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UniProtKB - P29275 (AA2BR_HUMAN)
Protein
Adenosine receptor A2b
Gene
ADORA2B
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
GO - Molecular functioni
- G protein-coupled adenosine receptor activity Source: InterPro
GO - Biological processi
- activation of adenylate cyclase activity Source: ProtInc
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
- cellular response to extracellular stimulus Source: Ensembl
- G protein-coupled receptor signaling pathway Source: ProtInc
- positive regulation of cGMP-mediated signaling Source: Ensembl
- positive regulation of chemokine production Source: Ensembl
- positive regulation of chronic inflammatory response to non-antigenic stimulus Source: Ensembl
- positive regulation of guanylate cyclase activity Source: Ensembl
- positive regulation of interleukin-6 production Source: Ensembl
- positive regulation of mast cell degranulation Source: Ensembl
- positive regulation of vascular endothelial growth factor production Source: Ensembl
- regulation of synaptic vesicle exocytosis Source: Ensembl
- relaxation of vascular associated smooth muscle Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P29275 |
Reactomei | R-HSA-417973, Adenosine P1 receptors R-HSA-418555, G alpha (s) signalling events R-HSA-5683826, Surfactant metabolism R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P29275 |
SIGNORi | P29275 |
Names & Taxonomyi
Protein namesi | Recommended name: Adenosine receptor A2b |
Gene namesi | Name:ADORA2B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:264, ADORA2B |
MIMi | 600446, gene |
neXtProti | NX_P29275 |
VEuPathDBi | HostDB:ENSG00000170425 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Other locations
- glutamatergic synapse Source: Ensembl
- Schaffer collateral - CA1 synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 8 | ExtracellularBy similarity | 8 | |
Transmembranei | 9 – 33 | Helical; Name=1By similarityAdd BLAST | 25 | |
Topological domaini | 34 – 43 | CytoplasmicBy similarity | 10 | |
Transmembranei | 44 – 67 | Helical; Name=2By similarityAdd BLAST | 24 | |
Topological domaini | 68 – 78 | ExtracellularBy similarityAdd BLAST | 11 | |
Transmembranei | 79 – 101 | Helical; Name=3By similarityAdd BLAST | 23 | |
Topological domaini | 102 – 121 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 122 – 144 | Helical; Name=4By similarityAdd BLAST | 23 | |
Topological domaini | 145 – 178 | ExtracellularBy similarityAdd BLAST | 34 | |
Transmembranei | 179 – 203 | Helical; Name=5By similarityAdd BLAST | 25 | |
Topological domaini | 204 – 235 | CytoplasmicBy similarityAdd BLAST | 32 | |
Transmembranei | 236 – 259 | Helical; Name=6By similarityAdd BLAST | 24 | |
Topological domaini | 260 – 267 | ExtracellularBy similarity | 8 | |
Transmembranei | 268 – 291 | Helical; Name=7By similarityAdd BLAST | 24 | |
Topological domaini | 292 – 332 | CytoplasmicBy similarityAdd BLAST | 41 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 136 |
OpenTargetsi | ENSG00000170425 |
PharmGKBi | PA24585 |
Miscellaneous databases
Pharosi | P29275, Tclin |
Chemistry databases
ChEMBLi | CHEMBL255 |
DrugBanki | DB00640, Adenosine DB00201, Caffeine DB05936, CVT-6883 DB04932, Defibrotide DB00824, Enprofylline DB00277, Theophylline |
DrugCentrali | P29275 |
GuidetoPHARMACOLOGYi | 20 |
Genetic variation databases
BioMutai | ADORA2B |
DMDMi | 112938 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069003 | 1 – 332 | Adenosine receptor A2bAdd BLAST | 332 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 78 ↔ 171 | PROSITE-ProRule annotation | ||
Glycosylationi | 153 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 163 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 311 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
MassIVEi | P29275 |
PaxDbi | P29275 |
PeptideAtlasi | P29275 |
PRIDEi | P29275 |
PTM databases
GlyGeni | P29275, 2 sites |
iPTMneti | P29275 |
PhosphoSitePlusi | P29275 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170425, Expressed in epithelium of bronchus and 159 other tissues |
Genevisiblei | P29275, HS |
Organism-specific databases
HPAi | ENSG00000170425, Tissue enhanced (brain, urinary bladder) |
Interactioni
Binary interactionsi
P29275
With | #Exp. | IntAct |
---|---|---|
ADORA2A [P29274] | 5 | EBI-3904751,EBI-2902702 |
Protein-protein interaction databases
BioGRIDi | 106648, 46 interactors |
IntActi | P29275, 3 interactors |
STRINGi | 9606.ENSP00000304501 |
Chemistry databases
BindingDBi | P29275 |
Miscellaneous databases
RNActi | P29275, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 173 – 182 | Agonist bindingBy similarity | 10 | |
Regioni | 247 – 254 | Agonist bindingBy similarity | 8 | |
Regioni | 266 – 276 | Agonist bindingBy similarityAdd BLAST | 11 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234555 |
HOGENOMi | CLU_009579_11_5_1 |
InParanoidi | P29275 |
OMAi | PVKCLFE |
OrthoDBi | 550297at2759 |
PhylomeDBi | P29275 |
TreeFami | TF325296 |
Family and domain databases
InterProi | View protein in InterPro IPR001435, Adeno_A2B_rcpt IPR001634, Adenosn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00554, ADENOSINA2BR PR00424, ADENOSINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P29275-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLETQDALY VALELVIAAL SVAGNVLVCA AVGTANTLQT PTNYFLVSLA
60 70 80 90 100
AADVAVGLFA IPFAITISLG FCTDFYGCLF LACFVLVLTQ SSIFSLLAVA
110 120 130 140 150
VDRYLAICVP LRYKSLVTGT RARGVIAVLW VLAFGIGLTP FLGWNSKDSA
160 170 180 190 200
TNNCTEPWDG TTNESCCLVK CLFENVVPMS YMVYFNFFGC VLPPLLIMLV
210 220 230 240 250
IYIKIFLVAC RQLQRTELMD HSRTTLQREI HAAKSLAMIV GIFALCWLPV
260 270 280 290 300
HAVNCVTLFQ PAQGKNKPKW AMNMAILLSH ANSVVNPIVY AYRNRDFRYT
310 320 330
FHKIISRYLL CQADVKSGNG QAGVQPALGV GL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M97759 mRNA Translation: AAA51598.1 X68487 mRNA Translation: CAA48505.1 AY136748 mRNA Translation: AAN01274.1 BC025722 mRNA Translation: AAH25722.1 |
CCDSi | CCDS11173.1 |
PIRi | JC1229 |
RefSeqi | NP_000667.1, NM_000676.2 |
Genome annotation databases
Ensembli | ENST00000304222.3; ENSP00000304501.2; ENSG00000170425.4 |
GeneIDi | 136 |
KEGGi | hsa:136 |
MANE-Selecti | ENST00000304222.3; ENSP00000304501.2; NM_000676.4; NP_000667.1 |
UCSCi | uc002gpd.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M97759 mRNA Translation: AAA51598.1 X68487 mRNA Translation: CAA48505.1 AY136748 mRNA Translation: AAN01274.1 BC025722 mRNA Translation: AAH25722.1 |
CCDSi | CCDS11173.1 |
PIRi | JC1229 |
RefSeqi | NP_000667.1, NM_000676.2 |
3D structure databases
AlphaFoldDBi | P29275 |
SMRi | P29275 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106648, 46 interactors |
IntActi | P29275, 3 interactors |
STRINGi | 9606.ENSP00000304501 |
Chemistry databases
BindingDBi | P29275 |
ChEMBLi | CHEMBL255 |
DrugBanki | DB00640, Adenosine DB00201, Caffeine DB05936, CVT-6883 DB04932, Defibrotide DB00824, Enprofylline DB00277, Theophylline |
DrugCentrali | P29275 |
GuidetoPHARMACOLOGYi | 20 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P29275, 2 sites |
iPTMneti | P29275 |
PhosphoSitePlusi | P29275 |
Genetic variation databases
BioMutai | ADORA2B |
DMDMi | 112938 |
Proteomic databases
MassIVEi | P29275 |
PaxDbi | P29275 |
PeptideAtlasi | P29275 |
PRIDEi | P29275 |
Protocols and materials databases
Antibodypediai | 25203, 312 antibodies from 36 providers |
DNASUi | 136 |
Genome annotation databases
Ensembli | ENST00000304222.3; ENSP00000304501.2; ENSG00000170425.4 |
GeneIDi | 136 |
KEGGi | hsa:136 |
MANE-Selecti | ENST00000304222.3; ENSP00000304501.2; NM_000676.4; NP_000667.1 |
UCSCi | uc002gpd.2, human |
Organism-specific databases
CTDi | 136 |
DisGeNETi | 136 |
GeneCardsi | ADORA2B |
HGNCi | HGNC:264, ADORA2B |
HPAi | ENSG00000170425, Tissue enhanced (brain, urinary bladder) |
MIMi | 600446, gene |
neXtProti | NX_P29275 |
OpenTargetsi | ENSG00000170425 |
PharmGKBi | PA24585 |
VEuPathDBi | HostDB:ENSG00000170425 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234555 |
HOGENOMi | CLU_009579_11_5_1 |
InParanoidi | P29275 |
OMAi | PVKCLFE |
OrthoDBi | 550297at2759 |
PhylomeDBi | P29275 |
TreeFami | TF325296 |
Enzyme and pathway databases
PathwayCommonsi | P29275 |
Reactomei | R-HSA-417973, Adenosine P1 receptors R-HSA-418555, G alpha (s) signalling events R-HSA-5683826, Surfactant metabolism R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P29275 |
SIGNORi | P29275 |
Miscellaneous databases
BioGRID-ORCSi | 136, 5 hits in 1076 CRISPR screens |
ChiTaRSi | ADORA2B, human |
GeneWikii | Adenosine_A2B_receptor |
GenomeRNAii | 136 |
Pharosi | P29275, Tclin |
PROi | PR:P29275 |
RNActi | P29275, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170425, Expressed in epithelium of bronchus and 159 other tissues |
Genevisiblei | P29275, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001435, Adeno_A2B_rcpt IPR001634, Adenosn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00554, ADENOSINA2BR PR00424, ADENOSINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AA2BR_HUMAN | |
Accessioni | P29275Primary (citable) accession number: P29275 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 190 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families