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Protein

Adenosine receptor A2b

Gene

Adora2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • G-protein coupled adenosine receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2b
Gene namesi
Name:Adora2b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2050 Adora2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8ExtracellularBy similarity8
Transmembranei9 – 33Helical; Name=1By similarityAdd BLAST25
Topological domaini34 – 43CytoplasmicBy similarity10
Transmembranei44 – 67Helical; Name=2By similarityAdd BLAST24
Topological domaini68 – 78ExtracellularBy similarityAdd BLAST11
Transmembranei79 – 101Helical; Name=3By similarityAdd BLAST23
Topological domaini102 – 121CytoplasmicBy similarityAdd BLAST20
Transmembranei122 – 144Helical; Name=4By similarityAdd BLAST23
Topological domaini145 – 178ExtracellularBy similarityAdd BLAST34
Transmembranei179 – 203Helical; Name=5By similarityAdd BLAST25
Topological domaini204 – 235CytoplasmicBy similarityAdd BLAST32
Transmembranei236 – 259Helical; Name=6By similarityAdd BLAST24
Topological domaini260 – 267ExtracellularBy similarity8
Transmembranei268 – 291Helical; Name=7By similarityAdd BLAST24
Topological domaini292 – 332CytoplasmicBy similarityAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2592
GuidetoPHARMACOLOGYi20

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690051 – 332Adenosine receptor A2bAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 171PROSITE-ProRule annotation
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi311S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP29276
PRIDEiP29276

PTM databases

PhosphoSitePlusiP29276

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003966

Chemistry databases

BindingDBiP29276

Structurei

3D structure databases

ProteinModelPortaliP29276
SMRiP29276
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 182Agonist bindingBy similarity10
Regioni247 – 254Agonist bindingBy similarity8
Regioni266 – 276Agonist bindingBy similarityAdd BLAST11

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiP29276
KOiK04267
PhylomeDBiP29276

Family and domain databases

InterProiView protein in InterPro
IPR001435 Adeno_A2B_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00554 ADENOSINA2BR
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P29276-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLETQDALY VALELVIAAL AVAGNVLVCA AVGASSALQT PTNYFLVSLA
60 70 80 90 100
TADVAVGLFA IPFAITISLG FCTDFHSCLF LACFVLVLTQ SSIFSLLAVA
110 120 130 140 150
VDRYLAIRVP LRYKGLVTGT RARGIIAVLW VLAFGIGLTP FLGWNSKDRA
160 170 180 190 200
TSNCTEPGDG ITNKSCCPVK CLFENVVPMS YMVYFNFFGC VLPPLLIMMV
210 220 230 240 250
IYIKIFMVAC KQLQHMELME HSRTTLQREI HAAKSLAMIV GIFALCWLPV
260 270 280 290 300
HAINCITLFH PALAKDKPKW VMNVAILLSH ANSVVNPIVY AYRNRDFRYS
310 320 330
FHRIISRYVL CQTDTKGGSG QAGGQSTFSL SL
Length:332
Mass (Da):36,367
Last modified:December 1, 1992 - v1
Checksum:iF0ABAB5CCACA8858
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1WBR3B1WBR3_RAT
Adenosine receptor A2
Adora2b rCG_33660
332Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91466 mRNA Translation: AAA20981.1
PIRiA42171
RefSeqiNP_058857.1, NM_017161.1
UniGeneiRn.89544

Genome annotation databases

GeneIDi29316
KEGGirno:29316
UCSCiRGD:2050 rat

Similar proteinsi

Entry informationi

Entry nameiAA2BR_RAT
AccessioniPrimary (citable) accession number: P29276
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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