Adora2b

Functionⁱ

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functionⁱ

G protein-coupled adenosine receptor activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 11882603

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of cell proliferation
Source: RGD
Inferred from mutant phenotypeⁱ
- 11230362
negative regulation of collagen biosynthetic process
Source: RGD
Inferred from mutant phenotypeⁱ
- 9535419
positive regulation of blood vessel diameter
Source: RGD
Inferred from mutant phenotypeⁱ
- 10666062
positive regulation of cAMP-mediated signaling
Source: RGD
Inferred from mutant phenotypeⁱ
- 8012696
positive regulation of catecholamine secretion
Source: RGD
Inferred from mutant phenotypeⁱ
- 18823369
positive regulation of cell proliferation
Source: RGD
Inferred from mutant phenotypeⁱ
- 12021208
positive regulation of norepinephrine secretion
Source: RGD
Inferred from mutant phenotypeⁱ
- 15223300
positive regulation of steroid biosynthetic process
Source: RGD
Inferred from mutant phenotypeⁱ
- 18582595
regulation of angiogenesis
Source: RGD
Inferred from mutant phenotypeⁱ
- 11882603

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Adenosine receptor A2b
Gene namesⁱ	Name:Adora2b
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	2050 Adora2b

RGDⁱ

2050 Adora2b

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 8	ExtracellularBy similarity	8
Transmembraneⁱ	9 – 33	Helical; Name=1By similarityAdd BLAST	25
Topological domainⁱ	34 – 43	CytoplasmicBy similarity	10
Transmembraneⁱ	44 – 67	Helical; Name=2By similarityAdd BLAST	24
Topological domainⁱ	68 – 78	ExtracellularBy similarityAdd BLAST	11
Transmembraneⁱ	79 – 101	Helical; Name=3By similarityAdd BLAST	23
Topological domainⁱ	102 – 121	CytoplasmicBy similarityAdd BLAST	20
Transmembraneⁱ	122 – 144	Helical; Name=4By similarityAdd BLAST	23
Topological domainⁱ	145 – 178	ExtracellularBy similarityAdd BLAST	34
Transmembraneⁱ	179 – 203	Helical; Name=5By similarityAdd BLAST	25
Topological domainⁱ	204 – 235	CytoplasmicBy similarityAdd BLAST	32
Transmembraneⁱ	236 – 259	Helical; Name=6By similarityAdd BLAST	24
Topological domainⁱ	260 – 267	ExtracellularBy similarity	8
Transmembraneⁱ	268 – 291	Helical; Name=7By similarityAdd BLAST	24
Topological domainⁱ	292 – 332	CytoplasmicBy similarityAdd BLAST	41

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2592
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	20

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069005	1 – 332	Adenosine receptor A2bAdd BLAST		332

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	78 ↔ 171	PROSITE-ProRule annotation
Glycosylationⁱ	153	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	163	N-linked (GlcNAc...) asparagineSequence analysis	1
Lipidationⁱ	311	S-palmitoyl cysteineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	P29276
PRIDEⁱ	P29276

PTM databases

PhosphoSitePlusⁱ	P29276

PhosphoSitePlusⁱ

P29276

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000003966

STRINGⁱ

10116.ENSRNOP00000003966

Chemistry databases

BindingDBⁱ

P29276

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P29276
SMRⁱ	P29276
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	173 – 182	Agonist bindingBy similarity	10
Regionⁱ	247 – 254	Agonist bindingBy similarity	8
Regionⁱ	266 – 276	Agonist bindingBy similarityAdd BLAST	11

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
HOGENOMⁱ	HOG000015770
HOVERGENⁱ	HBG106962
InParanoidⁱ	P29276
KEGG Orthology (KO) More...KOⁱ	K04267
PhylomeDBⁱ	P29276

Family and domain databases

InterProⁱ	View protein in InterPro IPR001435 Adeno_A2B_rcpt IPR001634 Adenosn_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00554 ADENOSINA2BR PR00424 ADENOSINER PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P29276-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQLETQDALY VALELVIAAL AVAGNVLVCA AVGASSALQT PTNYFLVSLA 
        60         70         80         90        100
TADVAVGLFA IPFAITISLG FCTDFHSCLF LACFVLVLTQ SSIFSLLAVA 
       110        120        130        140        150
VDRYLAIRVP LRYKGLVTGT RARGIIAVLW VLAFGIGLTP FLGWNSKDRA 
       160        170        180        190        200
TSNCTEPGDG ITNKSCCPVK CLFENVVPMS YMVYFNFFGC VLPPLLIMMV 
       210        220        230        240        250
IYIKIFMVAC KQLQHMELME HSRTTLQREI HAAKSLAMIV GIFALCWLPV 
       260        270        280        290        300
HAINCITLFH PALAKDKPKW VMNVAILLSH ANSVVNPIVY AYRNRDFRYS 
       310        320        330 
FHRIISRYVL CQTDTKGGSG QAGGQSTFSL SL

Length:332

Mass (Da):36,367

Last modified:December 1, 1992 - v1

Checksum:ⁱF0ABAB5CCACA8858

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	B1WBR3	B1WBR3_RAT		Adenosine receptor A2 Adenosine receptor A2	Adora2b rCG_33660	332	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M91466 mRNA Translation: AAA20981.1
PIRⁱ	A42171
NCBI Reference Sequences More...RefSeqⁱ	NP_058857.1, NM_017161.1
UniGeneⁱ	Rn.89544

Genome annotation databases

GeneIDⁱ	29316
KEGGⁱ	rno:29316
UCSC genome browser More...UCSCⁱ	RGD:2050 rat

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P29276	Adenosine receptor A2 (Fragment)		RAT		118	UniRef100_P29276

Protein	Similar proteins		Species	Score	Length	Source
P29276	Adenosine receptor A2b		MOUSE		332	UniRef90_Q60614
Adenosine receptor A2 (Fragment)		RAT		118
Adenosine receptor A2		MESAU		332
UPI00038C50BC		MICOH		332
UPI00042AE93C		PERMB		332
+6

Protein	Similar proteins		Species	Score	Length	Source
P29276	Adenosine receptor A2b		MOUSE		332	UniRef50_Q60614
Adenosine receptor A2b		CHICK		340
Adenosine receptor A2b		CANLF		332
Adenosine receptor A2b		RABIT		332
Adenosine receptor A2b		HUMAN		332
+296

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M91466 mRNA Translation: AAA20981.1
PIRⁱ	A42171
RefSeqⁱ	NP_058857.1, NM_017161.1
UniGeneⁱ	Rn.89544

3D structure databases

ProteinModelPortalⁱ	P29276
SMRⁱ	P29276
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000003966

STRINGⁱ

10116.ENSRNOP00000003966

Chemistry databases

BindingDBⁱ	P29276
ChEMBLⁱ	CHEMBL2592
GuidetoPHARMACOLOGYⁱ	20

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	P29276

PhosphoSitePlusⁱ

P29276

Proteomic databases

PaxDbⁱ	P29276
PRIDEⁱ	P29276

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	29316
KEGGⁱ	rno:29316
UCSCⁱ	RGD:2050 rat

Organism-specific databases

CTDⁱ	136
RGDⁱ	2050 Adora2b

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
HOGENOMⁱ	HOG000015770
HOVERGENⁱ	HBG106962
InParanoidⁱ	P29276
KOⁱ	K04267
PhylomeDBⁱ	P29276

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P29276

PROⁱ

PR:P29276

Family and domain databases

InterProⁱ	View protein in InterPro IPR001435 Adeno_A2B_rcpt IPR001634 Adenosn_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00554 ADENOSINA2BR PR00424 ADENOSINER PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AA2BR_RAT
Accessionⁱ	P29276Primary (citable) accession number: P29276
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	December 1, 1992
	Last modified:	November 7, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P29276 (AA2BR_RAT)

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Adenosine receptor A2b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ