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Protein

Bifunctional endo-1,4-beta-xylanase XylA

Gene

xynA

Organism
Ruminococcus flavefaciens
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Xylanase domain releases more xylo-oligosaccharides and GH10 domain more xylose.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

Pathwayi: xylan degradation

This protein is involved in the pathway xylan degradation, which is part of Glycan degradation.
View all proteins of this organism that are known to be involved in the pathway xylan degradation and in Glycan degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei122NucleophileBy similarity1
Active sitei223Proton donorPROSITE-ProRule annotation1
Active sitei774Proton donorPROSITE-ProRule annotation1
Active sitei884NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase, Multifunctional enzyme
Biological processCarbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

UniPathwayi
UPA00114

Protein family/group databases

CAZyiGH10 Glycoside Hydrolase Family 10
GH11 Glycoside Hydrolase Family 11
mycoCLAPiXYN11A_RUMFL

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional endo-1,4-beta-xylanase XylA (EC:3.2.1.8)
Gene namesi
Name:xynA
OrganismiRuminococcus flavefaciens
Taxonomic identifieri1265 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Or 28, or 29Sequence analysisAdd BLAST27
ChainiPRO_000000801528 – 954Bifunctional endo-1,4-beta-xylanase XylAAdd BLAST927

Structurei

3D structure databases

ProteinModelPortaliP29126
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 236GH11PROSITE-ProRule annotationAdd BLAST208
Domaini624 – 952GH10PROSITE-ProRule annotationAdd BLAST329

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi245 – 622Asn/Gln/Trp-rich (linker)Add BLAST378

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyl hydrolase 11 (cellulase G) family.Curated
In the C-terminal section; belongs to the glycosyl hydrolase 10 (cellulase F) family.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.120.180, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001000 GH10
IPR031158 GH10_AS
IPR013319 GH11/12
IPR018208 GH11_AS_1
IPR033119 GH11_AS_2
IPR033123 GH11_dom
IPR001137 Glyco_hydro_11
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00331 Glyco_hydro_10, 1 hit
PF00457 Glyco_hydro_11, 1 hit
PRINTSiPR00911 GLHYDRLASE11
SMARTiView protein in SMART
SM00633 Glyco_10, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00591 GH10_1, 1 hit
PS51760 GH10_2, 1 hit
PS00776 GH11_1, 1 hit
PS00777 GH11_2, 1 hit
PS51761 GH11_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29126-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLSKIKKVL SGTVSALMIA SAAPVVASAA DQQTRGNVGG YDYEMWNQNG
60 70 80 90 100
QGQASMNPGA GSFTCSWSNI ENFLARMGKN YDSQKKNYKA FGNIVLTYDV
110 120 130 140 150
EYTPRGNSYM CVYGWTRNPL MEYYIVEGWG DWRPPGNDGE VKGTVSANGN
160 170 180 190 200
TYDIRKTMRY NQPSLDGTAT FPQYWSVRQT SGSANNQTNY MKGTIDVTKH
210 220 230 240 250
FDAWSAAGLD MSGTLYEVSL NIEGYRSNGS ANVKSVSVTQ GGSSDNGGQQ
260 270 280 290 300
QNNDWNQQNN NQQQNNDWNN WGQQNNDWNQ WNNQGQQNND WNNWGQQNND
310 320 330 340 350
WNQWNNQGQQ QNNDWNNWGQ QNNDWNQWNN QGQQQNNDWN NWGQQNNDWN
360 370 380 390 400
QWNNQGQQQN NDWNNWGQQN NDWNQWNNQN NNQQNAWNGW DNNNNWNQNN
410 420 430 440 450
QQQNNWDWNN QNNWNNNQQQ NNDWNQWNNQ NNWNNNQQQN NDWNQWNNQG
460 470 480 490 500
QQNNDWNQWN NQNNWNQNNN QQNAWNGWDN NNNWNQWDQN NQWNNQQQNN
510 520 530 540 550
TWDWNNQNNW NNNQQNNDWN QWNNQGQQQN NDWNQWNNQN NNQNNGWDWN
560 570 580 590 600
NQNNWNQNNN QQNAWNGWDN NNNWNQWGGQ NNDWNNQQQN NDWNQWNNQG
610 620 630 640 650
QQQNNDWNNQ NNWNQGQQNN NNSAGSSDSL KGAFSKYFKI GTSVSPHELN
660 670 680 690 700
SGADFLKKHY NSITPENELK PESILDQGAC QQKGNNVNTQ ISLSRAAQTL
710 720 730 740 750
KFCEQNGIAL RGHTFVWYSQ TPDWFFRENF SQNGAYVSKD IMNQRLESMI
760 770 780 790 800
KNTFAALKSQ YPNLDVYSYD VCNELFLNNG GGMRGADNSN WVKIYGDDSF
810 820 830 840 850
VINAFKYARQ YAPAGCKLYL NDYNEYIPAK TNDIYNMAMK LKQLGYIDGI
860 870 880 890 900
GMQSHLATNY PDANTYETAL KKFLSTGLEV QITELDITCT NSAEQADLYE
910 920 930 940 950
KIFKLAMQNS AQIPAVTIWG TQDTVSWRSS QNPLLFSAGY QPKPAYDRVM

ALAK
Length:954
Mass (Da):111,362
Last modified:December 1, 1992 - v1
Checksum:i1033567D4B526EBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11127 Genomic DNA Translation: CAA77476.1
PIRiS20907

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11127 Genomic DNA Translation: CAA77476.1
PIRiS20907

3D structure databases

ProteinModelPortaliP29126
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH10 Glycoside Hydrolase Family 10
GH11 Glycoside Hydrolase Family 11
mycoCLAPiXYN11A_RUMFL

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00114

Family and domain databases

Gene3Di2.60.120.180, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001000 GH10
IPR031158 GH10_AS
IPR013319 GH11/12
IPR018208 GH11_AS_1
IPR033119 GH11_AS_2
IPR033123 GH11_dom
IPR001137 Glyco_hydro_11
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00331 Glyco_hydro_10, 1 hit
PF00457 Glyco_hydro_11, 1 hit
PRINTSiPR00911 GLHYDRLASE11
SMARTiView protein in SMART
SM00633 Glyco_10, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00591 GH10_1, 1 hit
PS51760 GH10_2, 1 hit
PS00776 GH11_1, 1 hit
PS00777 GH11_2, 1 hit
PS51761 GH11_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXYNA_RUMFL
AccessioniPrimary (citable) accession number: P29126
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 22, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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Main funding by: National Institutes of Health

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