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Protein

Connective tissue growth factor

Gene

CTGF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.2 Publications

GO - Molecular functioni

  • fibronectin binding Source: Ensembl
  • growth factor activity Source: Ensembl
  • heparin binding Source: GO_Central
  • insulin-like growth factor binding Source: ProtInc
  • integrin binding Source: GO_Central
  • protein C-terminus binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processCell adhesion, DNA synthesis

Enzyme and pathway databases

ReactomeiR-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription
SIGNORiP29279

Names & Taxonomyi

Protein namesi
Recommended name:
Connective tissue growth factor
Alternative name(s):
CCN family member 2
Hypertrophic chondrocyte-specific protein 24
Insulin-like growth factor-binding protein 8
Short name:
IBP-8
Short name:
IGF-binding protein 8
Short name:
IGFBP-8
Gene namesi
Name:CTGF
Synonyms:CCN2, HCS24, IGFBP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000118523.5
HGNCiHGNC:2500 CTGF
MIMi121009 gene
neXtProtiNX_P29279

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1490
MalaCardsiCTGF
OpenTargetsiENSG00000118523
Orphaneti220393 Diffuse cutaneous systemic sclerosis
220402 Limited cutaneous systemic sclerosis
PharmGKBiPA27003

Chemistry databases

ChEMBLiCHEMBL3712901

Polymorphism and mutation databases

BioMutaiCTGF
DMDMi116241320

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001440227 – 349Connective tissue growth factorAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi256 ↔ 293By similarity
Disulfide bondi273 ↔ 307By similarity
Disulfide bondi284 ↔ 323By similarity
Disulfide bondi287 ↔ 325By similarity
Disulfide bondi292 ↔ 329By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP29279
MaxQBiP29279
PaxDbiP29279
PeptideAtlasiP29279
PRIDEiP29279
ProteomicsDBi54533
54534 [P29279-2]

PTM databases

iPTMnetiP29279
PhosphoSitePlusiP29279

Expressioni

Tissue specificityi

Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.1 Publication

Gene expression databases

BgeeiENSG00000118523
CleanExiHS_CTGF
GenevisibleiP29279 HS

Organism-specific databases

HPAiCAB005123
HPA031075

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
FN1P027515EBI-2835375,EBI-1220319

GO - Molecular functioni

  • fibronectin binding Source: Ensembl
  • growth factor activity Source: Ensembl
  • insulin-like growth factor binding Source: ProtInc
  • integrin binding Source: GO_Central
  • protein C-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107872, 14 interactors
CORUMiP29279
IntActiP29279, 15 interactors
MINTiP29279
STRINGi9606.ENSP00000356954

Structurei

3D structure databases

ProteinModelPortaliP29279
SMRiP29279
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 98IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST72
Domaini101 – 167VWFCPROSITE-ProRule annotationAdd BLAST67
Domaini198 – 243TSP type-1PROSITE-ProRule annotationAdd BLAST46
Domaini256 – 330CTCKPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni247 – 349Heparin-bindingAdd BLAST103

Sequence similaritiesi

Belongs to the CCN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH0W Eukaryota
ENOG4111F77 LUCA
GeneTreeiENSGT00760000119225
HOGENOMiHOG000231462
HOVERGENiHBG000635
InParanoidiP29279
KOiK06827
OMAiCTPHRTA
OrthoDBiEOG091G0SQP
PhylomeDBiP29279
TreeFamiTF326070

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PF00219 IGFBP, 1 hit
PF00090 TSP_1, 1 hit
PF00093 VWC, 1 hit
PIRSFiPIRSF036495 IGFBP_rP_CNN, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P29279-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV
60 70 80 90 100
LDGCGCCRVC AKQLGELCTE RDPCDPHKGL FCHFGSPANR KIGVCTAKDG
110 120 130 140 150
APCIFGGTVY RSGESFQSSC KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF
160 170 180 190 200
PRRVKLPGKC CEEWVCDEPK DQTVVGPALA AYRLEDTFGP DPTMIRANCL
210 220 230 240 250
VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR PCEADLEENI
260 270 280 290 300
KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT
310 320 330 340
LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA
Length:349
Mass (Da):38,091
Last modified:October 17, 2006 - v2
Checksum:i62CF878C7F57EC1F
GO
Isoform 2 (identifier: P29279-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     172-198: Missing.

Note: No experimental confirmation available.
Show »
Length:322
Mass (Da):35,205
Checksum:i372DBF768AA2B2D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175V → L no nucleotide entry (PubMed:1756408).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02792583H → D8 PublicationsCorresponds to variant dbSNP:rs7451102Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002460172 – 198Missing in isoform 2. CuratedAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92934 mRNA Translation: AAA91279.1
X78947 mRNA Translation: CAA55544.1
AY395801 mRNA Translation: AAQ95223.1
AY550024 mRNA Translation: AAS55639.1
BT019794 mRNA Translation: AAV38597.1
BT019795 mRNA Translation: AAV38598.1
CR541759 mRNA Translation: CAG46559.1
AL354866 Genomic DNA No translation available.
X92511 Genomic DNA Translation: CAA63267.1
CH471051 Genomic DNA Translation: EAW48038.1
CH471051 Genomic DNA Translation: EAW48039.1
AF316366 Genomic DNA Translation: AAK60505.1
AF316367 Genomic DNA Translation: AAK60506.1
AF316368 Genomic DNA Translation: AAK60507.1
U14750 mRNA Translation: AAA75378.1
CCDSiCCDS5151.1 [P29279-1]
PIRiA40551
RefSeqiNP_001892.1, NM_001901.2
UniGeneiHs.410037

Genome annotation databases

EnsembliENST00000367976; ENSP00000356954; ENSG00000118523 [P29279-1]
GeneIDi1490
KEGGihsa:1490
UCSCiuc003qcz.4 human [P29279-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCTGF_HUMAN
AccessioniPrimary (citable) accession number: P29279
Secondary accession number(s): E1P578
, Q6LCY0, Q96A79, Q96QX2, Q9UDL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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