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Protein

40S ribosomal protein S6

Gene

RpS6

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • immune response Source: FlyBase
  • ribosomal small subunit biogenesis Source: GO_Central
  • rRNA processing Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-166208 mTORC1-mediated signalling
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-DME-72649 Translation initiation complex formation
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-DME-72702 Ribosomal scanning and start codon recognition
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S6
Gene namesi
Name:RpS6
Synonyms:hen, l(1)air8
ORF Names:CG10944
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0261592 RpS6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001373231 – 24840S ribosomal protein S6Add BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233Phosphoserine1 Publication1
Modified residuei235Phosphoserine1 Publication1
Modified residuei239Phosphoserine1 Publication1
Modified residuei242Phosphoserine1 Publication1
Modified residuei244Phosphoserine1 Publication1
Modified residuei245Phosphoserine1 Publication1

Post-translational modificationi

Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP29327
PeptideAtlasiP29327
PRIDEiP29327

PTM databases

iPTMnetiP29327

Expressioni

Gene expression databases

BgeeiFBgn0261592
ExpressionAtlasiP29327 baseline and differential
GenevisibleiP29327 DM

Interactioni

Protein-protein interaction databases

BioGridi58174, 29 interactors
IntActiP29327, 29 interactors
MINTiP29327
STRINGi7227.FBpp0071087

Structurei

3D structure databases

ProteinModelPortaliP29327
SMRiP29327
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1646 Eukaryota
COG2125 LUCA
GeneTreeiENSGT00390000009819
InParanoidiP29327
KOiK02991
OMAiKGYIFRI
OrthoDBiEOG091G089B
PhylomeDBiP29327

Family and domain databases

InterProiView protein in InterPro
IPR014401 Ribosomal_S6_euk
IPR001377 Ribosomal_S6e
IPR018282 Ribosomal_S6e_CS
PANTHERiPTHR11502 PTHR11502, 1 hit
PfamiView protein in Pfam
PF01092 Ribosomal_S6e, 1 hit
PIRSFiPIRSF002129 Ribosom_S6_euk, 1 hit
SMARTiView protein in SMART
SM01405 Ribosomal_S6e, 1 hit
PROSITEiView protein in PROSITE
PS00578 RIBOSOMAL_S6E, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P29327-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLNVSYPAT GCQKLFEVVD EHKLRVFYEK RMGQVVEADI LGDEWKGYQL
60 70 80 90 100
RIAGGNDKQG FPMKQGVLTH GRVRLLLKKG HSCYRPRRTG ERKRKSVRGC
110 120 130 140 150
IVDANMSVLA LVVLKKGEKD IPGLTDTTIP RRLGPKRASK IRKLYNLSKE
160 170 180 190 200
DDVRRFVVRR PLPAKDNKKA TSKAPKIQRL ITPVVLQRKH RRIALKKKRQ
210 220 230 240
IASKEASADY AKLLVQRKKE SKAKREEAKR RRSASIRESK SSVSSDKK
Length:248
Mass (Da):28,407
Last modified:December 1, 1992 - v1
Checksum:i4E781727C33B3B6D
GO
Isoform B (identifier: P29327-2) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     73-200: VRLLLKKGHS...RRIALKKKRQ → LRLLKKIHSC...PKSSVFSGKK
     201-248: Missing.

Show »
Length:200
Mass (Da):23,072
Checksum:iCEFD9B4CE67B2971
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00572773 – 200VRLLL…KKKRQ → LRLLKKIHSCFHPRCNKVRK CKTVRKYTVEANVSALTLVV LKKNPSPCRLGPVRSSNISK IYYLCEEDDEVIPVKLQRRH QKKRQNATKEAIAEYVKLLV KRKKESKANRGRYVTIRKPK SSVFSGKK in isoform B. CuratedAdd BLAST128
Alternative sequenceiVSP_005728201 – 248Missing in isoform B. CuratedAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01658 Genomic DNA Translation: AAC34306.1
L07881 mRNA Translation: AAA28871.1
L02074 Genomic DNA Translation: AAB05982.1
L02074 Genomic DNA Translation: AAB05983.1
L02074 Genomic DNA Translation: AAB05984.1
L02075 mRNA Translation: AAB05985.1
AE014298 Genomic DNA Translation: AAN09218.1
PIRiS30194
RefSeqiNP_511073.1, NM_078518.3 [P29327-1]
UniGeneiDm.2623

Genome annotation databases

EnsemblMetazoaiFBtr0071135; FBpp0071087; FBgn0261592 [P29327-1]
GeneIDi31700
KEGGidme:Dmel_CG10944

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRS6_DROME
AccessioniPrimary (citable) accession number: P29327
Secondary accession number(s): Q94993, Q9W3N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: July 18, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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