ADORA2B

Functionⁱ

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functionⁱ

G protein-coupled adenosine receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of adenylate cyclase activity
Source: ProtInc
Traceable author statementⁱ
- 8022409
activation of MAPK activity
Source: ProtInc
Traceable author statementⁱ
- 10101031
adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
cellular defense response
Source: ProtInc
Traceable author statementⁱ
- 10101031
cellular protein metabolic process Source: Reactome
cellular response to extracellular stimulus Source: Ensembl
excretion
Source: ProtInc
Traceable author statementⁱ
- 7836474
G protein-coupled receptor signaling pathway Source: Reactome
JNK cascade
Source: ProtInc
Traceable author statementⁱ
- 10101031
positive regulation of cGMP-mediated signaling Source: Ensembl
positive regulation of chemokine production Source: Ensembl
positive regulation of chronic inflammatory response to non-antigenic stimulus Source: Ensembl
positive regulation of guanylate cyclase activity Source: Ensembl
positive regulation of interleukin-6 production Source: Ensembl
positive regulation of mast cell degranulation Source: Ensembl
positive regulation of vascular endothelial growth factor production Source: Ensembl
regulation of synaptic vesicle exocytosis Source: Ensembl
relaxation of vascular smooth muscle Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-417973 Adenosine P1 receptors R-HSA-418555 G alpha (s) signalling events R-HSA-5683826 Surfactant metabolism

Reactomeⁱ

R-HSA-417973 Adenosine P1 receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-5683826 Surfactant metabolism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Adenosine receptor A2b
Gene namesⁱ	Name:ADORA2B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170425.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:264 ADORA2B
MIMⁱ	600446 gene
neXtProtⁱ	NX_P29275

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 8	ExtracellularBy similarity	8
Transmembraneⁱ	9 – 33	Helical; Name=1By similarityAdd BLAST	25
Topological domainⁱ	34 – 43	CytoplasmicBy similarity	10
Transmembraneⁱ	44 – 67	Helical; Name=2By similarityAdd BLAST	24
Topological domainⁱ	68 – 78	ExtracellularBy similarityAdd BLAST	11
Transmembraneⁱ	79 – 101	Helical; Name=3By similarityAdd BLAST	23
Topological domainⁱ	102 – 121	CytoplasmicBy similarityAdd BLAST	20
Transmembraneⁱ	122 – 144	Helical; Name=4By similarityAdd BLAST	23
Topological domainⁱ	145 – 178	ExtracellularBy similarityAdd BLAST	34
Transmembraneⁱ	179 – 203	Helical; Name=5By similarityAdd BLAST	25
Topological domainⁱ	204 – 235	CytoplasmicBy similarityAdd BLAST	32
Transmembraneⁱ	236 – 259	Helical; Name=6By similarityAdd BLAST	24
Topological domainⁱ	260 – 267	ExtracellularBy similarity	8
Transmembraneⁱ	268 – 291	Helical; Name=7By similarityAdd BLAST	24
Topological domainⁱ	292 – 332	CytoplasmicBy similarityAdd BLAST	41

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	136
Open Targets More...OpenTargetsⁱ	ENSG00000170425
PharmGKBⁱ	PA24585

Chemistry databases

ChEMBLⁱ	CHEMBL255
Drug and drug target database More...DrugBankⁱ	DB00640 Adenosine DB04932 Defibrotide DB00824 Enprofylline DB00277 Theophylline
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	20

Polymorphism and mutation databases

BioMutaⁱ	ADORA2B
DMDMⁱ	112938

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069003	1 – 332	Adenosine receptor A2bAdd BLAST		332

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	78 ↔ 171	PROSITE-ProRule annotation
Glycosylationⁱ	153	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	163	N-linked (GlcNAc...) asparagineSequence analysis	1
Lipidationⁱ	311	S-palmitoyl cysteineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	P29275
PeptideAtlas More...PeptideAtlasⁱ	P29275
PRIDEⁱ	P29275
ProteomicsDBⁱ	54532

PTM databases

iPTMnetⁱ	P29275
PhosphoSitePlusⁱ	P29275

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000170425 Expressed in 141 organ(s), highest expression level in epithelium of bronchus
CleanExⁱ	HS_ADORA2B
Genevisibleⁱ	P29275 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA073747

HPAⁱ

HPA073747

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	106648, 4 interactors
IntActⁱ	P29275, 2 interactors
STRINGⁱ	9606.ENSP00000304501

Chemistry databases

BindingDBⁱ

P29275

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P29275
SMRⁱ	P29275
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	173 – 182	Agonist bindingBy similarity	10
Regionⁱ	247 – 254	Agonist bindingBy similarity	8
Regionⁱ	266 – 276	Agonist bindingBy similarityAdd BLAST	11

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074524
HOGENOMⁱ	HOG000015770
HOVERGENⁱ	HBG106962
InParanoidⁱ	P29275
KEGG Orthology (KO) More...KOⁱ	K04267
OMAⁱ	CCLVKCL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I3U
PhylomeDBⁱ	P29275
TreeFamⁱ	TF325296

Family and domain databases

InterProⁱ	View protein in InterPro IPR001435 Adeno_A2B_rcpt IPR001634 Adenosn_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00554 ADENOSINA2BR PR00424 ADENOSINER PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P29275-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLETQDALY VALELVIAAL SVAGNVLVCA AVGTANTLQT PTNYFLVSLA 
        60         70         80         90        100
AADVAVGLFA IPFAITISLG FCTDFYGCLF LACFVLVLTQ SSIFSLLAVA 
       110        120        130        140        150
VDRYLAICVP LRYKSLVTGT RARGVIAVLW VLAFGIGLTP FLGWNSKDSA 
       160        170        180        190        200
TNNCTEPWDG TTNESCCLVK CLFENVVPMS YMVYFNFFGC VLPPLLIMLV 
       210        220        230        240        250
IYIKIFLVAC RQLQRTELMD HSRTTLQREI HAAKSLAMIV GIFALCWLPV 
       260        270        280        290        300
HAVNCVTLFQ PAQGKNKPKW AMNMAILLSH ANSVVNPIVY AYRNRDFRYT 
       310        320        330 
FHKIISRYLL CQADVKSGNG QAGVQPALGV GL

Length:332

Mass (Da):36,333

Last modified:December 1, 1992 - v1

Checksum:ⁱ38AD088E2439C7FA

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M97759 mRNA Translation: AAA51598.1 X68487 mRNA Translation: CAA48505.1 AY136748 mRNA Translation: AAN01274.1 BC025722 mRNA Translation: AAH25722.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11173.1
PIRⁱ	JC1229
NCBI Reference Sequences More...RefSeqⁱ	NP_000667.1, NM_000676.2
UniGeneⁱ	Hs.167046

Genome annotation databases

Ensemblⁱ	ENST00000304222; ENSP00000304501; ENSG00000170425
GeneIDⁱ	136
KEGGⁱ	hsa:136
UCSC genome browser More...UCSCⁱ	uc002gpd.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P29275	Adenosine A2b receptor (Fragment)		HUMAN		49	UniRef100_P29275

Protein	Similar proteins		Species	Score	Length	Source
P29275	Adenosine receptor A2b		CANLF		332	UniRef90_P29275
Adenosine receptor A2b		RABIT		332
Adenosine A2b receptor (Fragment)		HUMAN		49
Adenosine receptor A2		SAIBB		395
Adenosine receptor A2		CALJA		395
+76

Protein	Similar proteins		Species	Score	Length	Source
P29275	Adenosine receptor A2b		MOUSE		332	UniRef50_Q60614
Adenosine receptor A2b		RAT		332
Adenosine receptor A2b		CHICK		340
Adenosine receptor A2b		CANLF		332
Adenosine receptor A2b		RABIT		332
+296

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M97759 mRNA Translation: AAA51598.1 X68487 mRNA Translation: CAA48505.1 AY136748 mRNA Translation: AAN01274.1 BC025722 mRNA Translation: AAH25722.1
CCDSⁱ	CCDS11173.1
PIRⁱ	JC1229
RefSeqⁱ	NP_000667.1, NM_000676.2
UniGeneⁱ	Hs.167046

3D structure databases

ProteinModelPortalⁱ	P29275
SMRⁱ	P29275
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106648, 4 interactors
IntActⁱ	P29275, 2 interactors
STRINGⁱ	9606.ENSP00000304501

Chemistry databases

BindingDBⁱ	P29275
ChEMBLⁱ	CHEMBL255
DrugBankⁱ	DB00640 Adenosine DB04932 Defibrotide DB00824 Enprofylline DB00277 Theophylline
GuidetoPHARMACOLOGYⁱ	20

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P29275
PhosphoSitePlusⁱ	P29275

Polymorphism and mutation databases

BioMutaⁱ	ADORA2B
DMDMⁱ	112938

Proteomic databases

PaxDbⁱ	P29275
PeptideAtlasⁱ	P29275
PRIDEⁱ	P29275
ProteomicsDBⁱ	54532

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	136
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000304222; ENSP00000304501; ENSG00000170425
GeneIDⁱ	136
KEGGⁱ	hsa:136
UCSCⁱ	uc002gpd.2 human

Organism-specific databases

CTDⁱ	136
DisGeNETⁱ	136
EuPathDBⁱ	HostDB:ENSG00000170425.3
GeneCardsⁱ	ADORA2B
HGNCⁱ	HGNC:264 ADORA2B
HPAⁱ	HPA073747
MIMⁱ	600446 gene
neXtProtⁱ	NX_P29275
OpenTargetsⁱ	ENSG00000170425
PharmGKBⁱ	PA24585
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00550000074524
HOGENOMⁱ	HOG000015770
HOVERGENⁱ	HBG106962
InParanoidⁱ	P29275
KOⁱ	K04267
OMAⁱ	CCLVKCL
OrthoDBⁱ	EOG091G0I3U
PhylomeDBⁱ	P29275
TreeFamⁱ	TF325296

Enzyme and pathway databases

Reactomeⁱ	R-HSA-417973 Adenosine P1 receptors R-HSA-418555 G alpha (s) signalling events R-HSA-5683826 Surfactant metabolism

Reactomeⁱ

R-HSA-417973 Adenosine P1 receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-5683826 Surfactant metabolism

Miscellaneous databases

ChiTaRSⁱ	ADORA2B human
GeneWikiⁱ	Adenosine_A2B_receptor
GenomeRNAiⁱ	136
Protein Ontology More...PROⁱ	PR:P29275
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170425 Expressed in 141 organ(s), highest expression level in epithelium of bronchus
CleanExⁱ	HS_ADORA2B
Genevisibleⁱ	P29275 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001435 Adeno_A2B_rcpt IPR001634 Adenosn_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00554 ADENOSINA2BR PR00424 ADENOSINER PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AA2BR_HUMAN
Accessionⁱ	P29275Primary (citable) accession number: P29275
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	December 1, 1992
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - P29275 (AA2BR_HUMAN)

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Adenosine receptor A2b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ