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UniProtKB - P29276 (AA2BR_RAT)
Protein
Adenosine receptor A2b
Gene
Adora2b
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
GO - Molecular functioni
- G protein-coupled adenosine receptor activity Source: InterPro
- G protein-coupled receptor activity Source: RGD
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGD
- cellular response to extracellular stimulus Source: RGD
- negative regulation of cell population proliferation Source: RGD
- negative regulation of collagen biosynthetic process Source: RGD
- positive regulation of cAMP-mediated signaling Source: RGD
- positive regulation of catecholamine secretion Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of cGMP-mediated signaling Source: RGD
- positive regulation of chemokine production Source: RGD
- positive regulation of chronic inflammatory response to non-antigenic stimulus Source: RGD
- positive regulation of endothelial cell migration Source: RGD
- positive regulation of endothelial cell proliferation Source: RGD
- positive regulation of guanylate cyclase activity Source: RGD
- positive regulation of interleukin-6 production Source: RGD
- positive regulation of mast cell degranulation Source: RGD
- positive regulation of norepinephrine secretion Source: RGD
- positive regulation of steroid biosynthetic process Source: RGD
- positive regulation of vascular endothelial growth factor production Source: RGD
- regulation of glucose metabolic process Source: RGD
- regulation of synaptic vesicle exocytosis Source: RGD
- relaxation of vascular associated smooth muscle Source: RGD
- response to angiotensin Source: RGD
- vasodilation Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-417973, Adenosine P1 receptors R-RNO-5683826, Surfactant metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Adenosine receptor A2b |
Gene namesi | Name:Adora2b |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2050, Adora2b |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- cell surface Source: RGD
- glutamatergic synapse Source: RGD
- integral component of membrane Source: UniProtKB-KW
- Schaffer collateral - CA1 synapse Source: RGD
- synapse Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 8 | ExtracellularBy similarity | 8 | |
Transmembranei | 9 – 33 | Helical; Name=1By similarityAdd BLAST | 25 | |
Topological domaini | 34 – 43 | CytoplasmicBy similarity | 10 | |
Transmembranei | 44 – 67 | Helical; Name=2By similarityAdd BLAST | 24 | |
Topological domaini | 68 – 78 | ExtracellularBy similarityAdd BLAST | 11 | |
Transmembranei | 79 – 101 | Helical; Name=3By similarityAdd BLAST | 23 | |
Topological domaini | 102 – 121 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 122 – 144 | Helical; Name=4By similarityAdd BLAST | 23 | |
Topological domaini | 145 – 178 | ExtracellularBy similarityAdd BLAST | 34 | |
Transmembranei | 179 – 203 | Helical; Name=5By similarityAdd BLAST | 25 | |
Topological domaini | 204 – 235 | CytoplasmicBy similarityAdd BLAST | 32 | |
Transmembranei | 236 – 259 | Helical; Name=6By similarityAdd BLAST | 24 | |
Topological domaini | 260 – 267 | ExtracellularBy similarity | 8 | |
Transmembranei | 268 – 291 | Helical; Name=7By similarityAdd BLAST | 24 | |
Topological domaini | 292 – 332 | CytoplasmicBy similarityAdd BLAST | 41 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069005 | 1 – 332 | Adenosine receptor A2bAdd BLAST | 332 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 78 ↔ 171 | PROSITE-ProRule annotation | ||
Glycosylationi | 153 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 163 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 311 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P29276 |
PTM databases
GlyGeni | P29276, 2 sites |
PhosphoSitePlusi | P29276 |
Interactioni
Protein-protein interaction databases
IntActi | P29276, 1 interactor |
STRINGi | 10116.ENSRNOP00000003966 |
Chemistry databases
BindingDBi | P29276 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 173 – 182 | Agonist bindingBy similarity | 10 | |
Regioni | 247 – 254 | Agonist bindingBy similarity | 8 | |
Regioni | 266 – 276 | Agonist bindingBy similarityAdd BLAST | 11 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | P29276 |
OrthoDBi | 550297at2759 |
PhylomeDBi | P29276 |
Family and domain databases
InterProi | View protein in InterPro IPR001435, Adeno_A2B_rcpt IPR001634, Adenosn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00554, ADENOSINA2BR PR00424, ADENOSINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P29276-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQLETQDALY VALELVIAAL AVAGNVLVCA AVGASSALQT PTNYFLVSLA
60 70 80 90 100
TADVAVGLFA IPFAITISLG FCTDFHSCLF LACFVLVLTQ SSIFSLLAVA
110 120 130 140 150
VDRYLAIRVP LRYKGLVTGT RARGIIAVLW VLAFGIGLTP FLGWNSKDRA
160 170 180 190 200
TSNCTEPGDG ITNKSCCPVK CLFENVVPMS YMVYFNFFGC VLPPLLIMMV
210 220 230 240 250
IYIKIFMVAC KQLQHMELME HSRTTLQREI HAAKSLAMIV GIFALCWLPV
260 270 280 290 300
HAINCITLFH PALAKDKPKW VMNVAILLSH ANSVVNPIVY AYRNRDFRYS
310 320 330
FHRIISRYVL CQTDTKGGSG QAGGQSTFSL SL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB1WBR3 | B1WBR3_RAT | Adenosine receptor A2 | Adora2b rCG_33660 | 332 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M91466 mRNA Translation: AAA20981.1 |
PIRi | A42171 |
RefSeqi | NP_058857.1, NM_017161.1 |
Genome annotation databases
GeneIDi | 29316 |
KEGGi | rno:29316 |
UCSCi | RGD:2050, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M91466 mRNA Translation: AAA20981.1 |
PIRi | A42171 |
RefSeqi | NP_058857.1, NM_017161.1 |
3D structure databases
SMRi | P29276 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P29276, 1 interactor |
STRINGi | 10116.ENSRNOP00000003966 |
Chemistry databases
BindingDBi | P29276 |
ChEMBLi | CHEMBL2592 |
DrugCentrali | P29276 |
GuidetoPHARMACOLOGYi | 20 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P29276, 2 sites |
PhosphoSitePlusi | P29276 |
Proteomic databases
PaxDbi | P29276 |
Genome annotation databases
GeneIDi | 29316 |
KEGGi | rno:29316 |
UCSCi | RGD:2050, rat |
Organism-specific databases
CTDi | 136 |
RGDi | 2050, Adora2b |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | P29276 |
OrthoDBi | 550297at2759 |
PhylomeDBi | P29276 |
Enzyme and pathway databases
Reactomei | R-RNO-417973, Adenosine P1 receptors R-RNO-5683826, Surfactant metabolism |
Miscellaneous databases
PROi | PR:P29276 |
Family and domain databases
InterProi | View protein in InterPro IPR001435, Adeno_A2B_rcpt IPR001634, Adenosn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00554, ADENOSINA2BR PR00424, ADENOSINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AA2BR_RAT | |
Accessioni | P29276Primary (citable) accession number: P29276 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | September 29, 2021 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families