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UniProtKB - P29129 (ICP0_SUHVF)
Protein
E3 ubiquitin-protein ligase ICP0
Gene
EP0
Organism
Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))
Status
Functioni
Evades nuclear antiviral defenses triggered by dsDNA viruses. Acts during the initial stages of lytic infection and the reactivation of latent viral genome. Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100.
By similarityCatalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 46 – 85 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- transferase activity Source: UniProtKB-KW
GO - Biological processi
- disruption by symbiont of host cell PML body Source: UniProtKB
- modulation by virus of host protein ubiquitination Source: UniProtKB-KW
- release from viral latency Source: UniProtKB-KW
- suppression by virus of host exit from mitosis Source: UniProtKB-KW
- suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase ICP0 (EC:2.3.2.27)Alternative name(s): Early protein 0 Short name: EP0 RING-type E3 ubiquitin transferase ICP0Curated |
Gene namesi | Name:EP0 |
Organismi | Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker)) |
Taxonomic identifieri | 31523 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus › |
Virus hosti | Sus scrofa (Pig) [TaxID: 9823] |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056358 | 1 – 410 | E3 ubiquitin-protein ligase ICP0Add BLAST | 410 |
Post-translational modificationi
Auto-ubiquitinated.By similarity
Keywords - PTMi
Ubl conjugationFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 243 – 410 | DisorderedSequence analysisAdd BLAST | 168 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 259 – 274 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 275 – 289 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 290 – 313 | Basic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 322 – 337 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 351 – 374 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 386 – 402 | Polar residuesSequence analysisAdd BLAST | 17 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 46 – 85 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
Keywords - Domaini
Zinc-fingerFamily and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR018957, Znf_C3HC4_RING-type IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00097, zf-C3HC4, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P29129-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGCTVSRRRT TTAEASSAWG IFGFYRPRSP SPPPQRLSLP LTVMDCPICL
60 70 80 90 100
DVAATEAQTL PCMHKFCLDC IQRWTLTSTA CPLCNARVTS ILHHVDSDAS
110 120 130 140 150
FVETPVEGAT DVDGEEDEPV GGGFAVIWGE DYTEEVRHEE AEGQGSGSGS
160 170 180 190 200
RARPRVPVFN WLYGQVSTVI ESDPIREAVV DNIVEIIQEH GMNRQRVTEA
210 220 230 240 250
MLPMFGANTH ALVDTLFDIS AQWMRRMQRR APMSHQGVNY IDTSESEAHS
260 270 280 290 300
DSEVSSPDEE DSGASSSGVH TEDLTEASES ADDQRPAPRR SPRRARRAAV
310 320 330 340 350
LRREQRRTRC LRRGRTGGQA QGETPEAPSS GEGSSAQHGA SGAGAGPGSA
360 370 380 390 400
NTAASARSSP SSSPSSSMRR PSPSASAPET AAPRGGPPAS SSSGSPRSAT
410
IFIDLTQDDD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M57504 mRNA Translation: AAA47463.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M57504 mRNA Translation: AAA47463.1 |
3D structure databases
SMRi | P29129 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR018957, Znf_C3HC4_RING-type IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00097, zf-C3HC4, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ICP0_SUHVF | |
Accessioni | P29129Primary (citable) accession number: P29129 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |