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UniProtKB - P29138 (CUDP_METAN)
Protein
Cuticle-degrading protease
Gene
PR1
Organism
Metarhizium anisopliae (Entomophthora anisopliae)
Status
Functioni
Capable of breaching the insect cuticle.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 148 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 179 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 334 | Charge relay systemPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Protein family/group databases
MEROPSi | S08.056 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PR1 |
Organismi | Metarhizium anisopliae (Entomophthora anisopliae) |
Taxonomic identifieri | 5530 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Clavicipitaceae › Metarhizium |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
PropeptideiPRO_0000027006 | 19 – 107 | Sequence analysisAdd BLAST | 89 | |
ChainiPRO_0000027007 | 108 – 388 | Cuticle-degrading proteaseAdd BLAST | 281 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 143 ↔ 233 | By similarity | ||
Disulfide bondi | 288 ↔ 360 | By similarity | ||
Glycosylationi | 296 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 106 | Inhibitor I9Sequence analysisAdd BLAST | 66 | |
Domaini | 116 – 388 | Peptidase S8PROSITE-ProRule annotationAdd BLAST | 273 |
Sequence similaritiesi
Belongs to the peptidase S8 family.Curated
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd04077, Peptidases_S8_PCSK9_ProteinaseK_like, 1 hit |
Gene3Di | 3.30.70.80, 1 hit 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR034193, PCSK9_ProteinaseK-like IPR000209, Peptidase_S8/S53_dom IPR036852, Peptidase_S8/S53_dom_sf IPR023827, Peptidase_S8_Asp-AS IPR022398, Peptidase_S8_His-AS IPR023828, Peptidase_S8_Ser-AS IPR015500, Peptidase_S8_subtilisin-rel IPR010259, S8pro/Inhibitor_I9 IPR037045, S8pro/Inhibitor_I9_sf |
Pfami | View protein in Pfam PF05922, Inhibitor_I9, 1 hit PF00082, Peptidase_S8, 1 hit |
PRINTSi | PR00723, SUBTILISIN |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51892, SUBTILASE, 1 hit PS00136, SUBTILASE_ASP, 1 hit PS00137, SUBTILASE_HIS, 1 hit PS00138, SUBTILASE_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P29138-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHLSALLTLL PAVLAAPATI GRRAEPAPLF TPQAESIIAD KYIVKFKDDI
60 70 80 90 100
ARIATDDTVS ALTSKADFVY EHAFHGFAGS LTKEELKMLR EHPGVDFIEK
110 120 130 140 150
DAVMRISGIT EQSGAPWGLG RISHRSKGST TYRYDDSAGQ GTCVYIIDTG
160 170 180 190 200
IEASHPEFEG RATFLKSFIS GQNTDGHGHG THCAGTIGSK TYGVAKKAKL
210 220 230 240 250
YGVKVLDNQG SGSYSGIISG MDYVAQDSKT RGCPNGAIAS MSLGGGYSAS
260 270 280 290 300
VNQGAAALVN SGVFLAVAAG NDNRDAQNTS PASEPSACTV GASAENDSRS
310 320 330 340 350
SFSNYGRVVD IFAPGSNVLS TWIVGRTNSI SGTSMATPHI AGLAAYLSAL
360 370 380
QGKTTPAALC KKIQDTATKN VLTGVPSGTV NYLAYNGA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M73795 mRNA Translation: AAA33417.1 |
PIRi | S22387 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M73795 mRNA Translation: AAA33417.1 |
PIRi | S22387 |
3D structure databases
SMRi | P29138 |
ModBasei | Search... |
Protein family/group databases
MEROPSi | S08.056 |
Miscellaneous databases
PHI-basei | PHI:4615 |
Family and domain databases
CDDi | cd04077, Peptidases_S8_PCSK9_ProteinaseK_like, 1 hit |
Gene3Di | 3.30.70.80, 1 hit 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR034193, PCSK9_ProteinaseK-like IPR000209, Peptidase_S8/S53_dom IPR036852, Peptidase_S8/S53_dom_sf IPR023827, Peptidase_S8_Asp-AS IPR022398, Peptidase_S8_His-AS IPR023828, Peptidase_S8_Ser-AS IPR015500, Peptidase_S8_subtilisin-rel IPR010259, S8pro/Inhibitor_I9 IPR037045, S8pro/Inhibitor_I9_sf |
Pfami | View protein in Pfam PF05922, Inhibitor_I9, 1 hit PF00082, Peptidase_S8, 1 hit |
PRINTSi | PR00723, SUBTILISIN |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51892, SUBTILASE, 1 hit PS00136, SUBTILASE_ASP, 1 hit PS00137, SUBTILASE_HIS, 1 hit PS00138, SUBTILASE_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CUDP_METAN | |
Accessioni | P29138Primary (citable) accession number: P29138 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families