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Entry version 208 (16 Oct 2019)
Sequence version 2 (01 Jun 1994)
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Protein

Adenosine receptor A2a

Gene

ADORA2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-187024 NGF-independant TRKA activation
R-HSA-417973 Adenosine P1 receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-5683826 Surfactant metabolism

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P29274

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.3.8 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenosine receptor A2a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADORA2A
Synonyms:ADORA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:263 ADORA2A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
102776 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P29274

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7Extracellular1 Publication7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 32Helical; Name=1Add BLAST25
Topological domaini33 – 42Cytoplasmic1 Publication10
Transmembranei43 – 66Helical; Name=2Add BLAST24
Topological domaini67 – 77Extracellular1 PublicationAdd BLAST11
Transmembranei78 – 100Helical; Name=3Add BLAST23
Topological domaini101 – 120Cytoplasmic1 PublicationAdd BLAST20
Transmembranei121 – 143Helical; Name=4Add BLAST23
Topological domaini144 – 173Extracellular1 PublicationAdd BLAST30
Transmembranei174 – 198Helical; Name=5Add BLAST25
Topological domaini199 – 234Cytoplasmic1 PublicationAdd BLAST36
Transmembranei235 – 258Helical; Name=6Add BLAST24
Topological domaini259 – 266Extracellular1 Publication8
Transmembranei267 – 290Helical; Name=7Add BLAST24
Topological domaini291 – 412Cytoplasmic1 PublicationAdd BLAST122

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
135

MalaCards human disease database

More...
MalaCardsi
ADORA2A

Open Targets

More...
OpenTargetsi
ENSG00000128271

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
363549 Acute encephalopathy with biphasic seizures and late reduced diffusion

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24584

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P29274

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL251

Drug and drug target database

More...
DrugBanki
DB08770 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol
DB14132 8-chlorotheophylline
DB00640 Adenosine
DB05009 Apadenoson
DB05191 Atl146e
DB04853 Binodenoson
DB00201 Caffeine
DB04932 Defibrotide
DB09273 Doxofylline
DB00651 Dyphylline
DB00824 Enprofylline
DB00555 Lamotrigine
DB00358 Mefloquine
DB01303 Oxtriphylline
DB00806 Pentoxifylline
DB06213 Regadenoson
DB01412 Theobromine
DB00277 Theophylline

DrugCentral

More...
DrugCentrali
P29274

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
19

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADORA2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
543740

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000689991 – 412Adenosine receptor A2aAdd BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi71 ↔ 159PROSITE-ProRule annotation1 Publication
Disulfide bondi74 ↔ 146PROSITE-ProRule annotation1 Publication
Disulfide bondi77 ↔ 166PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi259 ↔ 262PROSITE-ProRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P29274

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29274

PeptideAtlas

More...
PeptideAtlasi
P29274

PRoteomics IDEntifications database

More...
PRIDEi
P29274

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
54531

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P29274

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P29274

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000128271 Expressed in 90 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P29274 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P29274 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB001943
HPA065566
HPA075997

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct (PubMed:16339847). May interact with DRD4 (PubMed:18832607).

Interacts with NECAB2 (PubMed:17689978).

Interacts (via cytoplasmic C-terminal domain) with GAS2L2; interaction enhances receptor-mediated adenylyl cyclase activity (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106647, 9 interactors

Protein interaction database and analysis system

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IntActi
P29274, 20 interactors

Molecular INTeraction database

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MINTi
P29274

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000480012

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P29274

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1412
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P29274

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P29274

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni168 – 177Agonist binding10
Regioni246 – 253Agonist binding8
Regioni264 – 274Agonist bindingAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182731

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015770

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P29274

KEGG Orthology (KO)

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KOi
K04266

Identification of Orthologs from Complete Genome Data

More...
OMAi
CAHAPLW

Database of Orthologous Groups

More...
OrthoDBi
550297at2759

TreeFam database of animal gene trees

More...
TreeFami
TF325296

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001513 Adeno_A2A_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00553 ADENOSINA2AR
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P29274-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIMGSSVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFVVSLAA
60 70 80 90 100
ADIAVGVLAI PFAITISTGF CAACHGCLFI ACFVLVLTQS SIFSLLAIAI
110 120 130 140 150
DRYIAIRIPL RYNGLVTGTR AKGIIAICWV LSFAIGLTPM LGWNNCGQPK
160 170 180 190 200
EGKNHSQGCG EGQVACLFED VVPMNYMVYF NFFACVLVPL LLMLGVYLRI
210 220 230 240 250
FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG LFALCWLPLH
260 270 280 290 300
IINCFTFFCP DCSHAPLWLM YLAIVLSHTN SVVNPFIYAY RIREFRQTFR
310 320 330 340 350
KIIRSHVLRQ QEPFKAAGTS ARVLAAHGSD GEQVSLRLNG HPPGVWANGS
360 370 380 390 400
APHPERRPNG YALGLVSGGS AQESQGNTGL PDVELLSHEL KGVCPEPPGL
410
DDPLAQDGAG VS
Length:412
Mass (Da):44,707
Last modified:June 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9438E9D64A6BE61B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQD8C9JQD8_HUMAN
Adenosine receptor A2
ADORA2A
365Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JFS2C9JFS2_HUMAN
Adenosine receptor A2
ADORA2A
87Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2Z8S4R2Z8_HUMAN
Adenosine receptor A2
ADORA2A
108Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0Z4C9J0Z4_HUMAN
Adenosine receptor A2a
ADORA2A
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3T2C9J3T2_HUMAN
Adenosine receptor A2a
ADORA2A
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3A7S4R3A7_HUMAN
Adenosine receptor A2a
ADORA2A
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R429S4R429_HUMAN
Adenosine receptor A2a
ADORA2A
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA58356 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01183550A → V1 PublicationCorresponds to variant dbSNP:rs4530Ensembl.1
Natural variantiVAR_011836300R → H. Corresponds to variant dbSNP:rs4990Ensembl.1
Natural variantiVAR_003451392G → R. Corresponds to variant dbSNP:rs1277013918Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M97370 mRNA Translation: AAA58356.1 Different initiation.
X68486 mRNA Translation: CAA48504.1
S46950 mRNA Translation: AAB23956.1
U40771, U40770 Genomic DNA Translation: AAA83270.1
AY136747 mRNA Translation: AAN01273.1
CR456367 mRNA Translation: CAG30253.1
BT006999 mRNA Translation: AAP35645.1
AK312946 mRNA Translation: BAG35787.1
CH471095 Genomic DNA Translation: EAW59658.1
BC013780 mRNA Translation: AAH13780.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13826.1

Protein sequence database of the Protein Information Resource

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PIRi
A48978

NCBI Reference Sequences

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RefSeqi
NP_000666.2, NM_000675.5
NP_001265426.1, NM_001278497.1
NP_001265427.1, NM_001278498.1
NP_001265428.1, NM_001278499.1
NP_001265429.1, NM_001278500.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000337539; ENSP00000336630; ENSG00000128271
ENST00000610595; ENSP00000480012; ENSG00000128271
ENST00000611543; ENSP00000483102; ENSG00000128271
ENST00000618076; ENSP00000481552; ENSG00000128271

Database of genes from NCBI RefSeq genomes

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GeneIDi
135

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:135

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97370 mRNA Translation: AAA58356.1 Different initiation.
X68486 mRNA Translation: CAA48504.1
S46950 mRNA Translation: AAB23956.1
U40771, U40770 Genomic DNA Translation: AAA83270.1
AY136747 mRNA Translation: AAN01273.1
CR456367 mRNA Translation: CAG30253.1
BT006999 mRNA Translation: AAP35645.1
AK312946 mRNA Translation: BAG35787.1
CH471095 Genomic DNA Translation: EAW59658.1
BC013780 mRNA Translation: AAH13780.1
CCDSiCCDS13826.1
PIRiA48978
RefSeqiNP_000666.2, NM_000675.5
NP_001265426.1, NM_001278497.1
NP_001265427.1, NM_001278498.1
NP_001265428.1, NM_001278499.1
NP_001265429.1, NM_001278500.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MMHmodel-16-36[»]
242-69[»]
378-102[»]
4117-143[»]
5175-203[»]
6233-260[»]
7264-296[»]
1UPEmodel-A1-304[»]
2YDOX-ray3.00A1-317[»]
2YDVX-ray2.60A1-317[»]
3EMLX-ray2.60A2-208[»]
A222-316[»]
3PWHX-ray3.30A1-317[»]
3QAKX-ray2.71A2-208[»]
A222-316[»]
3REYX-ray3.31A1-317[»]
3RFMX-ray3.60A1-317[»]
3UZAX-ray3.27A1-317[»]
3UZCX-ray3.34A1-317[»]
3VG9X-ray2.70A1-316[»]
3VGAX-ray3.10A1-316[»]
4EIYX-ray1.80A2-208[»]
A219-316[»]
4UG2X-ray2.60A/B1-317[»]
4UHRX-ray2.60A1-317[»]
5G53X-ray3.40A/B1-308[»]
5IU4X-ray1.72A2-208[»]
A219-318[»]
5IU7X-ray1.90A2-208[»]
A219-315[»]
5IU8X-ray2.00A2-208[»]
A219-315[»]
5IUAX-ray2.20A2-208[»]
A219-315[»]
5IUBX-ray2.10A2-208[»]
A219-315[»]
5JTBX-ray2.80A2-212[»]
A219-316[»]
5K2AX-ray2.50A2-208[»]
A219-316[»]
5K2BX-ray2.50A2-208[»]
A219-316[»]
5K2CX-ray1.90A2-208[»]
A219-316[»]
5K2DX-ray1.90A2-208[»]
A219-316[»]
5MZJX-ray2.00A2-208[»]
A219-318[»]
5MZPX-ray2.10A2-208[»]
A219-317[»]
5N2RX-ray2.80A2-208[»]
A219-318[»]
5NLXX-ray2.14A2-317[»]
5NM2X-ray1.95A2-317[»]
5NM4X-ray1.70A2-317[»]
5OLGX-ray1.87A2-208[»]
A219-317[»]
5OLHX-ray2.60A2-208[»]
A219-317[»]
5OLOX-ray3.10A2-208[»]
A219-318[»]
5OLVX-ray2.00A2-208[»]
A219-317[»]
5OLZX-ray1.90A2-208[»]
A219-317[»]
5OM1X-ray2.10A2-208[»]
A219-317[»]
5OM4X-ray2.00A2-208[»]
A219-317[»]
5UIGX-ray3.50A1-191[»]
A219-316[»]
5UVIX-ray3.20A2-212[»]
A219-316[»]
5VRAX-ray2.35A2-208[»]
A219-316[»]
5WF5X-ray2.60A2-208[»]
A222-316[»]
5WF6X-ray2.90A2-208[»]
A222-316[»]
6AQFX-ray2.51A2-208[»]
A219-316[»]
6GDGelectron microscopy4.11A8-316[»]
6GT3X-ray2.00A2-208[»]
A219-317[»]
6MH8X-ray4.20A2-208[»]
A219-316[»]
SMRiP29274
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi106647, 9 interactors
IntActiP29274, 20 interactors
MINTiP29274
STRINGi9606.ENSP00000480012

Chemistry databases

BindingDBiP29274
ChEMBLiCHEMBL251
DrugBankiDB08770 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol
DB14132 8-chlorotheophylline
DB00640 Adenosine
DB05009 Apadenoson
DB05191 Atl146e
DB04853 Binodenoson
DB00201 Caffeine
DB04932 Defibrotide
DB09273 Doxofylline
DB00651 Dyphylline
DB00824 Enprofylline
DB00555 Lamotrigine
DB00358 Mefloquine
DB01303 Oxtriphylline
DB00806 Pentoxifylline
DB06213 Regadenoson
DB01412 Theobromine
DB00277 Theophylline
DrugCentraliP29274
GuidetoPHARMACOLOGYi19

Protein family/group databases

TCDBi9.A.14.3.8 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiP29274
PhosphoSitePlusiP29274

Polymorphism and mutation databases

BioMutaiADORA2A
DMDMi543740

Proteomic databases

MassIVEiP29274
PaxDbiP29274
PeptideAtlasiP29274
PRIDEiP29274
ProteomicsDBi54531

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P29274

The DNASU plasmid repository

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DNASUi
135

Genome annotation databases

EnsembliENST00000337539; ENSP00000336630; ENSG00000128271
ENST00000610595; ENSP00000480012; ENSG00000128271
ENST00000611543; ENSP00000483102; ENSG00000128271
ENST00000618076; ENSP00000481552; ENSG00000128271
GeneIDi135
KEGGihsa:135

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
135
DisGeNETi135

GeneCards: human genes, protein and diseases

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GeneCardsi
ADORA2A
HGNCiHGNC:263 ADORA2A
HPAiCAB001943
HPA065566
HPA075997
MalaCardsiADORA2A
MIMi102776 gene
neXtProtiNX_P29274
OpenTargetsiENSG00000128271
Orphaneti363549 Acute encephalopathy with biphasic seizures and late reduced diffusion
PharmGKBiPA24584

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00950000182731
HOGENOMiHOG000015770
InParanoidiP29274
KOiK04266
OMAiCAHAPLW
OrthoDBi550297at2759
TreeFamiTF325296

Enzyme and pathway databases

ReactomeiR-HSA-187024 NGF-independant TRKA activation
R-HSA-417973 Adenosine P1 receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-5683826 Surfactant metabolism
SIGNORiP29274

Miscellaneous databases

EvolutionaryTraceiP29274

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Adenosine_A2A_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
135
PharosiP29274

Protein Ontology

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PROi
PR:P29274

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000128271 Expressed in 90 organ(s), highest expression level in cerebellum
ExpressionAtlasiP29274 baseline and differential
GenevisibleiP29274 HS

Family and domain databases

InterProiView protein in InterPro
IPR001513 Adeno_A2A_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00553 ADENOSINA2AR
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAA2AR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29274
Secondary accession number(s): B2R7E0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: June 1, 1994
Last modified: October 16, 2019
This is version 208 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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