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Entry version 184 (08 May 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Connective tissue growth factor

Gene

CTGF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • fibronectin binding Source: Ensembl
  • growth factor activity Source: Ensembl
  • heparin binding Source: GO_Central
  • insulin-like growth factor binding Source: ProtInc
  • integrin binding Source: GO_Central
  • protein C-terminus binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding
Biological processCell adhesion, DNA synthesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P29279

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Connective tissue growth factor
Alternative name(s):
CCN family member 2
Hypertrophic chondrocyte-specific protein 24
Insulin-like growth factor-binding protein 8
Short name:
IBP-8
Short name:
IGF-binding protein 8
Short name:
IGFBP-8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTGF
Synonyms:CCN2, HCS24, IGFBP8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2500 CTGF

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
121009 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P29279

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1490

MalaCards human disease database

More...
MalaCardsi
CTGF

Open Targets

More...
OpenTargetsi
ENSG00000118523

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
220393 Diffuse cutaneous systemic sclerosis
220402 Limited cutaneous systemic sclerosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27003

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3712901

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CTGF

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116241320

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001440227 – 349Connective tissue growth factorAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi256 ↔ 293By similarity
Disulfide bondi273 ↔ 307By similarity
Disulfide bondi284 ↔ 323By similarity
Disulfide bondi287 ↔ 325By similarity
Disulfide bondi292 ↔ 329By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P29279

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P29279

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P29279

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29279

PeptideAtlas

More...
PeptideAtlasi
P29279

PRoteomics IDEntifications database

More...
PRIDEi
P29279

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54533
54534 [P29279-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P29279

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P29279

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118523 Expressed in 229 organ(s), highest expression level in metanephric glomerulus

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P29279 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005123
HPA031075

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107872, 14 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P29279

Protein interaction database and analysis system

More...
IntActi
P29279, 17 interactors

Molecular INTeraction database

More...
MINTi
P29279

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356954

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P29279

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 98IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST72
Domaini101 – 167VWFCPROSITE-ProRule annotationAdd BLAST67
Domaini198 – 243TSP type-1PROSITE-ProRule annotationAdd BLAST46
Domaini256 – 330CTCKPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni247 – 349Heparin-bindingAdd BLAST103

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH0W Eukaryota
ENOG4111F77 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155019

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231462

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P29279

KEGG Orthology (KO)

More...
KOi
K06827

Identification of Orthologs from Complete Genome Data

More...
OMAi
CTPHRTA

Database of Orthologous Groups

More...
OrthoDBi
999958at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P29279

TreeFam database of animal gene trees

More...
TreeFami
TF326070

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00007 Cys_knot, 1 hit
PF00219 IGFBP, 1 hit
PF00090 TSP_1, 1 hit
PF00093 VWC, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036495 IGFBP_rP_CNN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00041 CT, 1 hit
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SM00214 VWC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P29279-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV
60 70 80 90 100
LDGCGCCRVC AKQLGELCTE RDPCDPHKGL FCHFGSPANR KIGVCTAKDG
110 120 130 140 150
APCIFGGTVY RSGESFQSSC KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF
160 170 180 190 200
PRRVKLPGKC CEEWVCDEPK DQTVVGPALA AYRLEDTFGP DPTMIRANCL
210 220 230 240 250
VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR PCEADLEENI
260 270 280 290 300
KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT
310 320 330 340
LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA
Length:349
Mass (Da):38,091
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62CF878C7F57EC1F
GO
Isoform 2 (identifier: P29279-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     172-198: Missing.

Note: No experimental confirmation available.
Show »
Length:322
Mass (Da):35,205
Checksum:i372DBF768AA2B2D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti175V → L no nucleotide entry (PubMed:1756408).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02792583H → D8 PublicationsCorresponds to variant dbSNP:rs7451102Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002460172 – 198Missing in isoform 2. CuratedAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M92934 mRNA Translation: AAA91279.1
X78947 mRNA Translation: CAA55544.1
AY395801 mRNA Translation: AAQ95223.1
AY550024 mRNA Translation: AAS55639.1
BT019794 mRNA Translation: AAV38597.1
BT019795 mRNA Translation: AAV38598.1
CR541759 mRNA Translation: CAG46559.1
AL354866 Genomic DNA No translation available.
X92511 Genomic DNA Translation: CAA63267.1
CH471051 Genomic DNA Translation: EAW48038.1
CH471051 Genomic DNA Translation: EAW48039.1
AF316366 Genomic DNA Translation: AAK60505.1
AF316367 Genomic DNA Translation: AAK60506.1
AF316368 Genomic DNA Translation: AAK60507.1
U14750 mRNA Translation: AAA75378.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5151.1 [P29279-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A40551

NCBI Reference Sequences

More...
RefSeqi
NP_001892.1, NM_001901.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367976; ENSP00000356954; ENSG00000118523 [P29279-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1490

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1490

UCSC genome browser

More...
UCSCi
uc003qcz.4 human [P29279-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92934 mRNA Translation: AAA91279.1
X78947 mRNA Translation: CAA55544.1
AY395801 mRNA Translation: AAQ95223.1
AY550024 mRNA Translation: AAS55639.1
BT019794 mRNA Translation: AAV38597.1
BT019795 mRNA Translation: AAV38598.1
CR541759 mRNA Translation: CAG46559.1
AL354866 Genomic DNA No translation available.
X92511 Genomic DNA Translation: CAA63267.1
CH471051 Genomic DNA Translation: EAW48038.1
CH471051 Genomic DNA Translation: EAW48039.1
AF316366 Genomic DNA Translation: AAK60505.1
AF316367 Genomic DNA Translation: AAK60506.1
AF316368 Genomic DNA Translation: AAK60507.1
U14750 mRNA Translation: AAA75378.1
CCDSiCCDS5151.1 [P29279-1]
PIRiA40551
RefSeqiNP_001892.1, NM_001901.2

3D structure databases

SMRiP29279
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107872, 14 interactors
CORUMiP29279
IntActiP29279, 17 interactors
MINTiP29279
STRINGi9606.ENSP00000356954

Chemistry databases

ChEMBLiCHEMBL3712901

PTM databases

iPTMnetiP29279
PhosphoSitePlusiP29279

Polymorphism and mutation databases

BioMutaiCTGF
DMDMi116241320

Proteomic databases

EPDiP29279
jPOSTiP29279
MaxQBiP29279
PaxDbiP29279
PeptideAtlasiP29279
PRIDEiP29279
ProteomicsDBi54533
54534 [P29279-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1490
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367976; ENSP00000356954; ENSG00000118523 [P29279-1]
GeneIDi1490
KEGGihsa:1490
UCSCiuc003qcz.4 human [P29279-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1490
DisGeNETi1490

GeneCards: human genes, protein and diseases

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GeneCardsi
CTGF
HGNCiHGNC:2500 CTGF
HPAiCAB005123
HPA031075
MalaCardsiCTGF
MIMi121009 gene
neXtProtiNX_P29279
OpenTargetsiENSG00000118523
Orphaneti220393 Diffuse cutaneous systemic sclerosis
220402 Limited cutaneous systemic sclerosis
PharmGKBiPA27003

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IH0W Eukaryota
ENOG4111F77 LUCA
GeneTreeiENSGT00940000155019
HOGENOMiHOG000231462
InParanoidiP29279
KOiK06827
OMAiCTPHRTA
OrthoDBi999958at2759
PhylomeDBiP29279
TreeFamiTF326070

Enzyme and pathway databases

ReactomeiR-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription
SIGNORiP29279

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CTGF human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CTGF

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1490

Protein Ontology

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PROi
PR:P29279

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000118523 Expressed in 229 organ(s), highest expression level in metanephric glomerulus
GenevisibleiP29279 HS

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PF00219 IGFBP, 1 hit
PF00090 TSP_1, 1 hit
PF00093 VWC, 1 hit
PIRSFiPIRSF036495 IGFBP_rP_CNN, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTGF_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29279
Secondary accession number(s): E1P578
, Q6LCY0, Q96A79, Q96QX2, Q9UDL6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 17, 2006
Last modified: May 8, 2019
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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