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Entry version 185 (22 Apr 2020)
Sequence version 1 (01 Dec 1992)
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Protein

14-3-3 protein zeta

Gene

14-3-3zeta

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development (PubMed:9159395). Acts upstream of Raf and downstream of Ras, and is essential for viability (PubMed:9159395). Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob (PubMed:10230800). Inhibits yki activity by restricting its nuclear localization (PubMed:19900439). Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes (PubMed:27015288).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-DME-165159 mTOR signalling
R-DME-166208 mTORC1-mediated signalling
R-DME-170968 Frs2-mediated activation
R-DME-2028269 Signaling by Hippo
R-DME-3769402 Deactivation of the beta-catenin transactivating complex
R-DME-390098 Phosphorylation-dependent inhibition of YKI
R-DME-392517 Rap1 signalling
R-DME-430116 GP1b-IX-V activation signalling
R-DME-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-DME-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-DME-450604 KSRP (KHSRP) binds and destabilizes mRNA
R-DME-5625740 RHO GTPases activate PKNs
R-DME-5628897 TP53 Regulates Metabolic Genes
R-DME-5673000 RAF activation
R-DME-5674135 MAP2K and MAPK activation
R-DME-5675221 Negative regulation of MAPK pathway
R-DME-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-DME-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-DME-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus
R-DME-9614399 Regulation of localization of FOXO transcription factors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P29310

Protein family/group databases

Transport Classification Database

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TCDBi
8.A.98.1.1 the 14-3-3 protein (14-3-3) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
14-3-3 protein zeta
Alternative name(s):
14-3-3-like protein
Protein Leonardo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:14-3-3zeta
Synonyms:14-3-3, 14-3-3EZ, leo, THAP
ORF Names:CG17870
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004907 14-3-3zeta

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi59R → A: Abolishes homodimerization but not regulatory function on Slo; when associated with A-63. 1 Publication1
Mutagenesisi63R → A: Abolishes homodimerization but not regulatory function on Slo; when associated with A-59. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000586511 – 24814-3-3 protein zetaAdd BLAST248

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P29310

PRoteomics IDEntifications database

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PRIDEi
P29310

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in the ventral nerve cord of the embryo, and in the neural tissues of the head. Also found in the region posterior to the morphogenetic furrow of the eye imaginal disk where cells differentiate as photoreceptors.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout all stages of embryonic and larval development.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0004907 Expressed in brain and 36 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P29310 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P29310 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; homodimerization is not essential for modulating the activity of Slo (PubMed:12529354).

Interacts with phosphorylated Slob; the interaction with Slob mediates an indirect interaction with Slo (PubMed:10230800).

Interacts with phosphorylated yki (PubMed:18256197, PubMed:19900439).

Interacts with hemo; this represses 14-3-3zeta activity which prevents the 14-3-3zeta-mediated activation of phosphoinositide 3-kinase Pi3K68D. This, in turn, inhibits the Pi3K68D-mediated conversion of phosphatidylinositol to phosphatidylinositol-3-phosphate and prevents progression of early endosomes through the maturation process which regulates subsequent steps of phagocytic processing (PubMed:27015288).

Interacts with REPTOR (when phosphorylated), this interaction may assist the cytoplasmic retention of REPTOR (PubMed:25920570).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
61887, 88 interactors

Database of interacting proteins

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DIPi
DIP-17371N

Protein interaction database and analysis system

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IntActi
P29310, 17 interactors

STRING: functional protein association networks

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STRINGi
7227.FBpp0087500

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P29310

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0841 Eukaryota
COG5040 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00970000193355

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_058290_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P29310

KEGG Orthology (KO)

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KOi
K16197

Identification of Orthologs from Complete Genome Data

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OMAi
SKMQSTH

Database for complete collections of gene phylogenies

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PhylomeDBi
P29310

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.190.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000308 14-3-3
IPR023409 14-3-3_CS
IPR036815 14-3-3_dom_sf
IPR023410 14-3-3_domain

The PANTHER Classification System

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PANTHERi
PTHR18860 PTHR18860, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00244 14-3-3, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000868 14-3-3, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00305 1433ZETA

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00101 14_3_3, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48445 SSF48445, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00796 1433_1, 1 hit
PS00797 1433_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform VI (identifier: P29310-1) [UniParc]FASTAAdd to basket
Also known as: D, J

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTVDKEELV QKAKLAEQSE RYDDMAQAMK SVTETGVELS NEERNLLSVA
60 70 80 90 100
YKNVVGARRS SWRVISSIEQ KTEASARKQQ LAREYRERVE KELREICYEV
110 120 130 140 150
LGLLDKYLIP KASNPESKVF YLKMKGDYYR YLAEVATGDA RNTVVDDSQT
160 170 180 190 200
AYQDAFDISK GKMQPTHPIR LGLALNFSVF YYEILNSPDK ACQLAKQAFD
210 220 230 240
DAIAELDTLN EDSYKDSTLI MQLLRDNLTL WTSDTQGDEA EPQEGGDN
Length:248
Mass (Da):28,228
Last modified:December 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC645CF3B10C6701A
GO
Isoform VI' (identifier: P29310-2) [UniParc]FASTAAdd to basket
Also known as: A, G, H, I

The sequence of this isoform differs from the canonical sequence as follows:
     149-161: QTAYQDAFDISKG → KNAYQEAFDIAKT

Show »
Length:248
Mass (Da):28,283
Checksum:i0A1C1005D62C9699
GO
Isoform C (identifier: P29310-3) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     146-161: DDSQTAYQDAFDISKG → EDSKKAYQEAFDIAKT
     185-193: LNSPDKACQ → INSPARACH

Show »
Length:248
Mass (Da):28,304
Checksum:i307C55638427FB57
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KEH0A0A0B4KEH0_DROME
14-3-3zeta, isoform K
14-3-3zeta 14-3-3, 14-3-3 zeta, 14-3-3-Leo, 14-3-3-zeta, 14-3-3leo
248Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform C (identifier: P29310-3)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti149K → E in AAN71617 (PubMed:12537569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010303146 – 161DDSQT…DISKG → EDSKKAYQEAFDIAKT in isoform C. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_000001149 – 161QTAYQ…DISKG → KNAYQEAFDIAKT in isoform VI'. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_010304185 – 193LNSPDKACQ → INSPARACH in isoform C. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M77518 mRNA Translation: AAA28324.1
Y12573 Genomic DNA Translation: CAA73152.1
Y12573 Genomic DNA Translation: CAA73153.1
AE013599 Genomic DNA Translation: AAF58842.4
AE013599 Genomic DNA Translation: AAF58843.3
AE013599 Genomic DNA Translation: AAM71060.1
AE013599 Genomic DNA Translation: AAM71063.2
AE013599 Genomic DNA Translation: AAM71064.2
AE013599 Genomic DNA Translation: AAS64884.1
AE013599 Genomic DNA Translation: AAX52715.1
AE013599 Genomic DNA Translation: AAX52716.1
BT001855 mRNA Translation: AAN71617.1
BT082022 mRNA Translation: ACO72859.1
BT088441 mRNA Translation: ACR44245.1
BT099909 mRNA Translation: ACX32980.1

Protein sequence database of the Protein Information Resource

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PIRi
JC1122

NCBI Reference Sequences

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RefSeqi
NP_001014515.1, NM_001014515.2 [P29310-1]
NP_001014516.1, NM_001014516.2 [P29310-2]
NP_001260845.1, NM_001273916.1 [P29310-1]
NP_001260846.1, NM_001273917.1 [P29310-1]
NP_476885.2, NM_057537.4 [P29310-1]
NP_724884.1, NM_165740.3 [P29310-1]
NP_724885.1, NM_165741.3 [P29310-2]
NP_724886.1, NM_165742.2 [P29310-2]
NP_724887.2, NM_165743.3 [P29310-3]
NP_724888.2, NM_165744.3 [P29310-3]
NP_724889.2, NM_165745.3 [P29310-2]
NP_995792.1, NM_206070.2 [P29310-2]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0088412; FBpp0087500; FBgn0004907 [P29310-2]
FBtr0088413; FBpp0087501; FBgn0004907 [P29310-2]
FBtr0088414; FBpp0087502; FBgn0004907 [P29310-1]
FBtr0088415; FBpp0087503; FBgn0004907 [P29310-1]
FBtr0088416; FBpp0087504; FBgn0004907 [P29310-3]
FBtr0088417; FBpp0087505; FBgn0004907 [P29310-2]
FBtr0088418; FBpp0089337; FBgn0004907 [P29310-2]
FBtr0088419; FBpp0089338; FBgn0004907 [P29310-3]
FBtr0100182; FBpp0099539; FBgn0004907 [P29310-2]
FBtr0100183; FBpp0099540; FBgn0004907 [P29310-1]
FBtr0332916; FBpp0305136; FBgn0004907 [P29310-1]
FBtr0332917; FBpp0305137; FBgn0004907 [P29310-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
36059

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG17870

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77518 mRNA Translation: AAA28324.1
Y12573 Genomic DNA Translation: CAA73152.1
Y12573 Genomic DNA Translation: CAA73153.1
AE013599 Genomic DNA Translation: AAF58842.4
AE013599 Genomic DNA Translation: AAF58843.3
AE013599 Genomic DNA Translation: AAM71060.1
AE013599 Genomic DNA Translation: AAM71063.2
AE013599 Genomic DNA Translation: AAM71064.2
AE013599 Genomic DNA Translation: AAS64884.1
AE013599 Genomic DNA Translation: AAX52715.1
AE013599 Genomic DNA Translation: AAX52716.1
BT001855 mRNA Translation: AAN71617.1
BT082022 mRNA Translation: ACO72859.1
BT088441 mRNA Translation: ACR44245.1
BT099909 mRNA Translation: ACX32980.1
PIRiJC1122
RefSeqiNP_001014515.1, NM_001014515.2 [P29310-1]
NP_001014516.1, NM_001014516.2 [P29310-2]
NP_001260845.1, NM_001273916.1 [P29310-1]
NP_001260846.1, NM_001273917.1 [P29310-1]
NP_476885.2, NM_057537.4 [P29310-1]
NP_724884.1, NM_165740.3 [P29310-1]
NP_724885.1, NM_165741.3 [P29310-2]
NP_724886.1, NM_165742.2 [P29310-2]
NP_724887.2, NM_165743.3 [P29310-3]
NP_724888.2, NM_165744.3 [P29310-3]
NP_724889.2, NM_165745.3 [P29310-2]
NP_995792.1, NM_206070.2 [P29310-2]

3D structure databases

SMRiP29310
ModBaseiSearch...

Protein-protein interaction databases

BioGridi61887, 88 interactors
DIPiDIP-17371N
IntActiP29310, 17 interactors
STRINGi7227.FBpp0087500

Protein family/group databases

TCDBi8.A.98.1.1 the 14-3-3 protein (14-3-3) family

Proteomic databases

PaxDbiP29310
PRIDEiP29310

Genome annotation databases

EnsemblMetazoaiFBtr0088412; FBpp0087500; FBgn0004907 [P29310-2]
FBtr0088413; FBpp0087501; FBgn0004907 [P29310-2]
FBtr0088414; FBpp0087502; FBgn0004907 [P29310-1]
FBtr0088415; FBpp0087503; FBgn0004907 [P29310-1]
FBtr0088416; FBpp0087504; FBgn0004907 [P29310-3]
FBtr0088417; FBpp0087505; FBgn0004907 [P29310-2]
FBtr0088418; FBpp0089337; FBgn0004907 [P29310-2]
FBtr0088419; FBpp0089338; FBgn0004907 [P29310-3]
FBtr0100182; FBpp0099539; FBgn0004907 [P29310-2]
FBtr0100183; FBpp0099540; FBgn0004907 [P29310-1]
FBtr0332916; FBpp0305136; FBgn0004907 [P29310-1]
FBtr0332917; FBpp0305137; FBgn0004907 [P29310-1]
GeneIDi36059
KEGGidme:Dmel_CG17870

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36059
FlyBaseiFBgn0004907 14-3-3zeta

Phylogenomic databases

eggNOGiKOG0841 Eukaryota
COG5040 LUCA
GeneTreeiENSGT00970000193355
HOGENOMiCLU_058290_1_0_1
InParanoidiP29310
KOiK16197
OMAiSKMQSTH
PhylomeDBiP29310

Enzyme and pathway databases

ReactomeiR-DME-165159 mTOR signalling
R-DME-166208 mTORC1-mediated signalling
R-DME-170968 Frs2-mediated activation
R-DME-2028269 Signaling by Hippo
R-DME-3769402 Deactivation of the beta-catenin transactivating complex
R-DME-390098 Phosphorylation-dependent inhibition of YKI
R-DME-392517 Rap1 signalling
R-DME-430116 GP1b-IX-V activation signalling
R-DME-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-DME-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-DME-450604 KSRP (KHSRP) binds and destabilizes mRNA
R-DME-5625740 RHO GTPases activate PKNs
R-DME-5628897 TP53 Regulates Metabolic Genes
R-DME-5673000 RAF activation
R-DME-5674135 MAP2K and MAPK activation
R-DME-5675221 Negative regulation of MAPK pathway
R-DME-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-DME-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-DME-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus
R-DME-9614399 Regulation of localization of FOXO transcription factors
SignaLinkiP29310

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
14-3-3zeta fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36059

Protein Ontology

More...
PROi
PR:P29310

Gene expression databases

BgeeiFBgn0004907 Expressed in brain and 36 other tissues
ExpressionAtlasiP29310 baseline and differential
GenevisibleiP29310 DM

Family and domain databases

Gene3Di1.20.190.20, 1 hit
InterProiView protein in InterPro
IPR000308 14-3-3
IPR023409 14-3-3_CS
IPR036815 14-3-3_dom_sf
IPR023410 14-3-3_domain
PANTHERiPTHR18860 PTHR18860, 1 hit
PfamiView protein in Pfam
PF00244 14-3-3, 1 hit
PIRSFiPIRSF000868 14-3-3, 1 hit
PRINTSiPR00305 1433ZETA
SMARTiView protein in SMART
SM00101 14_3_3, 1 hit
SUPFAMiSSF48445 SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796 1433_1, 1 hit
PS00797 1433_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei1433Z_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29310
Secondary accession number(s): A4UZB2
, A4UZB3, C1C593, C9QP27, O01665, Q0E9D5, Q0E9D6, Q0E9D7, Q8IGB9, Q8MKV5, Q9V5G6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 22, 2020
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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