UniProtKB - P29320 (EPHA3_HUMAN)
Ephrin type-A receptor 3
EPHA3
Functioni
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
1 PublicationCatalytic activityi
- EC:2.7.10.1PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 653 | ATP | 1 | |
Active sitei | 746 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 628 – 633 | ATP | 6 | |
Nucleotide bindingi | 700 – 706 | ATP | 7 | |
Nucleotide bindingi | 750 – 751 | ATP | 2 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ephrin receptor activity Source: ARUK-UCL
- GPI-linked ephrin receptor activity Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- transmembrane-ephrin receptor activity Source: GO_Central
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- axon guidance Source: GO_Central
- cell adhesion Source: UniProtKB-KW
- cell migration Source: UniProtKB
- cellular response to retinoic acid Source: BHF-UCL
- ephrin receptor signaling pathway Source: UniProtKB
- fasciculation of motor neuron axon Source: UniProtKB
- fasciculation of sensory neuron axon Source: UniProtKB
- negative regulation of endocytosis Source: UniProtKB
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of kinase activity Source: GO_Central
- positive regulation of neuron projection development Source: BHF-UCL
- positive regulation of protein localization to plasma membrane Source: UniProtKB
- regulation of actin cytoskeleton organization Source: UniProtKB
- regulation of epithelial to mesenchymal transition Source: UniProtKB
- regulation of focal adhesion assembly Source: UniProtKB
- regulation of GTPase activity Source: UniProtKB
- regulation of microtubule cytoskeleton organization Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Biological process | Cell adhesion |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 2681 |
PathwayCommonsi | P29320 |
Reactomei | R-HSA-2682334, EPH-Ephrin signaling R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-3928665, EPH-ephrin mediated repulsion of cells |
SignaLinki | P29320 |
SIGNORi | P29320 |
Names & Taxonomyi
Protein namesi | Recommended name: Ephrin type-A receptor 3 (EC:2.7.10.1)Alternative name(s): EPH-like kinase 4 Short name: EK4 Short name: hEK4 HEK Short name: Human embryo kinase Tyrosine-protein kinase TYRO4 Tyrosine-protein kinase receptor ETK1 Short name: Eph-like tyrosine kinase 1 |
Gene namesi | Name:EPHA3 Synonyms:ETK, ETK1, HEK, TYRO4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3387, EPHA3 |
MIMi | 179611, gene |
neXtProti | NX_P29320 |
VEuPathDBi | HostDB:ENSG00000044524 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
Extracellular region or secreted
- Secreted 1 Publication
Cytoskeleton
- actin cytoskeleton Source: HPA
Cytosol
- cytosol Source: HPA
Endosome
- early endosome Source: UniProtKB
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Nucleus
- nuclear membrane Source: HPA
- nucleoplasm Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: HPA
Other locations
- neuron projection Source: GO_Central
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 541 | ExtracellularSequence analysisAdd BLAST | 521 | |
Transmembranei | 542 – 565 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 566 – 983 | CytoplasmicSequence analysisAdd BLAST | 418 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Colorectal cancer (CRC)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 133 | V → E: Loss of EFNA5-binding ability and function. 1 Publication | 1 | |
Mutagenesisi | 152 | F → L: Loss of EFNA5-binding ability and function. 1 Publication | 1 | |
Mutagenesisi | 596 | Y → F: 10-fold suppression of kinase activity; when associated with F-602. Full kinase activity; when associated with F-602 and F-742. Full kinase activity; when associated with F-602 and A-768. 1 Publication | 1 | |
Mutagenesisi | 602 | Y → F: 10-fold suppression of kinase activity; when associated with F-596. Full kinase activity; when associated with F-596 and F-742. Full kinase activity; when associated with F-596 and A-768. 1 Publication | 1 | |
Mutagenesisi | 742 | Y → F: Full kinase activity; when associated with F-596 and F-602. 1 Publication | 1 | |
Mutagenesisi | 768 | S → A: Full kinase activity; when associated with F-596 and F-602. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 2042 |
MIMi | 114500, phenotype |
OpenTargetsi | ENSG00000044524 |
PharmGKBi | PA27819 |
Miscellaneous databases
Pharosi | P29320, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4954 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | P29320 |
GuidetoPHARMACOLOGYi | 1823 |
Genetic variation databases
BioMutai | EPHA3 |
DMDMi | 116241351 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 1 PublicationAdd BLAST | 20 | |
ChainiPRO_0000016802 | 21 – 983 | Ephrin type-A receptor 3Add BLAST | 963 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 232 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 337 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 391 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 404 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 493 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 596 | Phosphotyrosine; by autocatalysis2 Publications | 1 | |
Modified residuei | 602 | Phosphotyrosine; by autocatalysis2 Publications | 1 | |
Modified residuei | 701 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 779 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 937 | PhosphotyrosineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
CPTACi | CPTAC-1774 |
jPOSTi | P29320 |
MassIVEi | P29320 |
MaxQBi | P29320 |
PaxDbi | P29320 |
PeptideAtlasi | P29320 |
PRIDEi | P29320 |
ProteomicsDBi | 54536 [P29320-1] 54537 [P29320-2] |
PTM databases
GlyGeni | P29320, 5 sites |
iPTMneti | P29320 |
MetOSitei | P29320 |
PhosphoSitePlusi | P29320 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000044524, Expressed in subventricular zone (outer) (primate) and 187 other tissues |
ExpressionAtlasi | P29320, baseline and differential |
Genevisiblei | P29320, HS |
Organism-specific databases
HPAi | ENSG00000044524, Tissue enhanced (prostate) |
Interactioni
Subunit structurei
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses.
Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function.
Interacts with NCK1 (via SH2 domain); mediates EFNA5-EPHA3 signaling (By similarity).
Interacts (phosphorylated) with PTPN1; dephosphorylates EPHA3 and may regulate its trafficking and function.
Interacts (phosphorylated) with CRK; mediates EFNA5-EPHA3 signaling through RHOA GTPase activation.
By similarity5 PublicationsProtein-protein interaction databases
BioGRIDi | 108356, 51 interactors |
DIPi | DIP-40307N |
IntActi | P29320, 29 interactors |
MINTi | P29320 |
STRINGi | 9606.ENSP00000337451 |
Chemistry databases
BindingDBi | P29320 |
Miscellaneous databases
RNActi | P29320, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P29320 |
SMRi | P29320 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P29320 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 207 | Eph LBDPROSITE-ProRule annotationAdd BLAST | 179 | |
Domaini | 325 – 435 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 436 – 531 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 621 – 882 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 262 | |
Domaini | 911 – 975 | SAMPROSITE-ProRule annotationAdd BLAST | 65 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 981 – 983 | PDZ-bindingSequence analysis | 3 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0196, Eukaryota |
GeneTreei | ENSGT00940000157088 |
HOGENOMi | CLU_000288_141_3_1 |
InParanoidi | P29320 |
OMAi | NCKCEKN |
PhylomeDBi | P29320 |
TreeFami | TF315608 |
Family and domain databases
CDDi | cd10481, EphR_LBD_A3, 1 hit cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR034266, EphA3_rcpt_lig-bd IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR009030, Growth_fac_rcpt_cys_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR011641, Tyr-kin_ephrin_A/B_rcpt-like IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF07699, Ephrin_rec_like, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF07647, SAM_2, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDCQLSILLL LSCSVLDSFG ELIPQPSNEV NLLDSKTIQG ELGWISYPSH
60 70 80 90 100
GWEEISGVDE HYTPIRTYQV CNVMDHSQNN WLRTNWVPRN SAQKIYVELK
110 120 130 140 150
FTLRDCNSIP LVLGTCKETF NLYYMESDDD HGVKFREHQF TKIDTIAADE
160 170 180 190 200
SFTQMDLGDR ILKLNTEIRE VGPVNKKGFY LAFQDVGACV ALVSVRVYFK
210 220 230 240 250
KCPFTVKNLA MFPDTVPMDS QSLVEVRGSC VNNSKEEDPP RMYCSTEGEW
260 270 280 290 300
LVPIGKCSCN AGYEERGFMC QACRPGFYKA LDGNMKCAKC PPHSSTQEDG
310 320 330 340 350
SMNCRCENNY FRADKDPPSM ACTRPPSSPR NVISNINETS VILDWSWPLD
360 370 380 390 400
TGGRKDVTFN IICKKCGWNI KQCEPCSPNV RFLPRQFGLT NTTVTVTDLL
410 420 430 440 450
AHTNYTFEID AVNGVSELSS PPRQFAAVSI TTNQAAPSPV LTIKKDRTSR
460 470 480 490 500
NSISLSWQEP EHPNGIILDY EVKYYEKQEQ ETSYTILRAR GTNVTISSLK
510 520 530 540 550
PDTIYVFQIR ARTAAGYGTN SRKFEFETSP DSFSISGESS QVVMIAISAA
560 570 580 590 600
VAIILLTVVI YVLIGRFCGY KSKHGADEKR LHFGNGHLKL PGLRTYVDPH
610 620 630 640 650
TYEDPTQAVH EFAKELDATN ISIDKVVGAG EFGEVCSGRL KLPSKKEISV
660 670 680 690 700
AIKTLKVGYT EKQRRDFLGE ASIMGQFDHP NIIRLEGVVT KSKPVMIVTE
710 720 730 740 750
YMENGSLDSF LRKHDAQFTV IQLVGMLRGI ASGMKYLSDM GYVHRDLAAR
760 770 780 790 800
NILINSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TSPEAIAYRK
810 820 830 840 850
FTSASDVWSY GIVLWEVMSY GERPYWEMSN QDVIKAVDEG YRLPPPMDCP
860 870 880 890 900
AALYQLMLDC WQKDRNNRPK FEQIVSILDK LIRNPGSLKI ITSAAARPSN
910 920 930 940 950
LLLDQSNVDI TTFRTTGDWL NGVWTAHCKE IFTGVEYSSC DTIAKISTDD
960 970 980
MKKVGVTVVG PQKKIISSIK ALETQSKNGP VPV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JXA2 | C9JXA2_HUMAN | Receptor protein-tyrosine kinase | EPHA3 | 918 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 911 | T → S in AAA58633 (PubMed:1311845).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036086 | 37 | T → K in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_036087 | 85 | N → S in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_068853 | 207 | K → N in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200567888Ensembl. | 1 | |
Natural variantiVAR_042126 | 229 | S → Y in a lung large cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042127 | 449 | S → F in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042128 | 518 | G → L in a lung squamous cell carcinoma sample; somatic mutation; requires 2 nucleotide substitutions. 1 Publication | 1 | |
Natural variantiVAR_042129 | 564 | I → V1 PublicationCorresponds to variant dbSNP:rs55712516Ensembl. | 1 | |
Natural variantiVAR_042130 | 568 | C → S1 PublicationCorresponds to variant dbSNP:rs56077781Ensembl. | 1 | |
Natural variantiVAR_042131 | 590 | L → P1 PublicationCorresponds to variant dbSNP:rs56081642Ensembl. | 1 | |
Natural variantiVAR_036088 | 621 | I → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1414714315Ensembl. | 1 | |
Natural variantiVAR_065831 | 660 | T → K in a lung carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042132 | 766 | G → E in a lung adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042133 | 777 | A → G1 PublicationCorresponds to variant dbSNP:rs34437982EnsemblClinVar. | 1 | |
Natural variantiVAR_036089 | 806 | D → N in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_027919 | 914 | R → H1 PublicationCorresponds to variant dbSNP:rs17801309Ensembl. | 1 | |
Natural variantiVAR_042134 | 924 | W → R2 PublicationsCorresponds to variant dbSNP:rs35124509Ensembl. | 1 | |
Natural variantiVAR_065832 | 933 | T → M in a lung carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs372594677Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002995 | 532 – 539 | SFSISGES → CMYYFNAV in isoform 2. 1 Publication | 8 | |
Alternative sequenceiVSP_002996 | 540 – 983 | Missing in isoform 2. 1 PublicationAdd BLAST | 444 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83941 mRNA Translation: AAA58633.1 AF213459 mRNA Translation: AAG43576.1 AF213460 mRNA Translation: AAG43577.1 |
CCDSi | CCDS2922.1 [P29320-1] CCDS46875.1 [P29320-2] |
PIRi | A38224 |
RefSeqi | NP_005224.2, NM_005233.5 [P29320-1] NP_872585.1, NM_182644.2 [P29320-2] |
Genome annotation databases
Ensembli | ENST00000336596.7; ENSP00000337451.2; ENSG00000044524.11 ENST00000452448.6; ENSP00000399926.2; ENSG00000044524.11 [P29320-2] |
GeneIDi | 2042 |
KEGGi | hsa:2042 |
MANE-Selecti | ENST00000336596.7; ENSP00000337451.2; NM_005233.6; NP_005224.2 |
UCSCi | uc003dqx.2, human [P29320-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83941 mRNA Translation: AAA58633.1 AF213459 mRNA Translation: AAG43576.1 AF213460 mRNA Translation: AAG43577.1 |
CCDSi | CCDS2922.1 [P29320-1] CCDS46875.1 [P29320-2] |
PIRi | A38224 |
RefSeqi | NP_005224.2, NM_005233.5 [P29320-1] NP_872585.1, NM_182644.2 [P29320-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2GSF | X-ray | 1.77 | A | 577-947 | [»] | |
2QO2 | X-ray | 1.60 | A | 577-947 | [»] | |
2QO7 | X-ray | 1.60 | A | 577-947 | [»] | |
2QO9 | X-ray | 1.55 | A | 577-947 | [»] | |
2QOB | X-ray | 1.65 | A | 609-947 | [»] | |
2QOC | X-ray | 1.25 | A | 609-947 | [»] | |
2QOD | X-ray | 1.15 | A | 577-947 | [»] | |
2QOF | X-ray | 1.20 | A | 577-947 | [»] | |
2QOI | X-ray | 1.25 | A | 577-947 | [»] | |
2QOK | X-ray | 1.20 | A | 577-947 | [»] | |
2QOL | X-ray | 1.07 | A | 577-947 | [»] | |
2QON | X-ray | 1.79 | A | 577-947 | [»] | |
2QOO | X-ray | 1.25 | A | 577-947 | [»] | |
2QOQ | X-ray | 1.60 | A | 577-947 | [»] | |
3DZQ | X-ray | 1.75 | A | 609-947 | [»] | |
3FXX | X-ray | 1.70 | A | 577-947 | [»] | |
3FY2 | X-ray | 1.80 | A | 577-947 | [»] | |
4G2F | X-ray | 1.70 | A | 609-947 | [»] | |
4GK2 | X-ray | 2.20 | A | 609-947 | [»] | |
4GK3 | X-ray | 1.90 | A | 609-947 | [»] | |
4GK4 | X-ray | 2.10 | A | 609-947 | [»] | |
4L0P | X-ray | 2.26 | A | 29-201 | [»] | |
4P4C | X-ray | 1.60 | A | 609-947 | [»] | |
4P5Q | X-ray | 1.35 | A | 606-947 | [»] | |
4P5Z | X-ray | 2.00 | A | 606-947 | [»] | |
4TWN | X-ray | 1.71 | A | 609-947 | [»] | |
4TWO | X-ray | 2.05 | A | 609-947 | [»] | |
6IN0 | X-ray | 1.50 | A | 612-904 | [»] | |
AlphaFoldDBi | P29320 | |||||
SMRi | P29320 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108356, 51 interactors |
DIPi | DIP-40307N |
IntActi | P29320, 29 interactors |
MINTi | P29320 |
STRINGi | 9606.ENSP00000337451 |
Chemistry databases
BindingDBi | P29320 |
ChEMBLi | CHEMBL4954 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | P29320 |
GuidetoPHARMACOLOGYi | 1823 |
PTM databases
GlyGeni | P29320, 5 sites |
iPTMneti | P29320 |
MetOSitei | P29320 |
PhosphoSitePlusi | P29320 |
Genetic variation databases
BioMutai | EPHA3 |
DMDMi | 116241351 |
Proteomic databases
CPTACi | CPTAC-1774 |
jPOSTi | P29320 |
MassIVEi | P29320 |
MaxQBi | P29320 |
PaxDbi | P29320 |
PeptideAtlasi | P29320 |
PRIDEi | P29320 |
ProteomicsDBi | 54536 [P29320-1] 54537 [P29320-2] |
Protocols and materials databases
ABCDi | P29320, 1 sequenced antibody |
Antibodypediai | 4182, 521 antibodies from 36 providers |
DNASUi | 2042 |
Genome annotation databases
Ensembli | ENST00000336596.7; ENSP00000337451.2; ENSG00000044524.11 ENST00000452448.6; ENSP00000399926.2; ENSG00000044524.11 [P29320-2] |
GeneIDi | 2042 |
KEGGi | hsa:2042 |
MANE-Selecti | ENST00000336596.7; ENSP00000337451.2; NM_005233.6; NP_005224.2 |
UCSCi | uc003dqx.2, human [P29320-1] |
Organism-specific databases
CTDi | 2042 |
DisGeNETi | 2042 |
GeneCardsi | EPHA3 |
HGNCi | HGNC:3387, EPHA3 |
HPAi | ENSG00000044524, Tissue enhanced (prostate) |
MIMi | 114500, phenotype 179611, gene |
neXtProti | NX_P29320 |
OpenTargetsi | ENSG00000044524 |
PharmGKBi | PA27819 |
VEuPathDBi | HostDB:ENSG00000044524 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0196, Eukaryota |
GeneTreei | ENSGT00940000157088 |
HOGENOMi | CLU_000288_141_3_1 |
InParanoidi | P29320 |
OMAi | NCKCEKN |
PhylomeDBi | P29320 |
TreeFami | TF315608 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 2681 |
PathwayCommonsi | P29320 |
Reactomei | R-HSA-2682334, EPH-Ephrin signaling R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-3928665, EPH-ephrin mediated repulsion of cells |
SignaLinki | P29320 |
SIGNORi | P29320 |
Miscellaneous databases
BioGRID-ORCSi | 2042, 9 hits in 1108 CRISPR screens |
ChiTaRSi | EPHA3, human |
EvolutionaryTracei | P29320 |
GeneWikii | EPH_receptor_A3 |
GenomeRNAii | 2042 |
Pharosi | P29320, Tchem |
PROi | PR:P29320 |
RNActi | P29320, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000044524, Expressed in subventricular zone (outer) (primate) and 187 other tissues |
ExpressionAtlasi | P29320, baseline and differential |
Genevisiblei | P29320, HS |
Family and domain databases
CDDi | cd10481, EphR_LBD_A3, 1 hit cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR034266, EphA3_rcpt_lig-bd IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR009030, Growth_fac_rcpt_cys_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR011641, Tyr-kin_ephrin_A/B_rcpt-like IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF07699, Ephrin_rec_like, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF07647, SAM_2, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EPHA3_HUMAN | |
Accessioni | P29320Primary (citable) accession number: P29320 Secondary accession number(s): Q9H2V3, Q9H2V4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | October 17, 2006 | |
Last modified: | May 25, 2022 | |
This is version 222 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families