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Protein

Iron hydrogenase 1

Gene
N/A
Organism
Clostridium pasteurianum
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterNote: Binds 1 [2Fe-2S] cluster per subunit.
  • [4Fe-4S] clusterNote: Binds 4 [4Fe-4S] clusters per subunit.
  • Fe cationNote: Binds 2 iron ions per subunit. Besides cysteine ligand the diiron subcluster contains non-protein ligands including 2 sulfur atoms, 1 water and 5 cyanide or carbon monoxide ligands.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi34Iron-sulfur 1 (2Fe-2S)1 Publication1
Metal bindingi46Iron-sulfur 1 (2Fe-2S)1 Publication1
Metal bindingi49Iron-sulfur 1 (2Fe-2S)1 Publication1
Metal bindingi62Iron-sulfur 1 (2Fe-2S)1 Publication1
Metal bindingi94Iron-sulfur 2 (4Fe-4S); via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi98Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1 Publication1
Metal bindingi101Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1 Publication1
Metal bindingi107Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1 Publication1
Metal bindingi147Iron-sulfur 3 (4Fe-4S)1 Publication1
Metal bindingi150Iron-sulfur 3 (4Fe-4S)1 Publication1
Metal bindingi153Iron-sulfur 3 (4Fe-4S)1 Publication1
Metal bindingi157Iron-sulfur 4 (4Fe-4S)1 Publication1
Metal bindingi190Iron-sulfur 4 (4Fe-4S)1 Publication1
Metal bindingi193Iron-sulfur 4 (4Fe-4S)1 Publication1
Metal bindingi196Iron-sulfur 4 (4Fe-4S)1 Publication1
Metal bindingi200Iron-sulfur 3 (4Fe-4S)1 Publication1
Metal bindingi300Iron-sulfur 5 (4Fe-4S)1 Publication1
Metal bindingi355Iron-sulfur 5 (4Fe-4S)1 Publication1
Metal bindingi499Iron-sulfur 5 (4Fe-4S)1 Publication1
Metal bindingi503Diiron subcluster1
Metal bindingi503Iron-sulfur 5 (4Fe-4S)1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Iron hydrogenase 1 (EC:1.12.7.2)
Alternative name(s):
CpI
Fe-only hydrogenase
[Fe] hydrogenase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiClostridium pasteurianum
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1501 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00916 Metronidazole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001997321 – 574Iron hydrogenase 1Add BLAST574

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1574
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P29166

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P29166

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P29166

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 782Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST78
Domaini78 – 1174Fe-4S His(Cys)3-ligated-typePROSITE-ProRule annotationAdd BLAST40
Domaini138 – 1674Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST30
Domaini181 – 2104Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat

Phylogenomic databases

KEGG Orthology (KO)

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KOi
K00532

Family and domain databases

Conserved Domains Database

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CDDi
cd00207 fer2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.260.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR009016 Fe_hydrogenase
IPR004108 Fe_hydrogenase_lsu_C
IPR003149 Fe_hydrogenase_ssu
IPR036991 Fe_hydrogenase_ssu_sf
IPR013352 Fe_hydrogenase_subset
IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02906 Fe_hyd_lg_C, 1 hit
PF02256 Fe_hyd_SSU, 1 hit
PF12838 Fer4_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00902 Fe_hyd_SSU, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53920 SSF53920, 1 hit
SSF54292 SSF54292, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02512 FeFe_hydrog_A, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 2 hits
PS51379 4FE4S_FER_2, 2 hits
PS51839 4FE4S_HC3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P29166-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTIIINGVQ FNTDEDTTIL KFARDNNIDI SALCFLNNCN NDINKCEICT
60 70 80 90 100
VEVEGTGLVT ACDTLIEDGM IINTNSDAVN EKIKSRISQL LDIHEFKCGP
110 120 130 140 150
CNRRENCEFL KLVIKYKARA SKPFLPKDKT EYVDERSKSL TVDRTKCLLC
160 170 180 190 200
GRCVNACGKN TETYAMKFLN KNGKTIIGAE DEKCFDDTNC LLCGQCIIAC
210 220 230 240 250
PVAALSEKSH MDRVKNALNA PEKHVIVAMA PSVRASIGEL FNMGFGVDVT
260 270 280 290 300
GKIYTALRQL GFDKIFDINF GADMTIMEEA TELVQRIENN GPFPMFTSCC
310 320 330 340 350
PGWVRQAENY YPELLNNLSS AKSPQQIFGT ASKTYYPSIS GLDPKNVFTV
360 370 380 390 400
TVMPCTSKKF EADRPQMEKD GLRDIDAVIT TRELAKMIKD AKIPFAKLED
410 420 430 440 450
SEADPAMGEY SGAGAIFGAT GGVMEAALRS AKDFAENAEL EDIEYKQVRG
460 470 480 490 500
LNGIKEAEVE INNNKYNVAV INGASNLFKF MKSGMINEKQ YHFIEVMACH
510 520 530 540 550
GGCVNGGGQP HVNPKDLEKV DIKKVRASVL YNQDEHLSKR KSHENTALVK
560 570
MYQNYFGKPG EGRAHEILHF KYKK
Length:574
Mass (Da):63,828
Last modified:December 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i17E28A74E23C7DEE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M81737 Genomic DNA Translation: AAA23248.1

Protein sequence database of the Protein Information Resource

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PIRi
A40330 HQCL1P

NCBI Reference Sequences

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RefSeqi
WP_004455619.1, NZ_LFYL01000002.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ag:AAA23248

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81737 Genomic DNA Translation: AAA23248.1
PIRiA40330 HQCL1P
RefSeqiWP_004455619.1, NZ_LFYL01000002.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C4AX-ray2.40A1-574[»]
1C4CX-ray2.40A1-574[»]
1FEHX-ray1.80A1-574[»]
3C8YX-ray1.39A1-574[»]
4XDCX-ray1.63A/B1-574[»]
4XDDX-ray1.60A/B1-574[»]
5BYQX-ray1.73A/B1-574[»]
5BYRX-ray1.82A/B1-574[»]
5BYSX-ray1.93A/B1-574[»]
5LA3X-ray2.29A/B2-574[»]
5OEFX-ray2.05A/B1-574[»]
ProteinModelPortaliP29166
SMRiP29166
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB00916 Metronidazole

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAA23248

Phylogenomic databases

KOiK00532

Miscellaneous databases

EvolutionaryTraceiP29166

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di4.10.260.20, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR009016 Fe_hydrogenase
IPR004108 Fe_hydrogenase_lsu_C
IPR003149 Fe_hydrogenase_ssu
IPR036991 Fe_hydrogenase_ssu_sf
IPR013352 Fe_hydrogenase_subset
IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
PfamiView protein in Pfam
PF02906 Fe_hyd_lg_C, 1 hit
PF02256 Fe_hyd_SSU, 1 hit
PF12838 Fer4_7, 1 hit
SMARTiView protein in SMART
SM00902 Fe_hyd_SSU, 1 hit
SUPFAMiSSF53920 SSF53920, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR02512 FeFe_hydrog_A, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 2 hits
PS51379 4FE4S_FER_2, 2 hits
PS51839 4FE4S_HC3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHF1_CLOPA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29166
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: December 5, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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