Adenosine receptor A2b

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• G protein-coupled adenosine receptor activity Source: InterPro
• G protein-coupled receptor activity Source: RGDInferred from sequence orthologyⁱ
  • "Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury."
    Sun C.X., Zhong H., Mohsenin A., Morschl E., Chunn J.L., Molina J.G., Belardinelli L., Zeng D., Blackburn M.R.
    J. Clin. Invest. 116:2173-2182(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury."
    Sun C.X., Zhong H., Mohsenin A., Morschl E., Chunn J.L., Molina J.G., Belardinelli L., Zeng D., Blackburn M.R.
    J. Clin. Invest. 116:2173-2182(2006) [PubMed] [Europe PMC] [Abstract]
  • "Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling."
    Mi T., Abbasi S., Zhang H., Uray K., Chunn J.L., Xia L.W., Molina J.G., Weisbrodt N.W., Kellems R.E., Blackburn M.R., Xia Y.
    J. Clin. Invest. 118:1491-1501(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to extracellular stimulus Source: RGDInferred from sequence orthologyⁱ
  • "Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells."
    Marquardt D.L., Walker L.L., Heinemann S.
    J. Immunol. 152:4508-4515(1994) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "A(2b) receptors mediate the antimitogenic effects of adenosine in cardiac fibroblasts."
    Dubey R.K., Gillespie D.G., Zacharia L.C., Mi Z., Jackson E.K.
    Hypertension 37:716-721(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of collagen biosynthetic process Source: RGDInferred from mutant phenotypeⁱ
  • "Adenosine inhibits collagen and protein synthesis in cardiac fibroblasts: role of A2B receptors."
    Dubey R.K., Gillespie D.G., Jackson E.K.
    Hypertension 31:943-948(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of blood vessel diameter Source: RGDInferred from mutant phenotypeⁱ
  • "Role of adenosine A(2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation."
    Shin H.K., Shin Y.W., Hong K.W.
    Am. J. Physiol. Heart Circ. Physiol. 278:H339-44(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cAMP-mediated signaling Source: RGDInferred from mutant phenotypeⁱ
  • "A(2B) adenosine receptors stimulate growth of porcine and rat arterial endothelial cells."
    Dubey R.K., Gillespie D.G., Jackson E.K.
    Hypertension 39:530-535(2002) [PubMed] [Europe PMC] [Abstract]
  • "Adenosine A2B-receptor-mediated cyclic AMP accumulation in primary rat astrocytes."
    Peakman M.C., Hill S.J.
    Br. J. Pharmacol. 111:191-198(1994) [PubMed] [Europe PMC] [Abstract]
• positive regulation of catecholamine secretion Source: RGDInferred from mutant phenotypeⁱ
  • "An antagonistic interaction between A2B adenosine and D2 dopamine receptors modulates the function of rat carotid body chemoreceptor cells."
    Conde S.V., Gonzalez C., Batuca J.R., Monteiro E.C., Obeso A.
    J. Neurochem. 107:1369-1381(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "Adenosine-regulated cell proliferation in pituitary folliculostellate and endocrine cells: differential roles for the A(1) and A(2B) adenosine receptors."
    Rees D.A., Lewis M.D., Lewis B.M., Smith P.J., Scanlon M.F., Ham J.
    Endocrinology 143:2427-2436(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cGMP-mediated signaling Source: RGDInferred from sequence orthologyⁱ
  • "Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling."
    Mi T., Abbasi S., Zhang H., Uray K., Chunn J.L., Xia L.W., Molina J.G., Weisbrodt N.W., Kellems R.E., Blackburn M.R., Xia Y.
    J. Clin. Invest. 118:1491-1501(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of chemokine production Source: RGDInferred from sequence orthologyⁱ
  • "Adenosine receptors in regulation of dendritic cell differentiation and function."
    Novitskiy S.V., Ryzhov S., Zaynagetdinov R., Goldstein A.E., Huang Y., Tikhomirov O.Y., Blackburn M.R., Biaggioni I., Carbone D.P., Feoktistov I., Dikov M.M.
    Blood 112:1822-1831(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of chronic inflammatory response to non-antigenic stimulus Source: RGDInferred from sequence orthologyⁱ
  • "Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury."
    Sun C.X., Zhong H., Mohsenin A., Morschl E., Chunn J.L., Molina J.G., Belardinelli L., Zeng D., Blackburn M.R.
    J. Clin. Invest. 116:2173-2182(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of endothelial cell migration Source: RGDInferred from mutant phenotypeⁱ
  • "A(2B) adenosine receptors stimulate growth of porcine and rat arterial endothelial cells."
    Dubey R.K., Gillespie D.G., Jackson E.K.
    Hypertension 39:530-535(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of endothelial cell proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "A(2B) adenosine receptors stimulate growth of porcine and rat arterial endothelial cells."
    Dubey R.K., Gillespie D.G., Jackson E.K.
    Hypertension 39:530-535(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of guanylate cyclase activity Source: RGDInferred from sequence orthologyⁱ
  • "Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling."
    Mi T., Abbasi S., Zhang H., Uray K., Chunn J.L., Xia L.W., Molina J.G., Weisbrodt N.W., Kellems R.E., Blackburn M.R., Xia Y.
    J. Clin. Invest. 118:1491-1501(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-6 production Source: RGDInferred from sequence orthologyⁱ
  • "Adenosine receptors in regulation of dendritic cell differentiation and function."
    Novitskiy S.V., Ryzhov S., Zaynagetdinov R., Goldstein A.E., Huang Y., Tikhomirov O.Y., Blackburn M.R., Biaggioni I., Carbone D.P., Feoktistov I., Dikov M.M.
    Blood 112:1822-1831(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mast cell degranulation Source: RGDInferred from sequence orthologyⁱ
  • "Adenosine-mediated mast cell degranulation in adenosine deaminase-deficient mice."
    Zhong H., Chunn J.L., Volmer J.B., Fozard J.R., Blackburn M.R.
    J. Pharmacol. Exp. Ther. 298:433-440(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of norepinephrine secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Coupling to protein kinases A and C of adenosine A2B receptors involved in the facilitation of noradrenaline release in the prostatic portion of rat vas deferens."
    Queiroz G., Quintas C., Talaia C., Goncalves J.
    Neuropharmacology 47:216-224(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of steroid biosynthetic process Source: RGDInferred from mutant phenotypeⁱ
  • "Adenosine-stimulated adrenal steroidogenesis involves the adenosine A2A and A2B receptors and the Janus kinase 2-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase signaling pathway."
    Chen Y.C., Huang S.H., Wang S.M.
    Int. J. Biochem. Cell Biol. 40:2815-2825(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of vascular endothelial growth factor production Source: RGDInferred from sequence orthologyⁱ
  • "Adenosine receptors in regulation of dendritic cell differentiation and function."
    Novitskiy S.V., Ryzhov S., Zaynagetdinov R., Goldstein A.E., Huang Y., Tikhomirov O.Y., Blackburn M.R., Biaggioni I., Carbone D.P., Feoktistov I., Dikov M.M.
    Blood 112:1822-1831(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of glucose metabolic process Source: RGDInferred from mutant phenotypeⁱ
  • "Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension."
    Nayak S., Khan M.A., Wan T.C., Pei H., Linden J., Dwinell M.R., Geurts A.M., Imig J.D., Auchampach J.A.
    Purinergic Signal. 11:519-531(2015) [PubMed] [Europe PMC] [Abstract]
• regulation of synaptic vesicle exocytosis Source: RGDInferred from sequence orthologyⁱ
  • "Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus."
    Goncalves F.Q., Pires J., Pliassova A., Beleza R., Lemos C., Marques J.M., Rodrigues R.J., Canas P.M., Kofalvi A., Cunha R.A., Rial D.
    Eur. J. Neurosci. 41:878-888(2015) [PubMed] [Europe PMC] [Abstract]
• relaxation of vascular associated smooth muscle Source: RGDInferred from sequence orthologyⁱ
  • "Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling."
    Mi T., Abbasi S., Zhang H., Uray K., Chunn J.L., Xia L.W., Molina J.G., Weisbrodt N.W., Kellems R.E., Blackburn M.R., Xia Y.
    J. Clin. Invest. 118:1491-1501(2008) [PubMed] [Europe PMC] [Abstract]
• response to angiotensin Source: RGDInferred from mutant phenotypeⁱ
  • "Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension."
    Nayak S., Khan M.A., Wan T.C., Pei H., Linden J., Dwinell M.R., Geurts A.M., Imig J.D., Auchampach J.A.
    Purinergic Signal. 11:519-531(2015) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MQLETQDALY VALELVIAAL AVAGNVLVCA AVGASSALQT PTNYFLVSLA 
        60         70         80         90        100
TADVAVGLFA IPFAITISLG FCTDFHSCLF LACFVLVLTQ SSIFSLLAVA 
       110        120        130        140        150
VDRYLAIRVP LRYKGLVTGT RARGIIAVLW VLAFGIGLTP FLGWNSKDRA 
       160        170        180        190        200
TSNCTEPGDG ITNKSCCPVK CLFENVVPMS YMVYFNFFGC VLPPLLIMMV 
       210        220        230        240        250
IYIKIFMVAC KQLQHMELME HSRTTLQREI HAAKSLAMIV GIFALCWLPV 
       260        270        280        290        300
HAINCITLFH PALAKDKPKW VMNVAILLSH ANSVVNPIVY AYRNRDFRYS 
       310        320        330 
FHRIISRYVL CQTDTKGGSG QAGGQSTFSL SL                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. SIMILARITY comments
   Index of protein domains and families