1
BC014158 mRNA Translation: AAH14158.1
BC033925 mRNA Translation: AAH33925.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1076.1 [P29353-7]
CCDS30881.1 [P29353-1]
CCDS44233.1 [P29353-6]
CCDS44234.1 [P29353-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
S25776

NCBI Reference Sequences

More...
RefSeqi
NP_001123512.1, NM_001130040.1 [P29353-6]
NP_001123513.1, NM_001130041.1 [P29353-2]
NP_001189788.1, NM_001202859.1 [P29353-3]
NP_003020.2, NM_003029.4 [P29353-7]
NP_892113.4, NM_183001.4 [P29353-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.433795

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368445; ENSP00000357430; ENSG00000160691 [P29353-1]
ENST00000368450; ENSP00000357435; ENSG00000160691 [P29353-2]
ENST00000368453; ENSP00000357438; ENSG00000160691 [P29353-7]
ENST00000448116; ENSP00000401303; ENSG00000160691 [P29353-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6464

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6464

UCSC genome browser

More...
UCSCi
uc001ffv.4 human [P29353-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68148 mRNA Translation: CAA48251.1
U73377 mRNA Translation: AAB49972.1
Y09847 Genomic DNA Translation: CAA70977.1
AK292143 mRNA Translation: BAF84832.1
AK315842 mRNA Translation: BAF98733.1
AB451255 mRNA Translation: BAG70069.1
AB451379 mRNA Translation: BAG70193.1
AL451085 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53168.1
CH471121 Genomic DNA Translation: EAW53169.1
CH471121 Genomic DNA Translation: EAW53170.1
CH471121 Genomic DNA Translation: EAW53171.1
BC014158 mRNA Translation: AAH14158.1
BC033925 mRNA Translation: AAH33925.1
CCDSiCCDS1076.1 [P29353-7]
CCDS30881.1 [P29353-1]
CCDS44233.1 [P29353-6]
CCDS44234.1 [P29353-2]
PIRiS25776
RefSeqiNP_001123512.1, NM_001130040.1 [P29353-6]
NP_001123513.1, NM_001130041.1 [P29353-2]
NP_001189788.1, NM_001202859.1 [P29353-3]
NP_003020.2, NM_003029.4 [P29353-7]
NP_892113.4, NM_183001.4 [P29353-1]
UniGeneiHs.433795

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MILX-ray2.70A482-583[»]
1N3HNMR-A111-317[»]
1OY2NMR-A111-317[»]
1QG1NMR-I423-435[»]
1SHCNMR-A127-317[»]
1TCENMR-A480-583[»]
1WCPmodel-A127-583[»]
2L1CNMR-A127-317[»]
4JMHX-ray2.41B344-356[»]
4XWXX-ray1.87A147-311[»]
5CZIX-ray2.60B345-353[»]
6DM4X-ray1.90E/G/H425-431[»]
DisProtiDP00154
ProteinModelPortaliP29353
SMRiP29353
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112361, 240 interactors
CORUMiP29353
DIPiDIP-699N
ELMiP29353
IntActiP29353, 97 interactors
MINTiP29353
STRINGi9606.ENSP00000401303

Chemistry databases

BindingDBiP29353
ChEMBLiCHEMBL5626

PTM databases

iPTMnetiP29353
PhosphoSitePlusiP29353

Polymorphism and mutation databases

BioMutaiSHC1
DMDMi182676455

Proteomic databases

EPDiP29353
jPOSTiP29353
MaxQBiP29353
PaxDbiP29353
PeptideAtlasiP29353
PRIDEiP29353
ProteomicsDBi54546
54547 [P29353-2]
54548 [P29353-3]
54549 [P29353-5]
54550 [P29353-6]
54551 [P29353-7]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6464
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368445; ENSP00000357430; ENSG00000160691 [P29353-1]
ENST00000368450; ENSP00000357435; ENSG00000160691 [P29353-2]
ENST00000368453; ENSP00000357438; ENSG00000160691 [P29353-7]
ENST00000448116; ENSP00000401303; ENSG00000160691 [P29353-6]
GeneIDi6464
KEGGihsa:6464
UCSCiuc001ffv.4 human [P29353-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6464
DisGeNETi6464
EuPathDBiHostDB:ENSG00000160691.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SHC1
HGNCiHGNC:10840 SHC1
HPAiCAB005374
CAB016305
HPA001844
MIMi600560 gene
neXtProtiNX_P29353
OpenTargetsiENSG00000160691
PharmGKBiPA35746

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3697 Eukaryota
ENOG410XTJN LUCA
GeneTreeiENSGT00940000153127
HOVERGENiHBG050121
InParanoidiP29353
KOiK06279
OMAiASDCKQI
OrthoDBi1351843at2759
PhylomeDBiP29353
TreeFamiTF315807

Enzyme and pathway databases

ReactomeiR-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1250347 SHC1 events in ERBB4 signaling
R-HSA-167044 Signalling to RAS
R-HSA-180336 SHC1 events in EGFR signaling
R-HSA-210993 Tie2 Signaling
R-HSA-2424491 DAP12 signaling
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-381038 XBP1(S) activates chaperone genes
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-74749 Signal attenuation
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-8851805 MET activates RAS signaling
R-HSA-8853659 RET signaling
R-HSA-8983432 Interleukin-15 signaling
R-HSA-9020558 Interleukin-2 signaling
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9027284 Erythropoietin activates RAS
R-HSA-9034864 Activated NTRK3 signals through RAS
R-HSA-912526 Interleukin receptor SHC signaling
SignaLinkiP29353
SIGNORiP29353

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SHC1 human
EvolutionaryTraceiP29353

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SHC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6464

Protein Ontology

More...
PROi
PR:P29353

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160691 Expressed in 235 organ(s), highest expression level in left coronary artery
ExpressionAtlasiP29353 baseline and differential
GenevisibleiP29353 HS

Family and domain databases

CDDicd01209 PTB_Shc, 1 hit
cd09925 SH2_SHC, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR006019 PID_Shc-like
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029586 Shc1/ShcA
IPR035676 SHC_SH2
PANTHERiPTHR10337:SF2 PTHR10337:SF2, 1 hit
PfamiView protein in Pfam
PF00640 PID, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00629 SHCPIDOMAIN
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit
PS50001 SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29353
Secondary accession number(s): B5BU19
, D3DV78, O15290, Q5T180, Q5T183, Q5T184, Q5T185, Q5T186, Q8N4K5, Q96CL1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 8, 2008
Last modified: January 16, 2019
This is version 224 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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