UniProtKB - P29122 (PCSK6_HUMAN)
Proprotein convertase subtilisin/kexin type 6
PCSK6
Functioni
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 205 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 246 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 420 | Charge relay systemPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- endopeptidase activity Source: BHF-UCL
- heparin binding Source: BHF-UCL
- nerve growth factor binding Source: BHF-UCL
- serine-type endopeptidase activity Source: BHF-UCL
GO - Biological processi
- cornification Source: Reactome
- glycoprotein metabolic process Source: BHF-UCL
- nerve growth factor processing Source: Reactome
- nerve growth factor production Source: BHF-UCL
- peptide hormone processing Source: BHF-UCL
- protein processing Source: BHF-UCL
- regulation of BMP signaling pathway Source: BHF-UCL
- regulation of lipoprotein lipase activity Source: Reactome
- secretion by cell Source: BHF-UCL
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Ligand | Calcium |
Enzyme and pathway databases
BRENDAi | 3.4.21.B25, 2681 |
PathwayCommonsi | P29122 |
Reactomei | R-HSA-1181150, Signaling by NODAL R-HSA-167060, NGF processing R-HSA-6809371, Formation of the cornified envelope R-HSA-8963889, Assembly of active LPL and LIPC lipase complexes |
SignaLinki | P29122 |
SIGNORi | P29122 |
Protein family/group databases
MEROPSi | S08.075 |
Names & Taxonomyi
Protein namesi | Recommended name: Proprotein convertase subtilisin/kexin type 6 (EC:3.4.21.-)Alternative name(s): Paired basic amino acid cleaving enzyme 4 Subtilisin-like proprotein convertase 4 Short name: SPC4 Subtilisin/kexin-like protease PACE4 |
Gene namesi | Name:PCSK6 Synonyms:PACE4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8569, PCSK6 |
MIMi | 167405, gene |
neXtProti | NX_P29122 |
VEuPathDBi | HostDB:ENSG00000140479.16 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
Endoplasmic reticulum
Note: Not secreted, remains probably in zymogen form in endoplasmic reticulum.
Endoplasmic reticulum
Note: Not secreted, remains probably in zymogen form in endoplasmic reticulum.
Other locations
Note: Retained intracellularly probably through a hydrophobic cluster in their C-terminus.
Other locations
Note: Retained intracellularly probably through a hydrophobic cluster in their C-terminus.
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Golgi apparatus
- Golgi lumen Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cell surface Source: BHF-UCL
- membrane Source: GO_Central
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 5046 |
OpenTargetsi | ENSG00000140479 |
PharmGKBi | PA32895 |
Miscellaneous databases
Pharosi | P29122, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2951 |
GuidetoPHARMACOLOGYi | 2386 |
Genetic variation databases
BioMutai | PCSK6 |
DMDMi | 129542 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 63 | Sequence analysisAdd BLAST | 63 | |
PropeptideiPRO_0000027110 | 64 – 149 | 1 PublicationAdd BLAST | 86 | |
ChainiPRO_0000027111 | 150 – 969 | Proprotein convertase subtilisin/kexin type 6Add BLAST | 820 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 259 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 914 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 932 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 149 – 150 | Cleavage; by autolysis1 Publication | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Glycoprotein, ZymogenProteomic databases
MassIVEi | P29122 |
MaxQBi | P29122 |
PaxDbi | P29122 |
PeptideAtlasi | P29122 |
PRIDEi | P29122 |
ProteomicsDBi | 54520 [P29122-1] 54521 [P29122-2] 54522 [P29122-3] 54523 [P29122-4] 54524 [P29122-5] 54525 [P29122-6] 54526 [P29122-7] 54527 [P29122-8] |
TopDownProteomicsi | P29122-3 [P29122-3] |
PTM databases
GlyGeni | P29122, 4 sites, 1 O-linked glycan (1 site) |
iPTMneti | P29122 |
PhosphoSitePlusi | P29122 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000140479, Expressed in C1 segment of cervical spinal cord and 212 other tissues |
ExpressionAtlasi | P29122, baseline and differential |
Genevisiblei | P29122, HS |
Organism-specific databases
HPAi | ENSG00000140479, Tissue enhanced (brain, liver, lymphoid tissue) |
Interactioni
Subunit structurei
The PACE4A-I precursor protein seems to exist in the reticulum endoplasmic as both a monomer and a dimer-sized complex whereas mature PACE4A-I exists only as a monomer, suggesting that propeptide cleavage affects its tertiary or quaternary structure.
Interacts (immature form including the propeptide) with RCN3; probably involved in the maturation and the secretion of PCSK6 (PubMed:16433634).
1 PublicationBinary interactionsi
Hide detailsP29122
With | #Exp. | IntAct |
---|---|---|
PCSK5 - isoform PC6A [Q92824-2] | 3 | EBI-2683528,EBI-11956269 |
ZNF441 [Q8N8Z8] | 3 | EBI-2683528,EBI-17216366 |
GO - Molecular functioni
- nerve growth factor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 111083, 11 interactors |
DIPi | DIP-29903N |
IntActi | P29122, 11 interactors |
STRINGi | 9606.ENSP00000482760 |
Chemistry databases
BindingDBi | P29122 |
Miscellaneous databases
RNActi | P29122, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 168 – 487 | Peptidase S8PROSITE-ProRule annotationAdd BLAST | 320 | |
Domaini | 495 – 635 | P/Homo BPROSITE-ProRule annotationAdd BLAST | 141 | |
Repeati | 692 – 739 | FU 1Add BLAST | 48 | |
Repeati | 743 – 790 | FU 2Add BLAST | 48 | |
Repeati | 794 – 838 | FU 3Add BLAST | 45 | |
Repeati | 842 – 887 | FU 4Add BLAST | 46 | |
Repeati | 895 – 943 | FU 5Add BLAST | 49 | |
Domaini | 931 – 969 | PLACPROSITE-ProRule annotationAdd BLAST | 39 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 695 – 930 | CRM (Cys-rich motif)Add BLAST | 236 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 553 – 555 | Cell attachment siteSequence analysis | 3 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG3525, Eukaryota |
GeneTreei | ENSGT00940000159506 |
HOGENOMi | CLU_002976_4_1_1 |
InParanoidi | P29122 |
OrthoDBi | 308083at2759 |
PhylomeDBi | P29122 |
TreeFami | TF314277 |
Family and domain databases
CDDi | cd00064, FU, 4 hits cd04059, Peptidases_S8_Protein_convertases_Kexins_Furin-like, 1 hit |
Gene3Di | 2.60.120.260, 1 hit 3.30.70.850, 1 hit 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR006212, Furin_repeat IPR008979, Galactose-bd-like_sf IPR032778, GF_recep_IV IPR009030, Growth_fac_rcpt_cys_sf IPR034182, Kexin/furin IPR002884, P_dom IPR000209, Peptidase_S8/S53_dom IPR036852, Peptidase_S8/S53_dom_sf IPR023827, Peptidase_S8_Asp-AS IPR022398, Peptidase_S8_His-AS IPR023828, Peptidase_S8_Ser-AS IPR015500, Peptidase_S8_subtilisin-rel IPR010909, PLAC IPR032815, S8_pro-domain IPR038466, S8_pro-domain_sf |
Pfami | View protein in Pfam PF14843, GF_recep_IV, 1 hit PF01483, P_proprotein, 1 hit PF00082, Peptidase_S8, 1 hit PF08686, PLAC, 1 hit PF16470, S8_pro-domain, 1 hit |
PRINTSi | PR00723, SUBTILISIN |
SMARTi | View protein in SMART SM00181, EGF, 5 hits SM00261, FU, 5 hits |
SUPFAMi | SSF49785, SSF49785, 1 hit SSF52743, SSF52743, 1 hit SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS51829, P_HOMO_B, 1 hit PS50900, PLAC, 1 hit PS51892, SUBTILASE, 1 hit PS00136, SUBTILASE_ASP, 1 hit PS00137, SUBTILASE_HIS, 1 hit PS00138, SUBTILASE_SER, 1 hit |
s (8+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 8 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPPRAPPAPG PRPPPRAAAA TDTAAGAGGA GGAGGAGGPG FRPLAPRPWR
60 70 80 90 100
WLLLLALPAA CSAPPPRPVY TNHWAVQVLG GPAEADRVAA AHGYLNLGQI
110 120 130 140 150
GNLEDYYHFY HSKTFKRSTL SSRGPHTFLR MDPQVKWLQQ QEVKRRVKRQ
160 170 180 190 200
VRSDPQALYF NDPIWSNMWY LHCGDKNSRC RSEMNVQAAW KRGYTGKNVV
210 220 230 240 250
VTILDDGIER NHPDLAPNYD SYASYDVNGN DYDPSPRYDA SNENKHGTRC
260 270 280 290 300
AGEVAASANN SYCIVGIAYN AKIGGIRMLD GDVTDVVEAK SLGIRPNYID
310 320 330 340 350
IYSASWGPDD DGKTVDGPGR LAKQAFEYGI KKGRQGLGSI FVWASGNGGR
360 370 380 390 400
EGDYCSCDGY TNSIYTISVS SATENGYKPW YLEECASTLA TTYSSGAFYE
410 420 430 440 450
RKIVTTDLRQ RCTDGHTGTS VSAPMVAGII ALALEANSQL TWRDVQHLLV
460 470 480 490 500
KTSRPAHLKA SDWKVNGAGH KVSHFYGFGL VDAEALVVEA KKWTAVPSQH
510 520 530 540 550
MCVAASDKRP RSIPLVQVLR TTALTSACAE HSDQRVVYLE HVVVRTSISH
560 570 580 590 600
PRRGDLQIYL VSPSGTKSQL LAKRLLDLSN EGFTNWEFMT VHCWGEKAEG
610 620 630 640 650
QWTLEIQDLP SQVRNPEKQG KLKEWSLILY GTAEHPYHTF SAHQSRSRML
660 670 680 690 700
ELSAPELEPP KAALSPSQVE VPEDEEDYTA QSTPGSANIL QTSVCHPECG
710 720 730 740 750
DKGCDGPNAD QCLNCVHFSL GSVKTSRKCV SVCPLGYFGD TAARRCRRCH
760 770 780 790 800
KGCETCSSRA ATQCLSCRRG FYHHQEMNTC VTLCPAGFYA DESQKNCLKC
810 820 830 840 850
HPSCKKCVDE PEKCTVCKEG FSLARGSCIP DCEPGTYFDS ELIRCGECHH
860 870 880 890 900
TCGTCVGPGR EECIHCAKNF HFHDWKCVPA CGEGFYPEEM PGLPHKVCRR
910 920 930 940 950
CDENCLSCAG SSRNCSRCKT GFTQLGTSCI TNHTCSNADE TFCEMVKSNR
960
LCERKLFIQF CCRTCLLAG
The sequence of this isoform differs from the canonical sequence as follows:
680-693: AQSTPGSANILQTS → G
The sequence of this isoform differs from the canonical sequence as follows:
471-471: K → KGAAVAFWWTIGWPWNV
472-969: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
621-652: KLKEWSLILYGTAEHPYHTFSAHQSRSRMLEL → DLETPVANQLTTEEREPGLKHVFRWQIEQELW
653-969: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
621-623: KLK → NLD
624-969: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-167: Missing.
621-664: KLKEWSLILY...PELEPPKAAL → DLETPVANQL...YHIVLITVAL
665-969: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
901-969: CDENCLSCAG...FCCRTCLLAG → YGPPGGERQA...AVGRHRAAAG
The sequence of this isoform differs from the canonical sequence as follows:
680-693: AQSTPGSANILQTS → G
901-969: CDENCLSCAG...FCCRTCLLAG → YGPPGGERQA...AVGRHRAAAG
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WY68 | A0A087WY68_HUMAN | Proprotein convertase subtilisin/ke... | PCSK6 | 975 | Annotation score: | ||
H7BXT3 | H7BXT3_HUMAN | Proprotein convertase subtilisin/ke... | PCSK6 | 664 | Annotation score: | ||
A0A087WZR0 | A0A087WZR0_HUMAN | Proprotein convertase subtilisin/ke... | PCSK6 | 962 | Annotation score: | ||
H0Y3Q0 | H0Y3Q0_HUMAN | Proprotein convertase subtilisin/ke... | PCSK6 | 797 | Annotation score: | ||
H0YMW5 | H0YMW5_HUMAN | Proprotein convertase subtilisin/ke... | PCSK6 | 125 | Annotation score: | ||
H0YKZ4 | H0YKZ4_HUMAN | Proprotein convertase subtilisin/ke... | PCSK6 | 345 | Annotation score: | ||
H0YLC8 | H0YLC8_HUMAN | Proprotein convertase subtilisin/ke... | PCSK6 | 126 | Annotation score: | ||
A0A087X025 | A0A087X025_HUMAN | Proprotein convertase subtilisin/ke... | PCSK6 | 142 | Annotation score: | ||
A0A0J9YW51 | A0A0J9YW51_HUMAN | Proprotein convertase subtilisin/ke... | PCSK6 | 308 | Annotation score: | ||
H0YKK2 | H0YKK2_HUMAN | Proprotein convertase subtilisin/ke... | PCSK6 | 77 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 639 | T → I in BAA21624 (PubMed:9378725).Curated | 1 | |
Sequence conflicti | 639 | T → I in BAA21625 (PubMed:9378725).Curated | 1 | |
Sequence conflicti | 639 | T → I in BAA21626 (PubMed:9378725).Curated | 1 | |
Sequence conflicti | 639 | T → I in BAA21627 (PubMed:9378725).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051824 | 502 | C → R. Corresponds to variant dbSNP:rs1058260Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005427 | 1 – 167 | Missing in isoform PACE4D. 1 PublicationAdd BLAST | 167 | |
Alternative sequenceiVSP_005428 | 471 | K → KGAAVAFWWTIGWPWNV in isoform PACE4B. 1 Publication | 1 | |
Alternative sequenceiVSP_005429 | 472 – 969 | Missing in isoform PACE4B. 1 PublicationAdd BLAST | 498 | |
Alternative sequenceiVSP_005434 | 621 – 664 | KLKEW…PKAAL → DLETPVANQLTTEERFVSTP SILFHWSVYLSWSQYHIVLI TVAL in isoform PACE4D. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_005432 | 621 – 652 | KLKEW…RMLEL → DLETPVANQLTTEEREPGLK HVFRWQIEQELW in isoform PACE4C. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_005430 | 621 – 623 | KLK → NLD in isoform PACE4CS. Curated | 3 | |
Alternative sequenceiVSP_005431 | 624 – 969 | Missing in isoform PACE4CS. CuratedAdd BLAST | 346 | |
Alternative sequenceiVSP_005433 | 653 – 969 | Missing in isoform PACE4C. 1 PublicationAdd BLAST | 317 | |
Alternative sequenceiVSP_005435 | 665 – 969 | Missing in isoform PACE4D. 1 PublicationAdd BLAST | 305 | |
Alternative sequenceiVSP_005436 | 680 – 693 | AQSTP…ILQTS → G in isoform PACE4A-II and isoform PACE4E-II. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_005437 | 901 – 969 | CDENC…CLLAG → YGPPGGERQATVSSKGVPGG QSLSASSPGAGEGMLHHPTV DRSPFTELLRGLRPFVHWMH ICWVPAVGRHRAAAG in isoform PACE4E-I and isoform PACE4E-II. 1 PublicationAdd BLAST | 69 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000611716; ENSP00000482760; ENSG00000140479 [P29122-1] ENST00000611967; ENSP00000477768; ENSG00000140479 [P29122-4] ENST00000615296; ENSP00000478081; ENSG00000140479 [P29122-5] ENST00000618548; ENSP00000479496; ENSG00000140479 [P29122-2] |
GeneIDi | 5046 |
KEGGi | hsa:5046 |
UCSCi | uc032csi.2, human [P29122-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80482 mRNA Translation: AAA59998.1 AB001914 Genomic DNA Translation: BAA21620.1 AB001914 Genomic DNA Translation: BAA21621.1 AB001914 Genomic DNA Translation: BAA21622.1 AB001914 Genomic DNA Translation: BAA21623.1 AB001914 Genomic DNA Translation: BAA21624.1 AB001914 Genomic DNA Translation: BAA21625.1 AB001914 Genomic DNA Translation: BAA21626.1 AB001914 Genomic DNA Translation: BAA21627.1 D28513 mRNA Translation: BAA05871.1 D28514 mRNA Translation: BAA05872.1 D87995 mRNA Translation: BAA21793.1 D87993 mRNA Translation: BAA21791.1 D87994 mRNA Translation: BAA21792.1 |
CCDSi | CCDS73789.1 [P29122-2] CCDS73790.1 [P29122-1] CCDS73791.1 [P29122-5] CCDS73793.1 [P29122-4] |
PIRi | A39490 B39490 JC2191 JC2192 JC5570 JC5571 |
RefSeqi | NP_001278238.1, NM_001291309.1 NP_002561.1, NM_002570.4 [P29122-1] NP_612192.1, NM_138319.3 [P29122-2] NP_612195.1, NM_138322.3 [P29122-3] NP_612196.1, NM_138323.2 [P29122-5] NP_612197.1, NM_138324.2 [P29122-4] NP_612198.2, NM_138325.3 |
3D structure databases
SMRi | P29122 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111083, 11 interactors |
DIPi | DIP-29903N |
IntActi | P29122, 11 interactors |
STRINGi | 9606.ENSP00000482760 |
Chemistry databases
BindingDBi | P29122 |
ChEMBLi | CHEMBL2951 |
GuidetoPHARMACOLOGYi | 2386 |
Protein family/group databases
MEROPSi | S08.075 |
PTM databases
GlyGeni | P29122, 4 sites, 1 O-linked glycan (1 site) |
iPTMneti | P29122 |
PhosphoSitePlusi | P29122 |
Genetic variation databases
BioMutai | PCSK6 |
DMDMi | 129542 |
Proteomic databases
MassIVEi | P29122 |
MaxQBi | P29122 |
PaxDbi | P29122 |
PeptideAtlasi | P29122 |
PRIDEi | P29122 |
ProteomicsDBi | 54520 [P29122-1] 54521 [P29122-2] 54522 [P29122-3] 54523 [P29122-4] 54524 [P29122-5] 54525 [P29122-6] 54526 [P29122-7] 54527 [P29122-8] |
TopDownProteomicsi | P29122-3 [P29122-3] |
Protocols and materials databases
Antibodypediai | 1024, 310 antibodies |
Genome annotation databases
Ensembli | ENST00000611716; ENSP00000482760; ENSG00000140479 [P29122-1] ENST00000611967; ENSP00000477768; ENSG00000140479 [P29122-4] ENST00000615296; ENSP00000478081; ENSG00000140479 [P29122-5] ENST00000618548; ENSP00000479496; ENSG00000140479 [P29122-2] |
GeneIDi | 5046 |
KEGGi | hsa:5046 |
UCSCi | uc032csi.2, human [P29122-1] |
Organism-specific databases
CTDi | 5046 |
DisGeNETi | 5046 |
GeneCardsi | PCSK6 |
HGNCi | HGNC:8569, PCSK6 |
HPAi | ENSG00000140479, Tissue enhanced (brain, liver, lymphoid tissue) |
MIMi | 167405, gene |
neXtProti | NX_P29122 |
OpenTargetsi | ENSG00000140479 |
PharmGKBi | PA32895 |
VEuPathDBi | HostDB:ENSG00000140479.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3525, Eukaryota |
GeneTreei | ENSGT00940000159506 |
HOGENOMi | CLU_002976_4_1_1 |
InParanoidi | P29122 |
OrthoDBi | 308083at2759 |
PhylomeDBi | P29122 |
TreeFami | TF314277 |
Enzyme and pathway databases
BRENDAi | 3.4.21.B25, 2681 |
PathwayCommonsi | P29122 |
Reactomei | R-HSA-1181150, Signaling by NODAL R-HSA-167060, NGF processing R-HSA-6809371, Formation of the cornified envelope R-HSA-8963889, Assembly of active LPL and LIPC lipase complexes |
SignaLinki | P29122 |
SIGNORi | P29122 |
Miscellaneous databases
BioGRID-ORCSi | 5046, 6 hits in 126 CRISPR screens |
ChiTaRSi | PCSK6, human |
GeneWikii | PCSK6 |
GenomeRNAii | 5046 |
Pharosi | P29122, Tchem |
PROi | PR:P29122 |
RNActi | P29122, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140479, Expressed in C1 segment of cervical spinal cord and 212 other tissues |
ExpressionAtlasi | P29122, baseline and differential |
Genevisiblei | P29122, HS |
Family and domain databases
CDDi | cd00064, FU, 4 hits cd04059, Peptidases_S8_Protein_convertases_Kexins_Furin-like, 1 hit |
Gene3Di | 2.60.120.260, 1 hit 3.30.70.850, 1 hit 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR006212, Furin_repeat IPR008979, Galactose-bd-like_sf IPR032778, GF_recep_IV IPR009030, Growth_fac_rcpt_cys_sf IPR034182, Kexin/furin IPR002884, P_dom IPR000209, Peptidase_S8/S53_dom IPR036852, Peptidase_S8/S53_dom_sf IPR023827, Peptidase_S8_Asp-AS IPR022398, Peptidase_S8_His-AS IPR023828, Peptidase_S8_Ser-AS IPR015500, Peptidase_S8_subtilisin-rel IPR010909, PLAC IPR032815, S8_pro-domain IPR038466, S8_pro-domain_sf |
Pfami | View protein in Pfam PF14843, GF_recep_IV, 1 hit PF01483, P_proprotein, 1 hit PF00082, Peptidase_S8, 1 hit PF08686, PLAC, 1 hit PF16470, S8_pro-domain, 1 hit |
PRINTSi | PR00723, SUBTILISIN |
SMARTi | View protein in SMART SM00181, EGF, 5 hits SM00261, FU, 5 hits |
SUPFAMi | SSF49785, SSF49785, 1 hit SSF52743, SSF52743, 1 hit SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS51829, P_HOMO_B, 1 hit PS50900, PLAC, 1 hit PS51892, SUBTILASE, 1 hit PS00136, SUBTILASE_ASP, 1 hit PS00137, SUBTILASE_HIS, 1 hit PS00138, SUBTILASE_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCSK6_HUMAN | |
Accessioni | P29122Primary (citable) accession number: P29122 Secondary accession number(s): Q15099 Q9Y4H1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | February 10, 2021 | |
This is version 204 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families