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Protein

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Gene

folK

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Dihydroneopterin aldolase (folB)
  4. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (folK)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processFolate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU00790-MONOMER
UniPathwayiUPA00077; UER00155

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
Gene namesi
Name:folK
Ordered Locus Names:BSU00790
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682471 – 1672-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseAdd BLAST167

Proteomic databases

PaxDbiP29252

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100000400

Structurei

3D structure databases

ProteinModelPortaliP29252
SMRiP29252
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HPPK family.Curated

Phylogenomic databases

eggNOGiENOG4105K8U Bacteria
COG0801 LUCA
HOGENOMiHOG000217741
InParanoidiP29252
KOiK00950
OMAiKDERWGP
PhylomeDBiP29252

Family and domain databases

CDDicd00483 HPPK, 1 hit
Gene3Di3.30.70.5601 hit
InterProiView protein in InterPro
IPR000550 Hppk
IPR035907 Hppk_sf
PfamiView protein in Pfam
PF01288 HPPK, 1 hit
SUPFAMiSSF55083 SSF55083, 1 hit
TIGRFAMsiTIGR01498 folK, 1 hit
PROSITEiView protein in PROSITE
PS00794 HPPK, 1 hit

Sequencei

Sequence statusi: Complete.

P29252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNIAYIALG SNIGDRETYL RQAVALLHQH AAVTVTKVSS IYETDPVGYE
60 70 80 90 100
DQAQFLNMAV EIKTSLNPFE LLELTQQIEN ELGRTREVRW GPRTADLDIL
110 120 130 140 150
LFNRENIETE QLIVPHPRMY ERLFVLAPLA EICQQVEKEA TSAETDQEGV
160
RVWKQKSGVD EFVHSES
Length:167
Mass (Da):19,058
Last modified:October 1, 1994 - v2
Checksum:iBED6AA62C85E01E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26185 Genomic DNA Translation: BAA05314.1
AL009126 Genomic DNA Translation: CAB11855.1
M34053 Genomic DNA No translation available.
PIRiS66109
RefSeqiNP_387960.1, NC_000964.3
WP_003242690.1, NZ_JNCM01000028.1

Genome annotation databases

EnsemblBacteriaiCAB11855; CAB11855; BSU00790
GeneIDi936940
KEGGibsu:BSU00790
PATRICifig|224308.179.peg.79

Similar proteinsi

Entry informationi

Entry nameiHPPK_BACSU
AccessioniPrimary (citable) accession number: P29252
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 1, 1994
Last modified: October 25, 2017
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome