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Protein

Adenosine receptor A2a

Gene

ADORA2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-187024 NGF-independant TRKA activation
R-HSA-417973 Adenosine P1 receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-5683826 Surfactant metabolism

Protein family/group databases

TCDBi9.A.14.3.8 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2a
Gene namesi
Name:ADORA2A
Synonyms:ADORA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000128271.20
HostDB:ENSG00000258555.5
HGNCiHGNC:263 ADORA2A
MIMi102776 gene
neXtProtiNX_P29274

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7Extracellular1 Publication7
Transmembranei8 – 32Helical; Name=1Add BLAST25
Topological domaini33 – 42Cytoplasmic1 Publication10
Transmembranei43 – 66Helical; Name=2Add BLAST24
Topological domaini67 – 77Extracellular1 PublicationAdd BLAST11
Transmembranei78 – 100Helical; Name=3Add BLAST23
Topological domaini101 – 120Cytoplasmic1 PublicationAdd BLAST20
Transmembranei121 – 143Helical; Name=4Add BLAST23
Topological domaini144 – 173Extracellular1 PublicationAdd BLAST30
Transmembranei174 – 198Helical; Name=5Add BLAST25
Topological domaini199 – 234Cytoplasmic1 PublicationAdd BLAST36
Transmembranei235 – 258Helical; Name=6Add BLAST24
Topological domaini259 – 266Extracellular1 Publication8
Transmembranei267 – 290Helical; Name=7Add BLAST24
Topological domaini291 – 412Cytoplasmic1 PublicationAdd BLAST122

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi135
MalaCardsiADORA2A
OpenTargetsiENSG00000128271
Orphaneti363549 Acute encephalopathy with biphasic seizures and late reduced diffusion
PharmGKBiPA24584

Chemistry databases

ChEMBLiCHEMBL251
DrugBankiDB00640 Adenosine
DB05009 Apadenoson
DB05191 Atl146e
DB04853 Binodenoson
DB00201 Caffeine
DB04932 Defibrotide
DB00651 Dyphylline
DB00824 Enprofylline
DB00358 Mefloquine
DB01303 Oxtriphylline
DB00806 Pentoxifylline
DB06213 Regadenoson
DB01412 Theobromine
DB00277 Theophylline
GuidetoPHARMACOLOGYi19

Polymorphism and mutation databases

DMDMi543740

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689991 – 412Adenosine receptor A2aAdd BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi71 ↔ 159PROSITE-ProRule annotation1 Publication
Disulfide bondi74 ↔ 146PROSITE-ProRule annotation1 Publication
Disulfide bondi77 ↔ 166PROSITE-ProRule annotation1 Publication
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi259 ↔ 262PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiP29274
PeptideAtlasiP29274
PRIDEiP29274
ProteomicsDBi54531

PTM databases

iPTMnetiP29274
PhosphoSitePlusiP29274

Expressioni

Gene expression databases

BgeeiENSG00000128271 Expressed in 90 organ(s), highest expression level in cerebellum
CleanExiHS_ADORA2A
ExpressionAtlasiP29274 baseline and differential
GenevisibleiP29274 HS

Organism-specific databases

HPAiCAB001943
HPA065566
HPA075997

Interactioni

Subunit structurei

Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4. Interacts with NECAB2.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106647, 9 interactors
IntActiP29274, 9 interactors
MINTiP29274
STRINGi9606.ENSP00000336630

Chemistry databases

BindingDBiP29274

Structurei

Secondary structure

1412
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP29274
SMRiP29274
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29274

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni168 – 177Agonist binding10
Regioni246 – 253Agonist binding8
Regioni264 – 274Agonist bindingAdd BLAST11

Domaini

The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiP29274
KOiK04266
OMAiCIFMAAR
OrthoDBiEOG091G0I3U
TreeFamiTF325296

Family and domain databases

CDDicd15068 7tmA_Adenosine_R_A2A, 1 hit
InterProiView protein in InterPro
IPR001513 Adeno_A2A_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00553 ADENOSINA2AR
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P29274-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIMGSSVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFVVSLAA
60 70 80 90 100
ADIAVGVLAI PFAITISTGF CAACHGCLFI ACFVLVLTQS SIFSLLAIAI
110 120 130 140 150
DRYIAIRIPL RYNGLVTGTR AKGIIAICWV LSFAIGLTPM LGWNNCGQPK
160 170 180 190 200
EGKNHSQGCG EGQVACLFED VVPMNYMVYF NFFACVLVPL LLMLGVYLRI
210 220 230 240 250
FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG LFALCWLPLH
260 270 280 290 300
IINCFTFFCP DCSHAPLWLM YLAIVLSHTN SVVNPFIYAY RIREFRQTFR
310 320 330 340 350
KIIRSHVLRQ QEPFKAAGTS ARVLAAHGSD GEQVSLRLNG HPPGVWANGS
360 370 380 390 400
APHPERRPNG YALGLVSGGS AQESQGNTGL PDVELLSHEL KGVCPEPPGL
410
DDPLAQDGAG VS
Length:412
Mass (Da):44,707
Last modified:June 1, 1994 - v2
Checksum:i9438E9D64A6BE61B
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQD8C9JQD8_HUMAN
Adenosine receptor A2
ADORA2A
365Annotation score:
S4R2Z8S4R2Z8_HUMAN
Adenosine receptor A2
ADORA2A
108Annotation score:
C9JFS2C9JFS2_HUMAN
Adenosine receptor A2
ADORA2A
87Annotation score:
S4R3A7S4R3A7_HUMAN
Adenosine receptor A2a
ADORA2A
83Annotation score:
C9J0Z4C9J0Z4_HUMAN
Adenosine receptor A2a
ADORA2A
76Annotation score:
C9J3T2C9J3T2_HUMAN
Adenosine receptor A2a
ADORA2A
64Annotation score:
S4R429S4R429_HUMAN
Adenosine receptor A2a
ADORA2A
29Annotation score:

Sequence cautioni

The sequence AAA58356 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01183550A → V1 PublicationCorresponds to variant dbSNP:rs4530Ensembl.1
Natural variantiVAR_011836300R → H. Corresponds to variant dbSNP:rs4990Ensembl.1
Natural variantiVAR_003451392G → R. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97370 mRNA Translation: AAA58356.1 Different initiation.
X68486 mRNA Translation: CAA48504.1
S46950 mRNA Translation: AAB23956.1
U40771, U40770 Genomic DNA Translation: AAA83270.1
AY136747 mRNA Translation: AAN01273.1
CR456367 mRNA Translation: CAG30253.1
BT006999 mRNA Translation: AAP35645.1
AK312946 mRNA Translation: BAG35787.1
CH471095 Genomic DNA Translation: EAW59658.1
BC013780 mRNA Translation: AAH13780.1
CCDSiCCDS13826.1
PIRiA48978
RefSeqiNP_000666.2, NM_000675.5
NP_001265426.1, NM_001278497.1
NP_001265427.1, NM_001278498.1
NP_001265428.1, NM_001278499.1
NP_001265429.1, NM_001278500.1
UniGeneiHs.197029

Genome annotation databases

EnsembliENST00000337539; ENSP00000336630; ENSG00000128271
ENST00000610595; ENSP00000480012; ENSG00000128271
ENST00000611543; ENSP00000483102; ENSG00000128271
ENST00000618076; ENSP00000481552; ENSG00000128271
GeneIDi135
KEGGihsa:135

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97370 mRNA Translation: AAA58356.1 Different initiation.
X68486 mRNA Translation: CAA48504.1
S46950 mRNA Translation: AAB23956.1
U40771, U40770 Genomic DNA Translation: AAA83270.1
AY136747 mRNA Translation: AAN01273.1
CR456367 mRNA Translation: CAG30253.1
BT006999 mRNA Translation: AAP35645.1
AK312946 mRNA Translation: BAG35787.1
CH471095 Genomic DNA Translation: EAW59658.1
BC013780 mRNA Translation: AAH13780.1
CCDSiCCDS13826.1
PIRiA48978
RefSeqiNP_000666.2, NM_000675.5
NP_001265426.1, NM_001278497.1
NP_001265427.1, NM_001278498.1
NP_001265428.1, NM_001278499.1
NP_001265429.1, NM_001278500.1
UniGeneiHs.197029

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MMHmodel-16-36[»]
242-69[»]
378-102[»]
4117-143[»]
5175-203[»]
6233-260[»]
7264-296[»]
1UPEmodel-A1-304[»]
2YDOX-ray3.00A1-317[»]
2YDVX-ray2.60A1-317[»]
3EMLX-ray2.60A2-208[»]
A222-316[»]
3PWHX-ray3.30A1-317[»]
3QAKX-ray2.71A2-208[»]
A222-316[»]
3REYX-ray3.31A1-317[»]
3RFMX-ray3.60A1-317[»]
3UZAX-ray3.27A1-317[»]
3UZCX-ray3.34A1-317[»]
3VG9X-ray2.70A1-316[»]
3VGAX-ray3.10A1-316[»]
4EIYX-ray1.80A2-208[»]
A219-316[»]
4UG2X-ray2.60A/B1-317[»]
4UHRX-ray2.60A1-317[»]
5G53X-ray3.40A/B1-308[»]
5IU4X-ray1.72A2-208[»]
A219-318[»]
5IU7X-ray1.90A2-208[»]
A219-315[»]
5IU8X-ray2.00A2-208[»]
A219-315[»]
5IUAX-ray2.20A2-208[»]
A219-315[»]
5IUBX-ray2.10A2-208[»]
A219-315[»]
5JTBX-ray2.80A2-212[»]
A219-316[»]
5K2AX-ray2.50A2-208[»]
A219-316[»]
5K2BX-ray2.50A2-208[»]
A219-316[»]
5K2CX-ray1.90A2-208[»]
A219-316[»]
5K2DX-ray1.90A2-208[»]
A219-316[»]
5MZJX-ray2.00A2-208[»]
A219-318[»]
5MZPX-ray2.10A2-208[»]
A219-317[»]
5N2RX-ray2.80A2-208[»]
A219-318[»]
5NLXX-ray2.14A2-317[»]
5NM2X-ray1.95A2-317[»]
5NM4X-ray1.70A2-317[»]
5OLGX-ray1.87A2-208[»]
A219-317[»]
5OLHX-ray2.60A2-208[»]
A219-317[»]
5OLOX-ray3.10A2-208[»]
A219-318[»]
5OLVX-ray2.00A2-208[»]
A219-317[»]
5OLZX-ray1.90A2-208[»]
A219-317[»]
5OM1X-ray2.10A2-208[»]
A219-317[»]
5OM4X-ray2.00A2-208[»]
A219-317[»]
5UIGX-ray3.50A1-191[»]
A219-316[»]
5UVIX-ray3.20A2-212[»]
A219-316[»]
5VRAX-ray2.35A2-208[»]
A219-316[»]
5WF5X-ray2.60A2-208[»]
A222-316[»]
5WF6X-ray2.90A2-208[»]
A222-316[»]
6AQFX-ray2.51A2-208[»]
A219-316[»]
6GDGelectron microscopy4.11A8-316[»]
ProteinModelPortaliP29274
SMRiP29274
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106647, 9 interactors
IntActiP29274, 9 interactors
MINTiP29274
STRINGi9606.ENSP00000336630

Chemistry databases

BindingDBiP29274
ChEMBLiCHEMBL251
DrugBankiDB00640 Adenosine
DB05009 Apadenoson
DB05191 Atl146e
DB04853 Binodenoson
DB00201 Caffeine
DB04932 Defibrotide
DB00651 Dyphylline
DB00824 Enprofylline
DB00358 Mefloquine
DB01303 Oxtriphylline
DB00806 Pentoxifylline
DB06213 Regadenoson
DB01412 Theobromine
DB00277 Theophylline
GuidetoPHARMACOLOGYi19

Protein family/group databases

TCDBi9.A.14.3.8 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiP29274
PhosphoSitePlusiP29274

Polymorphism and mutation databases

DMDMi543740

Proteomic databases

PaxDbiP29274
PeptideAtlasiP29274
PRIDEiP29274
ProteomicsDBi54531

Protocols and materials databases

DNASUi135
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337539; ENSP00000336630; ENSG00000128271
ENST00000610595; ENSP00000480012; ENSG00000128271
ENST00000611543; ENSP00000483102; ENSG00000128271
ENST00000618076; ENSP00000481552; ENSG00000128271
GeneIDi135
KEGGihsa:135

Organism-specific databases

CTDi135
DisGeNETi135
EuPathDBiHostDB:ENSG00000128271.20
HostDB:ENSG00000258555.5
GeneCardsiADORA2A
HGNCiHGNC:263 ADORA2A
HPAiCAB001943
HPA065566
HPA075997
MalaCardsiADORA2A
MIMi102776 gene
neXtProtiNX_P29274
OpenTargetsiENSG00000128271
Orphaneti363549 Acute encephalopathy with biphasic seizures and late reduced diffusion
PharmGKBiPA24584
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiP29274
KOiK04266
OMAiCIFMAAR
OrthoDBiEOG091G0I3U
TreeFamiTF325296

Enzyme and pathway databases

ReactomeiR-HSA-187024 NGF-independant TRKA activation
R-HSA-417973 Adenosine P1 receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-5683826 Surfactant metabolism

Miscellaneous databases

EvolutionaryTraceiP29274
GeneWikiiAdenosine_A2A_receptor
GenomeRNAii135
PROiPR:P29274
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128271 Expressed in 90 organ(s), highest expression level in cerebellum
CleanExiHS_ADORA2A
ExpressionAtlasiP29274 baseline and differential
GenevisibleiP29274 HS

Family and domain databases

CDDicd15068 7tmA_Adenosine_R_A2A, 1 hit
InterProiView protein in InterPro
IPR001513 Adeno_A2A_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00553 ADENOSINA2AR
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAA2AR_HUMAN
AccessioniPrimary (citable) accession number: P29274
Secondary accession number(s): B2R7E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 198 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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