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Protein

Tyrosine-protein phosphatase non-receptor type 6

Gene

PTPN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei419SubstrateBy similarity1
Active sitei453Phosphocysteine intermediate1
Binding sitei500SubstrateBy similarity1

GO - Molecular functioni

  • cell adhesion molecule binding Source: Ensembl
  • phosphorylation-dependent protein binding Source: UniProtKB
  • phosphotyrosine residue binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein tyrosine phosphatase activity Source: UniProtKB
  • SH2 domain binding Source: Ensembl
  • SH3 domain binding Source: Ensembl
  • transmembrane receptor protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-114604 GPVI-mediated activation cascade
R-HSA-1433559 Regulation of KIT signaling
R-HSA-210990 PECAM1 interactions
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389948 PD-1 signaling
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-432142 Platelet sensitization by LDL
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
R-HSA-877312 Regulation of IFNG signaling
R-HSA-9008059 Interleukin-37 signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-912526 Interleukin receptor SHC signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-982772 Growth hormone receptor signaling
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiP29350
SIGNORiP29350

Protein family/group databases

MoonDBiP29350 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 6 (EC:3.1.3.48)
Alternative name(s):
Hematopoietic cell protein-tyrosine phosphatase
Protein-tyrosine phosphatase 1C
Short name:
PTP-1C
Protein-tyrosine phosphatase SHP-1
SH-PTP1
Gene namesi
Name:PTPN6
Synonyms:HCP, PTP1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111679.16
HGNCiHGNC:9658 PTPN6
MIMi176883 gene
neXtProtiNX_P29350

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5777
OpenTargetsiENSG00000111679
PharmGKBiPA34002

Chemistry databases

ChEMBLiCHEMBL3166

Polymorphism and mutation databases

BioMutaiPTPN6
DMDMi131469

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947581 – 595Tyrosine-protein phosphatase non-receptor type 6Add BLAST595

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Modified residuei57PhosphoserineBy similarity1
Modified residuei64PhosphotyrosineCombined sources1
Modified residuei377PhosphotyrosineBy similarity1
Modified residuei536PhosphotyrosineBy similarity1
Modified residuei564Phosphotyrosine; by LYN1 Publication1

Post-translational modificationi

Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity.By similarity2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP29350
MaxQBiP29350
PaxDbiP29350
PeptideAtlasiP29350
PRIDEiP29350
ProteomicsDBi54543
54544 [P29350-2]
54545 [P29350-3]

2D gel databases

OGPiP29350

PTM databases

DEPODiP29350
iPTMnetiP29350
PhosphoSitePlusiP29350

Miscellaneous databases

PMAP-CutDBiP29350

Expressioni

Tissue specificityi

Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.

Gene expression databases

BgeeiENSG00000111679 Expressed in 217 organ(s), highest expression level in blood
CleanExiHS_PTPN6
ExpressionAtlasiP29350 baseline and differential
GenevisibleiP29350 HS

Organism-specific databases

HPAiCAB004572
CAB072845
HPA001466

Interactioni

Subunit structurei

Monomer. Interacts with MTUS1 (By similarity). Interacts with MILR1 (tyrosine-phosphorylated) (By similarity). Interacts with KIT (By similarity). Interacts with SIRPA/PTPNS1 (PubMed:9712903). Interacts with LILRB1 and LILRB2 (PubMed:9285411, PubMed:9842885). Interacts with FCRL2 and FCRL4 (PubMed:11162587, PubMed:14597715). Interacts with FCRL3 and FCRL6 (tyrosine phosphorylated form) (PubMed:20933011, PubMed:11162587, PubMed:19843936). Interacts with CD84 (PubMed:11414741). Interacts with CD300LF (PubMed:15184070). Interacts with CDK2 (PubMed:21262353). Interacts with KIR2DL1; the interaction is enhanced by ARRB2 (PubMed:18604210). Interacts (via SH2 1 domain) with ROS1; the interaction is direct and promotes ROS1 dephosphorylation (PubMed:11266449). Interacts with EGFR; inhibits EGFR-dependent activation of MAPK/ERK (PubMed:21258366). Interacts with LYN (PubMed:10574931). Interacts with the tyrosine phosphorylated form of PDPK1 (PubMed:19591923). Interacts with CEACAM1 (via cytoplasmic domain); this interaction depends on the monomer/dimer equilibrium and is phosphorylation-dependent (By similarity). Interacts with MPIG6B (via ITIM motif) (PubMed:23112346).By similarity16 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111742, 116 interactors
DIPiDIP-31002N
IntActiP29350, 68 interactors
MINTiP29350
STRINGi9606.ENSP00000391592

Chemistry databases

BindingDBiP29350

Structurei

Secondary structure

1595
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP29350
SMRiP29350
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29350

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 100SH2 1PROSITE-ProRule annotationAdd BLAST97
Domaini110 – 213SH2 2PROSITE-ProRule annotationAdd BLAST104
Domaini244 – 515Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST272

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni453 – 459Substrate bindingBy similarity7

Domaini

The N-terminal SH2 domain functions as an auto-inhibitory domain, blocking the catalytic domain in the ligand-free close conformation.2 Publications

Sequence similaritiesi

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiKOG0790 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00920000148980
HOGENOMiHOG000273907
HOVERGENiHBG000223
InParanoidiP29350
KOiK05697
OMAiNTKTYIA
OrthoDBiEOG091G0VZ3
PhylomeDBiP29350
TreeFamiTF351632

Family and domain databases

Gene3Di3.30.505.10, 2 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012152 Tyr_Pase_non-rcpt_typ-6/11
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00017 SH2, 2 hits
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000929 Tyr-Ptase_nr_6, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
PR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 2 hits
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50001 SH2, 2 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P29350-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRWFHRDLS GLDAETLLKG RGVHGSFLAR PSRKNQGDFS LSVRVGDQVT
60 70 80 90 100
HIRIQNSGDF YDLYGGEKFA TLTELVEYYT QQQGVLQDRD GTIIHLKYPL
110 120 130 140 150
NCSDPTSERW YHGHMSGGQA ETLLQAKGEP WTFLVRESLS QPGDFVLSVL
160 170 180 190 200
SDQPKAGPGS PLRVTHIKVM CEGGRYTVGG LETFDSLTDL VEHFKKTGIE
210 220 230 240 250
EASGAFVYLR QPYYATRVNA ADIENRVLEL NKKQESEDTA KAGFWEEFES
260 270 280 290 300
LQKQEVKNLH QRLEGQRPEN KGKNRYKNIL PFDHSRVILQ GRDSNIPGSD
310 320 330 340 350
YINANYIKNQ LLGPDENAKT YIASQGCLEA TVNDFWQMAW QENSRVIVMT
360 370 380 390 400
TREVEKGRNK CVPYWPEVGM QRAYGPYSVT NCGEHDTTEY KLRTLQVSPL
410 420 430 440 450
DNGDLIREIW HYQYLSWPDH GVPSEPGGVL SFLDQINQRQ ESLPHAGPII
460 470 480 490 500
VHCSAGIGRT GTIIVIDMLM ENISTKGLDC DIDIQKTIQM VRAQRSGMVQ
510 520 530 540 550
TEAQYKFIYV AIAQFIETTK KKLEVLQSQK GQESEYGNIT YPPAMKNAHA
560 570 580 590
KASRTSSKHK EDVYENLHTK NKREEKVKKQ RSADKEKSKG SLKRK
Length:595
Mass (Da):67,561
Last modified:December 1, 1992 - v1
Checksum:i4D7736C21D3542D2
GO
Isoform 2 (identifier: P29350-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MVR → MLSRG

Show »
Length:597
Mass (Da):67,719
Checksum:i6A291A2860159389
GO
Isoform 3 (identifier: P29350-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     40-44: SLSVR → MLSRG

Show »
Length:556
Mass (Da):63,125
Checksum:iE903558D44643643
GO
Isoform 4 (identifier: P29350-4) [UniParc]FASTAAdd to basket
Also known as: 70-kDa, SHP-1L

The sequence of this isoform differs from the canonical sequence as follows:
     559-595: HKEDVYENLH...EKSKGSLKRK → SLESSAGTVA...CTLRTRGRRK

Show »
Length:624
Mass (Da):70,131
Checksum:iCB73D33EA910A7A0
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H5H9F5H5H9_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN6
130Annotation score:
F5GY79F5GY79_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN6
144Annotation score:
F5H0N8F5H0N8_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN6
165Annotation score:
F5H1Z8F5H1Z8_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN6
150Annotation score:
F5H1V7F5H1V7_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN6
56Annotation score:
F5GXD4F5GXD4_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN6
60Annotation score:
F5H4Z1F5H4Z1_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN6
58Annotation score:
U3KQS1U3KQS1_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN6
72Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6H → L in AAA82880 (PubMed:7665165).Curated1
Sequence conflicti86L → V in AAA36610 (PubMed:1736296).Curated1
Sequence conflicti86L → V in AAD53317 (PubMed:10497187).Curated1
Sequence conflicti146V → E in AAA82880 (PubMed:7665165).Curated1
Sequence conflicti146V → E in AAA82879 (PubMed:7665165).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0051291 – 39Missing in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_0077751 – 3MVR → MLSRG in isoform 2. 1 Publication3
Alternative sequenceiVSP_00513040 – 44SLSVR → MLSRG in isoform 3. 1 Publication5
Alternative sequenceiVSP_044447559 – 595HKEDV…SLKRK → SLESSAGTVAASPVRRGGQR GLPVPGPPVLSPDLHQLPVL APLHPAADTRRMCMRTCTLR TRGRRK in isoform 4. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74903 mRNA Translation: AAA35963.1
X62055 mRNA Translation: CAA43982.1
M77273 mRNA Translation: AAA36610.1
U15528
, U15536, U15535, U15534, U15533, U15532, U15531, U15530, U15529 Genomic DNA Translation: AAA82880.1
U15528
, U15537, U15535, U15534, U15533, U15532, U15531, U15530, U15529 Genomic DNA Translation: AAA82879.1
U47924 Genomic DNA Translation: AAB51322.1
U47924 Genomic DNA Translation: AAB51323.1
AF178946 mRNA Translation: AAD53317.1
AB079851 Genomic DNA Translation: BAC81774.1
AB079851 Genomic DNA Translation: BAC81775.1
AK290421 mRNA Translation: BAF83110.1
CH471116 Genomic DNA Translation: EAW88703.1
CH471116 Genomic DNA Translation: EAW88704.1
BC002523 mRNA Translation: AAH02523.1
BC007667 mRNA Translation: AAH07667.1
CCDSiCCDS41744.1 [P29350-3]
CCDS44820.1 [P29350-1]
CCDS44821.1 [P29350-4]
PIRiB42031 S20825
RefSeqiNP_002822.2, NM_002831.5 [P29350-1]
NP_536858.1, NM_080548.4 [P29350-3]
NP_536859.1, NM_080549.3 [P29350-4]
XP_011519290.1, XM_011520988.1 [P29350-3]
UniGeneiHs.63489

Genome annotation databases

EnsembliENST00000318974; ENSP00000326010; ENSG00000111679 [P29350-1]
ENST00000399448; ENSP00000382376; ENSG00000111679 [P29350-3]
ENST00000456013; ENSP00000391592; ENSG00000111679 [P29350-4]
GeneIDi5777
KEGGihsa:5777
UCSCiuc001qsb.3 human [P29350-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74903 mRNA Translation: AAA35963.1
X62055 mRNA Translation: CAA43982.1
M77273 mRNA Translation: AAA36610.1
U15528
, U15536, U15535, U15534, U15533, U15532, U15531, U15530, U15529 Genomic DNA Translation: AAA82880.1
U15528
, U15537, U15535, U15534, U15533, U15532, U15531, U15530, U15529 Genomic DNA Translation: AAA82879.1
U47924 Genomic DNA Translation: AAB51322.1
U47924 Genomic DNA Translation: AAB51323.1
AF178946 mRNA Translation: AAD53317.1
AB079851 Genomic DNA Translation: BAC81774.1
AB079851 Genomic DNA Translation: BAC81775.1
AK290421 mRNA Translation: BAF83110.1
CH471116 Genomic DNA Translation: EAW88703.1
CH471116 Genomic DNA Translation: EAW88704.1
BC002523 mRNA Translation: AAH02523.1
BC007667 mRNA Translation: AAH07667.1
CCDSiCCDS41744.1 [P29350-3]
CCDS44820.1 [P29350-1]
CCDS44821.1 [P29350-4]
PIRiB42031 S20825
RefSeqiNP_002822.2, NM_002831.5 [P29350-1]
NP_536858.1, NM_080548.4 [P29350-3]
NP_536859.1, NM_080549.3 [P29350-4]
XP_011519290.1, XM_011520988.1 [P29350-3]
UniGeneiHs.63489

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FPRX-ray2.50A243-526[»]
1GWZX-ray2.50A243-541[»]
1X6CNMR-A110-214[»]
2B3OX-ray2.80A1-532[»]
2RMXNMR-A110-214[»]
2YU7NMR-A110-214[»]
3PS5X-ray3.10A1-595[»]
4GRYX-ray1.70A243-528[»]
4GRZX-ray1.37A243-528[»]
4GS0X-ray1.80A/B243-528[»]
4HJPX-ray1.40A243-528[»]
4HJQX-ray1.80A/B243-528[»]
ProteinModelPortaliP29350
SMRiP29350
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111742, 116 interactors
DIPiDIP-31002N
IntActiP29350, 68 interactors
MINTiP29350
STRINGi9606.ENSP00000391592

Chemistry databases

BindingDBiP29350
ChEMBLiCHEMBL3166

Protein family/group databases

MoonDBiP29350 Predicted

PTM databases

DEPODiP29350
iPTMnetiP29350
PhosphoSitePlusiP29350

Polymorphism and mutation databases

BioMutaiPTPN6
DMDMi131469

2D gel databases

OGPiP29350

Proteomic databases

EPDiP29350
MaxQBiP29350
PaxDbiP29350
PeptideAtlasiP29350
PRIDEiP29350
ProteomicsDBi54543
54544 [P29350-2]
54545 [P29350-3]

Protocols and materials databases

DNASUi5777
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318974; ENSP00000326010; ENSG00000111679 [P29350-1]
ENST00000399448; ENSP00000382376; ENSG00000111679 [P29350-3]
ENST00000456013; ENSP00000391592; ENSG00000111679 [P29350-4]
GeneIDi5777
KEGGihsa:5777
UCSCiuc001qsb.3 human [P29350-1]

Organism-specific databases

CTDi5777
DisGeNETi5777
EuPathDBiHostDB:ENSG00000111679.16
GeneCardsiPTPN6
HGNCiHGNC:9658 PTPN6
HPAiCAB004572
CAB072845
HPA001466
MIMi176883 gene
neXtProtiNX_P29350
OpenTargetsiENSG00000111679
PharmGKBiPA34002
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0790 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00920000148980
HOGENOMiHOG000273907
HOVERGENiHBG000223
InParanoidiP29350
KOiK05697
OMAiNTKTYIA
OrthoDBiEOG091G0VZ3
PhylomeDBiP29350
TreeFamiTF351632

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-114604 GPVI-mediated activation cascade
R-HSA-1433559 Regulation of KIT signaling
R-HSA-210990 PECAM1 interactions
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389948 PD-1 signaling
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-432142 Platelet sensitization by LDL
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
R-HSA-877312 Regulation of IFNG signaling
R-HSA-9008059 Interleukin-37 signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-912526 Interleukin receptor SHC signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-982772 Growth hormone receptor signaling
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiP29350
SIGNORiP29350

Miscellaneous databases

ChiTaRSiPTPN6 human
EvolutionaryTraceiP29350
GeneWikiiPTPN6
GenomeRNAii5777
PMAP-CutDBiP29350
PROiPR:P29350
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111679 Expressed in 217 organ(s), highest expression level in blood
CleanExiHS_PTPN6
ExpressionAtlasiP29350 baseline and differential
GenevisibleiP29350 HS

Family and domain databases

Gene3Di3.30.505.10, 2 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012152 Tyr_Pase_non-rcpt_typ-6/11
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00017 SH2, 2 hits
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000929 Tyr-Ptase_nr_6, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
PR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 2 hits
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50001 SH2, 2 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTN6_HUMAN
AccessioniPrimary (citable) accession number: P29350
Secondary accession number(s): A8K306
, G3V0F8, Q969V8, Q9UK67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 7, 2018
This is version 218 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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