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Protein

Chaperonin CPN60-1, mitochondrial

Gene

CPN60I

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

GO - Molecular functioni

  • ATPase binding Source: AgBase
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • protein folding Source: AgBase
  • protein refolding Source: InterPro

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperonin CPN60-1, mitochondrial
Alternative name(s):
HSP60-1
Gene namesi
Name:CPN60I
Synonyms:CPNA
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Chromosome 5

Organism-specific databases

MaizeGDBi65669

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34Mitochondrion1 PublicationAdd BLAST34
ChainiPRO_000000501435 – 577Chaperonin CPN60-1, mitochondrialAdd BLAST543

Proteomic databases

PRIDEiP29185

Expressioni

Inductioni

By heat shock.

Gene expression databases

ExpressionAtlasiP29185 differential

Interactioni

GO - Molecular functioni

  • ATPase binding Source: AgBase

Structurei

3D structure databases

ProteinModelPortaliP29185
SMRiP29185
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0356 Eukaryota
COG0459 LUCA
HOGENOMiHOG000076290
KOiK04077

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRAAASLAS KARQAGNSLA TRQVGSRLAW SRNYAAKDIK FGVEARALML
60 70 80 90 100
RGVEELADAV KVTMGPKGRN VVIEQSFGAP KVTKDGVTVA KSIEFKDRVK
110 120 130 140 150
NVGASLVKQV ANATNDTAGD GTTCATVLTK AIFTEGCKSV AAGMNAMDLR
160 170 180 190 200
RGISMAVDAV VTNLKGMARM ISTSEEIAQV GTISANGERE IGELIAKAME
210 220 230 240 250
KVGKEGVITI ADGNTLYNEL EVVEGMKLDR GYISPYFITN SKTQKCELED
260 270 280 290 300
PLILIHDKKV TNMHAVVKVL EMALKKQKPL LIVAEDVESE ALGTLIINKL
310 320 330 340 350
RAGIKVCAVK APGFGENRKA NLQDLAILTG GEVITEELGM NLENFEPHML
360 370 380 390 400
GTCKKVTVSK DDTVILDGAG DKKSIEERAE QIRSAIENST SDYDKEKLQE
410 420 430 440 450
RLAKLSGGVA VLKIGGASEA EVGEKKDRVT DALNATKAAV EEGIVPGGGV
460 470 480 490 500
ALLYASKELD KLQTANFDQK IGVQIIQNAL KTPVHTIASN AGVEGAVVVG
510 520 530 540 550
KLLEQENTDL GYDAAKGEYV DMVKTGIIDP LKVIRTALVD AASVSSLMTT
560 570
TESIIVEIPK EEAPAPAMGG GMGGMDY
Length:577
Mass (Da):61,211
Last modified:November 1, 1997 - v2
Checksum:i31D3BFFD46701C0B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21T → A in CAA78100 (Ref. 3) Curated1
Sequence conflicti108 – 109KQ → NR in CAA77645 (PubMed:1349837).Curated2
Sequence conflicti125A → D in CAA77645 (PubMed:1349837).Curated1
Sequence conflicti148D → N in CAA77645 (PubMed:1349837).Curated1
Sequence conflicti241S → P in CAA78100 (Ref. 3) Curated1
Sequence conflicti328L → F in CAA77645 (PubMed:1349837).Curated1
Sequence conflicti382I → L in CAA77645 (PubMed:1349837).Curated1
Sequence conflicti403A → P in AAA33450 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11546 mRNA Translation: CAA77645.1
L21007 Genomic DNA Translation: AAA33450.1
Z12114 mRNA Translation: CAA78100.1
PIRiS20875
S26582
RefSeqiNP_001105716.1, NM_001112246.1
UniGeneiZm.2489

Genome annotation databases

EnsemblPlantsiZm00001d014090_T001; Zm00001d014090_P001; Zm00001d014090
Zm00001d014090_T002; Zm00001d014090_P002; Zm00001d014090
GeneIDi542736
GrameneiZm00001d014090_T001; Zm00001d014090_P001; Zm00001d014090
Zm00001d014090_T002; Zm00001d014090_P002; Zm00001d014090
KEGGizma:542736

Similar proteinsi

Entry informationi

Entry nameiCH61_MAIZE
AccessioniPrimary (citable) accession number: P29185
Secondary accession number(s): Q43251, Q43252
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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